IMP

Process View

Mus musculus

2 genes annotated in mouse

oculomotor nerve morphogenesis

The process in which the anatomical structure of the oculomotor nerve is generated and organized. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "oculomotor nerve morphogenesis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "oculomotor nerve morphogenesis" (in gray)

Name	Description	Probability	Func Analog Organism
Tcfap2a	transcription factor AP-2, alpha	0.999
Msx1	homeobox, msh-like 1	0.999
Isl1	ISL1 transcription factor, LIM/homeodomain	0.995
Eya1	eyes absent 1 homolog (Drosophila)	0.994
Hand2	heart and neural crest derivatives expressed transcript 2	0.992
Bmp7	bone morphogenetic protein 7	0.991
Pax3	paired box gene 3	0.990
Chrd	chordin	0.989
Dlx5	distal-less homeobox 5	0.987
Shh	sonic hedgehog	0.986
Tbx1	T-box 1	0.985
Sox9	SRY-box containing gene 9	0.972
Ednra	endothelin receptor type A	0.972
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.965
Foxc1	forkhead box C1	0.956
Foxc2	forkhead box C2	0.941
Hand1	heart and neural crest derivatives expressed transcript 1	0.938
Gli3	GLI-Kruppel family member GLI3	0.921
Smo	smoothened homolog (Drosophila)	0.905
Fgf8	fibroblast growth factor 8	0.903
Otx2	orthodenticle homolog 2 (Drosophila)	0.895
Bmp4	bone morphogenetic protein 4	0.857
Msx2	homeobox, msh-like 2	0.847
Fgfr2	fibroblast growth factor receptor 2	0.837
Gbx2	gastrulation brain homeobox 2	0.788
Hoxa1	homeobox A1	0.770
Prrx1	paired related homeobox 1	0.705	Mouse
Bmp2	bone morphogenetic protein 2	0.674
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.672
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.639
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.619
Ret	ret proto-oncogene	0.555
Runx2	runt related transcription factor 2	0.508
Ntf3	neurotrophin 3	0.505
Foxg1	forkhead box G1	0.494
Hoxa3	homeobox A3	0.447
Nrg1	neuregulin 1	0.444
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.425
Gsc	goosecoid homeobox	0.415
Pax9	paired box gene 9	0.410
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.405
Tbx15	T-box 15	0.354
Alx1	ALX homeobox 1	0.350
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.349
Fgfr1	fibroblast growth factor receptor 1	0.302
Pitx2	paired-like homeodomain transcription factor 2	0.234
Rarb	retinoic acid receptor, beta	0.203
Fgf10	fibroblast growth factor 10	0.191
Hoxa2	homeobox A2	0.183
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.180
Pax6	paired box gene 6	0.177
Tgfb2	transforming growth factor, beta 2	0.176
Hoxd3	homeobox D3	0.167
Foxi3	forkhead box I3	0.151
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.149
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.137
Prrx2	paired related homeobox 2	0.130	Mouse
Gli2	GLI-Kruppel family member GLI2	0.127
Alx4	aristaless-like homeobox 4	0.126
Acvr1	activin A receptor, type 1	0.106
Phox2b	paired-like homeobox 2b	0.101	Mouse
Hoxb3	homeobox B3	0.083
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.068
Pbx1	pre B-cell leukemia transcription factor 1	0.065
Phox2a	paired-like homeobox 2a	0.063
Gdnf	glial cell line derived neurotrophic factor	0.057
