IMP

Process View

Homo sapiens

1 genes annotated in human

establishment or maintenance of monopolar cell polarity

Any cellular process that results in the specification, formation or maintenance of monopolar intracellular organization or cell growth patterns. Monopolar cell organization is directional organization along an axis.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "establishment or maintenance of monopolar cell polarity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "establishment or maintenance of monopolar cell polarity" (in gray)

Name	Description	Probability	Func Analog Organism
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.932	Fly
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.919	Fly
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.910
LRRK2	leucine-rich repeat kinase 2	0.900
APC	adenomatous polyposis coli	0.845
CNKSR2	connector enhancer of kinase suppressor of Ras 2	0.604
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.535
AXIN1	axin 1	0.364
CEP164	centrosomal protein 164kDa	0.179
PKP4	plakophilin 4	0.144
JAM3	junctional adhesion molecule 3	0.144
ZNF512B	zinc finger protein 512B	0.138
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.131
CSNK1D	casein kinase 1, delta	0.116
TJP2	tight junction protein 2 (zona occludens 2)	0.110
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.109
CSNK1E	casein kinase 1, epsilon	0.097
KIAA1377	KIAA1377	0.096
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.085
MCC	mutated in colorectal cancers	0.083
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.077
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.069
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.063
WT1	Wilms tumor 1	0.062
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.055	Fly
GLIS2	GLIS family zinc finger 2	0.055
SMAD3	SMAD family member 3	0.052
PXN	paxillin	0.052
CDH5	cadherin 5, type 2 (vascular endothelium)	0.049
TRIP6	thyroid hormone receptor interactor 6	0.043
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.042
VCL	vinculin	0.042
PLCB3	phospholipase C, beta 3 (phosphatidylinositol-specific)	0.042
LRP6	low density lipoprotein receptor-related protein 6	0.039
BAHD1	bromo adjacent homology domain containing 1	0.039
PRPF3	PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)	0.039
HSPG2	heparan sulfate proteoglycan 2	0.038
STRN3	striatin, calmodulin binding protein 3	0.037
DST	dystonin	0.037
CTGF	connective tissue growth factor	0.036
ENG	endoglin	0.036
PDLIM5	PDZ and LIM domain 5	0.033
JAM2	junctional adhesion molecule 2	0.032
GAN	gigaxonin	0.032
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.029
CDH11	cadherin 11, type 2, OB-cadherin (osteoblast)	0.027
PRKCZ	protein kinase C, zeta	0.025
MYH10	myosin, heavy chain 10, non-muscle	0.025
SHOC2	soc-2 suppressor of clear homolog (C. elegans)	0.023
FHOD3	formin homology 2 domain containing 3	0.022
PIK3CB	phosphoinositide-3-kinase, catalytic, beta polypeptide	0.021
PSMF1	proteasome (prosome, macropain) inhibitor subunit 1 (PI31)	0.020
OCLN	occludin	0.020
TMEM147	transmembrane protein 147	0.020
RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2	0.019
ZFYVE9	zinc finger, FYVE domain containing 9	0.019
DPPA2	developmental pluripotency associated 2	0.018
ZMYND8	zinc finger, MYND-type containing 8	0.018
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.018
JUB	jub, ajuba homolog (Xenopus laevis)	0.018
DAAM1	dishevelled associated activator of morphogenesis 1	0.018
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	0.017	Zebrafish
C9orf100	chromosome 9 open reading frame 100	0.017
FBLN1	fibulin 1	0.017
PITX1	paired-like homeodomain 1	0.017
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.017
MAP2K6	mitogen-activated protein kinase kinase 6	0.017
BTRC	beta-transducin repeat containing	0.017
FAM110C	family with sequence similarity 110, member C	0.016
MYST2	MYST histone acetyltransferase 2	0.016
F11R	F11 receptor	0.016
PPP1R16A	protein phosphatase 1, regulatory (inhibitor) subunit 16A	0.016
CTNND2	catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)	0.015
CADM4	cell adhesion molecule 4	0.015
CHAC1	ChaC, cation transport regulator homolog 1 (E. coli)	0.015
PCGF2	polycomb group ring finger 2	0.015
SNIP1	Smad nuclear interacting protein 1	0.015
C16orf48	chromosome 16 open reading frame 48	0.014
PSMB7	proteasome (prosome, macropain) subunit, beta type, 7	0.014
MEX3C	mex-3 homolog C (C. elegans)	0.014
NUAK1	NUAK family, SNF1-like kinase, 1	0.014
CGN	cingulin	0.014
FAM110A	family with sequence similarity 110, member A	0.014
NKD2	naked cuticle homolog 2 (Drosophila)	0.013
ARHGEF19	Rho guanine nucleotide exchange factor (GEF) 19	0.013
TSC22D1	TSC22 domain family, member 1	0.013
BAD	BCL2-associated agonist of cell death	0.013
ATN1	atrophin 1	0.013
PSEN1	presenilin 1	0.013
KLHL12	kelch-like 12 (Drosophila)	0.013
CCDC92	coiled-coil domain containing 92	0.013
MAP1B	microtubule-associated protein 1B	0.013	Mouse
JUP	junction plakoglobin	0.012
YAP1	Yes-associated protein 1	0.012
PNMA1	paraneoplastic antigen MA1	0.012
RAB5B	RAB5B, member RAS oncogene family	0.012
SFN	stratifin	0.012
LLGL1	lethal giant larvae homolog 1 (Drosophila)	0.012
FLNA	filamin A, alpha	0.012
FIBP	fibroblast growth factor (acidic) intracellular binding protein	0.012
PNMA2	paraneoplastic antigen MA2	0.012
LAMC3	laminin, gamma 3	0.012
SMURF2	SMAD specific E3 ubiquitin protein ligase 2	0.012
GSK3B	glycogen synthase kinase 3 beta	0.012
RFWD2	ring finger and WD repeat domain 2	0.012
DTX2	deltex homolog 2 (Drosophila)	0.012
RHPN2	rhophilin, Rho GTPase binding protein 2	0.012
DBN1	drebrin 1	0.012
FOXF2	forkhead box F2	0.012
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.012
SPTBN1	spectrin, beta, non-erythrocytic 1	0.012
TNFAIP8L1	tumor necrosis factor, alpha-induced protein 8-like 1	0.011
AP1M1	adaptor-related protein complex 1, mu 1 subunit	0.011
FBN1	fibrillin 1	0.011
RAD23A	RAD23 homolog A (S. cerevisiae)	0.011
MYO6	myosin VI	0.011
SNF8	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)	0.011
PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	0.011
EMD	emerin	0.011
PTPN3	protein tyrosine phosphatase, non-receptor type 3	0.011
ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	0.011
ZBTB8A	zinc finger and BTB domain containing 8A	0.011
IGFBP3	insulin-like growth factor binding protein 3	0.010
RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1	0.010
USH1C	Usher syndrome 1C (autosomal recessive, severe)	0.010
ITGA4	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	0.010
ANXA2	annexin A2	0.010