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Danio rerio

12 genes annotated in zebrafish

mesodermal cell fate specification

The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "mesodermal cell fate specification"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "mesodermal cell fate specification" (in gray)

Name	Description	Probability	Func Analog Organism
chd	chordin	0.992
foxi1	forkhead box I1	0.944
hoxb3a	homeo box B3a	0.937	Zebrafish
pax2a	paired box gene 2a	0.857	Mouse
six4b	sine oculis homeobox homolog 4b	0.834	Worm
gli1	GLI-Kruppel family member 1	0.804
flh	floating head	0.789
tbx1	T-box 1	0.775
bmp4	bone morphogenetic protein 4	0.726
pax8	paired box gene 8	0.710
hoxa2b	homeo box A2b	0.695
mib	mind bomb	0.691
shha	sonic hedgehog a	0.672
ved	ventrally expressed dharma/bozozok antagonist	0.663
eya1	eyes absent homolog 1	0.620	Mouse Worm
hnf1ba	HNF1 homeobox Ba	0.605
ndr2	nodal-related 2	0.588
msxc	muscle segment homeobox C	0.579
tfap2a	transcription factor AP-2 alpha	0.556
dharma	dharma	0.544
hoxb2a	homeo box B2a	0.506
pcdh8	protocadherin 8	0.490
vent	ventral expressed homeobox	0.446
hoxa11a	homeo box A11a	0.442
tbx16	T-box gene 16	0.422
her5	hairy-related 5	0.396
oep	one-eyed pinhead	0.391
hmx4	H6 family homeobox 4	0.379	Worm
hoxd4a	homeo box D4a	0.377
foxg1a	forkhead box G1a	0.375
irx7	iroquois homeobox protein 7	0.359
hoxb5a	homeo box B5a	0.355
hoxa3a	homeo box A3a	0.343	Zebrafish
tll1	tolloid-like 1	0.336
her7	hairy and enhancer of split related-7	0.332
hoxb4a	homeo box B4a	0.312
mab21l2	mab-21-like 2	0.306
lhx5	LIM homeobox 5	0.303
tbx6	T-box gene 6	0.302
bmp7a	bone morphogenetic protein 7a	0.277
flot2a	flotillin 2a	0.277
foxd5	forkhead box D5	0.267
eng2b	engrailed 2b	0.260
fgf3	fibroblast growth factor 3	0.254
tbx18	T-box 18	0.254
bmp2b	bone morphogenetic protein 2b	0.246	Zebrafish
epha7	eph receptor A7	0.245
irx1a	iroquois homeobox protein 1, a	0.237
vox	ventral homeobox	0.236
lfng	lunatic fringe homolog	0.217
wnt5b	wingless-type MMTV integration site family, member 5b	0.216
gbx2	gastrulation brain homeo box 2	0.204
hoxb1b	homeo box B1b	0.204
tcf7l1a	transcription factor 7-like 1a (T-cell specific, HMG-box)	0.204
sox3	SRY-box containing gene 3	0.203
tbx2b	T-box 2b	0.201
gata3	GATA-binding protein 3	0.198
irx5a	iroquois homeobox protein 5a	0.190
neurod4	neurogenic differentiation 4	0.186
dlx4b	distal-less homeobox gene 4b	0.185
eve1	even-skipped-like1	0.184
cdx4	caudal type homeo box transcription factor 4	0.177
efnb3b	ephrin B3b	0.174
sox1a	SRY-box containing gene 1a	0.169
msxe	muscle segment homeobox E	0.163
dlx3b	distal-less homeobox gene 3b	0.160
hoxb5b	homeo box B5b	0.160
sox2	SRY-box containing gene 2	0.152
sall4	sal-like 4 (Drosophila)	0.151
notch1a	notch homolog 1a	0.147
mespa	mesoderm posterior a	0.143	Mouse
mespb	mesoderm posterior b	0.138	Mouse
smo	smoothened homolog (Drosophila)	0.135
dbx1b	developing brain homeobox 1b	0.131
hmx3	homeo box (H6 family) 3	0.130	Worm
hey1	hairy/enhancer-of-split related with YRPW motif 1	0.128
nkx2.2a	NK2 transcription factor related 2a	0.128
emx3	empty spiracles homeobox 3	0.127
lhx1b	LIM homeobox 1b	0.126
vsx2	visual system homeobox 2	0.125	Zebrafish
fgf8b	fibroblast growth factor 8 b	0.123
