IMP

Process View

Saccharomyces cerevisiae

30 genes annotated in yeast

Multi-species View

negative regulation of signaling

GO:0023057

Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process.

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Known genes in the process in yeast Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of signaling"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of signaling" (in gray)

Name	Description	Probability	Func Analog Organism
PPH21	Pph21p	0.838	Yeast
KSS1	Kss1p	0.640	Yeast
FUS3	Fus3p	0.475
BCK1	Bck1p	0.436
CDC25	Cdc25p	0.426	Mouse
SSN8	Ssn8p	0.379
BBC1	Bbc1p	0.376
DID4	Did4p	0.334	Fly
RTS1	Rts1p	0.321
BEM1	Bem1p	0.321	Yeast
STI1	Sti1p	0.282
SHO1	Sho1p	0.238
CHC1	Chc1p	0.206
IRA1	Ira1p	0.195
MKK1	Mkk1p	0.183
BOI1	Boi1p	0.178	Yeast
REG1	Reg1p	0.176
PPE1	Ppe1p	0.170
VPS20	Vps20p	0.167	Fly
VPS45	Vps45p	0.156
SIT4	Sit4p	0.152
YOL087C	hypothetical protein	0.149
MDS3	Mds3p	0.145
ROM2	Rom2p	0.136
SSA3	Ssa3p	0.122	Human
FAR1	Far1p	0.119
END3	End3p	0.119
STE7	Ste7p	0.118
GSC2	Gsc2p	0.113
TPS1	Tps1p	0.111
TPK2	Tpk2p	0.103	Mouse Fly
VMA13	Vma13p	0.103
RLM1	Rlm1p	0.103
TPK1	Tpk1p	0.101	Mouse Fly
PEP1	Pep1p	0.100	Mouse
VPS36	Vps36p	0.095
HKR1	Hkr1p	0.092
HSP60	Hsp60p	0.091
TEC1	Tec1p	0.090
CRG1	Crg1p	0.086
STE23	Ste23p	0.084	Fly
VPS4	Vps4p	0.082	Fly
ULP2	Ulp2p	0.082
GLC7	Glc7p	0.080	Yeast
PBS2	Pbs2p	0.079
CDC34	Cdc34p	0.079
CMK1	Cmk1p	0.077
CRZ1	Crz1p	0.077
RTT101	Rtt101p	0.075
SLA2	Sla2p	0.075
FAR11	Far11p	0.074
SCP1	Scp1p	0.072
FTH1	Fth1p	0.070
MSN2	Msn2p	0.069
STE20	Ste20p	0.066
EBS1	Ebs1p	0.064
SWI5	Swi5p	0.064
DID2	Did2p	0.063	Fly
ICE2	Ice2p	0.062
FPK1	Fpk1p	0.062	Mouse
SKT5	Skt5p	0.061
YCL042W	hypothetical protein	0.059
BMH1	Bmh1p	0.058
YKR017C	hypothetical protein	0.058
HRP1	Hrp1p	0.057
SLX5	Slx5p	0.056
MEH1	Meh1p	0.056
CDC55	Cdc55p	0.056
RAD16	Rad16p	0.055
MSS18	Mss18p	0.054
STE12	Ste12p	0.053
SOK1	Sok1p	0.053
KIC1	Kic1p	0.053
TAF8	Taf8p	0.053
SAC7	Sac7p	0.053
MSG5	Msg5p	0.052
BEM2	Bem2p	0.051
STE4	Ste4p	0.051
SLX8	Slx8p	0.051
NHA1	Nha1p	0.049
PEP5	Pep5p	0.048
PHO85	Pho85p	0.048
SIZ1	Siz1p	0.046	Human
YIL001W	hypothetical protein	0.046
SUR1	Sur1p	0.045
PMR1	Pmr1p	0.044
RHO1	Rho1p	0.043	Mouse
GIS1	Gis1p	0.043
CCL1	Ccl1p	0.042
HSV2	Hsv2p	0.042
