IMP

Process View

Homo sapiens

16 genes annotated in human

chemokine mediated signaling pathway

A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "chemokine mediated signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "chemokine mediated signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
CCR5	chemokine (C-C motif) receptor 5	1.000
CCL5	chemokine (C-C motif) ligand 5	0.997
DPP4	dipeptidyl-peptidase 4	0.993
IL8	interleukin 8	0.987	Human
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.958	Human
CCL20	chemokine (C-C motif) ligand 20	0.956	Human
IL1B	interleukin 1, beta	0.953
CCL4	chemokine (C-C motif) ligand 4	0.932	Human
CCL8	chemokine (C-C motif) ligand 8	0.923	Human
CCL2	chemokine (C-C motif) ligand 2	0.910	Human
CXCL9	chemokine (C-X-C motif) ligand 9	0.901	Human
CXCL2	chemokine (C-X-C motif) ligand 2	0.864	Human
CXCL10	chemokine (C-X-C motif) ligand 10	0.861
IL6	interleukin 6 (interferon, beta 2)	0.819
CXCL3	chemokine (C-X-C motif) ligand 3	0.814	Human
CXCL11	chemokine (C-X-C motif) ligand 11	0.803
IFNG	interferon, gamma	0.800
CXCL5	chemokine (C-X-C motif) ligand 5	0.718	Human
CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	0.669	Human
IL2RB	interleukin 2 receptor, beta	0.629
CCL22	chemokine (C-C motif) ligand 22	0.476
CCR1	chemokine (C-C motif) receptor 1	0.471
CCR7	chemokine (C-C motif) receptor 7	0.446
CCL19	chemokine (C-C motif) ligand 19	0.426	Human
PSEN2	presenilin 2 (Alzheimer disease 4)	0.417
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.414	Human
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.398
CCL7	chemokine (C-C motif) ligand 7	0.392	Human
IL10	interleukin 10	0.387
CXCL13	chemokine (C-X-C motif) ligand 13	0.370
CCR4	chemokine (C-C motif) receptor 4	0.281	Human Mouse
CCL13	chemokine (C-C motif) ligand 13	0.203	Human
CCL11	chemokine (C-C motif) ligand 11	0.187	Human
CCR2	chemokine (C-C motif) receptor 2	0.160	Human Mouse Rat
CXCR3	chemokine (C-X-C motif) receptor 3	0.151	Human Rat
MMP12	matrix metallopeptidase 12 (macrophage elastase)	0.120
LTA	lymphotoxin alpha (TNF superfamily, member 1)	0.094
VCAM1	vascular cell adhesion molecule 1	0.094
UBD	ubiquitin D	0.092
IL1R2	interleukin 1 receptor, type II	0.090
IL16	interleukin 16 (lymphocyte chemoattractant factor)	0.083
IRF4	interferon regulatory factor 4	0.081
MATK	megakaryocyte-associated tyrosine kinase	0.081
CD40LG	CD40 ligand	0.079
IL1RN	interleukin 1 receptor antagonist	0.076
IDE	insulin-degrading enzyme	0.068
CPE	carboxypeptidase E	0.063
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.058
CXCR6	chemokine (C-X-C motif) receptor 6	0.050	Human Mouse
RDH11	retinol dehydrogenase 11 (all-trans/9-cis/11-cis)	0.043
SELE	selectin E	0.043
ADAMDEC1	ADAM-like, decysin 1	0.042
PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	0.042
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.042
PPBP	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	0.041
SOD2	superoxide dismutase 2, mitochondrial	0.041
CLEC7A	C-type lectin domain family 7, member A	0.040
IL10RA	interleukin 10 receptor, alpha	0.040
CXCR2	chemokine (C-X-C motif) receptor 2	0.038
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.038
CCL3	chemokine (C-C motif) ligand 3	0.037	Human
CH25H	cholesterol 25-hydroxylase	0.037
CD83	CD83 molecule	0.036
TNF	tumor necrosis factor	0.036