epb4.1l4	erythrocyte protein band 4.1-like 4	0.121
notch3	notch homolog 3	0.120	Zebrafish
admp	anti-dorsalizing morphogenic protein	0.119
isl1	islet1	0.117
ephb4b	eph receptor B4b	0.106
vax2	ventral anterior homeobox 2	0.106
hbbe3	hemoglobin beta embryonic-3	0.105
her6	hairy-related 6	0.104
notch2	notch homolog 2	0.098	Zebrafish
hoxb8a	homeo box B8a	0.097
fgf8a	fibroblast growth factor 8 a	0.097
pdzrn3	PDZ domain containing RING finger 3 and PDZ domain containing ring finger 3	0.096
fgf10a	fibroblast growth factor 10a	0.096
hoxc6a	homeo box C6a	0.094
sp5l	Sp5 transcription factor-like	0.091
foxb1.2	forkhead box B1.2	0.089
gli2a	GLI-Kruppel family member GLI2a	0.089
irx1b	iroquois homeobox protein 1, b	0.088
vangl2	vang-like 2 (van gogh, Drosophila)	0.087
meis2.2	myeloid ecotropic viral integration site 2.2	0.083
foxh1	forkhead box H1	0.082
raraa	retinoic acid receptor, alpha a	0.080
ext1a	exostoses (multiple) 1a	0.079
zic1	zic family member 1 (odd-paired homolog, Drosophila)	0.079
jag2	jagged 2	0.079
myl7	myosin, light polypeptide 7, regulatory	0.076
tbx24	T-box 24	0.075
znfl2a	zinc finger-like gene 2a	0.073
fgfr1a	fibroblast growth factor receptor 1a	0.072	Mouse
boc	brother of CDO	0.072
wif1	wnt inhibitory factor 1	0.071
efna5a	ephrin A5a	0.071
alas2	aminolevulinate, delta-, synthetase 2	0.071
fzd5	frizzled homolog 5	0.070
eng2a	engrailed 2a	0.070
pou3f3b	POU class 3 homeobox 3b	0.068
tbx15	T-box 15	0.068
tbx5a	T-box 5a	0.066
ephb3a	eph receptor B3a	0.065
snai1b	snail homolog 1b (Drosophila)	0.064
hoxb6a	homeo box B6a	0.064
gata2a	GATA-binding protein 2a	0.063
wnt11	wingless-type MMTV integration site family, member 11	0.062
foxn4	forkhead box N4	0.062
pax6a	paired box gene 6a	0.061
plagl2	pleiomorphic adenoma gene-like 2	0.061
spaw	southpaw	0.060
vsx1	visual system homeobox 1 homolog, chx10-like	0.059
dact2	dapper homolog 2, antagonist of beta-catenin (xenopus)	0.058
mecom	MDS1 and EVI1 complex locus	0.058
otx1a	orthodenticle homolog 1a	0.057
rx2	retinal homeobox gene 2	0.056
ascl1b	achaete-scute complex-like 1b (Drosophila)	0.056
dbx1a	developing brain homeobox 1a	0.056
inka1a	induced in neural crest by AP2, 1a	0.056
six1b	sine oculis homeobox homolog 1b	0.055
dla	deltaA	0.055
tbx20	T-box 20	0.055
tp63	tumor protein p63	0.054
nkd1	naked cuticle homolog 1 (Drosophila)	0.053
cyp26c1	cytochrome P450, family 26, subfamily C, polypeptide 1	0.052
nog2	noggin 2	0.052
dhrs3a	dehydrogenase/reductase (SDR family) member 3a	0.051
lft1	lefty1	0.051
tfap2c	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	0.050
six4a	sine oculis homeobox homolog 4a	0.050
szl	sizzled	0.049
fzd8a	frizzled homolog 8a	0.049
met	met proto-oncogene (hepatocyte growth factor receptor)	0.048
wnt4a	wingless-type MMTV integration site family, member 4a	0.048
chrna2a	cholinergic receptor, nicotinic, alpha polypeptide 2a (neuronal)	0.047
isl2a	islet2a	0.047
mab21l1	mab-21-like 1	0.046
gdf6b	growth differentiation factor 6b	0.045
nog1	noggin 1	0.044
gpc4	glypican 4	0.044
col8a1a	collagen, type VIII, alpha 1a	0.044
her1	hairy-related 1	0.043
dkk1b	dickkopf 1b	0.043
znf503	zinc finger protein 503	0.043
crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.042
pitx2	paired-like homeodomain transcription factor 2	0.042
