IMP
Process View
negative regulation of epidermal growth factor activated receptor activity
Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity.
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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of epidermal growth factor activated receptor activity"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.989 | ||
| EGFR | epidermal growth factor receptor | 0.916 | ||
| EPOR | erythropoietin receptor | 0.434 | ||
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.382 | ||
| SOCS1 | suppressor of cytokine signaling 1 | 0.299 | Human | |
| GRB2 | growth factor receptor-bound protein 2 | 0.297 | Fly | |
| FLNB | filamin B, beta | 0.287 | ||
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.239 | ||
| PSEN1 | presenilin 1 | 0.238 | Mouse | |
| SOCS2 | suppressor of cytokine signaling 2 | 0.154 | Human | |
| ERBB2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 0.148 | ||
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.140 | ||
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 0.125 | Human Fly | |
| GAB1 | GRB2-associated binding protein 1 | 0.121 | ||
| SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 0.121 | ||
| PLCG1 | phospholipase C, gamma 1 | 0.104 | ||
| NCK1 | NCK adaptor protein 1 | 0.074 | ||
| ITCH | itchy E3 ubiquitin protein ligase homolog (mouse) | 0.073 | ||
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 0.070 | ||
| CRK | v-crk sarcoma virus CT10 oncogene homolog (avian) | 0.061 | ||
| JAK2 | Janus kinase 2 | 0.060 | ||
| SNX9 | sorting nexin 9 | 0.050 | ||
| SFN | stratifin | 0.047 | ||
| COMMD1 | copper metabolism (Murr1) domain containing 1 | 0.043 | ||
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.041 | ||
| ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase | 0.038 | ||
| NCSTN | nicastrin | 0.036 | ||
| GHR | growth hormone receptor | 0.034 | ||
| PSEN2 | presenilin 2 (Alzheimer disease 4) | 0.028 | Mouse | |
| ERBB3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 0.025 | ||
| CD28 | CD28 molecule | 0.025 | ||
| SORBS3 | sorbin and SH3 domain containing 3 | 0.025 | ||
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.025 | ||
| APH1A | anterior pharynx defective 1 homolog A (C. elegans) | 0.022 | ||
| SH2D3A | SH2 domain containing 3A | 0.021 | ||
| CBLB | Cas-Br-M (murine) ecotropic retroviral transforming sequence b | 0.021 | Human Fly | |
| MAP1S | microtubule-associated protein 1S | 0.021 | ||
| BCL2L1 | BCL2-like 1 | 0.020 | ||
| SH3GL2 | SH3-domain GRB2-like 2 | 0.020 | ||
| BAD | BCL2-associated agonist of cell death | 0.019 | ||
| VAV1 | vav 1 guanine nucleotide exchange factor | 0.018 | ||
| WASL | Wiskott-Aldrich syndrome-like | 0.017 | ||
| ARHGEF7 | Rho guanine nucleotide exchange factor (GEF) 7 | 0.016 | ||
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.016 | ||
| SOCS3 | suppressor of cytokine signaling 3 | 0.016 | Human | |
| TCEB1 | transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) | 0.015 | ||
| CIB1 | calcium and integrin binding 1 (calmyrin) | 0.014 | ||
| BLNK | B-cell linker | 0.014 | ||
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | 0.013 | ||
| PTPN23 | protein tyrosine phosphatase, non-receptor type 23 | 0.012 | ||
| INPP5D | inositol polyphosphate-5-phosphatase, 145kDa | 0.012 | ||
| APP | amyloid beta (A4) precursor protein | 0.012 | ||
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.012 | ||
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.011 | ||
| MET | met proto-oncogene (hepatocyte growth factor receptor) | 0.011 | ||
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.011 | ||
| SNX18 | sorting nexin 18 | 0.011 | ||
| PTK2 | PTK2 protein tyrosine kinase 2 | 0.011 | ||
| BCAR1 | breast cancer anti-estrogen resistance 1 | 0.011 | ||
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.010 | ||
| SGK3 | serum/glucocorticoid regulated kinase family, member 3 | 0.010 |