IMP

Process View

Rattus norvegicus

14 genes annotated in rat

modification dependent macromolecule catabolic process

The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule.

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "modification dependent macromolecule catabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "modification dependent macromolecule catabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
Psma3	proteasome (prosome, macropain) subunit, alpha type 3	0.990	Yeast
Psma5	proteasome (prosome, macropain) subunit, alpha type 5	0.986	Yeast
Dnaja2	DnaJ (Hsp40) homolog, subfamily A, member 2	0.981	Yeast
Psmb3	proteasome (prosome, macropain) subunit, beta type 3	0.956	Yeast
Psma7	proteasome (prosome, macropain) subunit, alpha type 7	0.887	Yeast
Psma4	proteasome (prosome, macropain) subunit, alpha type 4	0.882	Yeast
Psmc2	proteasome (prosome, macropain) 26S subunit, ATPase 2	0.839	Human Yeast
Psmb2	proteasome (prosome, macropain) subunit, beta type 2	0.808	Yeast
Psmc1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	0.731
Psmb6	proteasome (prosome, macropain) subunit, beta type 6	0.602	Yeast
Psma2	proteasome (prosome, macropain) subunit, alpha type 2	0.491	Yeast
Psmd13	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	0.460
Psmd6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.387
Psmc3	proteasome (prosome, macropain) 26S subunit, ATPase 3	0.377	Yeast
Psme2	proteasome (prosome, macropain) activator subunit 2	0.368
Nsfl1c	NSFL1 (p97) cofactor (p47)	0.322
Cnbp	CCHC-type zinc finger, nucleic acid binding protein	0.298
Psmb7	proteasome (prosome, macropain) subunit, beta type 7	0.279	Yeast
Ppp1cb	protein phosphatase 1, catalytic subunit, beta isoform	0.271
Eef2	eukaryotic translation elongation factor 2	0.270
Psmb1	proteasome (prosome, macropain) subunit, beta type 1	0.262	Yeast
Psmb10	proteasome (prosome, macropain) subunit, beta type 10	0.202	Yeast
Psmb4	proteasome (prosome, macropain) subunit, beta type 4	0.182	Yeast
Golph3	golgi phosphoprotein 3 (coat-protein)	0.178
Psmc4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	0.174	Yeast
Psmc5	proteasome (prosome, macropain) 26S subunit, ATPase, 5	0.173	Human Yeast
Ptges3	prostaglandin E synthase 3 (cytosolic)	0.147
Ndfip2	Nedd4 family interacting protein 2	0.142
Cwc15	CWC15 spliceosome-associated protein homolog (S. cerevisiae)	0.124
Zfand5	zinc finger, AN1-type domain 5	0.120
Psmb5	proteasome (prosome, macropain) subunit, beta type 5	0.120	Yeast Mouse
Psma1	proteasome (prosome, macropain) subunit, alpha type 1	0.119	Yeast
Phax	phosphorylated adaptor for RNA export	0.115
Rab21	RAB21, member RAS oncogene family	0.107
Dnajb9	DnaJ (Hsp40) homolog, subfamily B, member 9	0.103	Human Mouse
Txnrd1	thioredoxin reductase 1	0.102
Psma6	proteasome (prosome, macropain) subunit, alpha type 6	0.101	Yeast
Rad23b	RAD23 homolog B (S. cerevisiae)	0.098	Human
Csnk1d	casein kinase 1, delta	0.095	Mouse Fly
Hsph1	heat shock 105/110 protein 1	0.091
Psmd4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.089
Psmd7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.087
Nploc4	nuclear protein localization 4 homolog (S. cerevisiae)	0.082
Dnajb11	DnaJ (Hsp40) homolog, subfamily B, member 11	0.082
Manf	mesencephalic astrocyte-derived neurotrophic factor	0.080
Rnf146	ring finger protein 146	0.076	Human
Gorasp2	golgi reassembly stacking protein 2	0.076
Psmd2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.072
Pdia4	protein disulfide isomerase family A, member 4	0.068