sox19a	SRY-box containing gene 19a	0.042
neo1	neogenin 1	0.041
pax6b	paired box gene 6b	0.040
hoxa4a	homeo box A4a	0.040
ephb4a	eph receptor B4a	0.040
wnt8b	wingless-type MMTV integration site family, member 8b	0.040
dld	deltaD	0.039
cdh2	cadherin 2, neuronal	0.039
gli2b	GLI-Kruppel family member GLI2b	0.038
zfp36l1a	zinc finger protein 36, C3H type-like 1a	0.038
nkx1.2la	NK1 transcription factor related 2-like,a	0.035
znf703	zinc finger protein 703	0.035
dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.035
cobl	cordon-bleu homolog (mouse)	0.034
mnx1	motor neuron and pancreas homeobox 1	0.034
atoh1a	atonal homolog 1a	0.033
gata4	GATA-binding protein 4	0.033
hoxc4a	homeo box C4a	0.032
smad1	MAD homolog 1 (Drosophila)	0.032
hesx1	homeo box (expressed in ES cells) 1	0.032
irx4b	iroquois homeobox protein 4b	0.031
hey2	hairy/enhancer-of-split related with YRPW motif 2	0.030
cyp26a1	cytochrome P450, subfamily XXVIA, polypeptide 1	0.030
cyp26b1	cytochrome P450, family 26, subfamily b, polypeptide 1	0.030
runx3	runt-related transcription factor 3	0.029
fgfr4	fibroblast growth factor receptor 4	0.029
nrarpb	notch-regulated ankyrin repeat protein b	0.029
irx3a	iroquois homeobox protein 3a	0.028
twist1a	twist1a	0.028	Worm
her3	hairy-related 3	0.028
nr2f1a	nuclear receptor subfamily 2, group F, member 1a	0.028
pou5f1	POU domain, class 5, transcription factor 1	0.028
krt4	keratin 4	0.027
hbbe2	hemoglobin beta embryonic-2	0.027
sox9b	SRY-box containing gene 9b	0.027
lhx3	LIM homeobox 3	0.027
rarga	retinoic acid receptor gamma a	0.027
six2a	sine oculis-related homeobox 2a	0.026	Mouse
hoxd13a	homeo box D13a	0.026
tlx2	T-cell leukemia, homeobox 2	0.026
zic2a	zic family member 2 (odd-paired homolog, Drosophila), a	0.026
col27a1a	collagen, type XXVII, alpha 1a	0.025
rx3	retinal homeobox gene 3	0.025
epb41	erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)	0.025
rorb	RAR-related orphan receptor B	0.025
fgf24	fibroblast growth factor 24	0.025
frem3	Fras1 related extracellular matrix 3	0.024
zbtb16a	zinc finger and BTB domain containing 16a	0.024
cyp11a1	cytochrome P450, subfamily XIA, polypeptide 1	0.024
bmpr1aa	bone morphogenetic protein receptor, type 1aa	0.024	Mouse
sema3h	semaphorin 3h	0.024
tbx5b	T-box 5b	0.023
epha4a	eph receptor A4a	0.023
plekhh1	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	0.023
lft2	lefty2	0.023
odz4	odd Oz/ten-m homolog 4	0.023
cap1	Cap1 CAP, adenylate cyclase-associated protein 1	0.023
axin1	axin 1	0.023
tal1	T-cell acute lymphocytic leukemia 1	0.023
fzd10	frizzled homolog 10	0.022
prdm1a	PR domain containing 1a, with ZNF domain	0.022
foxa1	forkhead box A1	0.022
scn12ab	sodium channel, voltage gated, type XII, alpha b	0.021
jag1b	jagged 1b	0.021
sox32	SRY-box containing gene 32	0.020	Mouse
LOC100000500	sclerostin-like	0.020
zic2b	zic family member 2 (odd-paired homolog, Drosophila) b	0.020
drl	draculin	0.020
elk4	ELK4, ETS-domain protein	0.020
slc6a6	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	0.020
emx1	empty spiracles homeobox 1	0.020
hhex	hematopoietically expressed homeobox	0.019
coe2	coe2	0.019
rest	RE1-silencing transcription factor	0.019
msxb	muscle segment homeobox B	0.019