LHS1	Lhs1p	0.041	Mouse
NOG2	Nog2p	0.041
VTA1	Vta1p	0.041
CCR4	Ccr4p	0.040
DIG1	Dig1p	0.040
BRE5	Bre5p	0.040
MKK2	Mkk2p	0.040
STD1	Std1p	0.040
RSC8	Rsc8p	0.039
LSB1	Lsb1p	0.039
DMA2	Dma2p	0.038
ZPR1	Zpr1p	0.038
KSP1	Ksp1p	0.037
SSE1	Sse1p	0.037
VPS5	Vps5p	0.037
OSH3	Osh3p	0.037
AGE1	Age1p	0.036
SCH9	Sch9p	0.036	Mouse
YNR014W	hypothetical protein	0.036
PPH22	Pph22p	0.036	Yeast
STE5	Ste5p	0.035
GDB1	Gdb1p	0.034
RAS2	Ras2p	0.034	Fly
SSA4	Ssa4p	0.034	Human
DCN1	Dcn1p	0.034
PRB1	Prb1p	0.034
VPS24	Vps24p	0.033
TSC10	Tsc10p	0.033
ESP1	Esp1p	0.033
BEM4	Bem4p	0.032
YME1	Yme1p	0.032
YHR033W	hypothetical protein	0.032
GPB2	Gpb2p	0.031
GAL7	Gal7p	0.031
GPR1	Gpr1p	0.031
VPS64	Vps64p	0.031
KIN28	Kin28p	0.031
KOG1	Kog1p	0.031
BOI2	Boi2p	0.031	Yeast
GIC2	Gic2p	0.030
FUM1	Fum1p	0.030
IST1	Ist1p	0.030
SLT2	Slt2p	0.029	Yeast
MEC1	Mec1p	0.029
RPN14	Rpn14p	0.029
VIP1	Vip1p	0.029
MSS11	Mss11p	0.028
PKH2	Pkh2p	0.028	Human Mouse
CHS5	Chs5p	0.028
APS1	Aps1p	0.028
PRR1	Prr1p	0.028	Human
MIG1	Mig1p	0.028
PCL9	Pcl9p	0.028
SAP4	Sap4p	0.028
SLG1	Slg1p	0.027
UPS3	Ups3p	0.027
MKT1	Mkt1p	0.027
SPT15	Spt15p	0.027
CHS1	Chs1p	0.027
VPS71	Vps71p	0.027
APC11	Apc11p	0.027
RAD59	Rad59p	0.027
STE18	Ste18p	0.027
SET1	Set1p	0.026
PPH3	Pph3p	0.026
ATG27	Atg27p	0.026
CLA4	Cla4p	0.026
PPZ1	Ppz1p	0.026	Yeast
DUG2	Dug2p	0.025
RDH54	Rdh54p	0.025
PSY4	Psy4p	0.025
SAP30	Sap30p	0.025
ADR1	Adr1p	0.025
HSL7	Hsl7p	0.025
ALD6	Ald6p	0.025
KIN1	Kin1p	0.025
GPA1	Gpa1p	0.025	Rat
RGC1	Rgc1p	0.025
ZDS1	Zds1p	0.024
SNF6	Snf6p	0.024
CYK3	Cyk3p	0.024
PFK1	Pfk1p	0.024
VPS41	Vps41p	0.024	Fly
PGS1	Pgs1p	0.024
DIA2	Dia2p	0.024
STE2	Ste2p	0.023
PMA2	Pma2p	0.023
VPS21	Vps21p	0.023
ATG11	Atg11p	0.023
MPT5	Mpt5p	0.023
TRX2	Trx2p	0.023
FRT1	Frt1p	0.023
MHT1	Mht1p	0.023
YGR126W	hypothetical protein	0.023
CAF120	Caf120p	0.022
KCC4	Kcc4p	0.022
SWI1	Swi1p	0.022
GFA1	Gfa1p	0.022
CKA1	Cka1p	0.022
NPR3	Npr3p	0.022
VAM7	Vam7p	0.022
IRA2	Ira2p	0.022
YDC1	Ydc1p	0.021
SKN7	Skn7p	0.021	Yeast
RPN13	Rpn13p	0.021
RHO5	Rho5p	0.021
SAS4	Sas4p	0.021
RMD5	Rmd5p	0.021
PSY2	Psy2p	0.021
DUG3	Dug3p	0.021
VMR1	Vmr1p	0.021
YOL014W	hypothetical protein	0.021
APM4	Apm4p	0.021
ARE2	Are2p	0.021
CAK1	Cak1p	0.021
LSP1	Lsp1p	0.021
DBF2	Dbf2p	0.021
VPS27	Vps27p	0.021
MDH2	Mdh2p	0.020
