IMP
Process View
vascular endothelial growth factor receptor 1 signaling pathway
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-1 (VEGFR-1) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
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Click on a gene's description to view its network relationships with genes known to be involved in "vascular endothelial growth factor receptor 1 signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 1.000 | Human | |
| EGFR | epidermal growth factor receptor | 0.988 | ||
| VEGFA | vascular endothelial growth factor A | 0.981 | ||
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.894 | Human | |
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.888 | ||
| ERBB2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 0.867 | ||
| KDR | kinase insert domain receptor (a type III receptor tyrosine kinase) | 0.852 | Human | |
| NRP1 | neuropilin 1 | 0.772 | ||
| PDGFB | platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) | 0.726 | ||
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 0.662 | ||
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.655 | ||
| PLCG1 | phospholipase C, gamma 1 | 0.653 | ||
| LAT | linker for activation of T cells | 0.529 | ||
| CRK | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.434 | ||
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.375 | ||
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.262 | ||
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.230 | ||
| ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.220 | ||
| GAB1 | GRB2-associated binding protein 1 | 0.197 | ||
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.168 | ||
| PGF | placental growth factor | 0.165 | ||
| GRB2 | growth factor receptor-bound protein 2 | 0.162 | ||
| FLT1 | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 0.147 | ||
| BCAR1 | breast cancer anti-estrogen resistance 1 | 0.142 | ||
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.094 | ||
| FYN | FYN oncogene related to SRC, FGR, YES | 0.090 | ||
| PDGFC | platelet derived growth factor C | 0.089 | ||
| FGFR1 | fibroblast growth factor receptor 1 | 0.074 | ||
| ERBB3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 0.072 | ||
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.058 | ||
| SHC2 | SHC (Src homology 2 domain containing) transforming protein 2 | 0.055 | ||
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.051 | ||
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.047 | ||
| INSR | insulin receptor | 0.035 | ||
| GAB2 | GRB2-associated binding protein 2 | 0.033 | ||
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.031 | ||
| CDH5 | cadherin 5, type 2 (vascular endothelium) | 0.030 | ||
| SOS2 | son of sevenless homolog 2 (Drosophila) | 0.030 | ||
| PAG1 | phosphoprotein associated with glycosphingolipid microdomains 1 | 0.030 | ||
| SYK | spleen tyrosine kinase | 0.025 | ||
| SLA | Src-like-adaptor | 0.021 | ||
| GHR | growth hormone receptor | 0.021 | ||
| LCP2 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 0.017 | ||
| LDLR | low density lipoprotein receptor | 0.017 | ||
| IGF1R | insulin-like growth factor 1 receptor | 0.014 | ||
| IRS1 | insulin receptor substrate 1 | 0.014 | ||
| PTEN | phosphatase and tensin homolog | 0.013 | ||
| MET | met proto-oncogene (hepatocyte growth factor receptor) | 0.012 | ||
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 0.011 | Human | |
| KITLG | KIT ligand | 0.011 |