IMP

Process View

Homo sapiens

2 genes annotated in human

embryonic skeletal joint development

The process, occurring during the embryonic phase, whose specific outcome is the progression of the skeletal joints over time, from formation to mature structure.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "embryonic skeletal joint development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "embryonic skeletal joint development" (in gray)

Name	Description	Probability	Func Analog Organism
COL3A1	collagen, type III, alpha 1	0.998	Human
COL4A1	collagen, type IV, alpha 1	0.992
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.989
COL1A1	collagen, type I, alpha 1	0.985	Human
SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	0.982
COL5A1	collagen, type V, alpha 1	0.976	Human
COL1A2	collagen, type I, alpha 2	0.972	Human
TJP1	tight junction protein 1 (zona occludens 1)	0.971
DDR2	discoidin domain receptor tyrosine kinase 2	0.921
COL5A2	collagen, type V, alpha 2	0.911	Human
COL4A2	collagen, type IV, alpha 2	0.905
LOX	lysyl oxidase	0.510
SMAD7	SMAD family member 7	0.484
COL6A1	collagen, type VI, alpha 1	0.450
PXDN	peroxidasin homolog (Drosophila)	0.425
APC	adenomatous polyposis coli	0.356
POSTN	periostin, osteoblast specific factor	0.340
GSK3B	glycogen synthase kinase 3 beta	0.286
CSNK1E	casein kinase 1, epsilon	0.279
LAMB1	laminin, beta 1	0.231
BMP2	bone morphogenetic protein 2	0.216
BMP7	bone morphogenetic protein 7	0.206	Mouse
OCLN	occludin	0.185
COL16A1	collagen, type XVI, alpha 1	0.175
NOG	noggin	0.169
COL11A1	collagen, type XI, alpha 1	0.164	Human
GLIS2	GLIS family zinc finger 2	0.155
COL6A3	collagen, type VI, alpha 3	0.153
ADAM12	ADAM metallopeptidase domain 12	0.151
NID2	nidogen 2 (osteonidogen)	0.149
FSTL1	follistatin-like 1	0.141
MXRA5	matrix-remodelling associated 5	0.131
TCF4	transcription factor 4	0.127
THY1	Thy-1 cell surface antigen	0.124
HOXA10	homeobox A10	0.118
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.111
FNDC1	fibronectin type III domain containing 1	0.101
NID1	nidogen 1	0.094
ZFYVE9	zinc finger, FYVE domain containing 9	0.092
COL6A2	collagen, type VI, alpha 2	0.090
COL2A1	collagen, type II, alpha 1	0.089
UNC5B	unc-5 homolog B (C. elegans)	0.086
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.078
YAP1	Yes-associated protein 1	0.077
BTRC	beta-transducin repeat containing	0.076
COL7A1	collagen, type VII, alpha 1	0.072
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.069
CAV2	caveolin 2	0.066
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.061
BGN	biglycan	0.058
EMD	emerin	0.056
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.055
DVL2	dishevelled, dsh homolog 2 (Drosophila)	0.051
MFAP2	microfibrillar-associated protein 2	0.050
COL18A1	collagen, type XVIII, alpha 1	0.049
TWIST1	twist homolog 1 (Drosophila)	0.049
CTHRC1	collagen triple helix repeat containing 1	0.049
ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)	0.048
TJP2	tight junction protein 2 (zona occludens 2)	0.043
IGFBP3	insulin-like growth factor binding protein 3	0.043
SOX11	SRY (sex determining region Y)-box 11	0.042
CDC42BPB	CDC42 binding protein kinase beta (DMPK-like)	0.042
WWTR1	WW domain containing transcription regulator 1	0.041
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.041
PLXDC1	plexin domain containing 1	0.040
BMPR1A	bone morphogenetic protein receptor, type IA	0.039
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.039
AR	androgen receptor	0.038
PTK7	PTK7 protein tyrosine kinase 7	0.037
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.034
PDGFA	platelet-derived growth factor alpha polypeptide	0.034
HOXC6	homeobox C6	0.033
CAV1	caveolin 1, caveolae protein, 22kDa	0.033
CNTF	ciliary neurotrophic factor	0.031
COL10A1	collagen, type X, alpha 1	0.031
MCC	mutated in colorectal cancers	0.031
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.030
LTBP1	latent transforming growth factor beta binding protein 1	0.030
FERMT2	fermitin family member 2	0.028
CD248	CD248 molecule, endosialin	0.028
HOXB5	homeobox B5	0.027
DACT1	dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)	0.027
VMP1	vacuole membrane protein 1	0.027
FOXF2	forkhead box F2	0.027
SMO	smoothened homolog (Drosophila)	0.026
DAXX	death-domain associated protein	0.025
HOXC10	homeobox C10	0.025
COL12A1	collagen, type XII, alpha 1	0.025
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.025
OLFML3	olfactomedin-like 3	0.025
