IMP

Process View

Mus musculus

5 genes annotated in mouse

phospholipase c activating dopamine receptor signaling pathway

The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG).

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "phospholipase c activating dopamine receptor signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "phospholipase c activating dopamine receptor signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Slc34a1	solute carrier family 34 (sodium phosphate), member 1	0.982
Adrb1	adrenergic receptor, beta 1	0.866	Mouse
Pnpla2	patatin-like phospholipase domain containing 2	0.805
Sstr4	somatostatin receptor 4	0.573
Kl	klotho	0.559
Drd2	dopamine receptor D2	0.453
Pparg	peroxisome proliferator activated receptor gamma	0.303
Cckbr	cholecystokinin B receptor	0.263
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.202
Shc3	src homology 2 domain-containing transforming protein C3	0.175
Npy2r	neuropeptide Y receptor Y2	0.150
Adrb2	adrenergic receptor, beta 2	0.150	Mouse
Syn2	synapsin II	0.139
Lepr	leptin receptor	0.135
Cav1	caveolin 1, caveolae protein	0.116
Prkaca	protein kinase, cAMP dependent, catalytic, alpha	0.114
Vdr	vitamin D receptor	0.108
ND6	NADH dehydrogenase subunit 6	0.104
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.092
Chrm1	cholinergic receptor, muscarinic 1, CNS	0.081
Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.079
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.071
Tmed8	transmembrane emp24 domain containing 8	0.062
Pgr	progesterone receptor	0.057
C1ql1	complement component 1, q subcomponent-like 1	0.052
Tgfb1	transforming growth factor, beta 1	0.052
Slc12a1	solute carrier family 12, member 1	0.050
Sstr1	somatostatin receptor 1	0.044
Slc17a1	solute carrier family 17 (sodium phosphate), member 1	0.043
Crhr1	corticotropin releasing hormone receptor 1	0.043
Ar	androgen receptor	0.042
Smad3	MAD homolog 3 (Drosophila)	0.042
Adra2c	adrenergic receptor, alpha 2c	0.035	Mouse
Ptms	parathymosin	0.035
Sst	somatostatin	0.035
Clcnka	chloride channel Ka	0.033
Ghr	growth hormone receptor	0.032
Gria1	glutamate receptor, ionotropic, AMPA1 (alpha 1)	0.032
Adora2a	adenosine A2a receptor	0.032
Trpc5	transient receptor potential cation channel, subfamily C, member 5	0.032
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.032	Mouse
Htr4	5 hydroxytryptamine (serotonin) receptor 4	0.031	Mouse
Actr3	ARP3 actin-related protein 3 homolog (yeast)	0.031
Hrh1	histamine receptor H1	0.030
Grm8	glutamate receptor, metabotropic 8	0.029
Htr5a	5-hydroxytryptamine (serotonin) receptor 5A	0.029	Mouse
Col4a3	collagen, type IV, alpha 3	0.028
Oprm1	opioid receptor, mu 1	0.027
Otog	otogelin	0.026
Kcns2	K+ voltage-gated channel, subfamily S, 2	0.025
Gabrg3	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3	0.025
Lep	leptin	0.024
Rho	rhodopsin	0.024
Ikzf4	IKAROS family zinc finger 4	0.023
Npy5r	neuropeptide Y receptor Y5	0.023
F2rl2	coagulation factor II (thrombin) receptor-like 2	0.023
Tspo2	translocator protein 2	0.023
Adrb3	adrenergic receptor, beta 3	0.023	Mouse
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.022
Doc2b	double C2, beta	0.022
Csmd1	CUB and Sushi multiple domains 1	0.022
Insr	insulin receptor	0.022
Oprk1	opioid receptor, kappa 1	0.021
Gad2	glutamic acid decarboxylase 2	0.021
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.020
Fosb	FBJ osteosarcoma oncogene B	0.020
Rac1	RAS-related C3 botulinum substrate 1	0.020
Gpr12	G-protein coupled receptor 12	0.019