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.057
Dlx2	distal-less homeobox 2	0.052
Cldn4	claudin 4	0.050
Hmx1	H6 homeobox 1	0.050
Sox11	SRY-box containing gene 11	0.048
Col2a1	collagen, type II, alpha 1	0.046
Rarg	retinoic acid receptor, gamma	0.046
Nrtn	neurturin	0.045
Dlx6	distal-less homeobox 6	0.045
Hoxb1	homeobox B1	0.044
Sox10	SRY-box containing gene 10	0.044
Vegfa	vascular endothelial growth factor A	0.042
Ntf5	neurotrophin 5	0.042
Fgfr3	fibroblast growth factor receptor 3	0.040
Odz2	odd Oz/ten-m homolog 2 (Drosophila)	0.036
Foxd1	forkhead box D1	0.036
Krt15	keratin 15	0.034
Col9a1	collagen, type IX, alpha 1	0.032
Tcfap2c	transcription factor AP-2, gamma	0.027	Mouse
Hoxd9	homeobox D9	0.027
Hoxa9	homeobox A9	0.026
Twist1	twist homolog 1 (Drosophila)	0.026
Emid2	EMI domain containing 2	0.025
Fbln1	fibulin 1	0.024
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.024
Hoxc4	homeobox C4	0.023
Hoxc8	homeobox C8	0.023
Neurog2	neurogenin 2	0.023
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.022
Tcof1	Treacher Collins Franceschetti syndrome 1, homolog	0.020
Nkx3-2	NK3 homeobox 2	0.020
Bdnf	brain derived neurotrophic factor	0.020
Mab21l2	mab-21-like 2 (C. elegans)	0.019
Ebf3	early B-cell factor 3	0.019
Hoxd13	homeobox D13	0.019
Rara	retinoic acid receptor, alpha	0.018
Nrk	Nik related kinase	0.018
Efna4	ephrin A4	0.018
Hoxd8	homeobox D8	0.018
Cldn8	claudin 8	0.017
Capn6	calpain 6	0.017
Fgf15	fibroblast growth factor 15	0.017
Dlk1	delta-like 1 homolog (Drosophila)	0.016
Twist2	twist homolog 2 (Drosophila)	0.016
Chrna3	cholinergic receptor, nicotinic, alpha polypeptide 3	0.016
Mn1	meningioma 1	0.016
Uncx	UNC homeobox	0.016
Lhx1	LIM homeobox protein 1	0.016
Pkp1	plakophilin 1	0.015
Tgfbr2	transforming growth factor, beta receptor II	0.015
Tshz1	teashirt zinc finger family member 1	0.015
Zeb1	zinc finger E-box binding homeobox 1	0.015
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.015
Hoxc5	homeobox C5	0.015
Tyrp1	tyrosinase-related protein 1	0.015
Hoxb8	homeobox B8	0.015
Hoxb4	homeobox B4	0.015
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.014
Pitx1	paired-like homeodomain transcription factor 1	0.014
Hoxd4	homeobox D4	0.014
Bmp5	bone morphogenetic protein 5	0.014
Myog	myogenin	0.014
Ece1	endothelin converting enzyme 1	0.014
Chd7	chromodomain helicase DNA binding protein 7	0.014
Dkk2	dickkopf homolog 2 (Xenopus laevis)	0.014
Tcfap2b	transcription factor AP-2 beta	0.014	Mouse
En2	engrailed 2	0.014
Hoxd11	homeobox D11	0.014
Has2	hyaluronan synthase 2	0.014
Tead3	TEA domain family member 3	0.013
Gas1	growth arrest specific 1	0.013
Rdh10	retinol dehydrogenase 10 (all-trans)	0.013
Hoxb9	homeobox B9	0.012
Sall4	sal-like 4 (Drosophila)	0.012
En1	engrailed 1	0.012
Hoxd10	homeobox D10	0.011
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.011
Hbb-bh1	hemoglobin Z, beta-like embryonic chain	0.011
Mesp1	mesoderm posterior 1	0.011
Hoxc6	homeobox C6	0.011
Col17a1	collagen, type XVII, alpha 1	0.011
Col11a1	collagen, type XI, alpha 1	0.011
Plac1	placental specific protein 1	0.010
Zic2	zinc finger protein of the cerebellum 2	0.010
Cdh3	cadherin 3	0.010