IMP

Process View

Mus musculus

3 genes annotated in mouse

negative regulation of humoral immune response mediated by circulating immunoglobulin

Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of humoral immune response mediated by circulating immunoglobulin"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of humoral immune response mediated by circulating immunoglobulin" (in gray)

Name	Description	Probability	Func Analog Organism
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.368
Igh	immunoglobulin heavy chain complex	0.364
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.250
Lyz2	lysozyme 2	0.229
Cd19	CD19 antigen	0.224
Egfr	epidermal growth factor receptor	0.180
Inpp5d	inositol polyphosphate-5-phosphatase D	0.176
Ptprc	protein tyrosine phosphatase, receptor type, C	0.138
Trp53	transformation related protein 53	0.123
Cd22	CD22 antigen	0.111
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.110
Fas	Fas (TNF receptor superfamily member 6)	0.099
Sfpi1	SFFV proviral integration 1	0.094
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.086
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.084
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.070
Sykb	spleen tyrosine kinase	0.069
Vav1	vav 1 oncogene	0.068
Btk	Bruton agammaglobulinemia tyrosine kinase	0.065
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.056
Cd40	CD40 antigen	0.049
Noto	notochord homolog (Xenopus laevis)	0.048
Ccr1	chemokine (C-C motif) receptor 1	0.047
Ikzf1	IKAROS family zinc finger 1	0.042
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.040
Foxa2	forkhead box A2	0.039
Grb2	growth factor receptor bound protein 2	0.036
Pten	phosphatase and tensin homolog	0.034
Hck	hemopoietic cell kinase	0.033
Plcg2	phospholipase C, gamma 2	0.033
Lilrb3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.033
Isl1	ISL1 transcription factor, LIM/homeodomain	0.033
Tnf	tumor necrosis factor	0.032
Unc93b1	unc-93 homolog B1 (C. elegans)	0.032
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.032
Pstpip1	proline-serine-threonine phosphatase-interacting protein 1	0.032
Itgb2	integrin beta 2	0.031
Msr1	macrophage scavenger receptor 1	0.030
Aif1	allograft inflammatory factor 1	0.029
Rag1	recombination activating gene 1	0.027
Ifngr1	interferon gamma receptor 1	0.027
Clec4n	C-type lectin domain family 4, member n	0.027
Traf3ip2	TRAF3 interacting protein 2	0.026
Ms4a6d	membrane-spanning 4-domains, subfamily A, member 6D	0.025
Apoe	apolipoprotein E	0.023
Ncf1	neutrophil cytosolic factor 1	0.022
Tyrobp	TYRO protein tyrosine kinase binding protein	0.022
Igk	immunoglobulin kappa chain complex	0.021
C3	complement component 3	0.021
Hif1a	hypoxia inducible factor 1, alpha subunit	0.021
Il1b	interleukin 1 beta	0.021
Rxra	retinoid X receptor alpha	0.021
Cd68	CD68 antigen	0.020
Nf1	neurofibromatosis 1	0.020
Ccr7	chemokine (C-C motif) receptor 7	0.019
Cd72	CD72 antigen	0.019
Apc	adenomatosis polyposis coli	0.018
Lepr	leptin receptor	0.018
Ccl9	chemokine (C-C motif) ligand 9	0.018
C1qb	complement component 1, q subcomponent, beta polypeptide	0.018
Cd52	CD52 antigen	0.018
Tnip1	TNFAIP3 interacting protein 1	0.018
Ifng	interferon gamma	0.018
Cybb	cytochrome b-245, beta polypeptide	0.017
Il4	interleukin 4	0.016
Fcgr4	Fc receptor, IgG, low affinity IV	0.015
Ifitm6	interferon induced transmembrane protein 6	0.015
Vangl1	vang-like 1 (van gogh, Drosophila)	0.015
Sox9	SRY-box containing gene 9	0.015
Fasl	Fas ligand (TNF superfamily, member 6)	0.014
Pdha2	pyruvate dehydrogenase E1 alpha 2	0.014
Vegfa	vascular endothelial growth factor A	0.014
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.014
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.014
Cbl	Casitas B-lineage lymphoma	0.014
Il2rg	interleukin 2 receptor, gamma chain	0.014
Fcgr1	Fc receptor, IgG, high affinity I	0.013	Mouse
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.013
Csf3r	colony stimulating factor 3 receptor (granulocyte)	0.013
Dnahc11	dynein, axonemal, heavy chain 11	0.013
AF251705	cDNA sequence AF251705	0.013
Ncf4	neutrophil cytosolic factor 4	0.013
Kif19a	kinesin family member 19A	0.012
Ccl6	chemokine (C-C motif) ligand 6	0.012
Gtse1	G two S phase expressed protein 1	0.012
Fpr2	formyl peptide receptor 2	0.012
Fpr1	formyl peptide receptor 1	0.012
Fermt3	fermitin family homolog 3 (Drosophila)	0.012
Gja1	gap junction protein, alpha 1	0.012
Pou2af1	POU domain, class 2, associating factor 1	0.012
Apobec1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	0.012
Sos1	son of sevenless homolog 1 (Drosophila)	0.012
Ptk2	PTK2 protein tyrosine kinase 2	0.012
Cr2	complement receptor 2	0.011
Hmox1	heme oxygenase (decycling) 1	0.011
Ctnnb1	catenin (cadherin associated protein), beta 1	0.011
Cd48	CD48 antigen	0.011
Pik3cg	phosphoinositide-3-kinase, catalytic, gamma polypeptide	0.011
Smn1	survival motor neuron 1	0.011
Tlr7	toll-like receptor 7	0.011
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.011
Ccl12	chemokine (C-C motif) ligand 12	0.011
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.011
Ncf2	neutrophil cytosolic factor 2	0.011
Sell	selectin, lymphocyte	0.011
Selp	selectin, platelet	0.011
Vhl	von Hippel-Lindau tumor suppressor	0.011
Kif3a	kinesin family member 3A	0.011
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.011
Mmp8	matrix metallopeptidase 8	0.011
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.011
Clec4a2	C-type lectin domain family 4, member a2	0.010
Lyz1	lysozyme 1	0.010
Tcrb	T-cell receptor beta chain	0.010
Irf8	interferon regulatory factor 8	0.010
Cxcr2	chemokine (C-X-C motif) receptor 2	0.010
Mll3	myeloid/lymphoid or mixed-lineage leukemia 3	0.010
Vangl2	vang-like 2 (van gogh, Drosophila)	0.010