IMP

Process View

Homo sapiens

13 genes annotated in human

regulation of filopodium assembly

Any process that modulates the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of filopodium assembly"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of filopodium assembly" (in gray)

Name	Description	Probability	Func Analog Organism
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	1.000
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.755
PRKCZ	protein kinase C, zeta	0.662
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.592	Human Fly
ACTR3	ARP3 actin-related protein 3 homolog (yeast)	0.567	Rat Fly
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.546
DAAM1	dishevelled associated activator of morphogenesis 1	0.442	Fly
JAG1	jagged 1	0.386
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.330	Fly
ARPC5	actin related protein 2/3 complex, subunit 5, 16kDa	0.317
ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa	0.296
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.245
ARHGAP1	Rho GTPase activating protein 1	0.224
NOTCH1	notch 1	0.211	Fly
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.190
ARPC3	actin related protein 2/3 complex, subunit 3, 21kDa	0.125
BZW1	basic leucine zipper and W2 domains 1	0.093
SH3BGRL3	SH3 domain binding glutamic acid-rich protein like 3	0.089
RALB	v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)	0.088	Human
ARHGDIA	Rho GDP dissociation inhibitor (GDI) alpha	0.086
TWF2	twinfilin, actin-binding protein, homolog 2 (Drosophila)	0.086
RALA	v-ral simian leukemia viral oncogene homolog A (ras related)	0.082
GNAI2	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2	0.076
CAMK2A	calcium/calmodulin-dependent protein kinase II alpha	0.076	Fly
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.064
FNBP1L	formin binding protein 1-like	0.061
ARPC4	actin related protein 2/3 complex, subunit 4, 20kDa	0.059
ACTR2	ARP2 actin-related protein 2 homolog (yeast)	0.057	Fly
FKBP1A	FK506 binding protein 1A, 12kDa	0.056
ARFIP2	ADP-ribosylation factor interacting protein 2	0.054
RAB1A	RAB1A, member RAS oncogene family	0.045
F11R	F11 receptor	0.039
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.038	Fly
RHOG	ras homolog gene family, member G (rho G)	0.037	Human
ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta	0.037
DNM2	dynamin 2	0.037
GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1	0.033
ARPC1B	actin related protein 2/3 complex, subunit 1B, 41kDa	0.032	Fly
CORO1C	coronin, actin binding protein, 1C	0.030
NCF1	neutrophil cytosolic factor 1	0.027
ITGB4	integrin, beta 4	0.027
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.026	Fly
TRIP10	thyroid hormone receptor interactor 10	0.024	Human
TRPC4	transient receptor potential cation channel, subfamily C, member 4	0.024
PRKCB	protein kinase C, beta	0.023
CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.023
WIPF1	WAS/WASL interacting protein family, member 1	0.022
BAIAP2	BAI1-associated protein 2	0.022
CAMK2B	calcium/calmodulin-dependent protein kinase II beta	0.022	Fly
IQGAP1	IQ motif containing GTPase activating protein 1	0.021
MKL1	megakaryoblastic leukemia (translocation) 1	0.021
RHOA	ras homolog gene family, member A	0.021	Fly
CDC42EP3	CDC42 effector protein (Rho GTPase binding) 3	0.020
SRGAP2	SLIT-ROBO Rho GTPase activating protein 2	0.020
ITGB5	integrin, beta 5	0.020
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.019
NUMB	numb homolog (Drosophila)	0.019
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.019
TRAPPC1	trafficking protein particle complex 1	0.019
FASLG	Fas ligand (TNF superfamily, member 6)	0.018
JAG2	jagged 2	0.018
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.017
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.017	Fly
DLL1	delta-like 1 (Drosophila)	0.017
FAT1	FAT tumor suppressor homolog 1 (Drosophila)	0.017
ERBB2IP	erbb2 interacting protein	0.016
LLGL1	lethal giant larvae homolog 1 (Drosophila)	0.016
PRKCI	protein kinase C, iota	0.015
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.015
PFN1	profilin 1	0.015
ITSN1	intersectin 1 (SH3 domain protein)	0.015
UBE2R2	ubiquitin-conjugating enzyme E2R 2	0.015
CACNA1C	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.015
CAPZA2	capping protein (actin filament) muscle Z-line, alpha 2	0.014	Fly
ATF7IP	activating transcription factor 7 interacting protein	0.014
MYL12B	myosin, light chain 12B, regulatory	0.014
ANLN	anillin, actin binding protein	0.014
RAP1A	RAP1A, member of RAS oncogene family	0.014
CMTM6	CKLF-like MARVEL transmembrane domain containing 6	0.014
LRRK2	leucine-rich repeat kinase 2	0.014
NCF2	neutrophil cytosolic factor 2	0.013
ARPP19	cAMP-regulated phosphoprotein, 19kDa	0.013
SH3GL3	SH3-domain GRB2-like 3	0.013
LLGL2	lethal giant larvae homolog 2 (Drosophila)	0.013
SORBS3	sorbin and SH3 domain containing 3	0.013
DLG4	discs, large homolog 4 (Drosophila)	0.013
TGFB1	transforming growth factor, beta 1	0.013
ZNF71	zinc finger protein 71	0.013
RALGDS	ral guanine nucleotide dissociation stimulator	0.013
GMFB	glia maturation factor, beta	0.012
MYOCD	myocardin	0.012
PTOV1	prostate tumor overexpressed 1	0.012
JUP	junction plakoglobin	0.012
CCDC115	coiled-coil domain containing 115	0.012
ARL8B	ADP-ribosylation factor-like 8B	0.012
NOTCH3	notch 3	0.012	Fly
PAWR	PRKC, apoptosis, WT1, regulator	0.011
EFHD2	EF-hand domain family, member D2	0.011
CYTH2	cytohesin 2	0.011
ZYX	zyxin	0.011
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.011
CLTB	clathrin, light chain B	0.011
MAP3K11	mitogen-activated protein kinase kinase kinase 11	0.011
CTTN	cortactin	0.011
MYO10	myosin X	0.010