IMP

Process View

Mus musculus

2 genes annotated in mouse

regulation of spindle organization

Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of spindle organization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of spindle organization" (in gray)

Name	Description	Probability	Func Analog Organism
Cdk1	cyclin-dependent kinase 1	0.995
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.987
Ccna2	cyclin A2	0.977
Kif20a	kinesin family member 20A	0.949
Ccnb2	cyclin B2	0.814	Yeast
Hmmr	hyaluronan mediated motility receptor (RHAMM)	0.814
Prc1	protein regulator of cytokinesis 1	0.807	Worm Fly
Ccnb1	cyclin B1	0.798	Human Yeast
Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	0.795
Racgap1	Rac GTPase-activating protein 1	0.692
Kif22	kinesin family member 22	0.661
Ube2c	ubiquitin-conjugating enzyme E2C	0.576
Plk1	polo-like kinase 1 (Drosophila)	0.574
Meox2	mesenchyme homeobox 2	0.547
Birc5	baculoviral IAP repeat-containing 5	0.512
Ckap2	cytoskeleton associated protein 2	0.478
Ncaph	non-SMC condensin I complex, subunit H	0.388
Anln	anillin, actin binding protein	0.384
Top2a	topoisomerase (DNA) II alpha	0.335
Plk4	polo-like kinase 4 (Drosophila)	0.314
Aurka	aurora kinase A	0.294	Human Yeast
Bicc1	bicaudal C homolog 1 (Drosophila)	0.272
Aurkb	aurora kinase B	0.270	Human
Kif11	kinesin family member 11	0.267	Worm Fly
Cdca8	cell division cycle associated 8	0.256
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.247
Asf1b	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.209
Mad2l1	MAD2 mitotic arrest deficient-like 1 (yeast)	0.207
H2afx	H2A histone family, member X	0.190
Pbk	PDZ binding kinase	0.186
Kif2c	kinesin family member 2C	0.185
Mks1	Meckel syndrome, type 1	0.185
Depdc1a	DEP domain containing 1a	0.173
Ect2	ect2 oncogene	0.166
Kif4	kinesin family member 4	0.163
Pkd1	polycystic kidney disease 1 homolog	0.150
Nuf2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.148
Mki67	antigen identified by monoclonal antibody Ki 67	0.146
Cys1	cystin 1	0.143
Smc4	structural maintenance of chromosomes 4	0.137
Dlgap5	discs, large (Drosophila) homolog-associated protein 5	0.104
Kif23	kinesin family member 23	0.095
Ccdc99	coiled-coil domain containing 99	0.094
Pkd2	polycystic kidney disease 2	0.077	Mouse
Cdc25c	cell division cycle 25 homolog C (S. pombe)	0.076
Cks1b	CDC28 protein kinase 1b	0.076
D2Ertd750e	DNA segment, Chr 2, ERATO Doi 750, expressed	0.071
Macf1	microtubule-actin crosslinking factor 1	0.068
Exoc3	exocyst complex component 3	0.066
Invs	inversin	0.065
Rrm1	ribonucleotide reductase M1	0.065
Bub1	budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)	0.064
Cdkn3	cyclin-dependent kinase inhibitor 3	0.063
Jag1	jagged 1	0.061
Spag5	sperm associated antigen 5	0.061
Sae1	SUMO1 activating enzyme subunit 1	0.059
Gsg2	germ cell-specific gene 2	0.053
Cks2	CDC28 protein kinase regulatory subunit 2	0.049
Rrm2	ribonucleotide reductase M2	0.048
Cenpa	centromere protein A	0.047
Notch2	Notch gene homolog 2 (Drosophila)	0.044
Cep55	centrosomal protein 55	0.044
Gtse1	G two S phase expressed protein 1	0.044
Megf8	multiple EGF-like-domains 8	0.043
Tacc3	transforming, acidic coiled-coil containing protein 3	0.043
Cenpn	centromere protein N	0.042
Il6st	interleukin 6 signal transducer	0.041