VPS16	Vps16p	0.020
TIF6	Tif6p	0.020
SOG2	Sog2p	0.020
DOG2	Dog2p	0.020
CNB1	Cnb1p	0.020
RIF1	Rif1p	0.020
RAD3	Rad3p	0.020
SNG1	Sng1p	0.020
MPH1	Mph1p	0.020
SIS2	Sis2p	0.019
SOK2	Sok2p	0.019
RFT1	Rft1p	0.019
ACK1	Ack1p	0.019
PPG1	Ppg1p	0.019	Yeast
VAM3	Vam3p	0.019
YGR016W	hypothetical protein	0.019
MPD2	Mpd2p	0.019
EXO1	Exo1p	0.019
ULA1	Ula1p	0.019
PYK2	Pyk2p	0.019
YDR186C	hypothetical protein	0.019
REV1	Rev1p	0.019
SDS23	Sds23p	0.018
HHF1	Hhf1p	0.018
ATP1	Atp1p	0.018
ARG82	Arg82p	0.018
TPM1	Tpm1p	0.018
CHS2	Chs2p	0.018
ARP2	Arp2p	0.018
PIR3	Pir3p	0.018
APL5	Apl5p	0.018
SAS2	Sas2p	0.018
YEL043W	hypothetical protein	0.018
COX9	Cox9p	0.018
MSH3	Msh3p	0.018
SRL3	Srl3p	0.017
PEA2	Pea2p	0.017
TGL4	Tgl4p	0.017
TRK1	Trk1p	0.017
SAS5	Sas5p	0.017
SST2	Sst2p	0.017
SPG1	Spg1p	0.017
SSF2	Ssf2p	0.017
TAL1	Tal1p	0.017
RPO31	Rpo31p	0.017
LEU5	Leu5p	0.017
YDL233W	hypothetical protein	0.017
CAM1	Cam1p	0.017
TPK3	Tpk3p	0.017	Mouse Fly
CDC53	Cdc53p	0.017
VAM6	Vam6p	0.017
SML1	Sml1p	0.017
DOP1	Dop1p	0.017
HSF1	Hsf1p	0.016
NOP4	Nop4p	0.016
INP52	Inp52p	0.016
MDN1	Mdn1p	0.016
RAD51	Rad51p	0.016
COX13	Cox13p	0.016
ARP9	Arp9p	0.016
BEM3	Bem3p	0.016
RER2	Rer2p	0.016
CUP2	Cup2p	0.016
WSS1	Wss1p	0.016
AHP1	Ahp1p	0.016
YER140W	hypothetical protein	0.016
BNA5	Bna5p	0.016
SPC110	Spc110p	0.016
VPS30	Vps30p	0.016
HSL1	Hsl1p	0.016
SSA2	Ssa2p	0.016	Human
GRR1	Grr1p	0.016
YIL152W	hypothetical protein	0.016
TSA2	Tsa2p	0.016	Mouse
RSC3	Rsc3p	0.015
AIM43	Aim43p	0.015
NTO1	Nto1p	0.015
CCZ1	Ccz1p	0.015
GLC3	Glc3p	0.015
GRX5	Grx5p	0.015
YPR109W	hypothetical protein	0.015
APS3	Aps3p	0.015
MMS1	Mms1p	0.015
SLN1	Sln1p	0.015
BCK2	Bck2p	0.015
RNH202	Rnh202p	0.015
HOS4	Hos4p	0.015
TSC11	Tsc11p	0.015
FUS2	Fus2p	0.015
CWC23	Cwc23p	0.015
OCH1	Och1p	0.015
MGR1	Mgr1p	0.015
FAA3	Faa3p	0.015
GSY2	Gsy2p	0.015
UBA3	Uba3p	0.015
RSC1	Rsc1p	0.015
SPT5	Spt5p	0.015
YBL081W	hypothetical protein	0.015
AGP2	Agp2p	0.015
ATG22	Atg22p	0.015
SCT1	Sct1p	0.015
ANB1	Anb1p	0.015
XKS1	Xks1p	0.015
YBL104C	hypothetical protein	0.014
ARB1	Arb1p	0.014
ESA1	Esa1p	0.014
VMA7	Vma7p	0.014
YGK3	Ygk3p	0.014
MMS2	Mms2p	0.014
VAC8	Vac8p	0.014
VPS29	Vps29p	0.014
NPL6	Npl6p	0.014
RAS1	Ras1p	0.014	Fly
NTH2	Nth2p	0.014
SPP41	Spp41p	0.014
SAD1	Sad1p	0.014
PLC1	Plc1p	0.014