mafl	v-maf musculoaponeurotic fibrosarcoma (avian) oncogene family, protein L	0.019
insm1b	insulinoma-associated 1b	0.019
hoxd10a	homeo box D10a	0.018
nfatc4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.018
lmo4a	LIM domain only 4a	0.018
loxl2b	lysyl oxidase-like 2b	0.018
gbx1	gastrulation brain homeobox 1	0.018
gsc	goosecoid	0.017
ier2	immediate early response 2	0.017
fgfr2	fibroblast growth factor receptor 2	0.017
irx5b	iroquois homeobox protein 5b	0.017
pnx	posterior neuron-specific homeobox	0.016
stm	starmaker	0.016
wnt4b	wingless-type MMTV integration site family, member 4b	0.016
myo10l1	myosin X-like 1	0.016
meis2.1	myeloid ecotropic viral integration site 2.1	0.016
hoxa9b	homeo box A9b	0.016
brd4	bromodomain containing 4	0.016
notum3	notum 3	0.016
zic4	zic family member 4	0.015
pcdh18a	protocadherin 18a	0.015
eya4	eyes absent homolog 4 (Drosophila)	0.015	Worm
dmrt3a	doublesex and mab-3 related transcription factor 3a	0.015
epha4b	eph receptor A4b	0.015
sp7	Sp7 transcription factor	0.015
gyltl1b	glycosyltransferase-like 1b	0.015
nkx2.7	NK2 transcription factor related 7	0.014
hoxa9a	homeo box A9a	0.014
srf	serum response factor	0.014
tnfrsfa	tumor necrosis factor receptor superfamily, member a	0.014
nr2e1	nuclear receptor subfamily 2, group E, member 1	0.014
ahi1	Abelson helper integration site 1	0.014
nt5c2l1	5'-nucleotidase, cytosolic II, like 1	0.014
myod1	myogenic differentiation 1	0.014
hoxc1a	homeo box C1a	0.014
otpb	orthopedia homolog b	0.014
meis3	myeloid ecotropic viral integration site 3	0.014	Worm
ntla	no tail a	0.014
tpbgl	trophoblast glycoprotein-like	0.014
egfl6	EGF-like-domain, multiple 6	0.013
pax5	paired box gene 5	0.013
eng1a	engrailed 1a	0.013
sc:d411	sc:d411	0.013
runx2b	runt-related transcription factor 2b	0.013
hoxb1a	homeo box B1a	0.013
msgn1	mesogenin 1	0.013
pid1	phosphotyrosine interaction domain containing 1	0.013
etv2	ets variant gene 2	0.013
rarab	retinoic acid receptor, alpha b	0.012
olig3	oligodendrocyte transcription factor 3	0.012
rgma	RGM domain family, member A	0.012	Worm
irx4a	iroquois homeobox protein 4a	0.012
gdnf	glial cell derived neurotrophic factor	0.012
fbln1	fibulin 1	0.012
tuba1l	tubulin, alpha 1, like	0.012
mib2	mind bomb 2	0.012
nkx6.1	NK6 transcription factor related, locus 1 (Drosophila)	0.012
pou3f3a	POU class 3 homeobox 3a	0.012
grhl2b	grainyhead-like 2b (Drosophila)	0.012
nkx2.5	NK2 transcription factor related 5	0.012
sulf2	sulfatase 2	0.012
sox21a	SRY-box containing gene 21a	0.012
nkx2.3	NK2 transcription factor related 3	0.012
nkx3.2	NK3 homeobox 2	0.012
hmx2	H6 family homeobox 2	0.011
tnnt2a	troponin T2a, cardiac	0.011
hlxb9la	homeo box HB9 like a	0.011
dnmt3	DNA (cytosine-5-)-methyltransferase 3	0.011
LOC100536023	hypothetical protein LOC100536023	0.011
zgc:153997	zgc:153997	0.011
crabp2b	cellular retinoic acid binding protein 2, b	0.011
mpp5a	membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)	0.010
snai2	snail homolog 2 (Drosophila)	0.010
fstl1b	follistatin-like 1b	0.010
barhl2	BarH-like 2	0.010
rad21	RAD21 homolog (S. pombe)	0.010
notch1b	notch homolog 1b	0.010	Zebrafish
tjp1	tight junction protein 1 (zona occludens 1)	0.010
rx1	retinal homeobox gene 1	0.010
hbae3	hemoglobin alpha embryonic-3	0.010
wu:fv91b12	wu:fv91b12	0.010