IMP

Process View

Mus musculus

12 genes annotated in mouse

regulation of skeletal muscle adaptation

Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of skeletal muscle adaptation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of skeletal muscle adaptation" (in gray)

Name	Description	Probability	Func Analog Organism
Tnnc2	troponin C2, fast	0.897	Mouse
Hrc	histidine rich calcium binding protein	0.875
Ldb3	LIM domain binding 3	0.818
Cacna1s	calcium channel, voltage-dependent, L type, alpha 1S subunit	0.724
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.678
Yap1	yes-associated protein 1	0.672
Tnni2	troponin I, skeletal, fast 2	0.601	Mouse
Ttn	titin	0.564
Actn2	actinin alpha 2	0.525
Casq1	calsequestrin 1	0.467
Actn3	actinin alpha 3	0.465
Myom2	myomesin 2	0.419
Tnnt3	troponin T3, skeletal, fast	0.403	Mouse
Tnnt2	troponin T2, cardiac	0.311
Ryr1	ryanodine receptor 1, skeletal muscle	0.279
Atp2a1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.266	Mouse
Csrp3	cysteine and glycine-rich protein 3	0.256
Mylpf	myosin light chain, phosphorylatable, fast skeletal muscle	0.243
Srpk3	serine/arginine-rich protein specific kinase 3	0.229
Myh1	myosin, heavy polypeptide 1, skeletal muscle, adult	0.228	Mouse
Ckmt2	creatine kinase, mitochondrial 2	0.227
Tcap	titin-cap	0.207
Actc1	actin, alpha, cardiac muscle 1	0.189
Cox6a2	cytochrome c oxidase, subunit VI a, polypeptide 2	0.176
Myom1	myomesin 1	0.172
Xirp1	xin actin-binding repeat containing 1	0.172
Myh4	myosin, heavy polypeptide 4, skeletal muscle	0.159	Mouse
Myh3	myosin, heavy polypeptide 3, skeletal muscle, embryonic	0.151
Pgam2	phosphoglycerate mutase 2	0.151
Nfatc3	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	0.145	Mouse
Myh8	myosin, heavy polypeptide 8, skeletal muscle, perinatal	0.142
Myh7	myosin, heavy polypeptide 7, cardiac muscle, beta	0.137
Ppp3r1	protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)	0.128
Tnnt1	troponin T1, skeletal, slow	0.118
Myl3	myosin, light polypeptide 3	0.117
Gtf2ird1	general transcription factor II I repeat domain-containing 1	0.115
Acta1	actin, alpha 1, skeletal muscle	0.115
Cox8b	cytochrome c oxidase, subunit VIIIb	0.113
Mybph	myosin binding protein H	0.105
Myoz1	myozenin 1	0.104
Gtf2i	general transcription factor II I	0.100
Myl1	myosin, light polypeptide 1	0.089
Ski	ski sarcoma viral oncogene homolog (avian)	0.087
Pygm	muscle glycogen phosphorylase	0.086
Chrna1	cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)	0.081
Nfatc4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.081	Mouse
Apobec2	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2	0.080
Trim54	tripartite motif-containing 54	0.076
Mef2a	myocyte enhancer factor 2A	0.074
Nrap	nebulin-related anchoring protein	0.070
Casq2	calsequestrin 2	0.069
Wnt11	wingless-related MMTV integration site 11	0.068
Myh2	myosin, heavy polypeptide 2, skeletal muscle, adult	0.067
Tnni3	troponin I, cardiac 3	0.064	Mouse
Hspb7	heat shock protein family, member 7 (cardiovascular)	0.061
Tead1	TEA domain family member 1	0.061
Tnnc1	troponin C, cardiac/slow skeletal	0.059
Des	desmin	0.052
Pvalb	parvalbumin	0.051
Wwtr1	WW domain containing transcription regulator 1	0.051
Ckm	creatine kinase, muscle	0.050
Cav3	caveolin 3	0.050
Cacng1	calcium channel, voltage-dependent, gamma subunit 1	0.044
Map3k5	mitogen-activated protein kinase kinase kinase 5	0.041
Tead2	TEA domain family member 2	0.039	Mouse
Lmod2	leiomodin 2 (cardiac)	0.036
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.035
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.035
Fbn2	fibrillin 2	0.034
Cox7a1	cytochrome c oxidase, subunit VIIa 1	0.033
Oxr1	oxidation resistance 1	0.031
Col17a1	collagen, type XVII, alpha 1	0.030
Myl7	myosin, light polypeptide 7, regulatory	0.030
