IMP
Process View
vegf activated platelet derived growth factor receptor signaling pathway
A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
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Click on a gene's description to view its network relationships with genes known to be involved in "vegf activated platelet derived growth factor receptor signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 1.000 | ||
| VEGFA | vascular endothelial growth factor A | 1.000 | ||
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 1.000 | ||
| FLT1 | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 1.000 | Human | |
| PDGFB | platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) | 1.000 | Human | |
| NRP1 | neuropilin 1 | 1.000 | ||
| KDR | kinase insert domain receptor (a type III receptor tyrosine kinase) | 0.997 | Human | |
| PLCG1 | phospholipase C, gamma 1 | 0.977 | ||
| CRK | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.959 | ||
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.954 | ||
| EGFR | epidermal growth factor receptor | 0.948 | ||
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 0.902 | ||
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.894 | Human | |
| PGF | placental growth factor | 0.865 | Human | |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.846 | ||
| PDGFC | platelet derived growth factor C | 0.648 | ||
| ERBB2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 0.623 | ||
| LAT | linker for activation of T cells | 0.601 | ||
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.457 | ||
| CDH5 | cadherin 5, type 2 (vascular endothelium) | 0.395 | ||
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.288 | ||
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.227 | ||
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.183 | ||
| GAB1 | GRB2-associated binding protein 1 | 0.117 | ||
| FGFR1 | fibroblast growth factor receptor 1 | 0.111 | ||
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.083 | ||
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.073 | ||
| BCAR1 | breast cancer anti-estrogen resistance 1 | 0.063 | ||
| ERBB3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 0.062 | ||
| GAB2 | GRB2-associated binding protein 2 | 0.049 | ||
| KITLG | KIT ligand | 0.044 | ||
| FYN | FYN oncogene related to SRC, FGR, YES | 0.041 | ||
| FLT4 | fms-related tyrosine kinase 4 | 0.040 | Human | |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.037 | ||
| WAS | Wiskott-Aldrich syndrome (eczema-thrombocytopenia) | 0.034 | ||
| PIK3CB | phosphoinositide-3-kinase, catalytic, beta polypeptide | 0.033 | ||
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 0.030 | Human | |
| SHC2 | SHC (Src homology 2 domain containing) transforming protein 2 | 0.029 | ||
| SOS2 | son of sevenless homolog 2 (Drosophila) | 0.027 | ||
| LDLR | low density lipoprotein receptor | 0.027 | ||
| AES | amino-terminal enhancer of split | 0.023 | ||
| AXL | AXL receptor tyrosine kinase | 0.023 | ||
| STC1 | stanniocalcin 1 | 0.022 | ||
| COL6A1 | collagen, type VI, alpha 1 | 0.022 | ||
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 0.020 | ||
| SH2B2 | SH2B adaptor protein 2 | 0.019 | ||
| PAG1 | phosphoprotein associated with glycosphingolipid microdomains 1 | 0.019 | ||
| ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.017 | ||
| ROBO4 | roundabout homolog 4, magic roundabout (Drosophila) | 0.017 | ||
| WNT2 | wingless-type MMTV integration site family member 2 | 0.016 | ||
| GHR | growth hormone receptor | 0.015 | ||
| SYK | spleen tyrosine kinase | 0.014 | ||
| TEK | TEK tyrosine kinase, endothelial | 0.014 | ||
| MAP2 | microtubule-associated protein 2 | 0.013 | ||
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.013 | ||
| ANGPT2 | angiopoietin 2 | 0.012 | ||
| VSIG4 | V-set and immunoglobulin domain containing 4 | 0.012 | ||
| IRS1 | insulin receptor substrate 1 | 0.012 | ||
| TGFB3 | transforming growth factor, beta 3 | 0.011 | ||
| LCP2 | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 0.011 | ||
| VAV3 | vav 3 guanine nucleotide exchange factor | 0.010 | ||
| SIGLEC1 | sialic acid binding Ig-like lectin 1, sialoadhesin | 0.010 | ||
| COL1A1 | collagen, type I, alpha 1 | 0.010 |