IMP

Process View

Danio rerio

18 genes annotated in zebrafish

pharyngeal system development

The process whose specific outcome is the progression of the pharyngeal system over time, from its formation to the mature structure. The pharyngeal system is a transient embryonic complex that is specific to vertebrates. It comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming: the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "pharyngeal system development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "pharyngeal system development" (in gray)

Name	Description	Probability	Func Analog Organism
tbx1	T-box 1	0.864
hnf1ba	HNF1 homeobox Ba	0.785
bmp2b	bone morphogenetic protein 2b	0.708
chd	chordin	0.538
dlc	deltaC	0.514
myf5	myogenic factor 5	0.502
myod1	myogenic differentiation 1	0.490
atoh1a	atonal homolog 1a	0.392	Zebrafish
fgf10a	fibroblast growth factor 10a	0.369
bmp4	bone morphogenetic protein 4	0.352
aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.322
tbx2a	T-box gene 2a	0.298
col2a1a	collagen type II, alpha-1a	0.277
atoh1b	atonal homolog 1b	0.273	Zebrafish
raraa	retinoic acid receptor, alpha a	0.271	Zebrafish
gbx2	gastrulation brain homeo box 2	0.262
bmp2a	bone morphogenetic protein 2a	0.259
nkx3.2	NK3 homeobox 2	0.254
wnt9b	wingless-type MMTV integration site family, member 9B	0.249	Zebrafish
kctd12.1	potassium channel tetramerisation domain containing 12.1	0.246
wnt5b	wingless-type MMTV integration site family, member 5b	0.243	Zebrafish
sema3aa	semaphorin 3aa	0.233
dacha	dachshund a	0.221
fgf3	fibroblast growth factor 3	0.221
hand2	heart and neural crest derivatives expressed transcript 2	0.214	Zebrafish
hoxd4a	homeo box D4a	0.198
tfap2a	transcription factor AP-2 alpha	0.189
msxc	muscle segment homeobox C	0.175
eya1	eyes absent homolog 1	0.172	Mouse
her1	hairy-related 1	0.171
six2a	sine oculis-related homeobox 2a	0.162
wnt11	wingless-type MMTV integration site family, member 11	0.158	Zebrafish
wnt2bb	wingless-type MMTV integration site family, member 2Bb	0.157	Zebrafish
msxe	muscle segment homeobox E	0.141
neurod4	neurogenic differentiation 4	0.139	Zebrafish
notch1a	notch homolog 1a	0.137
wnt4a	wingless-type MMTV integration site family, member 4a	0.135	Zebrafish
si:ch211-173o4.2	si:ch211-173o4.2	0.118
twist1a	twist1a	0.111
sox1a	SRY-box containing gene 1a	0.111
robo2	roundabout homolog 2	0.110
pax2a	paired box gene 2a	0.110
lratb	lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)	0.109
tp63	tumor protein p63	0.108
hoxb6a	homeo box B6a	0.106
grem2	gremlin 2, cysteine knot superfamily	0.102
flh	floating head	0.095
tbx24	T-box 24	0.095	Zebrafish
rxrga	retinoid x receptor, gamma a	0.094
meis2.1	myeloid ecotropic viral integration site 2.1	0.092
notch1b	notch homolog 1b	0.092
prrx1a	paired related homeobox 1a	0.090
dld	deltaD	0.090
mab21l2	mab-21-like 2	0.084
otx5	orthodenticle homolog 5	0.082
hoxa13b	homeo box A13b	0.081
foxi1	forkhead box I1	0.080
prdm1a	PR domain containing 1a, with ZNF domain	0.079
nkx2.2b	NK2 transcription factor related 2b	0.077
tbx18	T-box 18	0.074	Zebrafish
twist3	twist3	0.070	Zebrafish
foxg1a	forkhead box G1a	0.069
vsx1	visual system homeobox 1 homolog, chx10-like	0.069
cyp26a1	cytochrome P450, subfamily XXVIA, polypeptide 1	0.068
wnt8b	wingless-type MMTV integration site family, member 8b	0.067	Zebrafish
map2k4a	mitogen-activated protein kinase kinase 4a	0.067
hoxa2b	homeo box A2b	0.066
nppa	natriuretic peptide precursor A	0.066
lft1	lefty1	0.065
