IMP
Process View
nodal signaling pathway
A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "nodal signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Nodal | nodal | 1.000 | ||
| Pbx1 | pre B-cell leukemia transcription factor 1 | 0.980 | ||
| Foxh1 | forkhead box H1 | 0.890 | ||
| Smad4 | MAD homolog 4 (Drosophila) | 0.802 | ||
| Wnt5a | wingless-related MMTV integration site 5A | 0.706 | ||
| Hoxa9 | homeobox A9 | 0.513 | ||
| Bmp4 | bone morphogenetic protein 4 | 0.379 | ||
| Hoxa13 | homeobox A13 | 0.313 | ||
| Lefty2 | left-right determination factor 2 | 0.302 | Mouse | |
| Gata4 | GATA binding protein 4 | 0.264 | ||
| Fgfr1 | fibroblast growth factor receptor 1 | 0.215 | ||
| Gdf1 | growth differentiation factor 1 | 0.213 | ||
| Smad3 | MAD homolog 3 (Drosophila) | 0.181 | Human | |
| Gdf6 | growth differentiation factor 6 | 0.181 | Mouse | |
| Axin1 | axin 1 | 0.178 | ||
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.149 | ||
| Gdf5 | growth differentiation factor 5 | 0.142 | Mouse | |
| Bptf | bromodomain PHD finger transcription factor | 0.130 | ||
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.129 | ||
| Bmpr1a | bone morphogenetic protein receptor, type 1A | 0.110 | ||
| Gli3 | GLI-Kruppel family member GLI3 | 0.100 | ||
| Acvr1 | activin A receptor, type 1 | 0.090 | ||
| Gas1 | growth arrest specific 1 | 0.089 | ||
| Lefty1 | left right determination factor 1 | 0.086 | ||
| Bmp7 | bone morphogenetic protein 7 | 0.081 | Mouse | |
| Pbx3 | pre B-cell leukemia transcription factor 3 | 0.078 | ||
| Meis1 | Meis homeobox 1 | 0.078 | Mouse | |
| Dact3 | dapper homolog 3, antagonist of beta-catenin (xenopus) | 0.074 | ||
| Nog | noggin | 0.068 | ||
| Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.064 | ||
| Msx2 | homeobox, msh-like 2 | 0.064 | ||
| Gdf3 | growth differentiation factor 3 | 0.056 | ||
| Dnahc5 | dynein, axonemal, heavy chain 5 | 0.055 | ||
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.055 | ||
| Pbx2 | pre B-cell leukemia transcription factor 2 | 0.052 | ||
| Tdgf1 | teratocarcinoma-derived growth factor 1 | 0.052 | ||
| Acvr1b | activin A receptor, type 1B | 0.051 | Human | |
| Apc | adenomatosis polyposis coli | 0.048 | ||
| Prrx1 | paired related homeobox 1 | 0.047 | ||
| Tcf7l1 | transcription factor 7-like 1 (T-cell specific, HMG box) | 0.046 | ||
| Hand2 | heart and neural crest derivatives expressed transcript 2 | 0.045 | ||
| Zic3 | zinc finger protein of the cerebellum 3 | 0.042 | ||
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.042 | ||
| Smo | smoothened homolog (Drosophila) | 0.041 | ||
| Efna4 | ephrin A4 | 0.038 | ||
| Shh | sonic hedgehog | 0.038 | ||
| Hoxb6 | homeobox B6 | 0.038 | ||
| Wt1 | Wilms tumor 1 homolog | 0.035 | ||
| Prrx2 | paired related homeobox 2 | 0.035 | ||
| Acvr2b | activin receptor IIB | 0.034 | ||
| Dnahc11 | dynein, axonemal, heavy chain 11 | 0.033 | ||
| Tbx15 | T-box 15 | 0.032 | ||
| Msx1 | homeobox, msh-like 1 | 0.030 | ||
| Cdon | cell adhesion molecule-related/down-regulated by oncogenes | 0.029 | ||
| Wnt3 | wingless-related MMTV integration site 3 | 0.027 | ||
| Fgfr2 | fibroblast growth factor receptor 2 | 0.025 | ||
| Rnf111 | ring finger 111 | 0.025 | ||
| Mapk7 | mitogen-activated protein kinase 7 | 0.024 | ||
| Hoxa6 | homeobox A6 | 0.023 | ||
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.023 | ||
| Tead2 | TEA domain family member 2 | 0.022 | ||
| Dusp9 | dual specificity phosphatase 9 | 0.022 | ||