TNFAIP6	tumor necrosis factor, alpha-induced protein 6	0.035
IL1A	interleukin 1, alpha	0.035
RGS1	regulator of G-protein signaling 1	0.033
CCR8	chemokine (C-C motif) receptor 8	0.031	Human Mouse
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.030
CD86	CD86 molecule	0.029
PF4	platelet factor 4	0.027	Human
FPR3	formyl peptide receptor 3	0.027
LAMP3	lysosomal-associated membrane protein 3	0.027
CCL21	chemokine (C-C motif) ligand 21	0.027
WASL	Wiskott-Aldrich syndrome-like	0.026
IDO1	indoleamine 2,3-dioxygenase 1	0.026
IL2RG	interleukin 2 receptor, gamma	0.026
BCL2A1	BCL2-related protein A1	0.026
SLAMF7	SLAM family member 7	0.025
CCR3	chemokine (C-C motif) receptor 3	0.025	Human Mouse
SOCS3	suppressor of cytokine signaling 3	0.025
IL18RAP	interleukin 18 receptor accessory protein	0.024
GNLY	granulysin	0.024
CCR6	chemokine (C-C motif) receptor 6	0.024	Human
KLRD1	killer cell lectin-like receptor subfamily D, member 1	0.024
AQP9	aquaporin 9	0.024
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.023
S100A12	S100 calcium binding protein A12	0.023
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.022
GPR109B	G protein-coupled receptor 109B	0.022
PF4V1	platelet factor 4 variant 1	0.021	Human
PI3	peptidase inhibitor 3, skin-derived	0.021
CCL23	chemokine (C-C motif) ligand 23	0.019	Human
TNFSF8	tumor necrosis factor (ligand) superfamily, member 8	0.019
TLR2	toll-like receptor 2	0.019
IL1F5	interleukin 1 family, member 5 (delta)	0.018
MSR1	macrophage scavenger receptor 1	0.018
CD80	CD80 molecule	0.018
GPR171	G protein-coupled receptor 171	0.018
IL21R	interleukin 21 receptor	0.018
ICAM1	intercellular adhesion molecule 1	0.018
INHBA	inhibin, beta A	0.017
PLEK	pleckstrin	0.017
DARC	Duffy blood group, chemokine receptor	0.017
CD74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.017
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.017
IL7R	interleukin 7 receptor	0.017
BIRC3	baculoviral IAP repeat containing 3	0.016
C2	complement component 2	0.016
CXCR1	chemokine (C-X-C motif) receptor 1	0.016
C5AR1	complement component 5a receptor 1	0.014
GZMK	granzyme K (granzyme 3; tryptase II)	0.014
CD28	CD28 molecule	0.014
CXCR5	chemokine (C-X-C motif) receptor 5	0.013	Human
LAG3	lymphocyte-activation gene 3	0.013
SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	0.013
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.013
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.013
CD69	CD69 molecule	0.012
KLRB1	killer cell lectin-like receptor subfamily B, member 1	0.012
SRCIN1	SRC kinase signaling inhibitor 1	0.012
OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	0.012
SLAMF1	signaling lymphocytic activation molecule family member 1	0.012
TREM1	triggering receptor expressed on myeloid cells 1	0.012
FGL2	fibrinogen-like 2	0.012
IER3	immediate early response 3	0.012
DPT	dermatopontin	0.011
CD163	CD163 molecule	0.011
PITPNM3	PITPNM family member 3	0.011
EBI3	Epstein-Barr virus induced 3	0.011
HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1	0.011
SLAMF8	SLAM family member 8	0.011
CD160	CD160 molecule	0.011
XCL2	chemokine (C motif) ligand 2	0.011
IL2RA	interleukin 2 receptor, alpha	0.011
CCRL2	chemokine (C-C motif) receptor-like 2	0.010	Human
CLEC5A	C-type lectin domain family 5, member A	0.010
TBX21	T-box 21	0.010
RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	0.010