IMP

Process View

Homo sapiens

28 genes annotated in human

cholesterol metabolic process

The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "cholesterol metabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "cholesterol metabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
FGFR2	fibroblast growth factor receptor 2	0.983
INSIG1	insulin induced gene 1	0.904	Mouse
SREBF2	sterol regulatory element binding transcription factor 2	0.851
AKR1C2	aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)	0.836	Human
HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	0.729
AKR1C1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)	0.700	Human
SC4MOL	sterol-C4-methyl oxidase-like	0.696
DHCR7	7-dehydrocholesterol reductase	0.695
SQLE	squalene epoxidase	0.588
FGF1	fibroblast growth factor 1 (acidic)	0.571
FDFT1	farnesyl-diphosphate farnesyltransferase 1	0.544
SCD	stearoyl-CoA desaturase (delta-9-desaturase)	0.526
IDI1	isopentenyl-diphosphate delta isomerase 1	0.399
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.361
IL4R	interleukin 4 receptor	0.353
LDLR	low density lipoprotein receptor	0.342	Mouse
HP	haptoglobin	0.340
AKR1C3	aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)	0.311	Human
CYP51A1	cytochrome P450, family 51, subfamily A, polypeptide 1	0.293	Rat
FGA	fibrinogen alpha chain	0.266
LRP1	low density lipoprotein receptor-related protein 1	0.244	Mouse
HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	0.222	Mouse
SNTB2	syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)	0.171
A2M	alpha-2-macroglobulin	0.144
C14orf1	chromosome 14 open reading frame 1	0.140
FGFR1	fibroblast growth factor receptor 1	0.125
FDPS	farnesyl diphosphate synthase	0.113
MVD	mevalonate (diphospho) decarboxylase	0.112
LSS	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	0.105
NSDHL	NAD(P) dependent steroid dehydrogenase-like	0.096
CRP	C-reactive protein, pentraxin-related	0.096
DHCR24	24-dehydrocholesterol reductase	0.078
FRS2	fibroblast growth factor receptor substrate 2	0.072
SLC25A1	solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1	0.071
APOA1	apolipoprotein A-I	0.066
APOC1	apolipoprotein C-I	0.058
APOE	apolipoprotein E	0.053
PGRMC1	progesterone receptor membrane component 1	0.053
APOA2	apolipoprotein A-II	0.053
LCAT	lecithin-cholesterol acyltransferase	0.048
PDIA3	protein disulfide isomerase family A, member 3	0.048
FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)	0.047	Human
APOC3	apolipoprotein C-III	0.047
FADS1	fatty acid desaturase 1	0.044
STARD4	StAR-related lipid transfer (START) domain containing 4	0.036
ACAA1	acetyl-CoA acyltransferase 1	0.036
PDZK1	PDZ domain containing 1	0.035
APP	amyloid beta (A4) precursor protein	0.033	Mouse
HNF4A	hepatocyte nuclear factor 4, alpha	0.032
MVK	mevalonate kinase	0.031
FASN	fatty acid synthase	0.031
PGD	phosphogluconate dehydrogenase	0.030
CANX	calnexin	0.027
SMAD3	SMAD family member 3	0.027
MBL2	mannose-binding lectin (protein C) 2, soluble	0.026
FGF10	fibroblast growth factor 10	0.026	Human
MED15	mediator complex subunit 15	0.026
FGF8	fibroblast growth factor 8 (androgen-induced)	0.026
CAPRIN2	caprin family member 2	0.025
PRMT2	protein arginine methyltransferase 2	0.025
SC5DL	sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like	0.024
SLC9A3R1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	0.023
SREBF1	sterol regulatory element binding transcription factor 1	0.022	Mouse Rat
COX6C	cytochrome c oxidase subunit VIc	0.022
EHHADH	enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase	0.021
CRYAB	crystallin, alpha B	0.019
CABIN1	calcineurin binding protein 1	0.018
BACE1	beta-site APP-cleaving enzyme 1	0.018
TMBIM6	transmembrane BAX inhibitor motif containing 6	0.018
ACACA	acetyl-CoA carboxylase alpha	0.018
SLC9A3R2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.017
HSD17B4	hydroxysteroid (17-beta) dehydrogenase 4	0.017
FGB	fibrinogen beta chain	0.017
MPZL1	myelin protein zero-like 1	0.017
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.017
GPLD1	glycosylphosphatidylinositol specific phospholipase D1	0.016
POR	P450 (cytochrome) oxidoreductase	0.016	Rat
HSPB1	heat shock 27kDa protein 1	0.016
PCSK9	proprotein convertase subtilisin/kexin type 9	0.016
MASP2	mannan-binding lectin serine peptidase 2	0.016
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.015
C8A	complement component 8, alpha polypeptide	0.014
CTSD	cathepsin D	0.014
STX12	syntaxin 12	0.014
CCNG2	cyclin G2	0.014
TKT	transketolase	0.014
DEDD	death effector domain containing	0.014
HADHB	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	0.014
EPHX1	epoxide hydrolase 1, microsomal (xenobiotic)	0.014
APOC2	apolipoprotein C-II	0.014
AKR1C4	aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)	0.013	Human
PTPN5	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	0.013
IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	0.013
ATP6AP1	ATPase, H+ transporting, lysosomal accessory protein 1	0.013
APOB	apolipoprotein B (including Ag(x) antigen)	0.013
APCS	amyloid P component, serum	0.012
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.012
ABCG1	ATP-binding cassette, sub-family G (WHITE), member 1	0.012
FGF3	fibroblast growth factor 3	0.012	Human
CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.012
AADAC	arylacetamide deacetylase (esterase)	0.012
F11	coagulation factor XI	0.012
TM7SF2	transmembrane 7 superfamily member 2	0.012
HAO2	hydroxyacid oxidase 2 (long chain)	0.012
ST13	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	0.012
PSAP	prosaposin	0.012
SCP2	sterol carrier protein 2	0.012
PCYT2	phosphate cytidylyltransferase 2, ethanolamine	0.012
JAK3	Janus kinase 3	0.012
HNF1B	HNF1 homeobox B	0.012
PRDX6	peroxiredoxin 6	0.011
ITGB5	integrin, beta 5	0.011
TXNDC2	thioredoxin domain containing 2 (spermatozoa)	0.011
PCBD2	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2	0.011
F9	coagulation factor IX	0.011
OGDH	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	0.011
CLCN3	chloride channel 3	0.011
PCBD1	pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha	0.011
ACSS2	acyl-CoA synthetase short-chain family member 2	0.011
BCR	breakpoint cluster region	0.011
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	0.010
ALDH3A2	aldehyde dehydrogenase 3 family, member A2	0.010
ECHDC2	enoyl CoA hydratase domain containing 2	0.010
PKLR	pyruvate kinase, liver and RBC	0.010
PEX19	peroxisomal biogenesis factor 19	0.010
TBC1D10A	TBC1 domain family, member 10A	0.010
PIR	pirin (iron-binding nuclear protein)	0.010