Cdca5	cell division cycle associated 5	0.040
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.037
Ttk	Ttk protein kinase	0.036
Mis18bp1	MIS18 binding protein 1	0.036
Foxm1	forkhead box M1	0.031
Stag1	stromal antigen 1	0.030
Ccnf	cyclin F	0.030
Mastl	microtubule associated serine/threonine kinase-like	0.028
Slc25a2	solute carrier family 25 (mitochondrial carrier, ornithine transporter) member 2	0.028
C330027C09Rik	RIKEN cDNA C330027C09 gene	0.027
Lmnb1	lamin B1	0.026
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.026
Nek8	NIMA (never in mitosis gene a)-related expressed kinase 8	0.025
Ube2t	ubiquitin-conjugating enzyme E2T (putative)	0.025
Tk1	thymidine kinase 1	0.025
Uhrf1	ubiquitin-like, containing PHD and RING finger domains, 1	0.024
Cenpf	centromere protein F	0.024
Cdc45	cell division cycle 45 homolog (S. cerevisiae)	0.024
Ift140	intraflagellar transport 140 homolog (Chlamydomonas)	0.024
Ccdc39	coiled-coil domain containing 39	0.023
Chek2	CHK2 checkpoint homolog (S. pombe)	0.023
Neil3	nei like 3 (E. coli)	0.022
Fam64a	family with sequence similarity 64, member A	0.020
Cenph	centromere protein H	0.018
Stil	Scl/Tal1 interrupting locus	0.018
Nusap1	nucleolar and spindle associated protein 1	0.018
Tpx2	TPX2, microtubule-associated protein homolog (Xenopus laevis)	0.017
Trp53	transformation related protein 53	0.017
Aspm	asp (abnormal spindle)-like, microcephaly associated (Drosophila)	0.017
Depdc1b	DEP domain containing 1B	0.016
4930571B16Rik	RIKEN cDNA 4930571B16 gene	0.016
Trim59	tripartite motif-containing 59	0.015
Fam83d	family with sequence similarity 83, member D	0.015
Thra	thyroid hormone receptor alpha	0.015
Fbn1	fibrillin 1	0.015
2810417H13Rik	RIKEN cDNA 2810417H13 gene	0.014
Arhgap21	Rho GTPase activating protein 21	0.014
Lphn1	latrophilin 1	0.014
Ckap5	cytoskeleton associated protein 5	0.014
Stat3	signal transducer and activator of transcription 3	0.014
Fgfr1	fibroblast growth factor receptor 1	0.013
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.013
Ska1	spindle and kinetochore associated complex subunit 1	0.013
Med23	mediator complex subunit 23	0.013
Cenpe	centromere protein E	0.013
Exoc7	exocyst complex component 7	0.013
Tcf19	transcription factor 19	0.013
Lsg1	large subunit GTPase 1 homolog (S. cerevisiae)	0.012
Cdc27	cell division cycle 27 homolog (S. cerevisiae)	0.012
Vhl	von Hippel-Lindau tumor suppressor	0.012
Espl1	extra spindle poles-like 1 (S. cerevisiae)	0.012
Vangl2	vang-like 2 (van gogh, Drosophila)	0.012
Npr2	natriuretic peptide receptor 2	0.012
Cdc25b	cell division cycle 25 homolog B (S. pombe)	0.012
Hnrnpf	heterogeneous nuclear ribonucleoprotein F	0.011
Tcf4	transcription factor 4	0.011
Srsf6	serine/arginine-rich splicing factor 6	0.011
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.011
Rad51ap1	RAD51 associated protein 1	0.011
Cenpm	centromere protein M	0.011
Pole2	polymerase (DNA directed), epsilon 2 (p59 subunit)	0.011
Spnb2	spectrin beta 2	0.011
Cenpc1	centromere protein C1	0.011
Eme1	essential meiotic endonuclease 1 homolog 1 (S. pombe)	0.011
Pros1	protein S (alpha)	0.010
Rb1	retinoblastoma 1	0.010
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.010
Ercc6l	excision repair cross-complementing rodent repair deficiency complementation group 6 - like	0.010