IMP

Process View

Homo sapiens

15 genes annotated in human

detection of abiotic stimulus

The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "detection of abiotic stimulus"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "detection of abiotic stimulus" (in gray)

Name	Description	Probability	Func Analog Organism
COL1A1	collagen, type I, alpha 1	0.953	Human
ACTN2	actinin, alpha 2	0.925
COL4A1	collagen, type IV, alpha 1	0.824
COL5A2	collagen, type V, alpha 2	0.795	Human
COL4A2	collagen, type IV, alpha 2	0.682
DLG4	discs, large homolog 4 (Drosophila)	0.646
LAMB1	laminin, beta 1	0.525
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.496
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.477
COL1A2	collagen, type I, alpha 2	0.465	Human
CABP1	calcium binding protein 1	0.422
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.383	Fly
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.330
PKD2	polycystic kidney disease 2 (autosomal dominant)	0.326	Mouse
SPARC	secreted protein, acidic, cysteine-rich (osteonectin)	0.308
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.307
COL3A1	collagen, type III, alpha 1	0.296	Human
KCNA4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.271	Fly
PDGFB	platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)	0.260
MYOZ1	myozenin 1	0.198
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.160
PXDN	peroxidasin homolog (Drosophila)	0.152
FAM162A	family with sequence similarity 162, member A	0.144
GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.125
BLOC1S2	biogenesis of lysosomal organelles complex-1, subunit 2	0.121
TTN	titin	0.115
AFF2	AF4/FMR2 family, member 2	0.114
COL6A1	collagen, type VI, alpha 1	0.113
NGF	nerve growth factor (beta polypeptide)	0.113
HDAC6	histone deacetylase 6	0.104
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	0.103
FGFR1	fibroblast growth factor receptor 1	0.098
ADRBK1	adrenergic, beta, receptor kinase 1	0.098	Human
GRB7	growth factor receptor-bound protein 7	0.092
GUCY1B3	guanylate cyclase 1, soluble, beta 3	0.092
ITPR2	inositol 1,4,5-trisphosphate receptor, type 2	0.091
COL5A1	collagen, type V, alpha 1	0.089	Human
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.085
SALL2	sal-like 2 (Drosophila)	0.070
CALCA	calcitonin-related polypeptide alpha	0.070
KCNA5	potassium voltage-gated channel, shaker-related subfamily, member 5	0.067	Fly
UQCRFS1	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1	0.063
GRIN2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.062
CYFIP2	cytoplasmic FMR1 interacting protein 2	0.061
DLGAP1	discs, large (Drosophila) homolog-associated protein 1	0.061
PKD1	polycystic kidney disease 1 (autosomal dominant)	0.052	Mouse
POSTN	periostin, osteoblast specific factor	0.047
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.047	Mouse
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.046
DLG2	discs, large homolog 2 (Drosophila)	0.045
RICTOR	RPTOR independent companion of MTOR, complex 2	0.043
NID1	nidogen 1	0.043
NID2	nidogen 2 (osteonidogen)	0.042
APP	amyloid beta (A4) precursor protein	0.042
TTR	transthyretin	0.039
TRIM63	tripartite motif containing 63	0.037
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.036
KITLG	KIT ligand	0.034
COL6A2	collagen, type VI, alpha 2	0.032
BAI1	brain-specific angiogenesis inhibitor 1	0.032
COL6A3	collagen, type VI, alpha 3	0.032
MYOZ2	myozenin 2	0.031
MAPK10	mitogen-activated protein kinase 10	0.031
POU5F1	POU class 5 homeobox 1	0.031
ACTL6B	actin-like 6B	0.030
TUBB2B	tubulin, beta 2B	0.030
GRIN1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	0.027
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.026	Fly
SCNN1G	sodium channel, nonvoltage-gated 1, gamma	0.026	Fly
NCF1	neutrophil cytosolic factor 1	0.026
GPR6	G protein-coupled receptor 6	0.026
RHO	rhodopsin	0.026	Human Zebrafish Mouse Rat
IGFBP3	insulin-like growth factor binding protein 3	0.026
FERMT2	fermitin family member 2	0.025
VDAC2	voltage-dependent anion channel 2	0.024	Fly
COL11A1	collagen, type XI, alpha 1	0.023
PKN3	protein kinase N3	0.023
UQCRC2	ubiquinol-cytochrome c reductase core protein II	0.023
CFL1	cofilin 1 (non-muscle)	0.023
THY1	Thy-1 cell surface antigen	0.022
PKM2	pyruvate kinase, muscle	0.022
AP1M1	adaptor-related protein complex 1, mu 1 subunit	0.022
GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	0.021
COL16A1	collagen, type XVI, alpha 1	0.021
