IMP

Process View

Danio rerio

6 genes annotated in zebrafish

endocardial cushion development

The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "endocardial cushion development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "endocardial cushion development" (in gray)

Name	Description	Probability	Func Analog Organism
tbx1	T-box 1	1.000
bmp4	bone morphogenetic protein 4	0.974
fgf8a	fibroblast growth factor 8 a	0.710	Mouse
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.631
myod1	myogenic differentiation 1	0.466
hand2	heart and neural crest derivatives expressed transcript 2	0.452
bmp2b	bone morphogenetic protein 2b	0.423	Mouse
wnt11r	wingless-type MMTV integration site family, member 11, related	0.368
msxc	muscle segment homeobox C	0.294
cdh2	cadherin 2, neuronal	0.285
wnt5b	wingless-type MMTV integration site family, member 5b	0.273
ryk	receptor-like tyrosine kinase	0.271
fgf3	fibroblast growth factor 3	0.254
mib	mind bomb	0.248
shha	sonic hedgehog a	0.223
hnf1ba	HNF1 homeobox Ba	0.201
pax2a	paired box gene 2a	0.161
eya1	eyes absent homolog 1	0.146
alcama	activated leukocyte cell adhesion molecule a	0.119
lmo4a	LIM domain only 4a	0.105
msxd	muscle segment homeobox D	0.103
notch1b	notch homolog 1b	0.099	Mouse
ptch1	patched 1	0.097
tbx18	T-box 18	0.094
myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.094
met	met proto-oncogene (hepatocyte growth factor receptor)	0.086
notch2	notch homolog 2	0.081
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.077
myl7	myosin, light polypeptide 7, regulatory	0.072
rbfox1l	RNA binding protein, fox-1 homolog (C. elegans) 1-like	0.069
hmx4	H6 family homeobox 4	0.067
kdrl	kinase insert domain receptor like	0.064
atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	0.064
twist1a	twist1a	0.063
col1a1a	collagen, type I, alpha 1a	0.059
hey2	hairy/enhancer-of-split related with YRPW motif 2	0.057
oep	one-eyed pinhead	0.056
nkx2.5	NK2 transcription factor related 5	0.056
dlx2a	distal-less homeobox gene 2a	0.055
tnnc1a	troponin C type 1a (slow)	0.054
edn1	endothelin 1	0.054
desma	desmin a	0.054
erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog	0.053
bmp2a	bone morphogenetic protein 2a	0.052	Mouse
fgf10a	fibroblast growth factor 10a	0.049
rest	RE1-silencing transcription factor	0.048
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.047
gli2a	GLI-Kruppel family member GLI2a	0.046
bactin1	bactin1	0.045	Zebrafish
actc1a	actin, alpha, cardiac muscle 1a	0.045
eng2b	engrailed 2b	0.044
sox32	SRY-box containing gene 32	0.043
myf5	myogenic factor 5	0.042
wls	wntless homolog (Drosophila)	0.042
prkci	protein kinase C, iota	0.039
six2a	sine oculis-related homeobox 2a	0.038
pard6gb	par-6 partitioning defective 6 homolog gamma B (C. elegans)	0.038
tnnt2a	troponin T2a, cardiac	0.037
lef1	lymphocyte enhancer binding factor 1	0.036
ippk	inositol 1,3,4,5,6-pentakisphosphate 2-kinase	0.036
dlx5a	distal-less homeobox gene 5a	0.036
tbx16	T-box gene 16	0.035
aldoab	aldolase a, fructose-bisphosphate, b	0.034
tmem2	transmembrane protein 2	0.032
zgc:172136	zgc:172136	0.031
wnt11	wingless-type MMTV integration site family, member 11	0.031
lft2	lefty2	0.031
hoxa2b	homeo box A2b	0.030
fbn2b	fibrillin 2b	0.030
sox11b	SRY-box containing gene 11b	0.030
atoh1a	atonal homolog 1a	0.030
nog1	noggin 1	0.029
vmhc	ventricular myosin heavy chain	0.029
fsta	follistatin a	0.029
slc6a6	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	0.028
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.028
gcga	glucagon a and glucagon a-like	0.028
