IMP

Process View

Mus musculus

3 genes annotated in mouse

muscle atrophy

A process, occurring in the muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "muscle atrophy"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "muscle atrophy" (in gray)

Name	Description	Probability	Func Analog Organism
Dmd	dystrophin, muscular dystrophy	0.944
Pax7	paired box gene 7	0.929
Pitx2	paired-like homeodomain transcription factor 2	0.789
Myf5	myogenic factor 5	0.747	Mouse
Trim55	tripartite motif-containing 55	0.652
Wfikkn2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.531
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.482
Mybph	myosin binding protein H	0.269
Pax3	paired box gene 3	0.258
Pparg	peroxisome proliferator activated receptor gamma	0.247
Myog	myogenin	0.205
Myf6	myogenic factor 6	0.167	Mouse
Tbx15	T-box 15	0.097
Chrna1	cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)	0.090
Fst	follistatin	0.081
Itch	itchy, E3 ubiquitin protein ligase	0.080
Klhl24	kelch-like 24 (Drosophila)	0.078
Atp2a1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.074
Tnnc2	troponin C2, fast	0.070
Wfikkn1	WAP, FS, Ig, KU, and NTR-containing protein 1	0.070
Lep	leptin	0.058
Casq1	calsequestrin 1	0.053
Mdm2	transformed mouse 3T3 cell double minute 2	0.050
Myod1	myogenic differentiation 1	0.050	Mouse
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.050
Fbxo32	F-box protein 32	0.047
Plin1	perilipin 1	0.045
Nos1	nitric oxide synthase 1, neuronal	0.044
Cacna1s	calcium channel, voltage-dependent, L type, alpha 1S subunit	0.041
Adam17	a disintegrin and metallopeptidase domain 17	0.041
Myh1	myosin, heavy polypeptide 1, skeletal muscle, adult	0.040
Mtmr1	myotubularin related protein 1	0.040
Cacng1	calcium channel, voltage-dependent, gamma subunit 1	0.038
Ncoa1	nuclear receptor coactivator 1	0.036
Myh8	myosin, heavy polypeptide 8, skeletal muscle, perinatal	0.035
Cav3	caveolin 3	0.035
Esr1	estrogen receptor 1 (alpha)	0.034
Tnni2	troponin I, skeletal, fast 2	0.033
Mybpc1	myosin binding protein C, slow-type	0.032
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.031
Trp53	transformation related protein 53	0.027
Hif1a	hypoxia inducible factor 1, alpha subunit	0.026
Smad3	MAD homolog 3 (Drosophila)	0.024
Zfp260	zinc finger protein 260	0.023
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.023
Uimc1	ubiquitin interaction motif containing 1	0.023
Zic3	zinc finger protein of the cerebellum 3	0.022
Gpd2	glycerol phosphate dehydrogenase 2, mitochondrial	0.022
Creb1	cAMP responsive element binding protein 1	0.022
Suv39h1	suppressor of variegation 3-9 homolog 1 (Drosophila)	0.021
Shox2	short stature homeobox 2	0.021
Epas1	endothelial PAS domain protein 1	0.020
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.020
Tnnt3	troponin T3, skeletal, fast	0.020
Inhba	inhibin beta-A	0.020
Rock2	Rho-associated coiled-coil containing protein kinase 2	0.020
Igbp1	immunoglobulin (CD79A) binding protein 1	0.020
Hrc	histidine rich calcium binding protein	0.019
Egln3	EGL nine homolog 3 (C. elegans)	0.019
Vav3	vav 3 oncogene	0.019
Agtr2	angiotensin II receptor, type 2	0.018
Il6st	interleukin 6 signal transducer	0.018
En1	engrailed 1	0.018
Isl1	ISL1 transcription factor, LIM/homeodomain	0.018
Ryr1	ryanodine receptor 1, skeletal muscle	0.017
Myh3	myosin, heavy polypeptide 3, skeletal muscle, embryonic	0.017
Rapsn	receptor-associated protein of the synapse	0.017
Vdr	vitamin D receptor	0.016
Pax2	paired box gene 2	0.016
Tnni1	troponin I, skeletal, slow 1	0.016
Mc2r	melanocortin 2 receptor	0.016
Met	met proto-oncogene	0.016
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.015
Clk1	CDC-like kinase 1	0.015
Vegfa	vascular endothelial growth factor A	0.015
Cav1	caveolin 1, caveolae protein	0.014
Tbk1	TANK-binding kinase 1	0.014
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.013
Xiap	X-linked inhibitor of apoptosis	0.013
Ldb3	LIM domain binding 3	0.013
Mecom	MDS1 and EVI1 complex locus	0.013
Crh	corticotropin releasing hormone	0.013
Tcf15	transcription factor 15	0.013
Gpr50	G-protein-coupled receptor 50	0.013
Atp1b4	ATPase, (Na+)/K+ transporting, beta 4 polypeptide	0.012
Fktn	fukutin	0.012
Myot	myotilin	0.012
Cyp2b19	cytochrome P450, family 2, subfamily b, polypeptide 19	0.012
Clock	circadian locomotor output cycles kaput	0.012
Tgfbr1	transforming growth factor, beta receptor I	0.012
Tbx1	T-box 1	0.012
Myom3	myomesin family, member 3	0.012
Myl1	myosin, light polypeptide 1	0.011
Hoxd8	homeobox D8	0.011
Hoxc4	homeobox C4	0.011
2310003F16Rik	RIKEN cDNA 2310003F16 gene	0.011
Pomc	pro-opiomelanocortin-alpha	0.011
Csrp3	cysteine and glycine-rich protein 3	0.011
Slc23a2	solute carrier family 23 (nucleobase transporters), member 2	0.011
Cdh15	cadherin 15	0.011
Sim2	single-minded homolog 2 (Drosophila)	0.011
Neurod4	neurogenic differentiation 4	0.011
Hoxa9	homeobox A9	0.011
Cyld	cylindromatosis (turban tumor syndrome)	0.011
Foxd3	forkhead box D3	0.010
Pten	phosphatase and tensin homolog	0.010
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.010
Clk4	CDC like kinase 4	0.010
Acvr2b	activin receptor IIB	0.010
Stat3	signal transducer and activator of transcription 3	0.010
Hoxd9	homeobox D9	0.010
Actn3	actinin alpha 3	0.010
Meox2	mesenchyme homeobox 2	0.010