IMP

Process View

Mus musculus

5 genes annotated in mouse

metanephric distal convoluted tubule development

The process whose specific outcome is the progression of the metanephric distal convoluted tubule over time, from its formation to the mature structure. The metanephric distal convoluted tubule is the first segment of the metanephric nephron lying just downstream from the loop of Henle, immediately after the macula densa. Among other functions, in humans it is responsible for the reabsorption of about 5% of filtered sodium via the thiazide-sensitive Na-Cl symporter.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "metanephric distal convoluted tubule development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "metanephric distal convoluted tubule development" (in gray)

Name	Description	Probability	Func Analog Organism
Sox2	SRY-box containing gene 2	0.962
Lhx1	LIM homeobox protein 1	0.938
Otx2	orthodenticle homolog 2 (Drosophila)	0.853
Emx2	empty spiracles homolog 2 (Drosophila)	0.847
Nanog	Nanog homeobox	0.557
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.498
Lmx1a	LIM homeobox transcription factor 1 alpha	0.457
Tbx10	T-box 10	0.397
Hmx3	H6 homeobox 3	0.378
Wnt9b	wingless-type MMTV integration site 9B	0.322
Lhx3	LIM homeobox protein 3	0.315
Sall3	sal-like 3 (Drosophila)	0.307
Otx1	orthodenticle homolog 1 (Drosophila)	0.297
Lef1	lymphoid enhancer binding factor 1	0.291
Eya1	eyes absent 1 homolog (Drosophila)	0.256
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.241
Pax2	paired box gene 2	0.240
Pax8	paired box gene 8	0.216
Pax6	paired box gene 6	0.210
Slc12a1	solute carrier family 12, member 1	0.208
Sall4	sal-like 4 (Drosophila)	0.205
T	brachyury	0.190
Chd7	chromodomain helicase DNA binding protein 7	0.184
Neurod1	neurogenic differentiation 1	0.183
Atoh7	atonal homolog 7 (Drosophila)	0.169
Zic2	zinc finger protein of the cerebellum 2	0.164
Gbx2	gastrulation brain homeobox 2	0.156
Emx1	empty spiracles homolog 1 (Drosophila)	0.155
Kcne1	potassium voltage-gated channel, Isk-related subfamily, member 1	0.154
Pax3	paired box gene 3	0.123
Rarg	retinoic acid receptor, gamma	0.121
Slc26a4	solute carrier family 26, member 4	0.109
Hoxd11	homeobox D11	0.105
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.102
S1pr2	sphingosine-1-phosphate receptor 2	0.099
Vangl2	vang-like 2 (van gogh, Drosophila)	0.092
Hoxa11	homeobox A11	0.091
Gdf11	growth differentiation factor 11	0.086
Hmx1	H6 homeobox 1	0.078
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.074
Foxd2	forkhead box D2	0.068
Insm1	insulinoma-associated 1	0.066
Hes5	hairy and enhancer of split 5 (Drosophila)	0.065
Wnt7b	wingless-related MMTV integration site 7B	0.059
Atoh1	atonal homolog 1 (Drosophila)	0.056
Pou3f3	POU domain, class 3, transcription factor 3	0.055
Gata3	GATA binding protein 3	0.052
Sim1	single-minded homolog 1 (Drosophila)	0.052
Thrb	thyroid hormone receptor beta	0.051
Sall1	sal-like 1 (Drosophila)	0.051
Foxi1	forkhead box I1	0.051
Kcnk7	potassium channel, subfamily K, member 7	0.047
Wnt1	wingless-related MMTV integration site 1	0.046
Shh	sonic hedgehog	0.045
Fgf3	fibroblast growth factor 3	0.043
Bcl2	B-cell leukemia/lymphoma 2	0.043
Foxg1	forkhead box G1	0.042
Dlx1	distal-less homeobox 1	0.041
Kcnj10	potassium inwardly-rectifying channel, subfamily J, member 10	0.038
Uncx	UNC homeobox	0.037
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.037
Sox3	SRY-box containing gene 3	0.036
Hoxd13	homeobox D13	0.034
Rara	retinoic acid receptor, alpha	0.030
Oprd1	opioid receptor, delta 1	0.029
Tlx3	T-cell leukemia, homeobox 3	0.029
Bdnf	brain derived neurotrophic factor	0.029
Cbln1	cerebellin 1 precursor protein	0.028
Isl1	ISL1 transcription factor, LIM/homeodomain	0.027
Drd2	dopamine receptor D2	0.027
