IMP
Process View
heart looping
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "heart looping"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| NKX2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.739 | Mouse | |
| JAG1 | jagged 1 | 0.452 | ||
| TBX5 | T-box 5 | 0.370 | Zebrafish | |
| SMAD3 | SMAD family member 3 | 0.275 | Mouse | |
| BMP2 | bone morphogenetic protein 2 | 0.216 | ||
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.153 | ||
| SMAD1 | SMAD family member 1 | 0.143 | ||
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.126 | ||
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.104 | ||
| SMAD2 | SMAD family member 2 | 0.088 | ||
| TJP1 | tight junction protein 1 (zona occludens 1) | 0.086 | ||
| TGFB1 | transforming growth factor, beta 1 | 0.076 | ||
| NOTCH3 | notch 3 | 0.075 | ||
| GATA4 | GATA binding protein 4 | 0.068 | Zebrafish Mouse | |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.053 | ||
| HIPK2 | homeodomain interacting protein kinase 2 | 0.051 | ||
| FZD1 | frizzled homolog 1 (Drosophila) | 0.049 | ||
| BMPR1A | bone morphogenetic protein receptor, type IA | 0.049 | Zebrafish | |
| FSTL1 | follistatin-like 1 | 0.048 | ||
| BBS2 | Bardet-Biedl syndrome 2 | 0.047 | ||
| PRKG1 | protein kinase, cGMP-dependent, type I | 0.044 | ||
| GLI1 | GLI family zinc finger 1 | 0.041 | ||
| PKD1 | polycystic kidney disease 1 (autosomal dominant) | 0.040 | ||
| SASS6 | spindle assembly 6 homolog (C. elegans) | 0.040 | ||
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.036 | ||
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.035 | ||
| CENPJ | centromere protein J | 0.034 | ||
| ATP6V0C | ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c | 0.028 | ||
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.027 | Mouse | |
| PTCH1 | patched 1 | 0.026 | ||
| SP1 | Sp1 transcription factor | 0.026 | ||
| ACVR1 | activin A receptor, type I | 0.025 | ||
| GSK3B | glycogen synthase kinase 3 beta | 0.025 | ||
| SMAD4 | SMAD family member 4 | 0.023 | ||
| NFIX | nuclear factor I/X (CCAAT-binding transcription factor) | 0.023 | ||
| MAML1 | mastermind-like 1 (Drosophila) | 0.022 | ||
| ZFYVE9 | zinc finger, FYVE domain containing 9 | 0.021 | ||
| SMAD7 | SMAD family member 7 | 0.020 | ||
| BMP1 | bone morphogenetic protein 1 | 0.020 | ||
| TOP1 | topoisomerase (DNA) I | 0.019 | ||
| DSP | desmoplakin | 0.018 | ||
| PKP4 | plakophilin 4 | 0.015 | ||
| MEIS2 | Meis homeobox 2 | 0.015 | ||
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.015 | ||
| LMAN1 | lectin, mannose-binding, 1 | 0.015 | ||
| EPAS1 | endothelial PAS domain protein 1 | 0.014 | ||
| MYOD1 | myogenic differentiation 1 | 0.014 | ||
| AR | androgen receptor | 0.013 | ||
| XIAP | X-linked inhibitor of apoptosis | 0.013 | ||
| SFPQ | splicing factor proline/glutamine-rich | 0.013 | ||
| TRPC1 | transient receptor potential cation channel, subfamily C, member 1 | 0.012 | ||
| YBX1 | Y box binding protein 1 | 0.012 | ||
| MYOCD | myocardin | 0.012 | ||
| SNX5 | sorting nexin 5 | 0.011 | ||
| HDAC4 | histone deacetylase 4 | 0.011 | ||
| ATXN3 | ataxin 3 | 0.011 | ||
| LRRK2 | leucine-rich repeat kinase 2 | 0.011 | ||
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.011 | ||
| CANX | calnexin | 0.011 | ||
| TCF4 | transcription factor 4 | 0.011 | ||
| MEF2A | myocyte enhancer factor 2A | 0.010 | ||
| NOG | noggin | 0.010 | ||
| GNB5 | guanine nucleotide binding protein (G protein), beta 5 | 0.010 |