SLC25A3	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3	0.021
TRIM9	tripartite motif containing 9	0.020
LCK	lymphocyte-specific protein tyrosine kinase	0.020
BAK1	BCL2-antagonist/killer 1	0.020
MT3	metallothionein 3	0.020
NLGN1	neuroligin 1	0.019
ARHGAP22	Rho GTPase activating protein 22	0.019
RET	ret proto-oncogene	0.019
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.019
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.019
HCN4	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	0.019	Human
AHSA1	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)	0.019
DLGAP2	discs, large (Drosophila) homolog-associated protein 2	0.019
MXRA5	matrix-remodelling associated 5	0.018
PRKCD	protein kinase C, delta	0.018
ADAM12	ADAM metallopeptidase domain 12	0.018
APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.018
PLCG1	phospholipase C, gamma 1	0.018
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.017
FGF4	fibroblast growth factor 4	0.017
KALRN	kalirin, RhoGEF kinase	0.017
PLXDC1	plexin domain containing 1	0.017
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.017
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.017
DDX24	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	0.017
SLC17A6	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6	0.016
LOXL1	lysyl oxidase-like 1	0.016
VDAC1	voltage-dependent anion channel 1	0.016	Fly
CYCS	cytochrome c, somatic	0.016
COL18A1	collagen, type XVIII, alpha 1	0.016
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	0.016
PRKCA	protein kinase C, alpha	0.016	Fly
S100A6	S100 calcium binding protein A6	0.015
SPRR2A	small proline-rich protein 2A	0.015
CYFIP1	cytoplasmic FMR1 interacting protein 1	0.015
HCN2	hyperpolarization activated cyclic nucleotide-gated potassium channel 2	0.015	Human
ACHE	acetylcholinesterase	0.015
MYT1	myelin transcription factor 1	0.015
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.015
PDE6G	phosphodiesterase 6G, cGMP-specific, rod, gamma	0.014
SRRM4	serine/arginine repetitive matrix 4	0.014
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.014
EPN1	epsin 1	0.014
GRM7	glutamate receptor, metabotropic 7	0.014	Human
PPM1B	protein phosphatase, Mg2+/Mn2+ dependent, 1B	0.014
MAGEB18	melanoma antigen family B, 18	0.014
ATP5B	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	0.014
GNAO1	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	0.013	Human
TIMM23	translocase of inner mitochondrial membrane 23 homolog (yeast) and translocase of inner mitochondrial membrane 23 homolog (yeast)	0.013
LOX	lysyl oxidase	0.013
SIX6	SIX homeobox 6	0.013
DSP	desmoplakin	0.013
TNC	tenascin C	0.013
GIT1	G protein-coupled receptor kinase interacting ArfGAP 1	0.013
MAG	myelin associated glycoprotein	0.012
CACYBP	calcyclin binding protein	0.012
CACNA1B	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.012	Human Fly
PRSS23	protease, serine, 23	0.012
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.012
CHORDC1	cysteine and histidine-rich domain (CHORD) containing 1	0.012
FSTL1	follistatin-like 1	0.012
IGFBP5	insulin-like growth factor binding protein 5	0.012
ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif, 2	0.011
LPHN1	latrophilin 1	0.011
FSTL4	follistatin-like 4	0.011
NTNG1	netrin G1	0.011
PIK3CA	phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.011
GNAT1	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1	0.011
NELL1	NEL-like 1 (chicken)	0.011
BZRAP1	benzodiazapine receptor (peripheral) associated protein 1	0.011
CDK5R2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.011
MYLK	myosin light chain kinase	0.011
CPNE6	copine VI (neuronal)	0.011
CTNND2	catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)	0.011
GDF9	growth differentiation factor 9	0.011
TMEM59L	transmembrane protein 59-like	0.011
NECAB2	N-terminal EF-hand calcium binding protein 2	0.010
GLT8D2	glycosyltransferase 8 domain containing 2	0.010
HCN1	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	0.010	Human
RGS4	regulator of G-protein signaling 4	0.010
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.010
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.010
CADM3	cell adhesion molecule 3	0.010
GRB10	growth factor receptor-bound protein 10	0.010
PRKAA1	protein kinase, AMP-activated, alpha 1 catalytic subunit	0.010
ATP5G3	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)	0.010
NEUROD2	neurogenic differentiation 2	0.010