IMP
Process View
isotype switching to ige isotypes
The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "isotype switching to ige isotypes"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Foxp3 | forkhead box P3 | 0.999 | ||
| Stat3 | signal transducer and activator of transcription 3 | 0.946 | Mouse | |
| Il10 | interleukin 10 | 0.912 | ||
| Ifng | interferon gamma | 0.850 | ||
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.803 | ||
| Il4 | interleukin 4 | 0.785 | ||
| Lyz2 | lysozyme 2 | 0.777 | ||
| Stat6 | signal transducer and activator of transcription 6 | 0.703 | ||
| Tnf | tumor necrosis factor | 0.700 | ||
| Il4ra | interleukin 4 receptor, alpha | 0.684 | ||
| Fas | Fas (TNF receptor superfamily member 6) | 0.631 | ||
| Il6st | interleukin 6 signal transducer | 0.601 | ||
| Il2 | interleukin 2 | 0.593 | ||
| Irf9 | interferon regulatory factor 9 | 0.522 | ||
| Il6 | interleukin 6 | 0.415 | ||
| Prf1 | perforin 1 (pore forming protein) | 0.388 | ||
| Kit | kit oncogene | 0.378 | ||
| Myd88 | myeloid differentiation primary response gene 88 | 0.327 | ||
| Trp53 | transformation related protein 53 | 0.312 | ||
| Lyn | Yamaguchi sarcoma viral (v-yes-1) oncogene homolog | 0.288 | ||
| Tlr4 | toll-like receptor 4 | 0.209 | ||
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.187 | ||
| Stat5b | signal transducer and activator of transcription 5B | 0.179 | Mouse | |
| Il1r1 | interleukin 1 receptor, type I | 0.168 | ||
| Rag1 | recombination activating gene 1 | 0.148 | ||
| Mmp9 | matrix metallopeptidase 9 | 0.132 | ||
| Smad3 | MAD homolog 3 (Drosophila) | 0.128 | ||
| Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 0.107 | ||
| Inpp5d | inositol polyphosphate-5-phosphatase D | 0.101 | ||
| Relb | avian reticuloendotheliosis viral (v-rel) oncogene related B | 0.096 | ||
| Tcra | T-cell receptor alpha chain | 0.096 | ||
| Rc3h1 | RING CCCH (C3H) domains 1 | 0.084 | ||
| Cd28 | CD28 antigen | 0.083 | ||
| Cd19 | CD19 antigen | 0.073 | ||
| Tgfb1 | transforming growth factor, beta 1 | 0.063 | ||
| Map3k14 | mitogen-activated protein kinase kinase kinase 14 | 0.061 | ||
| Spna1 | spectrin alpha 1 | 0.056 | ||
| Nfil3 | nuclear factor, interleukin 3, regulated | 0.054 | ||
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.053 | ||
| Rela | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.051 | ||
| Gli2 | GLI-Kruppel family member GLI2 | 0.041 | ||
| Ahr | aryl-hydrocarbon receptor | 0.041 | ||
| Trim21 | tripartite motif-containing 21 | 0.041 | ||
| Rag2 | recombination activating gene 2 | 0.039 | ||
| Agap2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 | 0.037 | ||
| Irf1 | interferon regulatory factor 1 | 0.037 | ||
| Igh | immunoglobulin heavy chain complex | 0.036 | ||
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.034 | ||
| Nckap1l | NCK associated protein 1 like | 0.032 | ||
| Ttc7 | tetratricopeptide repeat domain 7 | 0.029 | ||
| Ikzf1 | IKAROS family zinc finger 1 | 0.025 | ||
| Arid1b | AT rich interactive domain 1B (SWI-like) | 0.023 | ||
| Pgrmc1 | progesterone receptor membrane component 1 | 0.022 | ||
| Tapbp | TAP binding protein | 0.021 | ||
| Gnai2 | guanine nucleotide binding protein (G protein), alpha inhibiting 2 | 0.021 | ||
| Card11 | caspase recruitment domain family, member 11 | 0.019 | ||
| Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 | 0.019 | ||
| Pten | phosphatase and tensin homolog | 0.019 | ||
| Stat1 | signal transducer and activator of transcription 1 | 0.018 | Mouse | |
| Ptpn6 | protein tyrosine phosphatase, non-receptor type 6 | 0.018 | ||
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.017 | ||
| Stat5a | signal transducer and activator of transcription 5A | 0.017 | Mouse | |
| Socs3 | suppressor of cytokine signaling 3 | 0.015 | ||
| Col1a1 | collagen, type I, alpha 1 | 0.015 | ||
| Il27ra | interleukin 27 receptor, alpha | 0.014 | ||
| Cd40 | CD40 antigen | 0.014 | ||
| Nr3c1 | nuclear receptor subfamily 3, group C, member 1 | 0.013 | ||
| Ifnar2 | interferon (alpha and beta) receptor 2 | 0.013 | ||
| Pik3cd | phosphatidylinositol 3-kinase catalytic delta polypeptide | 0.013 | ||
| Batf | basic leucine zipper transcription factor, ATF-like | 0.012 | ||
| Cd79a | CD79A antigen (immunoglobulin-associated alpha) | 0.012 | ||
| Socs1 | suppressor of cytokine signaling 1 | 0.012 | ||
| Ncoa3 | nuclear receptor coactivator 3 | 0.011 | ||
| Ccr7 | chemokine (C-C motif) receptor 7 | 0.011 | ||
| Tbx21 | T-box 21 | 0.011 | ||
| H2-K1 | histocompatibility 2, K1, K region | 0.011 | ||
| Ifnar1 | interferon (alpha and beta) receptor 1 | 0.010 | ||
| Jak2 | Janus kinase 2 | 0.010 |