IMP

Process View

Mus musculus

6 genes annotated in mouse

t helper cell lineage commitment

The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "t helper cell lineage commitment"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "t helper cell lineage commitment" (in gray)

Name	Description	Probability	Func Analog Organism
Foxp3	forkhead box P3	0.980
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.935
Il10	interleukin 10	0.728
Irf9	interferon regulatory factor 9	0.681	Mouse
Ifng	interferon gamma	0.679
Tnf	tumor necrosis factor	0.654
Stat5a	signal transducer and activator of transcription 5A	0.649	Mouse
Stat5b	signal transducer and activator of transcription 5B	0.569	Mouse
Il4ra	interleukin 4 receptor, alpha	0.527
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.512
Stat2	signal transducer and activator of transcription 2	0.506	Mouse
Lyz2	lysozyme 2	0.492
Fas	Fas (TNF receptor superfamily member 6)	0.487
Stat6	signal transducer and activator of transcription 6	0.405
Il6st	interleukin 6 signal transducer	0.400
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.384
Socs1	suppressor of cytokine signaling 1	0.380
Stat3	signal transducer and activator of transcription 3	0.378	Mouse
Cd19	CD19 antigen	0.213
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.175
Ikzf1	IKAROS family zinc finger 1	0.163
Batf	basic leucine zipper transcription factor, ATF-like	0.162
Prf1	perforin 1 (pore forming protein)	0.155
Il2	interleukin 2	0.146
Rag1	recombination activating gene 1	0.127
Sfpi1	SFFV proviral integration 1	0.114
Stat1	signal transducer and activator of transcription 1	0.111	Mouse
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.109
Mmp9	matrix metallopeptidase 9	0.106
Trp53	transformation related protein 53	0.105
Cd28	CD28 antigen	0.103
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.096
Tlr4	toll-like receptor 4	0.089
Uba7	ubiquitin-like modifier activating enzyme 7	0.085
Irf4	interferon regulatory factor 4	0.080
Kit	kit oncogene	0.067
Ccl2	chemokine (C-C motif) ligand 2	0.052
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.051
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.050
Irf5	interferon regulatory factor 5	0.049	Mouse
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.046
Il1r1	interleukin 1 receptor, type I	0.046
Ciita	class II transactivator	0.045
Pdcd1	programmed cell death 1	0.045
Igh	immunoglobulin heavy chain complex	0.041
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.041
Ifnar2	interferon (alpha and beta) receptor 2	0.038
Irf8	interferon regulatory factor 8	0.038	Mouse
Nckap1l	NCK associated protein 1 like	0.037
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.037
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.035
Cd40	CD40 antigen	0.034
Nfil3	nuclear factor, interleukin 3, regulated	0.030
Il21r	interleukin 21 receptor	0.029
Ptgs2	prostaglandin-endoperoxide synthase 2	0.027
Usp18	ubiquitin specific peptidase 18	0.027
Trim21	tripartite motif-containing 21	0.026
Il27ra	interleukin 27 receptor, alpha	0.026
Itgal	integrin alpha L	0.025
Tapbp	TAP binding protein	0.025
Bcl3	B-cell leukemia/lymphoma 3	0.022
Inpp5d	inositol polyphosphate-5-phosphatase D	0.022
Myd88	myeloid differentiation primary response gene 88	0.022
Mx2	myxovirus (influenza virus) resistance 2	0.022
Lepr	leptin receptor	0.021
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.021
Irgm2	immunity-related GTPase family M member 2	0.020
Foxn1	forkhead box N1	0.020
Il4	interleukin 4	0.020
Jak3	Janus kinase 3	0.020
Il6	interleukin 6	0.019
Card11	caspase recruitment domain family, member 11	0.019
Tor3a	torsin family 3, member A	0.019
Lgals9	lectin, galactose binding, soluble 9	0.018
Il17ra	interleukin 17 receptor A	0.018
Socs3	suppressor of cytokine signaling 3	0.017
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.017
Isg15	ISG15 ubiquitin-like modifier	0.017
Il12b	interleukin 12b	0.016
Ncoa3	nuclear receptor coactivator 3	0.016
Znfx1	zinc finger, NFX1-type containing 1	0.016
Smad3	MAD homolog 3 (Drosophila)	0.015
Junb	Jun-B oncogene	0.015
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.015
Mefv	Mediterranean fever	0.014
Nlrp3	NLR family, pyrin domain containing 3	0.014
Zfp36	zinc finger protein 36	0.013
Ccl4	chemokine (C-C motif) ligand 4	0.013
Sfn	stratifin	0.012
Unc93b1	unc-93 homolog B1 (C. elegans)	0.012
Tgfb1	transforming growth factor, beta 1	0.012
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.012
Adar	adenosine deaminase, RNA-specific	0.011
Irf7	interferon regulatory factor 7	0.011	Mouse
Mvp	major vault protein	0.011
Ifit3	interferon-induced protein with tetratricopeptide repeats 3	0.010
Rel	reticuloendotheliosis oncogene	0.010