| Dkk1 | dickkopf homolog 1 (Xenopus laevis) | 0.022 | ||
| Ptk2 | PTK2 protein tyrosine kinase 2 | 0.021 | ||
| Cilp2 | cartilage intermediate layer protein 2 | 0.021 | ||
| Zfp503 | zinc finger protein 503 | 0.021 | ||
| Alx1 | ALX homeobox 1 | 0.019 | ||
| Ptk7 | PTK7 protein tyrosine kinase 7 | 0.019 | ||
| App | amyloid beta (A4) precursor protein | 0.018 | ||
| Hoxa11 | homeobox A11 | 0.018 | ||
| Hoxc4 | homeobox C4 | 0.018 | ||
| Megf8 | multiple EGF-like-domains 8 | 0.017 | ||
| Sfrp2 | secreted frizzled-related protein 2 | 0.017 | ||
| Lef1 | lymphoid enhancer binding factor 1 | 0.017 | ||
| Qrich1 | glutamine-rich 1 | 0.016 | ||
| Meis2 | Meis homeobox 2 | 0.016 | Mouse | |
| Fgf8 | fibroblast growth factor 8 | 0.016 | ||
| Ascl2 | achaete-scute complex homolog 2 (Drosophila) | 0.016 | ||
| Pbx4 | pre-B-cell leukemia homeobox 4 | 0.016 | ||
| Slc22a6 | solute carrier family 22 (organic anion transporter), member 6 | 0.016 | ||
| Hoxb3 | homeobox B3 | 0.016 | ||
| Zfp36l1 | zinc finger protein 36, C3H type-like 1 | 0.016 | ||
| Pou5f1 | POU domain, class 5, transcription factor 1 | 0.015 | ||
| Slc23a3 | solute carrier family 23 (nucleobase transporters), member 3 | 0.015 | ||
| Ptgdr | prostaglandin D receptor | 0.015 | ||
| Efs | embryonal Fyn-associated substrate | 0.015 | ||
| Tcf21 | transcription factor 21 | 0.015 | ||
| Pnliprp2 | pancreatic lipase-related protein 2 | 0.014 | ||
| Scn7a | sodium channel, voltage-gated, type VII, alpha | 0.014 | ||
| Fgfr3 | fibroblast growth factor receptor 3 | 0.014 | ||
| Acvr2a | activin receptor IIA | 0.014 | ||
| H1fx | H1 histone family, member X | 0.014 | ||
| Tcf7 | transcription factor 7, T-cell specific | 0.013 | ||
| Gdf7 | growth differentiation factor 7 | 0.013 | Mouse | |
| Reck | reversion-inducing-cysteine-rich protein with kazal motifs | 0.013 | ||
| Nr2f2 | nuclear receptor subfamily 2, group F, member 2 | 0.013 | ||
| Crlf1 | cytokine receptor-like factor 1 | 0.012 | ||
| Bcl10 | B-cell leukemia/lymphoma 10 | 0.012 | ||
| Foxc1 | forkhead box C1 | 0.012 | ||
| Ovol2 | ovo-like 2 (Drosophila) | 0.012 | ||
| Fxyd2 | FXYD domain-containing ion transport regulator 2 | 0.012 | ||
| Clcn1 | chloride channel 1 | 0.012 | ||
| Ptch1 | patched homolog 1 | 0.012 | ||
| Foxl2 | forkhead box L2 | 0.012 | ||
| Lhx1 | LIM homeobox protein 1 | 0.012 | ||
| Tnfrsf19 | tumor necrosis factor receptor superfamily, member 19 | 0.012 | ||
| Lrp6 | low density lipoprotein receptor-related protein 6 | 0.012 | ||
| Igfbp6 | insulin-like growth factor binding protein 6 | 0.011 | ||
| Batf3 | basic leucine zipper transcription factor, ATF-like 3 | 0.011 | ||
| Invs | inversin | 0.011 | ||
| Mgrn1 | mahogunin, ring finger 1 | 0.011 | ||
| Peg10 | paternally expressed 10 | 0.011 | ||
| Sox3 | SRY-box containing gene 3 | 0.011 | ||
| Hoxd9 | homeobox D9 | 0.011 | ||
| Foxa2 | forkhead box A2 | 0.011 | ||
| Tsx | testis specific X-linked gene | 0.011 | ||
| Il12b | interleukin 12b | 0.011 | ||
| Drd4 | dopamine receptor D4 | 0.011 | ||
| Bmpr1b | bone morphogenetic protein receptor, type 1B | 0.011 | ||
| Angpt1 | angiopoietin 1 | 0.010 | ||
| Mafa | v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian) | 0.010 | ||
| Ppap2b | phosphatidic acid phosphatase type 2B | 0.010 | ||
| Crhr2 | corticotropin releasing hormone receptor 2 | 0.010 | ||
| Hrh1 | histamine receptor H1 | 0.010 | ||
| Rgma | RGM domain family, member A | 0.010 | ||
| Rem1 | rad and gem related GTP binding protein 1 | 0.010 |