pold1	polymerase (DNA directed), delta 1, catalytic subunit	0.065
tbx6	T-box gene 6	0.065	Zebrafish
dmrt3a	doublesex and mab-3 related transcription factor 3a	0.063
wnt10b	wingless-type MMTV integration site family, member 10b	0.062	Zebrafish
otx1b	orthodenticle homolog 1b	0.062
rarab	retinoic acid receptor, alpha b	0.062	Zebrafish
unc5b	unc-5 homolog B (C. elegans)	0.061
rxraa	retinoid X receptor, alpha a	0.061
neurod6b	neurogenic differentiation 6b	0.061	Zebrafish
brpf1	bromodomain and PHD finger containing, 1	0.060
meis2.2	myeloid ecotropic viral integration site 2.2	0.060
tbx5a	T-box 5a	0.058	Zebrafish
pcdh10b	protocadherin 10b	0.058
wnt7aa	wingless-type MMTV integration site family, member 7Aa	0.058	Zebrafish
dlx2a	distal-less homeobox gene 2a	0.058
fgf8a	fibroblast growth factor 8 a	0.057
hmx3	homeo box (H6 family) 3	0.057
six4b	sine oculis homeobox homolog 4b	0.056	Mouse
dlx3b	distal-less homeobox gene 3b	0.056
hoxb5a	homeo box B5a	0.055
cyp26b1	cytochrome P450, family 26, subfamily b, polypeptide 1	0.054
vcanb	versican b	0.053
wnt2	wingless-type MMTV integration site family member 2	0.053	Zebrafish
rarga	retinoic acid receptor gamma a	0.053
dlx5a	distal-less homeobox gene 5a	0.053
cdkn1c	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	0.052
sox9a	SRY-box containing gene 9a	0.052
mef2a	myocyte enhancer factor 2a	0.051
otx2	orthodenticle homolog 2	0.050
rxrab	retinoid x receptor, alpha b	0.049
rx2	retinal homeobox gene 2	0.048
neurod6a	neurogenic differentiation 6a	0.048
dnmt5	DNA (cytosine-5-)-methyltransferase 5	0.048	Zebrafish
hoxa9a	homeo box A9a	0.047
fbln1	fibulin 1	0.046
eng2a	engrailed 2a	0.045
hmx4	H6 family homeobox 4	0.044
gli1	GLI-Kruppel family member 1	0.043
barx1	BarH-like homeobox 1	0.042
aldoca	aldolase C, fructose-bisphosphate, a	0.042
isl2a	islet2a	0.040
dnmt8	DNA (cytosine-5-)-methyltransferase 8	0.039
trpv4	transient receptor potential cation channel, subfamily V, member 4	0.039
myl7	myosin, light polypeptide 7, regulatory	0.038
rargb	retinoic acid receptor, gamma b	0.038	Zebrafish
ncam1b	neural cell adhesion molecule 1b	0.038
mef2d	myocyte enhancer factor 2d	0.038
igfbp3	insulin-like growth factor binding protein 3	0.037
hmx1	H6 homeo box 1	0.037
dcn	decorin	0.037
irx1a	iroquois homeobox protein 1, a	0.037
pdlim3b	PDZ and LIM domain 3b	0.037
hoxb1b	homeo box B1b	0.036
prox1	prospero-related homeobox gene 1	0.036
wnt9a	wingless-type MMTV integration site family, member 9A	0.036
chaf1b	chromatin assembly factor 1, subunit B	0.036
msxd	muscle segment homeobox D	0.035
ephb4b	eph receptor B4b	0.035
zbtb4	zinc finger and BTB domain containing 4	0.035
wu:fv91b12	wu:fv91b12	0.035
zeb2a	zinc finger E-box binding homeobox 2a	0.035
irx2a	iroquois homeobox protein 2, a	0.034
tcf21	transcription factor 21	0.033
egr1	early growth response 1	0.033
wnt3a	wingless-type MMTV integration site family, member 3A	0.033	Zebrafish
elk4	ELK4, ETS-domain protein	0.032
pcdh18b	protocadherin 18b	0.032
wnt1	wingless-type MMTV integration site family, member 1	0.032	Zebrafish
hoxb5b	homeo box B5b	0.032
evx1	even-skipped homeobox 1	0.032
hey2	hairy/enhancer-of-split related with YRPW motif 2	0.032
loxl3b	lysyl oxidase-like 3b	0.031
pax6a	paired box gene 6a	0.030
dnmt3	DNA (cytosine-5-)-methyltransferase 3	0.030
sox2	SRY-box containing gene 2	0.030
nkx2.5	NK2 transcription factor related 5	0.029
nr2e1	nuclear receptor subfamily 2, group E, member 1	0.029
her5	hairy-related 5	0.029
tbr1b	T-box, brain, 1b	0.029	Zebrafish