Canx	calnexin	0.067
Psmd3	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	0.065
Vcp	valosin-containing protein	0.062
Mapre1	microtubule-associated protein, RP/EB family, member 1	0.060
Cdc37	cell division cycle 37 homolog (S. cerevisiae)	0.057
Syngr2	synaptogyrin 2	0.052
Calr	calreticulin	0.049
Usp47	ubiquitin specific peptidase 47	0.049
Ubc	ubiquitin C	0.048
LOC100366237	prefoldin subunit 4-like	0.047
Ppp1r2	protein phosphatase 1, regulatory (inhibitor) subunit 2	0.046
Psmd1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.045
Pomp	proteasome maturation protein	0.044
LOC362855	P55	0.043
Ufd1l	ubiquitin fusion degradation 1 like (yeast)	0.043
Ptp4a1	protein tyrosine phosphatase type IVA, member 1	0.042
Ppm1b	protein phosphatase 1B, magnesium dependent, beta isoform	0.041
Cmtm6	CKLF-like MARVEL transmembrane domain containing 6	0.041
Hprt1	hypoxanthine phosphoribosyltransferase 1	0.040
Cops5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	0.040
Hk1	hexokinase 1	0.039
Cdk7	cyclin-dependent kinase 7	0.039
Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	0.039	Yeast
Cand1	cullin-associated and neddylation-dissociated 1	0.039
Dnaja1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.039	Yeast
Txnl1	thioredoxin-like 1	0.038
Psmd14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14	0.037
Rbbp7	retinoblastoma binding protein 7	0.034
Oaz1	ornithine decarboxylase antizyme 1	0.034
Irf1	interferon regulatory factor 1	0.033
Lgals3bp	lectin, galactoside-binding, soluble, 3 binding protein	0.033
Ppp1cc	protein phosphatase 1, catalytic subunit, gamma isoform	0.032	Yeast
Higd1a	HIG1 hypoxia inducible domain family, member 1A	0.032
Acyp2	acylphosphatase 2, muscle type	0.032
Ube2d2	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	0.031
Eif5a	eukaryotic translation initiation factor 5A	0.031
Ube2i	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.030
Rgs19	regulator of G-protein signaling 19	0.029
Rab11a	RAB11a, member RAS oncogene family	0.028
Pctk2	PCTAIRE protein kinase 2	0.028
Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.028
Creld2	cysteine-rich with EGF-like domains 2	0.027
Dlg1	discs, large homolog 1 (Drosophila)	0.027
Usp14	ubiquitin specific peptidase 14	0.026
St13	suppression of tumorigenicity 13	0.026
Mgat2	mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	0.026
Clns1a	chloride channel, nucleotide-sensitive, 1A	0.025
LOC100364212	heterogeneous nuclear ribonucleoprotein K-like	0.024
Csnk2b	casein kinase 2, beta polypeptide	0.024
Rnf2	ring finger protein 2	0.024
Rnf19a	ring finger protein 19A	0.023
Alkbh5	alkB, alkylation repair homolog 5 (E. coli)	0.022
Pdcl3	phosducin-like 3	0.022	Human
Sfpq	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	0.022
Clic4	chloride intracellular channel 4	0.021
Ifi35	interferon-induced protein 35	0.021
Rbm18	RNA binding motif protein 18	0.021
Psmd8	proteasome (prosome, macropain) 26S subunit, non-ATPase, 8	0.021
March5	membrane-associated ring finger (C3HC4) 5	0.021
Rybp	RING1 and YY1 binding protein	0.021
Hsp90b1	heat shock protein 90, beta, member 1	0.020	Human
Tiprl	TIP41, TOR signaling pathway regulator-like (S. cerevisiae)	0.020
Dr1	down-regulator of transcription 1	0.020
Usf2	upstream transcription factor 2, c-fos interacting	0.019
Dnpep	aspartyl aminopeptidase	0.019
RGD1305938	similar to expressed sequence AW549877	0.019
Herpud1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	0.019
Tax1bp1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.019
