IMP

Process View

Homo sapiens

12 genes annotated in human

negative regulation of small gtpase mediated signal transduction

Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of small gtpase mediated signal transduction"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of small gtpase mediated signal transduction" (in gray)

Name	Description	Probability	Func Analog Organism
MAPK1	mitogen-activated protein kinase 1	0.995
MAPK14	mitogen-activated protein kinase 14	0.985
HDAC1	histone deacetylase 1	0.938	Worm
CBX5	chromobox homolog 5	0.494	Worm
TNFAIP1	tumor necrosis factor, alpha-induced protein 1 (endothelial)	0.381
DUSP1	dual specificity phosphatase 1	0.248
CBX1	chromobox homolog 1	0.242	Worm
C19orf50	chromosome 19 open reading frame 50	0.237
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.190
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.189
NCOA3	nuclear receptor coactivator 3	0.150
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.141
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.137	Mouse
MAPK3	mitogen-activated protein kinase 3	0.133
RIN1	Ras and Rab interactor 1	0.129
MAP2K1	mitogen-activated protein kinase kinase 1	0.127
PDCD6IP	programmed cell death 6 interacting protein	0.114
GBP3	guanylate binding protein 3	0.110
KIF1B	kinesin family member 1B	0.099
KCTD10	potassium channel tetramerisation domain containing 10	0.095	Human
E2F6	E2F transcription factor 6	0.092
DUSP3	dual specificity phosphatase 3	0.084
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.081
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.075
MARCH5	membrane-associated ring finger (C3HC4) 5	0.069
FHL2	four and a half LIM domains 2	0.062
ARRB2	arrestin, beta 2	0.061
DUSP7	dual specificity phosphatase 7	0.055
ATF2	activating transcription factor 2	0.052
SH3KBP1	SH3-domain kinase binding protein 1	0.049
NCOA1	nuclear receptor coactivator 1	0.045
PTPRR	protein tyrosine phosphatase, receptor type, R	0.043	Fly
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.038	Fly
GSK3B	glycogen synthase kinase 3 beta	0.038
PEA15	phosphoprotein enriched in astrocytes 15	0.038
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.038
NCOR2	nuclear receptor corepressor 2	0.035
SPRY2	sprouty homolog 2 (Drosophila)	0.034	Mouse
HDAC2	histone deacetylase 2	0.033	Worm
RBBP4	retinoblastoma binding protein 4	0.033
MBD3	methyl-CpG binding domain protein 3	0.033
E2F4	E2F transcription factor 4, p107/p130-binding	0.032
YBX1	Y box binding protein 1	0.029
RICTOR	RPTOR independent companion of MTOR, complex 2	0.029
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.029
LBR	lamin B receptor	0.028
RB1	retinoblastoma 1	0.027
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.025
EGFR	epidermal growth factor receptor	0.025
RANBP3	RAN binding protein 3	0.024
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.021
SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.021
PCDH9	protocadherin 9	0.021
PTPN7	protein tyrosine phosphatase, non-receptor type 7	0.020	Fly
PRKCA	protein kinase C, alpha	0.020
PPAP2B	phosphatidic acid phosphatase type 2B	0.020
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.019
VPS24	vacuolar protein sorting 24 homolog (S. cerevisiae)	0.019
MAP2K4	mitogen-activated protein kinase kinase 4	0.018
RHOB	ras homolog gene family, member B	0.018
MBP	myelin basic protein	0.017
STAM	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	0.017
ADNP	activity-dependent neuroprotector homeobox	0.017
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.016
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.016
MED31	mediator complex subunit 31	0.016
ITGB4	integrin, beta 4	0.016
ATN1	atrophin 1	0.015
RXRA	retinoid X receptor, alpha	0.015
IQGAP1	IQ motif containing GTPase activating protein 1	0.014
HDAC5	histone deacetylase 5	0.014
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.014
RASA1	RAS p21 protein activator (GTPase activating protein) 1	0.014
SOX4	SRY (sex determining region Y)-box 4	0.013
BAIAP2	BAI1-associated protein 2	0.013
EEF2K	eukaryotic elongation factor-2 kinase	0.013
XPO6	exportin 6	0.013
HDAC6	histone deacetylase 6	0.013
DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.013
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.013
PXN	paxillin	0.012
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.012
DUSP6	dual specificity phosphatase 6	0.012
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.012
AKAP9	A kinase (PRKA) anchor protein (yotiao) 9	0.012
TFDP2	transcription factor Dp-2 (E2F dimerization partner 2)	0.011	Worm
AKT1S1	AKT1 substrate 1 (proline-rich)	0.011
C10orf116	chromosome 10 open reading frame 116	0.011
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.011
ARHGAP9	Rho GTPase activating protein 9	0.011
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	0.011
KCTD13	potassium channel tetramerisation domain containing 13	0.011
ATXN3	ataxin 3	0.010
TOP2B	topoisomerase (DNA) II beta 180kDa	0.010
OPA1	optic atrophy 1 (autosomal dominant)	0.010
RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	0.010	Fly
GATAD2B	GATA zinc finger domain containing 2B	0.010