zic5	zic family member 5 (odd-paired homolog, Drosophila)	0.029
rx1	retinal homeobox gene 1	0.028
irx3a	iroquois homeobox protein 3a	0.028
LOC565256	similar to Metabotropic glutamate receptor 3 precursor (mGluR3)	0.028
lhx1b	LIM homeobox 1b	0.028
ptch1	patched 1	0.028
zgc:66382	zgc:66382	0.028
pdlim3a	PDZ and LIM domain 3a	0.028
pax6b	paired box gene 6b	0.027
pax3a	paired box gene 3a	0.027
twist1b	twist1b	0.027
hoxa13a	homeo box A13a	0.027
msxb	muscle segment homeobox B	0.027
syt9a	synaptotagmin IXa	0.026
gpr126	G protein-coupled receptor 126	0.026
cry3	cryptochrome 3	0.026
fn1	fibronectin 1	0.026
LOC100000500	sclerostin-like	0.026
loxl2b	lysyl oxidase-like 2b	0.026
jag2	jagged 2	0.025
hoxb2a	homeo box B2a	0.025
sid4	secreted immunoglobulin domain 4	0.025
nkx2.1b	NK2 homeobox 1b	0.025
hoxc6a	homeo box C6a	0.025
fli1a	friend leukemia integration 1a	0.025
melk	maternal embryonic leucine zipper kinase	0.025
epb4.1l4	erythrocyte protein band 4.1-like 4	0.025
meis3	myeloid ecotropic viral integration site 3	0.024	Zebrafish
hoxb3a	homeo box B3a	0.024
zgc:171802	zgc:171802	0.024
hoxa1a	homeo box A1a	0.024
nr1d2b	nuclear receptor subfamily 1, group D, member 2b	0.024	Zebrafish
klf4	Kruppel-like factor 4	0.024
pcdh18a	protocadherin 18a	0.024
sox9b	SRY-box containing gene 9b	0.024
lbx1a	ladybird homeobox 1a	0.024
klf4a	Kruppel-like transcription factor 4a	0.024
LOC556647	GDNF family receptor alpha-4-like	0.024
nr2e3	nuclear receptor subfamily 2, group E, member 3	0.023
lzts2a	leucine zipper, putative tumor suppressor 2a	0.023
mib	mind bomb	0.023
otomp	otolith matrix protein	0.023
per2	period homolog 2 (Drosophila)	0.022
pds5b	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.022
mafl	v-maf musculoaponeurotic fibrosarcoma (avian) oncogene family, protein L	0.022
mef2ca	myocyte enhancer factor 2ca	0.022
gata1a	GATA binding protein 1a	0.022
LOC566708	FL cytokine receptor-like	0.022
nrip1b	nuclear receptor interacting protein 1b	0.022
pcdh8	protocadherin 8	0.022
vasp	vasodilator-stimulated phosphoprotein	0.022
fgf4	fibroblast growth factor 4	0.022
zic1	zic family member 1 (odd-paired homolog, Drosophila)	0.022
metrn	meteorin, glial cell differentiation regulator	0.022
stmn2a	stathmin-like 2a	0.021
vsx2	visual system homeobox 2	0.021
barhl2	BarH-like 2	0.021
wif1	wnt inhibitory factor 1	0.021
gata2a	GATA-binding protein 2a	0.021
olfm2	olfactomedin 2	0.021
tll1	tolloid-like 1	0.021
nr3c1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.021
aldh1a3	aldehyde dehydrogenase 1 family, member A3	0.021
egr2b	early growth response 2b	0.021
cart1	cartilage paired-class homeoprotein 1	0.021
bhlhe22	basic helix-loop-helix family, member e22	0.020
hoxd11a	homeo box D11a	0.020
klf2a	Kruppel-like factor 2a	0.020
jam3b	junctional adhesion molecule 3b	0.020
hhip	hedgehog interacting protein	0.020
nfatc1	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1	0.020
epha4b	eph receptor A4b	0.020
atoh1c	atonal homolog 1c	0.019	Zebrafish
fgf24	fibroblast growth factor 24	0.019	Zebrafish
tp53inp1	tumor protein p53 inducible nuclear protein 1	0.019
nr1d2a	nuclear receptor subfamily 1, group D, member 2a	0.019	Zebrafish
zfyve26	zinc finger, FYVE domain containing 26	0.019
spaw	southpaw	0.019
igfbp6b	insulin-like growth factor binding protein 6b	0.018
si:dkey-236e20.2	si:dkey-236e20.2	0.018
barx2	BarH-like homeobox 2	0.018	Zebrafish
wnt3	wingless-type MMTV integration site family, member 3	0.018	Zebrafish
hapln3	hyaluronan and proteoglycan link protein 3	0.018
