IMP

Process View

Rattus norvegicus

23 genes annotated in rat

erbb signaling pathway

A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "erbb signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "erbb signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Grb2	growth factor receptor bound protein 2	0.632	Fly
Sgk1	serum/glucocorticoid regulated kinase 1	0.156
Sirpa	signal-regulatory protein alpha	0.148
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.125	Fly
Egfr	epidermal growth factor receptor	0.125
Atp6v1b2	ATPase, H transporting, lysosomal V1 subunit B2	0.099
Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.058
Nsf	N-ethylmaleimide-sensitive factor	0.057
Shc1	SHC (Src homology 2 domain containing) transforming protein 1	0.053	Mouse Fly
Hk1	hexokinase 1	0.052
Litaf	lipopolysaccharide-induced TNF factor	0.049
Prkcd	protein kinase C, delta	0.047
Cd86	CD86 molecule	0.047
Ptafr	platelet-activating factor receptor	0.045
Pfn1	profilin 1	0.044
Vcan	versican	0.044
Ptprs	protein tyrosine phosphatase, receptor type, S	0.044
RGD1308350	similar to hypothetical protein MGC13251	0.042
Grip1	glutamate receptor interacting protein 1	0.042
Cbl	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.041
Ube2h	ubiquitin-conjugating enzyme E2H	0.040
Muc4	mucin 4, cell surface associated	0.040
Cxcr4	chemokine (C-X-C motif) receptor 4	0.039
Il2rb	interleukin 2 receptor, beta	0.039
Plcg2	phospholipase C, gamma 2	0.038	Fly
Rin1	Ras and Rab interactor 1	0.033
Ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform	0.033
Pld2	phospholipase D2	0.032
Lcp2	lymphocyte cytosolic protein 2	0.030
Inpp5d	inositol polyphosphate-5-phosphatase D	0.029
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.028
Pitpna	phosphatidylinositol transfer protein, alpha	0.028
Ap2b1	adaptor-related protein complex 2, beta 1 subunit	0.027
Il1a	interleukin 1 alpha	0.027
Met	met proto-oncogene	0.027
Klf9	Kruppel-like factor 9	0.027
Tle4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0.026
Stk10	serine/threonine kinase 10	0.026
Dab2	disabled homolog 2 (Drosophila)	0.026
Grin2b	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.026
Gfi1	growth factor independent 1 transcription repressor	0.025
Ptprc	protein tyrosine phosphatase, receptor type, C	0.025
Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	0.025
Fgr	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.024	Rat
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.023
Ciita	class II, major histocompatibility complex, transactivator	0.023
Ppp3r1	protein phosphatase 3, regulatory subunit B, alpha isoform	0.023
Tnf	tumor necrosis factor (TNF superfamily, member 2)	0.023	Rat
Foxs1	forkhead box S1	0.023
Bdkrb2	bradykinin receptor B2	0.022
Apba3	amyloid beta (A4) precursor protein-binding, family A, member 3	0.022
Rab21	RAB21, member RAS oncogene family	0.022
Efhd2	EF-hand domain family, member D2	0.022
Ceacam10	carcinoembryonic antigen-related cell adhesion molecule 10	0.022
PVR	poliovirus receptor	0.022
Fmnl1	formin-like 1	0.022
Gpr173	G-protein coupled receptor 173	0.021
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.021
Lhx5	LIM homeobox 5	0.021
Smad1	SMAD family member 1	0.021
Rhoa	ras homolog gene family, member A	0.021
Grin2a	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	0.021
Hpcal4	hippocalcin-like 4	0.020
Ttyh3	tweety homolog 3 (Drosophila)	0.020
Anxa2	annexin A2	0.020
Grasp	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein	0.020
Ifrd1	interferon-related developmental regulator 1	0.020
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.019
Gata2	GATA binding protein 2	0.019
Agrn	agrin	0.019
Fosl2	fos-like antigen 2	0.019
Hnrnpab	heterogeneous nuclear ribonucleoprotein A/B	0.019
Cd38	CD38 molecule	0.019
Cpne5	copine V	0.019