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.019
Pde6a	phosphodiesterase 6A, cGMP-specific, rod, alpha	0.019
Lipa	lysosomal acid lipase A	0.019
Tyr	tyrosinase	0.018
Sstr2	somatostatin receptor 2	0.018
Oprd1	opioid receptor, delta 1	0.017
Grid1	glutamate receptor, ionotropic, delta 1	0.017
Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	0.017
Cdc42	cell division cycle 42 homolog (S. cerevisiae)	0.017
Dlg4	discs, large homolog 4 (Drosophila)	0.017
Gpr83	G protein-coupled receptor 83	0.017
Gcgr	glucagon receptor	0.017
Krt12	keratin 12	0.017
Cotl1	coactosin-like 1 (Dictyostelium)	0.017
Grin2d	glutamate receptor, ionotropic, NMDA2D (epsilon 4)	0.017
Kcnd3	potassium voltage-gated channel, Shal-related family, member 3	0.016
Nrgn	neurogranin	0.016
Lag3	lymphocyte-activation gene 3	0.016
Glra1	glycine receptor, alpha 1 subunit	0.016
Atp2b1	ATPase, Ca++ transporting, plasma membrane 1	0.016
Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	0.016	Mouse
Kcnk3	potassium channel, subfamily K, member 3	0.015
Tgfbr3	transforming growth factor, beta receptor III	0.015
Kcnj1	potassium inwardly-rectifying channel, subfamily J, member 1	0.015
Shank3	SH3/ankyrin domain gene 3	0.015
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.015
Thra	thyroid hormone receptor alpha	0.014
Atp4a	ATPase, H+/K+ exchanging, gastric, alpha polypeptide	0.014
Chrna7	cholinergic receptor, nicotinic, alpha polypeptide 7	0.014
Gabrb2	gamma-aminobutyric acid (GABA) A receptor, subunit beta 2	0.014
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.014
Galnt6	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6	0.013
St6galnac3	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	0.013
Lhx6	LIM homeobox protein 6	0.013
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.013
Trpv5	transient receptor potential cation channel, subfamily V, member 5	0.013
Atxn1	ataxin 1	0.013
Gsx1	GS homeobox 1	0.013
Fut4	fucosyltransferase 4	0.012
Mog	myelin oligodendrocyte glycoprotein	0.012
Klf6	Kruppel-like factor 6	0.012
Slc12a5	solute carrier family 12, member 5	0.012
Chrna6	cholinergic receptor, nicotinic, alpha polypeptide 6	0.012
Plxna1	plexin A1	0.012
Epha6	Eph receptor A6	0.012
Grm2	glutamate receptor, metabotropic 2	0.012
Dlx4	distal-less homeobox 4	0.012
Rcvrn	recoverin	0.012
Ltc4s	leukotriene C4 synthase	0.012
Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4	0.012
Ncan	neurocan	0.012
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.012
Tenc1	tensin like C1 domain-containing phosphatase	0.011
Kcna1	potassium voltage-gated channel, shaker-related subfamily, member 1	0.011
Nt5e	5' nucleotidase, ecto	0.011
Dpysl2	dihydropyrimidinase-like 2	0.011
Gabra2	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2	0.011
Cux2	cut-like homeobox 2	0.011
Nos1	nitric oxide synthase 1, neuronal	0.011
Ppard	peroxisome proliferator activator receptor delta	0.011
Csf3	colony stimulating factor 3 (granulocyte)	0.011
Bcl10	B-cell leukemia/lymphoma 10	0.011
Ids	iduronate 2-sulfatase	0.011
Pcp2	Purkinje cell protein 2 (L7)	0.011
Adra2b	adrenergic receptor, alpha 2b	0.011	Mouse
Fshb	follicle stimulating hormone beta	0.011
Cnr1	cannabinoid receptor 1 (brain)	0.010
Ncoa3	nuclear receptor coactivator 3	0.010
Ltk	leukocyte tyrosine kinase	0.010
Ilk	integrin linked kinase	0.010
Kcnc1	potassium voltage gated channel, Shaw-related subfamily, member 1	0.010
Mas1	MAS1 oncogene	0.010
Trh	thyrotropin releasing hormone	0.010
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.010
Gpr3	G-protein coupled receptor 3	0.010