tbx2b	T-box 2b	0.018	Zebrafish
ahctf1	AT hook containing transcription factor 1	0.018
wnt11r	wingless-type MMTV integration site family, member 11, related	0.018	Zebrafish
plxnb2b	plexin b2b	0.018
wnt10a	wingless-type MMTV integration site family, member 10a	0.018	Zebrafish
gdf11	growth differentiation factor 11	0.018
and2	actinodin2	0.018
cdkn1a	cyclin-dependent kinase inhibitor 1A	0.017
egr2a	early growth response 2a	0.017
foxn4	forkhead box N4	0.017
tef	thyrotroph embryonic factor	0.017
fzd8a	frizzled homolog 8a	0.017
cyp1a	cytochrome P450, family 1, subfamily A	0.017
hmx2	H6 family homeobox 2	0.017
smc2	structural maintenance of chromosomes 2	0.017
osr2	odd-skipped related 2 (Drosophila)	0.017
ulk2	unc-51-like kinase 2 (C. elegans)	0.017
wu:fb01h12	wu:fb01h12	0.017
trpc5	transient receptor potential cation channel, subfamily C, member 5	0.017
cbfb	core-binding factor, beta subunit	0.017
tfap2c	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.017
tnc	tenascin C	0.017
tbx16	T-box gene 16	0.017	Zebrafish
hoxb6b	homeo box B6b	0.017
szl	sizzled	0.017
mych	myelocytomatosis oncogene homolog	0.016
prtga	protogenin homolog a (Gallus gallus)	0.016
si:dkeyp-34c12.2	si:dkeyp-34c12.2	0.016
sass6	spindle assembly 6 homolog (C. elegans)	0.016
met	met proto-oncogene (hepatocyte growth factor receptor)	0.016
utx	ubiquitously transcribed tetratricopeptide repeat, X chromosome	0.016
mitfa	microphthalmia-associated transcription factor a	0.016
myo6b	myosin VIb	0.016
ctsk	cathepsin K	0.016
tbx3	T-box 3	0.016	Zebrafish
fsta	follistatin a	0.016
wu:fj52c07	wu:fj52c07	0.016
mespb	mesoderm posterior b	0.015
notch2	notch homolog 2	0.015
eng1a	engrailed 1a	0.015
ptger4a	prostaglandin E receptor 4 (subtype EP4) a	0.015
oep	one-eyed pinhead	0.015
arpc1b	actin related protein 2/3 complex, subunit 1B	0.015
mespa	mesoderm posterior a	0.015
pitx3	paired-like homeodomain transcription factor 3	0.015
npy8br	neuropeptide Y receptor Y8b	0.015
hey1	hairy/enhancer-of-split related with YRPW motif 1	0.015
hbbe3	hemoglobin beta embryonic-3	0.015
prrx1b	paired related homeobox 1b	0.015
atp1a2a	ATPase, Na+/K+ transporting, alpha 2a polypeptide	0.015
adarb1	adenosine deaminase, RNA-specific, B1	0.015
mapk12	mitogen-activated protein kinase 12	0.015
xylt1	xylosyltransferase 1	0.015
atoh7	atonal homolog 7	0.015	Zebrafish
zgc:77517	zgc:77517	0.014
baxb	bcl2-associated X protein, b	0.014
six4a	sine oculis homeobox homolog 4a	0.014
ascl1a	achaete-scute complex-like 1a (Drosophila)	0.014
tfap2b	transcription factor AP-2 beta	0.014
hoxa11b	homeo box A11b	0.014
trpc1	transient receptor potential cation channel, subfamily C, member 1	0.014
dlx6a	distal-less homeobox gene 6a	0.014
LOC100331502	melanopsin-B-like	0.014
ggct	gamma-glutamyl cyclotransferase	0.014
fezf2	FEZ family zinc finger 2	0.014
igfbp1b	insulin-like growth factor binding protein 1b	0.014	Zebrafish
nr1h5	nuclear receptor subfamily 1, group H, member 5	0.014
dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.014
pvrl1b	poliovirus receptor-related 1b	0.014
sox11a	SRY-box containing gene 11a	0.014
large	like-glycosyltransferase	0.014
rest	RE1-silencing transcription factor	0.014
bmp3	bone morphogenetic protein 3	0.014
fgf18a	fibroblast growth factor 18a	0.014
pwp2h	PWP2 periodic tryptophan protein homolog (yeast)	0.014
appl2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	0.014
olfm3a	olfactomedin 3a	0.013
kal1a	Kallmann syndrome 1a sequence	0.013
hgd	homogentisate 1,2-dioxygenase	0.013
