IMP

Process View

Homo sapiens

3 genes annotated in human

regulation of endosome size

Any process that modulates the volume of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of endosome size"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of endosome size" (in gray)

Name	Description	Probability	Func Analog Organism
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	1.000	Yeast
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.878
ZFYVE9	zinc finger, FYVE domain containing 9	0.705
RNF11	ring finger protein 11	0.700
NEDD4	neural precursor cell expressed, developmentally down-regulated 4	0.677	Yeast
FBXL15	F-box and leucine-rich repeat protein 15	0.445
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.441	Yeast
WWP2	WW domain containing E3 ubiquitin protein ligase 2	0.438	Yeast
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.396	Yeast
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.322
ANKRD13A	ankyrin repeat domain 13A	0.295
WWP1	WW domain containing E3 ubiquitin protein ligase 1	0.192	Yeast
SMAD4	SMAD family member 4	0.180
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like	0.145	Yeast
RAB11FIP1	RAB11 family interacting protein 1 (class I)	0.140
EEA1	early endosome antigen 1	0.117
RAB1A	RAB1A, member RAS oncogene family	0.106
POU5F1	POU class 5 homeobox 1	0.098
NAPA	N-ethylmaleimide-sensitive factor attachment protein, alpha	0.085
TAX1BP1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.066
ARRB2	arrestin, beta 2	0.064
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.064
OCRL	oculocerebrorenal syndrome of Lowe	0.061
CXXC5	CXXC finger protein 5	0.059
SNX9	sorting nexin 9	0.050
RAB5A	RAB5A, member RAS oncogene family	0.050
RHOA	ras homolog gene family, member A	0.050
RAPGEF2	Rap guanine nucleotide exchange factor (GEF) 2	0.049
SCNN1B	sodium channel, nonvoltage-gated 1, beta	0.048
ADIPOR1	adiponectin receptor 1	0.048
SMAD1	SMAD family member 1	0.048
DEDD	death effector domain containing	0.044
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.039
RAC1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	0.038
ZFAND5	zinc finger, AN1-type domain 5	0.035
SMAD7	SMAD family member 7	0.035
SCNN1A	sodium channel, nonvoltage-gated 1 alpha	0.031
LRRK2	leucine-rich repeat kinase 2	0.031
RAB7A	RAB7A, member RAS oncogene family	0.030
CALCOCO1	calcium binding and coiled-coil domain 1	0.029
RAB14	RAB14, member RAS oncogene family	0.029
VPS24	vacuolar protein sorting 24 homolog (S. cerevisiae)	0.028
RAP1B	RAP1B, member of RAS oncogene family	0.027
TRAF4	TNF receptor-associated factor 4	0.026
RAB11FIP3	RAB11 family interacting protein 3 (class II)	0.024
CCDC127	coiled-coil domain containing 127	0.023
CALM1	calmodulin 1 (phosphorylase kinase, delta)	0.023
SOX7	SRY (sex determining region Y)-box 7	0.023
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.023
RAB11FIP2	RAB11 family interacting protein 2 (class I)	0.022
ING2	inhibitor of growth family, member 2	0.022
ZRANB1	zinc finger, RAN-binding domain containing 1	0.021
ARRDC3	arrestin domain containing 3	0.021
PTP4A1	protein tyrosine phosphatase type IVA, member 1	0.021
MARCH5	membrane-associated ring finger (C3HC4) 5	0.020
SNX18	sorting nexin 18	0.020
DYNLT3	dynein, light chain, Tctex-type 3	0.020
WNK1	WNK lysine deficient protein kinase 1	0.020
ARL8B	ADP-ribosylation factor-like 8B	0.019
CLPTM1	cleft lip and palate associated transmembrane protein 1	0.018
DTX1	deltex homolog 1 (Drosophila)	0.018
UBE2A	ubiquitin-conjugating enzyme E2A (RAD6 homolog)	0.017
WBP2	WW domain binding protein 2	0.017
UBE2B	ubiquitin-conjugating enzyme E2B (RAD6 homolog)	0.017
ADARB1	adenosine deaminase, RNA-specific, B1	0.017
NCKAP1	NCK-associated protein 1	0.017
PDLIM7	PDZ and LIM domain 7 (enigma)	0.017
UBQLN2	ubiquilin 2	0.017
KLF5	Kruppel-like factor 5 (intestinal)	0.016
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.016
AIG1	androgen-induced 1	0.016
ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A	0.016
RYBP	RING1 and YY1 binding protein	0.015
NDFIP2	Nedd4 family interacting protein 2	0.014
POLH	polymerase (DNA directed), eta	0.014
OPTN	optineurin	0.014
GDI1	GDP dissociation inhibitor 1	0.014
UBE2E1	ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)	0.014
MAP3K2	mitogen-activated protein kinase kinase kinase 2	0.014
TM9SF4	transmembrane 9 superfamily protein member 4	0.014
ACVR1B	activin A receptor, type IB	0.013
STAM2	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	0.013
FEM1C	fem-1 homolog c (C. elegans)	0.013
PLEKHO1	pleckstrin homology domain containing, family O member 1	0.013
RABGEF1	RAB guanine nucleotide exchange factor (GEF) 1	0.013
ZFAND3	zinc finger, AN1-type domain 3	0.012
FTH1	ferritin, heavy polypeptide 1	0.012
ATP6V1B2	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	0.012
CAPZA2	capping protein (actin filament) muscle Z-line, alpha 2	0.012
FGFR1	fibroblast growth factor receptor 1	0.012
DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.012
GGA1	golgi-associated, gamma adaptin ear containing, ARF binding protein 1	0.011
CALCOCO2	calcium binding and coiled-coil domain 2	0.011
UBE2Z	ubiquitin-conjugating enzyme E2Z	0.011
YAP1	Yes-associated protein 1	0.011
APPL2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	0.010
SMAD5	SMAD family member 5	0.010
EPS15	epidermal growth factor receptor pathway substrate 15	0.010
RIOK3	RIO kinase 3 (yeast)	0.010
MAP2K4	mitogen-activated protein kinase kinase 4	0.010
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.010