Fgf5	fibroblast growth factor 5	0.019
Dchs1	dachsous 1 (Drosophila)	0.019
Arf3	ADP-ribosylation factor 3	0.019	Rat
Mapre1	microtubule-associated protein, RP/EB family, member 1	0.019
Slc6a9	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	0.018
Irf1	interferon regulatory factor 1	0.018
Lyn	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.018	Rat
Rab7a	RAB7A, member RAS oncogene family	0.018
F2rl1	coagulation factor II (thrombin) receptor-like 1	0.018
Epha2	Eph receptor A2	0.018
Fgd2	FYVE, RhoGEF and PH domain containing 2	0.018
Il2rg	interleukin 2 receptor, gamma	0.017
Sorbs1	sorbin and SH3 domain containing 1	0.017
Cadm1	cell adhesion molecule 1	0.017
Jak1	Janus kinase 1	0.017
Vav1	vav 1 guanine nucleotide exchange factor	0.017
Cd37	CD37 molecule	0.017
Pfkfb2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	0.016
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.016
Rhob	ras homolog gene family, member B	0.016
Sash3	SAM and SH3 domain containing 3	0.016
Cd40	CD40 molecule, TNF receptor superfamily member 5	0.016
Adora2a	adenosine A2a receptor	0.016	Rat
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.016
Pxn	paxillin	0.016
Itpr3	inositol 1,4,5-triphosphate receptor, type 3	0.016
Rab2a	RAB2A, member RAS oncogene family	0.016
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.016
Arhgap27	Rho GTPase activating protein 27	0.016
Nrxn1	neurexin 1	0.015
Itgb1	integrin, beta 1	0.015
Apc	adenomatous polyposis coli	0.015
Med21	mediator complex subunit 21	0.015
Prkch	protein kinase C, eta	0.015
Grm5	glutamate receptor, metabotropic 5	0.015
Adam2	ADAM metallopeptidase domain 2	0.015
RGD1559588	similar to cell surface receptor FDFACT	0.015
Sdk2	sidekick homolog 2 (chicken)	0.015
Myo1e	myosin IE	0.015
Prss22	protease, serine, 22	0.015
Cxcl1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.015
Rac1	ras-related C3 botulinum toxin substrate 1	0.015
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.015
Lum	lumican	0.014
Igf2r	insulin-like growth factor 2 receptor	0.014
Gnb2	guanine nucleotide binding protein (G protein), beta polypeptide 2	0.014
Lalba	lactalbumin, alpha	0.014
Morf4l2	mortality factor 4 like 2	0.014
Rab12	RAB12, member RAS oncogene family	0.014
Nrg2	neuregulin 2	0.014
Elmo2	engulfment and cell motility 2	0.014
Il1b	interleukin 1 beta	0.014
Mprip	myosin phosphatase Rho interacting protein	0.014
Itgam	integrin, alpha M	0.014
Tpm3	tropomyosin 3, gamma	0.014
Ell	elongation factor RNA polymerase II	0.014
Notch1	Notch homolog 1, translocation-associated (Drosophila)	0.014
Cugbp2	CUG triplet repeat, RNA binding protein 2	0.014
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.014
RGD1564163	similar to RIKEN cDNA 1700025K23	0.014
Syt6	synaptotagmin VI	0.014
Baiap2	BAI1-associated protein 2	0.014
Hdlbp	high density lipoprotein binding protein	0.014
Adora1	adenosine A1 receptor	0.014
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.013
Ptn	pleiotrophin	0.013
Srpk2	SFRS protein kinase 2	0.013
Cx3cr1	chemokine (C-X3-C motif) receptor 1	0.013
Itgb4	integrin, beta 4	0.013
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.013
Pafah1b2	platelet-activating factor acetylhydrolase, isoform 1b, subunit 2	0.013
Prelid1	PRELI domain containing 1	0.013
Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	0.013
Plekhg2	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	0.013
Lphn2	latrophilin 2	0.013
Glg1	golgi apparatus protein 1	0.013
Dlg4	discs, large homolog 4 (Drosophila)	0.013	Fly
Man2b1	mannosidase, alpha, class 2B, member 1	0.013
Bcar1	breast cancer anti-estrogen resistance 1	0.013
Gzmb	granzyme B	0.013
Rasgrp1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	0.013
Gcm1	glial cells missing homolog 1 (Drosophila)	0.013
Gzmk	granzyme K	0.013
Bcl2l1	Bcl2-like 1	0.013