Kcnj2	potassium inwardly-rectifying channel, subfamily J, member 2	0.028
Rpl3l	ribosomal protein L3-like	0.027
Tnni1	troponin I, skeletal, slow 1	0.027
Hhat	hedgehog acyltransferase	0.027
Myoz2	myozenin 2	0.025
Rrad	Ras-related associated with diabetes	0.024
Flnc	filamin C, gamma	0.023
Itgb1bp2	integrin beta 1 binding protein 2	0.023
Trim63	tripartite motif-containing 63	0.023
Myl4	myosin, light polypeptide 4	0.023
Tpm2	tropomyosin 2, beta	0.023
Gdpd5	glycerophosphodiester phosphodiesterase domain containing 5	0.022
Sos2	son of sevenless homolog 2 (Drosophila)	0.022
Myot	myotilin	0.021
Txlnb	taxilin beta	0.021
Myf6	myogenic factor 6	0.021
Trdn	triadin	0.021
Prkce	protein kinase C, epsilon	0.021
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.020
Dlk1	delta-like 1 homolog (Drosophila)	0.020
Smpx	small muscle protein, X-linked	0.019
Vegfa	vascular endothelial growth factor A	0.019
Notch4	Notch gene homolog 4 (Drosophila)	0.019
Lmod3	leiomodin 3 (fetal)	0.018
Fbxo32	F-box protein 32	0.018
Hfe2	hemochromatosis type 2 (juvenile) (human homolog)	0.018
Akap5	A kinase (PRKA) anchor protein 5	0.018
Hspb2	heat shock protein 2	0.018
Rapsn	receptor-associated protein of the synapse	0.017
Mef2c	myocyte enhancer factor 2C	0.016
Ager	advanced glycosylation end product-specific receptor	0.016
Itgb3	integrin beta 3	0.016
Fgf18	fibroblast growth factor 18	0.016
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.016
Mybpc3	myosin binding protein C, cardiac	0.016
Tfg	Trk-fused gene	0.016
Pthlh	parathyroid hormone-like peptide	0.015
Shox2	short stature homeobox 2	0.015
Eno3	enolase 3, beta muscle	0.015
Prx	periaxin	0.014
Mt4	metallothionein 4	0.014
Myf5	myogenic factor 5	0.014
Dlg1	discs, large homolog 1 (Drosophila)	0.014
Stk10	serine/threonine kinase 10	0.014
Pds5b	PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)	0.014
Tmod4	tropomodulin 4	0.014
Rasgrp2	RAS, guanyl releasing protein 2	0.013
Ank	progressive ankylosis	0.013
Ankrd2	ankyrin repeat domain 2 (stretch responsive muscle)	0.013
Qk	quaking	0.013
Dtnbp1	dystrobrevin binding protein 1	0.013
Ttc3	tetratricopeptide repeat domain 3	0.013
Krt15	keratin 15	0.013
Zmynd11	zinc finger, MYND domain containing 11	0.013
Stac3	SH3 and cysteine rich domain 3	0.013
Sfn	stratifin	0.012
Ppfia4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	0.012
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.012
Atp2b1	ATPase, Ca++ transporting, plasma membrane 1	0.012
Pgf	placental growth factor	0.012
Vgll2	vestigial like 2 homolog (Drosophila)	0.012
Eef1a2	eukaryotic translation elongation factor 1 alpha 2	0.012
Ighmbp2	immunoglobulin mu binding protein 2	0.012
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.012
Dkk2	dickkopf homolog 2 (Xenopus laevis)	0.012
Fbp2	fructose bisphosphatase 2	0.011
Prkacb	protein kinase, cAMP dependent, catalytic, beta	0.011
Cbfa2t3	core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)	0.011
Myog	myogenin	0.011
Kbtbd10	kelch repeat and BTB (POZ) domain containing 10	0.011
Vamp4	vesicle-associated membrane protein 4	0.011
Six5	sine oculis-related homeobox 5 homolog (Drosophila)	0.011
Idua	iduronidase, alpha-L-	0.011
Prkd2	protein kinase D2	0.011
Celf2	CUGBP, Elav-like family member 2	0.011
Spry4	sprouty homolog 4 (Drosophila)	0.011
Crabp1	cellular retinoic acid binding protein I	0.011
Mlf1	myeloid leukemia factor 1	0.011
Map4k2	mitogen-activated protein kinase kinase kinase kinase 2	0.011
2310014L17Rik	RIKEN cDNA 2310014L17 gene	0.010
Tal1	T-cell acute lymphocytic leukemia 1	0.010
Chrnb1	cholinergic receptor, nicotinic, beta polypeptide 1 (muscle)	0.010
Hoxa5	homeobox A5	0.010
Tcf15	transcription factor 15	0.010
Hdac7	histone deacetylase 7	0.010
Synpo2l	synaptopodin 2-like	0.010
Murc	muscle-related coiled-coil protein	0.010
Pfkm	phosphofructokinase, muscle	0.010