IMP

Process View

Homo sapiens

16 genes annotated in human

establishment of endothelial barrier

The establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in human Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "establishment of endothelial barrier"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "establishment of endothelial barrier" (in gray)

Name	Description	Probability	Func Analog Organism
PAX3	paired box 3	0.926
PTPN13	protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)	0.601
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.561
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.436
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.421
TGFB1	transforming growth factor, beta 1	0.416
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.319
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.307
SCHIP1	schwannomin interacting protein 1	0.252
EZR	ezrin	0.204
SMAD7	SMAD family member 7	0.203
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.171
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.170
RAP1A	RAP1A, member of RAS oncogene family	0.159
RUNDC3A	RUN domain containing 3A	0.100
CXCR5	chemokine (C-X-C motif) receptor 5	0.074
MSN	moesin	0.073
POU3F2	POU class 3 homeobox 2	0.072
TJP1	tight junction protein 1 (zona occludens 1)	0.069
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.056
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.051
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.049
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.047
ABI1	abl-interactor 1	0.047
ACTR3	ARP3 actin-related protein 3 homolog (yeast)	0.047
FGFR1	fibroblast growth factor receptor 1	0.042
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.041
IRAK2	interleukin-1 receptor-associated kinase 2	0.040
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.038
PLCG1	phospholipase C, gamma 1	0.037
CD44	CD44 molecule (Indian blood group)	0.036
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.036
MED28	mediator complex subunit 28	0.035
TLR4	toll-like receptor 4	0.030
RALGDS	ral guanine nucleotide dissociation stimulator	0.029
RHOG	ras homolog gene family, member G (rho G)	0.028
TJP2	tight junction protein 2 (zona occludens 2)	0.028
GAB1	GRB2-associated binding protein 1	0.027
CXXC5	CXXC finger protein 5	0.026
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.025
MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1	0.024
CSNK1E	casein kinase 1, epsilon	0.024
MAP4K5	mitogen-activated protein kinase kinase kinase kinase 5	0.024
TGFBR1	transforming growth factor, beta receptor 1	0.024
ZC3H12A	zinc finger CCCH-type containing 12A	0.023
TGFB3	transforming growth factor, beta 3	0.022
KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	0.022
ATP8	ATP synthase F0 subunit 8	0.022
LAT	linker for activation of T cells	0.021
JUP	junction plakoglobin	0.021
BCR	breakpoint cluster region	0.020
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.020
BZW1	basic leucine zipper and W2 domains 1	0.019
CDH5	cadherin 5, type 2 (vascular endothelium)	0.019
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.018
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.018
SOS1	son of sevenless homolog 1 (Drosophila)	0.017	Human
RAMP3	receptor (G protein-coupled) activity modifying protein 3	0.016
SOS2	son of sevenless homolog 2 (Drosophila)	0.016	Human
ITM2A	integral membrane protein 2A	0.015
TBC1D10A	TBC1 domain family, member 10A	0.014
RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	0.014
TFG	TRK-fused gene	0.014
QKI	quaking homolog, KH domain RNA binding (mouse)	0.014
SALL2	sal-like 2 (Drosophila)	0.013
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.013
IRAK4	interleukin-1 receptor-associated kinase 4	0.013
PKN2	protein kinase N2	0.013
APC	adenomatous polyposis coli	0.013
CLDN5	claudin 5	0.013
MCC	mutated in colorectal cancers	0.013
FSTL1	follistatin-like 1	0.013
GNAI1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	0.013	Fly
YAP1	Yes-associated protein 1	0.012
CAV2	caveolin 2	0.012
AXL	AXL receptor tyrosine kinase	0.012
ADRBK1	adrenergic, beta, receptor kinase 1	0.012
HSD3B7	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	0.012
ZEB2	zinc finger E-box binding homeobox 2	0.012
GJA1	gap junction protein, alpha 1, 43kDa	0.012
ITSN2	intersectin 2	0.011
INADL	InaD-like (Drosophila)	0.011
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.011
OLIG2	oligodendrocyte lineage transcription factor 2	0.011
NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	0.011
GAB2	GRB2-associated binding protein 2	0.011
IRAK1	interleukin-1 receptor-associated kinase 1	0.011
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.011
CD97	CD97 molecule	0.011
NCF4	neutrophil cytosolic factor 4, 40kDa	0.011
RHOA	ras homolog gene family, member A	0.010
PCDH17	protocadherin 17	0.010
RGS19	regulator of G-protein signaling 19	0.010
FOXG1	forkhead box G1	0.010