Cap1	CAP, adenylate cyclase-associated protein 1 (yeast)	0.012
Prkar1a	protein kinase, cAMP-dependent, regulatory, type I, alpha	0.012
Sema6b	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	0.012
Rab1	RAB1, member RAS oncogene family	0.012
Col4a4	collagen, type IV, alpha 4	0.012
Adcy10	adenylate cyclase 10 (soluble)	0.012
Klre1	killer cell lectin-like receptor, family E, member 1	0.012
Cd247	Cd247 molecule	0.012
Ubn2	ubinuclein 2	0.012
Spint1	serine peptidase inhibitor, Kunitz type 1	0.012
Pdyn	prodynorphin	0.012
Tln1	talin 1	0.012
Myo1g	myosin IG	0.012
Mobkl2a	MOB1, Mps One Binder kinase activator-like 2A (yeast)	0.012
RT1-EC2	RT1 class Ib, locus EC2	0.012
Hrh1	histamine receptor H 1	0.012
Ppard	peroxisome proliferator-activated receptor delta	0.012
Rorb	RAR-related orphan receptor B	0.012
Tcrb	T-cell receptor beta chain	0.012
Ptpre	protein tyrosine phosphatase, receptor type, E	0.011
Dnah9	dynein, axonemal, heavy polypeptide 9	0.011
Fgf7	fibroblast growth factor 7	0.011
Stx6	syntaxin 6	0.011
Myo1f	myosin IF	0.011
Map2	microtubule-associated protein 2	0.011
Ptger2	prostaglandin E receptor 2 (subtype EP2)	0.011
Rnf4	ring finger protein 4	0.011
Kif1b	kinesin family member 1B	0.011
Col4a5	collagen, type IV, alpha 5	0.011
Stxbp5	syntaxin binding protein 5 (tomosyn)	0.011
Dlgap1	discs, large (Drosophila) homolog-associated protein 1	0.011
RGD1311224	similar to fatty acid desaturase 2; linoleoyl-CoA desaturase (delta-6-desaturase)-like 2; delta-6 fatty acid desaturase	0.011
Dbh	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	0.011
Sec61a1	Sec61 alpha 1 subunit (S. cerevisiae)	0.011
Fgf18	fibroblast growth factor 18	0.011
Pgf	placental growth factor	0.011
Il4ra	interleukin 4 receptor, alpha	0.011
Lmna	lamin A	0.011
Ccl5	chemokine (C-C motif) ligand 5	0.011
Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.011
Icam1	intercellular adhesion molecule 1	0.011
Cd79b	Cd79b molecule, immunoglobulin-associated beta	0.011
Orai1	ORAI calcium release-activated calcium modulator 1	0.011
Tgfb1	transforming growth factor, beta 1	0.011	Human
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.011
Klrc2	killer cell lectin-like receptor subfamily C, member 2	0.011
Plek	pleckstrin	0.011
Rab4a	RAB4A, member RAS oncogene family	0.011
Mllt3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	0.011
Cdc42bpb	CDC42 binding protein kinase beta (DMPK-like)	0.011
Fgfr2	fibroblast growth factor receptor 2	0.011
Bid	BH3 interacting domain death agonist	0.011
Ctsw	cathepsin W	0.011
Itih3	inter-alpha trypsin inhibitor, heavy chain 3	0.011
Ntrk1	neurotrophic tyrosine kinase, receptor, type 1	0.010
Cmtm6	CKLF-like MARVEL transmembrane domain containing 6	0.010
Akt1	v-akt murine thymoma viral oncogene homolog 1	0.010
Kcnf1	potassium voltage-gated channel, subfamily F, member 1	0.010
Mbd2	methyl-CpG binding domain protein 2	0.010
Pik3cd	phosphoinositide-3-kinase, catalytic, delta polypeptide	0.010	Fly
Il1rl1	interleukin 1 receptor-like 1	0.010
Prdm2	PR domain containing 2, with ZNF domain	0.010
Bak1	BCL2-antagonist/killer 1	0.010
Smap2	small ArfGAP2	0.010
Stxbp2	syntaxin binding protein 2	0.010
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.010
Adap1	ArfGAP with dual PH domains 1	0.010
Mapkapk3	mitogen-activated protein kinase-activated protein kinase 3	0.010
Pde4b	phosphodiesterase 4B, cAMP specific	0.010
Jak2	Janus kinase 2	0.010
Plat	plasminogen activator, tissue	0.010
Rasgef1c	RasGEF domain family, member 1C	0.010
Prp15	proline-rich protein 15	0.010
Ispd	isoprenoid synthase domain containing	0.010
Klhl17	kelch-like 17 (Drosophila)	0.010
Padi2	peptidyl arginine deiminase, type II	0.010
Irs1	insulin receptor substrate 1	0.010
Rnf139	ring finger protein 139	0.010
Il7	interleukin 7	0.010
Map4k1	mitogen activated protein kinase kinase kinase kinase 1	0.010