IMP

Process View

Homo sapiens

4 genes annotated in human

positive regulation of lipopolysaccharide mediated signaling pathway

Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of lipopolysaccharide mediated signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of lipopolysaccharide mediated signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
NCF1	neutrophil cytosolic factor 1	1.000
TLR4	toll-like receptor 4	1.000	Human
MYD88	myeloid differentiation primary response gene (88)	1.000
NCF2	neutrophil cytosolic factor 2	1.000
NCF4	neutrophil cytosolic factor 4, 40kDa	1.000
LY96	lymphocyte antigen 96	0.996	Mouse
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.996
TICAM2	toll-like receptor adaptor molecule 2	0.995
PRKCA	protein kinase C, alpha	0.995
IRAK2	interleukin-1 receptor-associated kinase 2	0.992
TLR1	toll-like receptor 1	0.990	Human
CYBA	cytochrome b-245, alpha polypeptide	0.968
PRKCD	protein kinase C, delta	0.957
RNASE6	ribonuclease, RNase A family, k6	0.955
IRAK1	interleukin-1 receptor-associated kinase 1	0.944
TRIM9	tripartite motif containing 9	0.928
RICTOR	RPTOR independent companion of MTOR, complex 2	0.894
HDAC6	histone deacetylase 6	0.859
BTK	Bruton agammaglobulinemia tyrosine kinase	0.847
IRAK3	interleukin-1 receptor-associated kinase 3	0.800
BRAF	v-raf murine sarcoma viral oncogene homolog B1	0.736
LY86	lymphocyte antigen 86	0.669
MS4A6A	membrane-spanning 4-domains, subfamily A, member 6A	0.656
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.507
RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2	0.498
LRMP	lymphoid-restricted membrane protein	0.441
PELI3	pellino homolog 3 (Drosophila)	0.385
NUMBL	numb homolog (Drosophila)-like	0.376
CYBB	cytochrome b-245, beta polypeptide	0.361
CD86	CD86 molecule	0.301
ACTB	actin, beta	0.271
TAB3	TGF-beta activated kinase 1/MAP3K7 binding protein 3	0.253
AIF1	allograft inflammatory factor 1	0.229
TLR2	toll-like receptor 2	0.228
TLR7	toll-like receptor 7	0.227
PSMD4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.205
ENTPD1	ectonucleoside triphosphate diphosphohydrolase 1	0.203
VNN2	vanin 2	0.187
EVI2A	ecotropic viral integration site 2A	0.185
P2RY13	purinergic receptor P2Y, G-protein coupled, 13	0.152
TRAF3IP3	TRAF3 interacting protein 3	0.150
EVI2B	ecotropic viral integration site 2B	0.148
TFEC	transcription factor EC	0.140
SLC7A7	solute carrier family 7 (cationic amino acid transporter, y+ system), member 7	0.131
SLA	Src-like-adaptor	0.129
CD180	CD180 molecule	0.117
IL1R1	interleukin 1 receptor, type I	0.114
HCLS1	hematopoietic cell-specific Lyn substrate 1	0.114
PLEK	pleckstrin	0.111
MNDA	myeloid cell nuclear differentiation antigen	0.111
XIAP	X-linked inhibitor of apoptosis	0.109
PRKCB	protein kinase C, beta	0.102	Human
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.100
CD163	CD163 molecule	0.093
TLR6	toll-like receptor 6	0.089	Human
MS4A4A	membrane-spanning 4-domains, subfamily A, member 4	0.083
GLIPR1	GLI pathogenesis-related 1	0.080
PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.075
RALBP1	ralA binding protein 1	0.073
ADRBK1	adrenergic, beta, receptor kinase 1	0.070
SASH3	SAM and SH3 domain containing 3	0.067	Human
CCR1	chemokine (C-C motif) receptor 1	0.066
C3AR1	complement component 3a receptor 1	0.065
CCR2	chemokine (C-C motif) receptor 2	0.063
APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.063
FGL2	fibrinogen-like 2	0.059
BIN2	bridging integrator 2	0.052
CARD16	caspase recruitment domain family, member 16	0.052
EGF	epidermal growth factor	0.052
MSR1	macrophage scavenger receptor 1	0.052
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.048
SIRPB1	signal-regulatory protein beta 1	0.046
LST1	leukocyte specific transcript 1	0.045
CD33	CD33 molecule	0.045
PARVG	parvin, gamma	0.041
BLNK	B-cell linker	0.041
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.040
NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	0.039
EGFR	epidermal growth factor receptor	0.039
ZNF675	zinc finger protein 675	0.038
BAG3	BCL2-associated athanogene 3	0.038
HLA-DMB	major histocompatibility complex, class II, DM beta	0.035
MCTP1	multiple C2 domains, transmembrane 1	0.035
SELL	selectin L	0.035
SESN2	sestrin 2	0.035
IL1RAP	interleukin 1 receptor accessory protein	0.033
CMTM8	CKLF-like MARVEL transmembrane domain containing 8	0.032
CD93	CD93 molecule	0.031
CD1D	CD1d molecule	0.030
MARCH1	membrane-associated ring finger (C3HC4) 1	0.029
CECR1	cat eye syndrome chromosome region, candidate 1	0.029
GPR34	G protein-coupled receptor 34	0.029
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.029
PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	0.028
TRAF5	TNF receptor-associated factor 5	0.027
PIK3CG	phosphoinositide-3-kinase, catalytic, gamma polypeptide	0.027