pou3f3b	POU class 3 homeobox 3b	0.013
igf1rb	insulin-like growth factor 1b receptor	0.013
pomt2	protein-O-mannosyltransferase 2	0.013
lhx5	LIM homeobox 5	0.013
gli2b	GLI-Kruppel family member GLI2b	0.013
irx5a	iroquois homeobox protein 5a	0.013
slc27a2	solute carrier family 27 (fatty acid transporter), member 2	0.013
her7	hairy and enhancer of split related-7	0.013
c8a	complement component 8, alpha polypeptide	0.013
crx	cone-rod homeobox	0.013
tnfsf10l3	tumor necrosis factor (ligand) superfamily, member 10 like 3	0.013
hoxc1a	homeo box C1a	0.013
rbfox1l	RNA binding protein, fox-1 homolog (C. elegans) 1-like	0.013
plcb3	phospholipase C, beta 3 (phosphatidylinositol-specific)	0.013
dmrt2a	doublesex and mab-3 related transcription factor 2a	0.013
pou3f2	POU class 3 homeobox 2	0.013
jam2b	junctional adhesion molecule 2b	0.013
rbp4	retinol binding protein 4, plasma	0.012
tmem178	transmembrane protein 178	0.012
foxa1	forkhead box A1	0.012
thrab	thyroid hormone receptor alpha b	0.012	Zebrafish
gad2	glutamate decarboxylase 2	0.012
fgf8b	fibroblast growth factor 8 b	0.012	Zebrafish Mouse
LOC100003330	melanocortin-2 receptor accessory protein 2-like	0.012
si:dkey-273o13.1	si:dkey-273o13.1	0.012
clrn1	clarin 1	0.012
LOC100536175	cortexin-2-like	0.012
kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2	0.012
ppargc1al	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha like	0.012
hes6	hairy and enhancer of split 6 (Drosophila)	0.012
hoxa3a	homeo box A3a	0.012
zgc:73189	zgc:73189	0.012
vars	valyl-tRNA synthetase	0.012
pacsin3	protein kinase C and casein kinase substrate in neurons 3	0.012
smc3	structural maintenance of chromosomes 3	0.012
tcf12	transcription factor 12	0.012
alcama	activated leukocyte cell adhesion molecule a	0.012
tgfbi	transforming growth factor, beta-induced	0.012
spry1	sprouty homolog 1 (Drosophila)	0.011
mycl1a	v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) a	0.011
col5a1	procollagen, type V, alpha 1	0.011
gro1	groucho 1	0.011
fos	v-fos FBJ murine osteosarcoma viral oncogene homolog	0.011
ptger4b	prostaglandin E receptor 4 (subtype EP4) b	0.011
foxo3b	forkhead box O3b	0.011
ptger2a	prostaglandin E receptor 2a (subtype EP2)	0.011
satb2	SATB homeobox 2	0.011
hoxa5a	homeo box A5a	0.011
tbx5b	T-box 5b	0.011
csnk1g2a	casein kinase 1, gamma 2a	0.011
LOC100002342	carboxypeptidase A6-like	0.011
hsf2	heat shock factor 2	0.011
rbpms2	RNA binding protein with multiple splicing 2	0.011
smc4	structural maintenance of chromosomes 4	0.011
tfr1a	transferrin receptor 1a	0.011
hoxc8a	homeo box C8a	0.011
robo1	roundabout homolog 1	0.011
kal1b	Kallmann syndrome 1b sequence	0.011
sox3	SRY-box containing gene 3	0.011
cenph	centromere protein H	0.011
map2k4b	mitogen-activated protein kinase kinase 4b	0.010
sfrp1a	secreted frizzled-related protein 1a	0.010
lhx2b	LIM homeobox 2b	0.010
cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.010
cdh6	cadherin 6	0.010
rbfox2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.010
fbxl14b	F-box and leucine-rich repeat protein 14b	0.010
slc25a37	solute carrier family 25, member 37	0.010
dmbx1b	diencephalon/mesencephalon homeobox 1b	0.010
e2f5	E2F transcription factor 5	0.010
csrp3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.010
mapk1	mitogen-activated protein kinase 1	0.010
gng7	guanine nucleotide binding protein (G protein), gamma 7	0.010
thoc1	THO complex 1	0.010
zgc:136894	zgc:136894	0.010
uxs1	UDP-glucuronic acid decarboxylase 1	0.010