PEX32	Pex32p	0.014
HUR1	Hur1p	0.014
KRE2	Kre2p	0.014
HXK1	Hxk1p	0.014	Rat
FIG4	Fig4p	0.014
LRO1	Lro1p	0.014
MRL1	Mrl1p	0.014
MNN9	Mnn9p	0.014
YIL077C	hypothetical protein	0.014
RSC9	Rsc9p	0.014
IQG1	Iqg1p	0.014
MRPL51	Mrpl51p	0.014
INO4	Ino4p	0.014
PIL1	Pil1p	0.014
SKO1	Sko1p	0.014
YIL151C	hypothetical protein	0.014
CKS1	Cks1p	0.014
SPR6	Spr6p	0.014
RPS14B	Rps14bp	0.014
YOR111W	hypothetical protein	0.014
APL4	Apl4p	0.014
AKL1	Akl1p	0.013
SGE1	Sge1p	0.013
SNF8	Snf8p	0.013
OPY2	Opy2p	0.013
GLO4	Glo4p	0.013
PTP2	Ptp2p	0.013
YTM1	Ytm1p	0.013
PIB2	Pib2p	0.013
BOP3	Bop3p	0.013
SCC4	Scc4p	0.013
NFI1	Nfi1p	0.013	Human
VPS3	Vps3p	0.013
SPT16	Spt16p	0.013
YGR205W	hypothetical protein	0.013
FIT2	Fit2p	0.013
ICY1	Icy1p	0.013
TAX4	Tax4p	0.013
TIP1	Tip1p	0.013
SHE3	She3p	0.013
YJR085C	hypothetical protein	0.013
GDA1	Gda1p	0.013
YPT10	Ypt10p	0.013
SSP1	Ssp1p	0.013
REB1	Reb1p	0.013
RLF2	Rlf2p	0.013
NUP192	Nup192p	0.013
PTC2	Ptc2p	0.013
CRS5	Crs5p	0.013
ENO1	Eno1p	0.013
MMP1	Mmp1p	0.013
EMI2	Emi2p	0.013
TIM44	Tim44p	0.013
ARP10	Arp10p	0.013
CHA1	Cha1p	0.013
YCR061W	hypothetical protein	0.013
YLR264C-A	hypothetical protein	0.013
FMS1	Fms1p	0.012
CTR2	Ctr2p	0.012
ICS2	Ics2p	0.012
YDR132C	hypothetical protein	0.012
CYR1	Cyr1p	0.012
SDP1	Sdp1p	0.012
YAR068W	hypothetical protein	0.012
YDR018C	hypothetical protein	0.012
NAS2	Nas2p	0.012
TUB3	Tub3p	0.012
MDR1	Mdr1p	0.012
ECT1	Ect1p	0.012
NDC1	Ndc1p	0.012
RUB1	Rub1p	0.012
BDH1	Bdh1p	0.012
DCS2	Dcs2p	0.012
SKG6	Skg6p	0.012
VPS68	Vps68p	0.012
VPS75	Vps75p	0.012
YBR225W	hypothetical protein	0.012
APM2	Apm2p	0.012
YFR016C	hypothetical protein	0.012
SRD1	Srd1p	0.012
ZPS1	Zps1p	0.012
FAR3	Far3p	0.012
KNS1	Kns1p	0.012
AOS1	Aos1p	0.012
TFC4	Tfc4p	0.012
CEF1	Cef1p	0.012
KIN2	Kin2p	0.012
HEM3	Hem3p	0.012
TCM62	Tcm62p	0.012
BDH2	Bdh2p	0.012
BUR6	Bur6p	0.012
YOL038C-A	hypothetical protein	0.012
NAB3	Nab3p	0.012
VID24	Vid24p	0.012
YIR007W	hypothetical protein	0.012
LAP4	Lap4p	0.012
PRP24	Prp24p	0.012
YJL213W	hypothetical protein	0.012
FET5	Fet5p	0.012
ASK10	Ask10p	0.012
AFI1	Afi1p	0.012
NAM9	Nam9p	0.012
FYV6	Fyv6p	0.012
MTL1	Mtl1p	0.012
ASH1	Ash1p	0.012
YEL023C	hypothetical protein	0.012
RAT1	Rat1p	0.012
ARC15	Arc15p	0.012
POX1	Pox1p	0.011
HUA1	Hua1p	0.011
TFB4	Tfb4p	0.011