ARAF	v-raf murine sarcoma 3611 viral oncogene homolog	0.026
SLFN12	schlafen family member 12	0.026
CLEC4A	C-type lectin domain family 4, member A	0.025
CYTH4	cytohesin 4	0.025
NPL	N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)	0.024
TRIM41	tripartite motif containing 41	0.024
TRIM39	tripartite motif containing 39	0.022
CD37	CD37 molecule	0.022
MR1	major histocompatibility complex, class I-related	0.022
GRB10	growth factor receptor-bound protein 10	0.022
TLR10	toll-like receptor 10	0.022	Human
C17orf60	chromosome 17 open reading frame 60	0.022
ZRANB1	zinc finger, RAN-binding domain containing 1	0.022
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.021
CX3CR1	chemokine (C-X3-C motif) receptor 1	0.021
IRAK4	interleukin-1 receptor-associated kinase 4	0.020
ADORA3	adenosine A3 receptor	0.020
DHRS9	dehydrogenase/reductase (SDR family) member 9	0.020
RASSF2	Ras association (RalGDS/AF-6) domain family member 2	0.020
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.020
ALOX5AP	arachidonate 5-lipoxygenase-activating protein	0.019
PTAFR	platelet-activating factor receptor	0.019
ABL2	v-abl Abelson murine leukemia viral oncogene homolog 2	0.019
AHNAK	AHNAK nucleoprotein	0.019
GPR18	G protein-coupled receptor 18	0.018
BBS10	Bardet-Biedl syndrome 10	0.018
IKZF1	IKAROS family zinc finger 1 (Ikaros)	0.018
TLR5	toll-like receptor 5	0.018	Human
PSMD6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.017
KMO	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	0.017
RGL1	ral guanine nucleotide dissociation stimulator-like 1	0.017
DPEP2	dipeptidase 2	0.017
CYSLTR1	cysteinyl leukotriene receptor 1	0.017
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.017
CLEC2B	C-type lectin domain family 2, member B	0.017
MEX3B	mex-3 homolog B (C. elegans)	0.017
SH2D3A	SH2 domain containing 3A	0.017
IGSF6	immunoglobulin superfamily, member 6	0.016
GPR65	G protein-coupled receptor 65	0.016
ZNRF1	zinc and ring finger 1	0.016
PTPN7	protein tyrosine phosphatase, non-receptor type 7	0.016
PIK3AP1	phosphoinositide-3-kinase adaptor protein 1	0.016
RIN2	Ras and Rab interactor 2	0.016
BST1	bone marrow stromal cell antigen 1	0.015
FAM65B	family with sequence similarity 65, member B	0.015
CISH	cytokine inducible SH2-containing protein	0.015
CR1	complement component (3b/4b) receptor 1 (Knops blood group)	0.015
C1orf162	chromosome 1 open reading frame 162	0.014
ST8SIA4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.014
IRF8	interferon regulatory factor 8	0.014
CTNND1	catenin (cadherin-associated protein), delta 1	0.014
TPK1	thiamin pyrophosphokinase 1	0.014
C21orf7	chromosome 21 open reading frame 7	0.014
ELMO1	engulfment and cell motility 1	0.013
TRIM25	tripartite motif containing 25	0.013
RGS18	regulator of G-protein signaling 18	0.013
IGJ	immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides	0.013
EMILIN2	elastin microfibril interfacer 2	0.013
FCER1G	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	0.013
MPEG1	macrophage expressed 1	0.013
CPVL	carboxypeptidase, vitellogenic-like	0.013
MS4A14	membrane-spanning 4-domains, subfamily A, member 14	0.013
MERTK	c-mer proto-oncogene tyrosine kinase	0.012
FPR3	formyl peptide receptor 3	0.012
SLC29A3	solute carrier family 29 (nucleoside transporters), member 3	0.012
MX2	myxovirus (influenza virus) resistance 2 (mouse)	0.012
FAM49A	family with sequence similarity 49, member A	0.012
TRAF4	TNF receptor-associated factor 4	0.012
F13A1	coagulation factor XIII, A1 polypeptide	0.012
CD40	CD40 molecule, TNF receptor superfamily member 5	0.012
BANK1	B-cell scaffold protein with ankyrin repeats 1	0.012
TGFA	transforming growth factor, alpha	0.012
DOK5	docking protein 5	0.012
MS4A7	membrane-spanning 4-domains, subfamily A, member 7	0.011
CSTA	cystatin A (stefin A)	0.011
CD48	CD48 molecule	0.011
PTPRF	protein tyrosine phosphatase, receptor type, F	0.011
ADAM28	ADAM metallopeptidase domain 28	0.011
FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0.011
TNFAIP8L2	tumor necrosis factor, alpha-induced protein 8-like 2	0.011
ADAP2	ArfGAP with dual PH domains 2	0.011
CTSS	cathepsin S	0.011
APBB1IP	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	0.011
AMFR	autocrine motility factor receptor	0.011
CARD6	caspase recruitment domain family, member 6	0.010
FCGR2C	Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)	0.010
CLEC5A	C-type lectin domain family 5, member A	0.010
INADL	InaD-like (Drosophila)	0.010
IPCEF1	interaction protein for cytohesin exchange factors 1	0.010
TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	0.010
CYTIP	cytohesin 1 interacting protein	0.010
SH2B3	SH2B adaptor protein 3	0.010
EPB41L3	erythrocyte membrane protein band 4.1-like 3	0.010