Map2k4	mitogen activated protein kinase kinase 4	0.019
Ube2d3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.018
Rab5a	RAB5A, member RAS oncogene family	0.018
Dnajc5	DnaJ (Hsp40) homolog, subfamily C, member 5	0.017
RGD1309102	similar to TRS85 homolog	0.017
Ube2g1	ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)	0.017
Suv420h1	suppressor of variegation 4-20 homolog 1 (Drosophila)	0.017
Akirin2	akirin 2	0.017
Ifi27l2b	interferon, alpha-inducible protein 27 like 2B	0.017
Spcs3	signal peptidase complex subunit 3 homolog (S. cerevisiae)	0.017
Sec61a1	Sec61 alpha 1 subunit (S. cerevisiae)	0.017
Ap1ar	adaptor-related protein complex 1 associated regulatory protein	0.017
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.016
Mrpl22	mitochondrial ribosomal protein L22	0.016
Senp2	Sumo1/sentrin/SMT3 specific peptidase 2	0.016
Mbd2	methyl-CpG binding domain protein 2	0.016
Vapa	VAMP (vesicle-associated membrane protein)-associated protein A	0.016
Rab10	RAB10, member RAS oncogene family	0.016
Hspa5	heat shock protein 5	0.016	Yeast
Tbpl1	TATA box binding protein-like 1	0.016
Lmtk2	lemur tyrosine kinase 2	0.016
Cnot7	CCR4-NOT transcription complex, subunit 7	0.015
Akt1s1	AKT1 substrate 1 (proline-rich)	0.015
Dnajc3	DnaJ (Hsp40) homolog, subfamily C, member 3	0.015
Ift20	intraflagellar transport 20 homolog (Chlamydomonas)	0.015
Rnf139	ring finger protein 139	0.015
Cdc42	cell division cycle 42 (GTP binding protein)	0.015
Rbm8a	RNA binding motif protein 8A	0.014
Ppp2r2a	protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform	0.014
Brcc3	BRCA1/BRCA2-containing complex, subunit 3	0.014
Rap1b	RAP1B, member of RAS oncogene family	0.014
Bcr	breakpoint cluster region	0.014
Tspyl1	TSPY-like 1	0.014
Csnk1g2	casein kinase 1, gamma 2	0.014
Axin1	axin 1	0.014
Coq10b	coenzyme Q10 homolog B (S. cerevisiae)	0.014
Sumo1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.013	Human
Psmd11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	0.013
Usp15	ubiquitin specific peptidase 15	0.013
Pfdn2	prefoldin subunit 2	0.013
Dnajc21	DnaJ (Hsp40) homolog, subfamily C, member 21	0.013
Dctn4	dynactin 4	0.013
Cugbp1	CUG triplet repeat, RNA binding protein 1	0.013
Ppp2r4	protein phosphatase 2A activator, regulatory subunit 4	0.013
Bat5	HLA-B associated transcript 5	0.013
Nars	asparaginyl-tRNA synthetase	0.013
Wdr26	WD repeat domain 26	0.012
Xpnpep1	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	0.012
Prdm4	PR domain containing 4	0.012
Tollip	toll interacting protein	0.012
Kif22	kinesin family member 22	0.012
Nfix	nuclear factor I/X (CCAAT-binding transcription factor)	0.012
Mdm2	Mdm2 p53 binding protein homolog (mouse)	0.012
Pcmtd2	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2	0.012
Ccdc47	coiled-coil domain containing 47	0.011
Pds5a	PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)	0.011
Mlec	malectin	0.011
Metap2	methionyl aminopeptidase 2	0.011
Rab35	RAB35, member RAS oncogene family	0.011
Akap11	A kinase (PRKA) anchor protein 11	0.011
Ppm1a	protein phosphatase 1A, magnesium dependent, alpha isoform	0.011
Azi2	5-azacytidine induced 2	0.011
Ube2b	ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae)	0.010
March8	membrane-associated ring finger (C3HC4) 8	0.010
Mdfic	MyoD family inhibitor domain containing	0.010
LOC100360501	ribonuclease inhibitor-like	0.010
Jtb	jumping translocation breakpoint	0.010
Ppp1r10	protein phosphatase 1, regulatory subunit 10	0.010
Smad4	SMAD family member 4	0.010
Ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform	0.010