IMP

Process View

Homo sapiens

17 genes annotated in human

negative regulation of transcription factor import into nucleus

Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of transcription factor import into nucleus"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of transcription factor import into nucleus" (in gray)

Name	Description	Probability	Func Analog Organism
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.413
FBXW11	F-box and WD repeat domain containing 11	0.363	Mouse Fly
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.246
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.223
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.207
TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy	0.152
ZNF420	zinc finger protein 420	0.107
PRKACA	protein kinase, cAMP-dependent, catalytic, alpha	0.078
BTRC	beta-transducin repeat containing	0.077	Fly
PML	promyelocytic leukemia	0.075
CHUK	conserved helix-loop-helix ubiquitous kinase	0.072
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.070
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.070
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.067	Human Rat
PRKAR2A	protein kinase, cAMP-dependent, regulatory, type II, alpha	0.065
CREBBP	CREB binding protein	0.064
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.059
C3orf15	chromosome 3 open reading frame 15	0.056
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.054
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.043
ZNF260	zinc finger protein 260	0.042
BBS10	Bardet-Biedl syndrome 10	0.041
CKAP5	cytoskeleton associated protein 5	0.041
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.040
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.039
NCOA6	nuclear receptor coactivator 6	0.038
ZNF84	zinc finger protein 84	0.037
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.033
HIPK3	homeodomain interacting protein kinase 3	0.032
FAS	Fas (TNF receptor superfamily, member 6)	0.030
ZNF432	zinc finger protein 432	0.030
BCL3	B-cell CLL/lymphoma 3	0.029	Human
PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)	0.029
MAP2K5	mitogen-activated protein kinase kinase 5	0.027
DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	0.027
RANBP3	RAN binding protein 3	0.027
AXIN1	axin 1	0.026
GRB10	growth factor receptor-bound protein 10	0.025
PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.025
PSEN2	presenilin 2 (Alzheimer disease 4)	0.025
SUV39H1	suppressor of variegation 3-9 homolog 1 (Drosophila)	0.024
SKP1	S-phase kinase-associated protein 1	0.024
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.024	Rat
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.023
IRS2	insulin receptor substrate 2	0.023
SNAI1	snail homolog 1 (Drosophila)	0.022
ZNF585A	zinc finger protein 585A	0.022
PSMC4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	0.022
RARA	retinoic acid receptor, alpha	0.021
ACTN1	actinin, alpha 1	0.020
DYRK4	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	0.020	Human
ZNF529	zinc finger protein 529	0.020
IRS1	insulin receptor substrate 1	0.019
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.019
MAP3K3	mitogen-activated protein kinase kinase kinase 3	0.018
SMAD3	SMAD family member 3	0.017
PRKCZ	protein kinase C, zeta	0.016
ZNF140	zinc finger protein 140	0.016	Human
LZTS2	leucine zipper, putative tumor suppressor 2	0.016
STX8	syntaxin 8	0.016
GLI1	GLI family zinc finger 1	0.015
PEX26	peroxisomal biogenesis factor 26	0.015
FLNB	filamin B, beta	0.014
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.014
CUL1	cullin 1	0.014
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.014
NCOR2	nuclear receptor corepressor 2	0.014
ZNF571	zinc finger protein 571	0.014
RPTOR	regulatory associated protein of MTOR, complex 1	0.014
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.013
ZNF12	zinc finger protein 12	0.013
SMAD1	SMAD family member 1	0.013
PJA2	praja ring finger 2	0.013
SETD7	SET domain containing (lysine methyltransferase) 7	0.012
ZNF304	zinc finger protein 304	0.012
NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	0.012
CFLAR	CASP8 and FADD-like apoptosis regulator	0.012
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.012
MAGI3	membrane associated guanylate kinase, WW and PDZ domain containing 3	0.012
PSMD6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.012
GSK3B	glycogen synthase kinase 3 beta	0.011
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.011
RB1	retinoblastoma 1	0.011
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.011
ZNF623	zinc finger protein 623	0.011
ZNF567	zinc finger protein 567	0.011
ZNF189	zinc finger protein 189	0.010
ZNF83	zinc finger protein 83	0.010
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	0.010
FBXW2	F-box and WD repeat domain containing 2	0.010