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.026
Gatad2b	GATA zinc finger domain containing 2B	0.026
Cckbr	cholecystokinin B receptor	0.025
Sox11	SRY-box containing gene 11	0.025
Cd19	CD19 antigen	0.024
Pou3f2	POU domain, class 3, transcription factor 2	0.024	Mouse
Pde6b	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	0.024
Neurog3	neurogenin 3	0.024
Cacng2	calcium channel, voltage-dependent, gamma subunit 2	0.023
Lhx5	LIM homeobox protein 5	0.023
Fgf4	fibroblast growth factor 4	0.023
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.023
Hoxb1	homeobox B1	0.022
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.021
Hand1	heart and neural crest derivatives expressed transcript 1	0.021
Slc5a1	solute carrier family 5 (sodium/glucose cotransporter), member 1	0.021
Aym1	activator of yeast meiotic promoters 1	0.021
Hoxa1	homeobox A1	0.021
Arid3b	AT rich interactive domain 3B (BRIGHT-like)	0.020
Dlx5	distal-less homeobox 5	0.020
Lhx9	LIM homeobox protein 9	0.020
Mmp24	matrix metallopeptidase 24	0.020
En2	engrailed 2	0.020
Slc14a2	solute carrier family 14 (urea transporter), member 2	0.020
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.019
Robo3	roundabout homolog 3 (Drosophila)	0.019
Fgf15	fibroblast growth factor 15	0.019
Pcsk2	proprotein convertase subtilisin/kexin type 2	0.019
Dab1	disabled homolog 1 (Drosophila)	0.019
Hoxd3	homeobox D3	0.018
Fgf5	fibroblast growth factor 5	0.018
Hoxd1	homeobox D1	0.017
Cdx1	caudal type homeobox 1	0.017
Msi1	Musashi homolog 1(Drosophila)	0.017
Gsx1	GS homeobox 1	0.017
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.017
Sox1	SRY-box containing gene 1	0.017
Vax1	ventral anterior homeobox containing gene 1	0.017
Dlx4	distal-less homeobox 4	0.017
Brd4	bromodomain containing 4	0.016
En1	engrailed 1	0.016
Paxip1	PAX interacting (with transcription-activation domain) protein 1	0.016
Adcyap1	adenylate cyclase activating polypeptide 1	0.016
Mta1	metastasis associated 1	0.016
Tcfap2c	transcription factor AP-2, gamma	0.015
Foxb1	forkhead box B1	0.015
Wnt7a	wingless-related MMTV integration site 7A	0.015
Hoxb7	homeobox B7	0.014
Wt1	Wilms tumor 1 homolog	0.014
Zic3	zinc finger protein of the cerebellum 3	0.014
Hoxa4	homeobox A4	0.014
Sox8	SRY-box containing gene 8	0.014
Wnt4	wingless-related MMTV integration site 4	0.014
Foxe1	forkhead box E1	0.014
Socs1	suppressor of cytokine signaling 1	0.014
Sox21	SRY-box containing gene 21	0.014
Wnt6	wingless-related MMTV integration site 6	0.013
Nos1	nitric oxide synthase 1, neuronal	0.013
Pou4f3	POU domain, class 4, transcription factor 3	0.013	Mouse
Msx3	homeobox, msh-like 3	0.013
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.013
Phox2a	paired-like homeobox 2a	0.013
Srrm4	serine/arginine repetitive matrix 4	0.012
Slc5a2	solute carrier family 5 (sodium/glucose cotransporter), member 2	0.012
Rhcg	Rhesus blood group-associated C glycoprotein	0.012
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.012
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.012
Adra2b	adrenergic receptor, alpha 2b	0.011
Cdk5r2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	0.011
Htr5b	5-hydroxytryptamine (serotonin) receptor 5B	0.011
Rnf208	ring finger protein 208	0.011
Neurog2	neurogenin 2	0.011
Tlx2	T-cell leukemia, homeobox 2	0.011
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.011
Tacr1	tachykinin receptor 1	0.011
Slc12a3	solute carrier family 12, member 3	0.010
Sin3a	transcriptional regulator, SIN3A (yeast)	0.010
Ret	ret proto-oncogene	0.010
Cyp24a1	cytochrome P450, family 24, subfamily a, polypeptide 1	0.010
Ren1	renin 1 structural	0.010
Efna3	ephrin A3	0.010
Nkx2-1	NK2 homeobox 1	0.010
Cabp7	calcium binding protein 7	0.010
Rag2	recombination activating gene 2	0.010