IMP

Process View

Homo sapiens

3 genes annotated in human

bmp signaling pathway involved in heart induction

A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to heart induction.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "bmp signaling pathway involved in heart induction"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "bmp signaling pathway involved in heart induction" (in gray)

Name	Description	Probability	Func Analog Organism
SP1	Sp1 transcription factor	1.000
BMPR1A	bone morphogenetic protein receptor, type IA	0.997
FOXD3	forkhead box D3	0.997
SOX10	SRY (sex determining region Y)-box 10	0.987
PAX3	paired box 3	0.978
SOX2	SRY (sex determining region Y)-box 2	0.937
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.929
FSTL1	follistatin-like 1	0.761
ZFYVE9	zinc finger, FYVE domain containing 9	0.499
HMGA1	high mobility group AT-hook 1	0.414
GABPA	GA binding protein transcription factor, alpha subunit 60kDa	0.284
MEOX2	mesenchyme homeobox 2	0.254
HCFC1	host cell factor C1 (VP16-accessory protein)	0.254
ESR1	estrogen receptor 1	0.250
HTT	huntingtin	0.179
EP300	E1A binding protein p300	0.155
SMAD7	SMAD family member 7	0.101
SOX11	SRY (sex determining region Y)-box 11	0.072
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.064
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.056
NOG	noggin	0.053
SOX1	SRY (sex determining region Y)-box 1	0.052
OTP	orthopedia homeobox	0.051
NR0B1	nuclear receptor subfamily 0, group B, member 1	0.044
POU4F1	POU class 4 homeobox 1	0.044	Human
SOX21	SRY (sex determining region Y)-box 21	0.039
NOVA2	neuro-oncological ventral antigen 2	0.037
POU3F1	POU class 3 homeobox 1	0.033	Human
ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	0.031
HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	0.031
BMP2	bone morphogenetic protein 2	0.029
FOXE1	forkhead box E1 (thyroid transcription factor 2)	0.028
POGZ	pogo transposable element with ZNF domain	0.027
FOXB1	forkhead box B1	0.024
TP73	tumor protein p73	0.024
BMPR1B	bone morphogenetic protein receptor, type IB	0.024
ADARB1	adenosine deaminase, RNA-specific, B1	0.023
LHX1	LIM homeobox 1	0.023
NEUROG3	neurogenin 3	0.022
ATF7IP	activating transcription factor 7 interacting protein	0.022
ELF1	E74-like factor 1 (ets domain transcription factor)	0.020
FBXL15	F-box and leucine-rich repeat protein 15	0.020
PAX6	paired box 6	0.020
NKX2-1	NK2 homeobox 1	0.019
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.019
HTR2C	5-hydroxytryptamine (serotonin) receptor 2C	0.019
CD22	CD22 molecule	0.018
ESR2	estrogen receptor 2 (ER beta)	0.018
SIT1	signaling threshold regulating transmembrane adaptor 1	0.017
OLIG2	oligodendrocyte lineage transcription factor 2	0.017
HES2	hairy and enhancer of split 2 (Drosophila)	0.016
ASCL1	achaete-scute complex homolog 1 (Drosophila)	0.016
RBP3	retinol binding protein 3, interstitial	0.016
TFAP2B	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	0.016
NFYA	nuclear transcription factor Y, alpha	0.016
PGR	progesterone receptor	0.015
SMAD3	SMAD family member 3	0.015
MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.015
ZNF143	zinc finger protein 143	0.015
GRIP1	glutamate receptor interacting protein 1	0.015
NKX2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.015
ISL1	ISL LIM homeobox 1	0.015
NHLH2	nescient helix loop helix 2	0.014
FOXA2	forkhead box A2	0.014
HOXB7	homeobox B7	0.014
NFYC	nuclear transcription factor Y, gamma	0.014
SALL2	sal-like 2 (Drosophila)	0.014
HIST1H1A	histone cluster 1, H1a	0.014
HOXB13	homeobox B13	0.014
GHSR	growth hormone secretagogue receptor	0.014
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	0.013
VASP	vasodilator-stimulated phosphoprotein	0.013
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.013
HOXD3	homeobox D3	0.013
PITX2	paired-like homeodomain 2	0.013
SPIB	Spi-B transcription factor (Spi-1/PU.1 related)	0.013
NELL1	NEL-like 1 (chicken)	0.013
SIX2	SIX homeobox 2	0.013
TACR1	tachykinin receptor 1	0.012
SOX18	SRY (sex determining region Y)-box 18	0.012
NCOR2	nuclear receptor corepressor 2	0.012
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.012
MTA2	metastasis associated 1 family, member 2	0.012
LPAR4	lysophosphatidic acid receptor 4	0.012
PAX7	paired box 7	0.012
L1TD1	LINE-1 type transposase domain containing 1	0.011
TLX2	T-cell leukemia homeobox 2	0.011
BMP4	bone morphogenetic protein 4	0.011
EYA2	eyes absent homolog 2 (Drosophila)	0.011
FST	follistatin	0.011
HOXC4	homeobox C4	0.011
HAP1	huntingtin-associated protein 1	0.011
TBX5	T-box 5	0.011
TCL1A	T-cell leukemia/lymphoma 1A	0.011
TGFB1	transforming growth factor, beta 1	0.011
SALL1	sal-like 1 (Drosophila)	0.011
NXPH1	neurexophilin 1	0.011
DCX	doublecortin	0.011
GABRA5	gamma-aminobutyric acid (GABA) A receptor, alpha 5	0.011
ALX1	ALX homeobox 1	0.011
ZBTB17	zinc finger and BTB domain containing 17	0.011
TAF4	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	0.011
NKX2-8	NK2 homeobox 8	0.011
EPHX3	epoxide hydrolase 3	0.011
ST8SIA2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.011
PNOC	prepronociceptin	0.011
FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	0.011
BMP7	bone morphogenetic protein 7	0.011
ACAN	aggrecan	0.010
DLX4	distal-less homeobox 4	0.010
ADARB2	adenosine deaminase, RNA-specific, B2	0.010
TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)	0.010
SLC30A3	solute carrier family 30 (zinc transporter), member 3	0.010
HTR7	5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)	0.010
WT1	Wilms tumor 1	0.010
PRMT2	protein arginine methyltransferase 2	0.010