IMP

Process View

Mus musculus

6 genes annotated in mouse

Multi-species View

positive regulation of fever generation

GO:0031622

Any process that activates or increases the frequency, rate, or extent of fever generation.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of fever generation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of fever generation" (in gray)

Name	Description	Probability	Func Analog Organism
Tnf	tumor necrosis factor	1.000
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.977
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.952
Lta	lymphotoxin A	0.903	Mouse
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.808	Mouse
Ptgs2	prostaglandin-endoperoxide synthase 2	0.783
Il10	interleukin 10	0.754
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.707
Igh	immunoglobulin heavy chain complex	0.651
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.624
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.486
Cd40	CD40 antigen	0.458	Mouse
Ifng	interferon gamma	0.413
Il6	interleukin 6	0.299
Ltb	lymphotoxin B	0.288
Nos2	nitric oxide synthase 2, inducible	0.288
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.278	Mouse
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.252
Il1r1	interleukin 1 receptor, type I	0.240
Cxcl13	chemokine (C-X-C motif) ligand 13	0.237
Il1b	interleukin 1 beta	0.233
Il7	interleukin 7	0.219
Ccl2	chemokine (C-C motif) ligand 2	0.217
Cd19	CD19 antigen	0.140
Fas	Fas (TNF receptor superfamily member 6)	0.134
Il4	interleukin 4	0.130
Ikzf1	IKAROS family zinc finger 1	0.128
Btk	Bruton agammaglobulinemia tyrosine kinase	0.114
Tlr4	toll-like receptor 4	0.107
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.082
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.081
Cxcr5	chemokine (C-X-C motif) receptor 5	0.080
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.049
Icos	inducible T-cell co-stimulator	0.026
Lepr	leptin receptor	0.026
Selp	selectin, platelet	0.026
Plau	plasminogen activator, urokinase	0.025
Il1a	interleukin 1 alpha	0.022	Mouse
Spp1	secreted phosphoprotein 1	0.022
Ccl4	chemokine (C-C motif) ligand 4	0.021
Pou2af1	POU domain, class 2, associating factor 1	0.021
Ch25h	cholesterol 25-hydroxylase	0.020
Lyz2	lysozyme 2	0.019
Tox	thymocyte selection-associated high mobility group box	0.019
Esr1	estrogen receptor 1 (alpha)	0.019
Socs1	suppressor of cytokine signaling 1	0.018
Casp1	caspase 1	0.018
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.018
Irg1	immunoresponsive gene 1	0.018
Col4a3	collagen, type IV, alpha 3	0.016
Bcl6	B-cell leukemia/lymphoma 6	0.016
Irak4	interleukin-1 receptor-associated kinase 4	0.016
Apoe	apolipoprotein E	0.016
Csf1	colony stimulating factor 1 (macrophage)	0.016
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.015
Cd28	CD28 antigen	0.014
Clec4d	C-type lectin domain family 4, member d	0.014
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.014
Il1rn	interleukin 1 receptor antagonist	0.014	Mouse
Bcl3	B-cell leukemia/lymphoma 3	0.014
Fgd3	FYVE, RhoGEF and PH domain containing 3	0.013
Ccr1	chemokine (C-C motif) receptor 1	0.013
Ccr2	chemokine (C-C motif) receptor 2	0.013
Cxcl2	chemokine (C-X-C motif) ligand 2	0.012
Casp12	caspase 12	0.012
Nos3	nitric oxide synthase 3, endothelial cell	0.011
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.011
Il12b	interleukin 12b	0.011
Cxcl1	chemokine (C-X-C motif) ligand 1	0.011
Ccr7	chemokine (C-C motif) receptor 7	0.011
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.011
Cd44	CD44 antigen	0.010
Mmp9	matrix metallopeptidase 9	0.010
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.010
Ccl17	chemokine (C-C motif) ligand 17	0.010
F2rl2	coagulation factor II (thrombin) receptor-like 2	0.010
Vdr	vitamin D receptor	0.010