PRKCDBP	protein kinase C, delta binding protein	0.025
FKBP10	FK506 binding protein 10, 65 kDa	0.025
GLT8D2	glycosyltransferase 8 domain containing 2	0.024
HOXD13	homeobox D13	0.024
CRMP1	collapsin response mediator protein 1	0.023
TGFB1I1	transforming growth factor beta 1 induced transcript 1	0.023
GJD3	gap junction protein, delta 3, 31.9kDa	0.023
FBN1	fibrillin 1	0.022
LOXL1	lysyl oxidase-like 1	0.022
MXRA8	matrix-remodelling associated 8	0.021
HOXD9	homeobox D9	0.021
GSK3A	glycogen synthase kinase 3 alpha	0.021
SFRP2	secreted frizzled-related protein 2	0.020
EDNRA	endothelin receptor type A	0.020
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.020
LRP6	low density lipoprotein receptor-related protein 6	0.020
MAX	MYC associated factor X	0.020
HES1	hairy and enhancer of split 1, (Drosophila)	0.020
MSX1	msh homeobox 1	0.019
LUM	lumican	0.018
GREM1	gremlin 1	0.018
WISP1	WNT1 inducible signaling pathway protein 1	0.018
COL5A3	collagen, type V, alpha 3	0.018	Human
LRRC17	leucine rich repeat containing 17	0.018
HOXC13	homeobox C13	0.017
COCH	coagulation factor C homolog, cochlin (Limulus polyphemus)	0.017
SKP1	S-phase kinase-associated protein 1	0.017
HOXD10	homeobox D10	0.017
HOXA13	homeobox A13	0.016
GPR124	G protein-coupled receptor 124	0.016
LOXL2	lysyl oxidase-like 2	0.016
PMEPA1	prostate transmembrane protein, androgen induced 1	0.016
SULF1	sulfatase 1	0.016
COL9A1	collagen, type IX, alpha 1	0.015
PDGFRL	platelet-derived growth factor receptor-like	0.015
FAM110C	family with sequence similarity 110, member C	0.015
ANGPTL2	angiopoietin-like 2	0.015
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.015
PKP4	plakophilin 4	0.015
HYAL1	hyaluronoglucosaminidase 1	0.015
HOXC5	homeobox C5	0.015
COL8A2	collagen, type VIII, alpha 2	0.015
HOXB9	homeobox B9	0.014
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.014
FAM83D	family with sequence similarity 83, member D	0.014
SFRP4	secreted frizzled-related protein 4	0.014
DLX4	distal-less homeobox 4	0.014
FBXW11	F-box and WD repeat domain containing 11	0.014
FAM110A	family with sequence similarity 110, member A	0.014
HOXB6	homeobox B6	0.014
AXIN2	axin 2	0.014
COL13A1	collagen, type XIII, alpha 1	0.014
CADM4	cell adhesion molecule 4	0.014
WNT5A	wingless-type MMTV integration site family, member 5A	0.013
COL9A2	collagen, type IX, alpha 2	0.013
IGFBP5	insulin-like growth factor binding protein 5	0.013
HOXA11	homeobox A11	0.013	Mouse
GPX8	glutathione peroxidase 8 (putative)	0.013
WNT11	wingless-type MMTV integration site family, member 11	0.013
ZMYND8	zinc finger, MYND-type containing 8	0.013
ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)	0.013
HOXA7	homeobox A7	0.013
SNAI2	snail homolog 2 (Drosophila)	0.012
NUAK1	NUAK family, SNF1-like kinase, 1	0.012
HOXC11	homeobox C11	0.012	Mouse
SLIT2	slit homolog 2 (Drosophila)	0.012
PSEN1	presenilin 1	0.012
PRSS23	protease, serine, 23	0.012
FBXW7	F-box and WD repeat domain containing 7	0.012
CTNNBIP1	catenin, beta interacting protein 1	0.012
PAX2	paired box 2	0.012
NFATC4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.012
FOXD1	forkhead box D1	0.012
IGF2BP1	insulin-like growth factor 2 mRNA binding protein 1	0.012
FZD10	frizzled homolog 10 (Drosophila)	0.012
SDC2	syndecan 2	0.012
ISLR	immunoglobulin superfamily containing leucine-rich repeat	0.012
SERPINH1	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	0.012
PAX3	paired box 3	0.011
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.011
MDFI	MyoD family inhibitor	0.011
MAG	myelin associated glycoprotein	0.011
THBS1	thrombospondin 1	0.011
NIN	ninein (GSK3B interacting protein)	0.011
EFNB3	ephrin-B3	0.011
HOXC8	homeobox C8	0.011
SOX10	SRY (sex determining region Y)-box 10	0.011
IRX5	iroquois homeobox 5	0.011
HS3ST3A1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	0.011
GLI3	GLI family zinc finger 3	0.011
EPHB3	EPH receptor B3	0.011
NKX3-2	NK3 homeobox 2	0.011
TMEM119	transmembrane protein 119	0.010
TAOK1	TAO kinase 1	0.010
PTHLH	parathyroid hormone-like hormone	0.010
BMP1	bone morphogenetic protein 1	0.010
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.010
MRC2	mannose receptor, C type 2	0.010
ITGA11	integrin, alpha 11	0.010
FAM123B	family with sequence similarity 123B	0.010
SPON2	spondin 2, extracellular matrix protein	0.010
PCOLCE	procollagen C-endopeptidase enhancer	0.010
FBLN2	fibulin 2	0.010
CCDC80	coiled-coil domain containing 80	0.010