gsc	goosecoid	0.028
nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.027
gli1	GLI-Kruppel family member 1	0.027
zfand5a	zinc finger, AN1-type domain 5a	0.027
wnt1	wingless-type MMTV integration site family, member 1	0.026
cx43	connexin 43	0.026
smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.026
cdkn1c	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	0.026
ntla	no tail a	0.026
dlx3b	distal-less homeobox gene 3b	0.026
dld	deltaD	0.025
med12	mediator of RNA polymerase II transcription, subunit 12 homolog	0.025
rhoab	ras homolog gene family, member Ab	0.025
jag1b	jagged 1b	0.024	Mouse
hmgcrb	3-hydroxy-3-methylglutaryl-Coenzyme A reductase b	0.024
crip2	cysteine-rich protein 2	0.024
plcg1	phospholipase C, gamma 1	0.024
tpma	alpha-tropomyosin	0.023
ctgf	connective tissue growth factor	0.023
chd	chordin	0.023
myl10	myosin, light chain 10, regulatory	0.022
hsp47	heat shock protein 47	0.022
ptch2	patched 2	0.022
tfe3b	transcription factor binding to IGHM enhancer 3b	0.021
tbx2b	T-box 2b	0.021
tie1	endothelium-specific receptor tyrosine kinase 1	0.021
acta2	actin, alpha 2, smooth muscle, aorta	0.021	Zebrafish
sox10	SRY-box containing gene 10	0.021
cdx4	caudal type homeo box transcription factor 4	0.020
ckma	creatine kinase, muscle a	0.020
efnb2a	ephrin B2a	0.020
dlc	deltaC	0.020
gata5	GATA-binding protein 5	0.019
etv2	ets variant gene 2	0.019
tal1	T-cell acute lymphocytic leukemia 1	0.019
hspb7	heat shock protein family, alpha-crystallin-related, b7	0.019
nrarpa	notch-regulated ankyrin repeat protein a	0.019
mapk3	mitogen-activated protein kinase 3	0.019
mapk14a	mitogen-activated protein kinase 14a	0.018
gro1	groucho 1	0.018
dlx4b	distal-less homeobox gene 4b	0.018
sulf1	sulfatase 1	0.018
tagln	transgelin	0.017
pax6a	paired box gene 6a	0.017
eng1a	engrailed 1a	0.016
wu:fb99e06	wu:fb99e06	0.016
gpr126	G protein-coupled receptor 126	0.016
cdh5	cadherin 5	0.016
hoxa9b	homeo box A9b	0.016
stat1b	signal transducer and activator of transcription 1b	0.015
bmpr1aa	bone morphogenetic protein receptor, type 1aa	0.015	Mouse
fn1	fibronectin 1	0.015
gja3	gap junction protein, alpha 3	0.015
bhlhe40	basic helix-loop-helix family, member e40	0.015
vasa	vasa homolog	0.015
foxn4	forkhead box N4	0.015
wif1	wnt inhibitory factor 1	0.014
vcana	versican a	0.014
cmlc1	cardiac myosin light chain-1	0.014
cxcl12b	chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)	0.013
tp53	tumor protein p53	0.013
cp	ceruloplasmin	0.013
chsy1	chondroitin sulfate synthase 1	0.013
spns2	spinster homolog 2 (Drosophila)	0.013
foxi1	forkhead box I1	0.012
tll1	tolloid-like 1	0.012
gdnf	glial cell derived neurotrophic factor	0.012
her1	hairy-related 1	0.012
efemp2	EGF-containing fibulin-like extracellular matrix protein 2	0.012
nkx3.2	NK3 homeobox 2	0.012
nexn	nexilin (F actin binding protein)	0.011
tnnc2	troponin C type 2 (fast)	0.011
clic4	chloride intracellular channel 4	0.011
xirp1	xin actin-binding repeat containing 1	0.011
wnt10a	wingless-type MMTV integration site family, member 10a	0.011
ptenb	phosphatase and tensin homolog B (mutated in multiple advanced cancers 1)	0.011
cnn2	calponin 2	0.011
tgfb3	transforming growth factor, beta 3	0.011
rel	v-rel reticuloendotheliosis viral oncogene homolog	0.011
ednra	endothelin receptor type A	0.011
nos1	nitric oxide synthase 1 (neuronal)	0.011
dlb	deltaB	0.010
wnt8b	wingless-type MMTV integration site family, member 8b	0.010
frem2a	Fras1 related extracellular matrix protein 2a	0.010
fgf17	fibroblast growth factor 17	0.010
vasp	vasodilator-stimulated phosphoprotein	0.010