SSK2	Ssk2p	0.011
PKC1	Pkc1p	0.011	Human Mouse Rat Fly
TMA108	Tma108p	0.011
YEL057C	hypothetical protein	0.011
SKG3	Skg3p	0.011
LDB7	Ldb7p	0.011
PRP19	Prp19p	0.011
RAM1	Ram1p	0.011
FIG2	Fig2p	0.011
UBP15	Ubp15p	0.011
RPH1	Rph1p	0.011
SFP1	Sfp1p	0.011
MSK1	Msk1p	0.011
PRS2	Prs2p	0.011
YMR244C-A	hypothetical protein	0.011
MON2	Mon2p	0.011
MTM1	Mtm1p	0.011
SSA1	Ssa1p	0.011	Human
VAC7	Vac7p	0.011
HAP1	Hap1p	0.011
GNP1	Gnp1p	0.011
YPS5	Yps5p	0.011
YIR014W	hypothetical protein	0.011
GLN1	Gln1p	0.011
TFB3	Tfb3p	0.011
YNR065C	hypothetical protein	0.011	Mouse
SNP1	Snp1p	0.011
PRP4	Prp4p	0.011
ATG4	Atg4p	0.011
TWF1	Twf1p	0.011
JEM1	Jem1p	0.011
RKR1	Rkr1p	0.011
YKR041W	hypothetical protein	0.011
ARG8	Arg8p	0.011
YPL191C	hypothetical protein	0.011
SUB1	Sub1p	0.011
PET54	Pet54p	0.011
DUR1,2	Dur1,2p	0.011
YEL007W	hypothetical protein	0.011
YBR013C	hypothetical protein	0.011
RTG3	Rtg3p	0.011
FDC1	Fdc1p	0.011
YBL039W-B	hypothetical protein	0.011
PLB2	Plb2p	0.011
CHZ1	Chz1p	0.011
VCX1	Vcx1p	0.011
YCH1	Ych1p	0.011
LSB6	Lsb6p	0.011
PAH1	Pah1p	0.011
CBT1	Cbt1p	0.011
KCS1	Kcs1p	0.011
LEU2	Leu2p	0.011
BRR2	Brr2p	0.011
YNL058C	hypothetical protein	0.011
YML002W	hypothetical protein	0.011
SSP120	Ssp120p	0.011
YJU2	Yju2p	0.011
YAP1801	hypothetical protein	0.011
YNL190W	hypothetical protein	0.011
HUT1	Hut1p	0.011
VPS51	Vps51p	0.011
RPN4	Rpn4p	0.011
NCE103	Nce103p	0.011
UBC4	Ubc4p	0.011
PXA1	Pxa1p	0.011
CLB1	Clb1p	0.011
FMN1	Fmn1p	0.011
CCT6	Cct6p	0.011
RTF1	Rtf1p	0.011
YJL107C	hypothetical protein	0.010
VPS15	Vps15p	0.010
AGA1	Aga1p	0.010
RAP1	Rap1p	0.010
DUG1	Dug1p	0.010
AMD1	Amd1p	0.010
SFH1	Sfh1p	0.010
MON1	Mon1p	0.010
SCM4	Scm4p	0.010
GPI12	Gpi12p	0.010
YMR114C	hypothetical protein	0.010
YFR006W	hypothetical protein	0.010
AYT1	Ayt1p	0.010
KNH1	Knh1p	0.010
URN1	Urn1p	0.010
YCF1	Ycf1p	0.010
AUA1	Aua1p	0.010
MBR1	Mbr1p	0.010
CNA1	Cna1p	0.010	Rat
YGR210C	hypothetical protein	0.010
AST1	Ast1p	0.010
PST1	Pst1p	0.010
YBR184W	hypothetical protein	0.010
AST2	Ast2p	0.010
UBP9	Ubp9p	0.010	Fly
CCC1	Ccc1p	0.010
NAR1	Nar1p	0.010
YHR078W	hypothetical protein	0.010
AHC2	Ahc2p	0.010
TFC8	Tfc8p	0.010
AAC3	Aac3p	0.010	Human
FIR1	Fir1p	0.010
YLR177W	hypothetical protein	0.010
RPS28B	Rps28bp	0.010
MTC5	Mtc5p	0.010
AAC1	Aac1p	0.010	Human