IMP

Process View

Danio rerio

11 genes annotated in zebrafish

endothelial cell proliferation

GO:0001935

The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in zebrafish Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "endothelial cell proliferation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "endothelial cell proliferation" (in gray)

Name	Description	Probability	Func Analog Organism
notch3	notch homolog 3	0.983
bmp2b	bone morphogenetic protein 2b	0.889	Human
kdrl	kinase insert domain receptor like	0.887
nf1a	neurofibromin 1a	0.634	Mouse
dlx5a	distal-less homeobox gene 5a	0.626
bmpr2a	bone morphogenetic protein receptor, type II a (serine/threonine kinase)	0.364
bmp4	bone morphogenetic protein 4	0.364	Human Mouse
prox1b	prospero-related homeobox gene 1b	0.348
tie2	endothelium-specific receptor tyrosine kinase 2	0.331	Mouse
col4a6	collagen, type IV, alpha 6	0.308
flt1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.306
vegfaa	vascular endothelial growth factor Aa	0.262
efnb2a	ephrin B2a	0.260
ccm2	cerebral cavernous malformation 2	0.199
dld	deltaD	0.197	Zebrafish
flt4	fms-related tyrosine kinase 4	0.181	Human
apobl	apolipoprotein B, like	0.173
nrp2b	neuropilin 2b	0.166
cxcl12b	chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)	0.152
hbbe1.1	hemoglobin beta embryonic-1.1	0.151
sox9a	SRY-box containing gene 9a	0.148
vegfc	vascular endothelial growth factor c	0.148
cdh5	cadherin 5	0.144
col4a3	collagen, type IV, alpha 3	0.139
dla	deltaA	0.133	Zebrafish
dlb	deltaB	0.133	Zebrafish
wu:fv91b12	wu:fv91b12	0.122
ccbe1	collagen and calcium binding EGF domains 1	0.117
hey2	hairy/enhancer-of-split related with YRPW motif 2	0.115
zgc:111961	zgc:111961	0.114
cyp26a1	cytochrome P450, subfamily XXVIA, polypeptide 1	0.104
dlc	deltaC	0.098	Zebrafish
evx1	even-skipped homeobox 1	0.094
etv2	ets variant gene 2	0.093
ptprb	protein tyrosine phosphatase, receptor type, b	0.087
neurog1	neurogenin 1	0.078
kdr	kinase insert domain receptor (a type III receptor tyrosine kinase)	0.078	Human
nf1b	neurofibromin 1b	0.077	Mouse
lamc1	laminin, gamma 1	0.076
hoxd4a	homeo box D4a	0.075
notch2	notch homolog 2	0.075
jag1b	jagged 1b	0.075	Zebrafish
si:ch73-60e21.1	si:ch73-60e21.1	0.072
lama5	laminin, alpha 5	0.070
edn1	endothelin 1	0.069
ahr2	aryl hydrocarbon receptor 2	0.066
cyp26b1	cytochrome P450, family 26, subfamily b, polypeptide 1	0.065
dab2	disabled homolog 2 (Drosophila)	0.064
aox3	aldehyde oxidase 3	0.060
lmo4a	LIM domain only 4a	0.058
hmgb2b	high-mobility group box 2b	0.058	Human
mtmr8	myotubularin related protein 8	0.055
emilin1a	elastin microfibril interfacer 1a	0.053
junbl	jun B proto-oncogene, like	0.052
mmp14a	matrix metalloproteinase 14a (membrane-inserted)	0.051
fos	v-fos FBJ murine osteosarcoma viral oncogene homolog	0.047
esama	endothelial cell adhesion molecule a	0.047
krit1	KRIT1, ankyrin repeat containing	0.046	Human
eya1	eyes absent homolog 1	0.045
si:ch211-212m21.5	si:ch211-212m21.5	0.044
scinla	scinderin like a	0.043
prox1	prospero-related homeobox gene 1	0.043
LOC557062	hypothetical protein LOC557062	0.042
fgfr2	fibroblast growth factor receptor 2	0.042
nphs2	nephrosis 2, idiopathic, steroid-resistant (podocin)	0.040
ren	renin	0.039
hand2	heart and neural crest derivatives expressed transcript 2	0.039
emx2	empty spiracles homeobox 2	0.037
cxcr4a	chemokine (C-X-C motif) receptor 4a	0.037
nr4a3	nuclear receptor subfamily 4, group A, member 3	0.037
efemp2	EGF-containing fibulin-like extracellular matrix protein 2	0.036
trpm7	transient receptor potential cation channel, subfamily M, member 7	0.035
alpi	alkaline phosphatase, intestinal	0.035
ntn1a	netrin 1a	0.035
tgfb1a	transforming growth factor, beta 1a	0.035
pax2a	paired box gene 2a	0.035
fgf8a	fibroblast growth factor 8 a	0.034
nphs1l	nephrosis 1, congenital, Finnish type (nephrin)-like	0.034
mmp2	matrix metalloproteinase 2	0.033
LOC569128	hypothetical protein LOC569128	0.033
h3f3a	H3 histone, family 3A	0.033
fmnl2a	formin-like 2a	0.033
tgfbr2	transforming growth factor, beta receptor II	0.033
zgc:194131	zgc:194131	0.032
mrc1a	mannose receptor, C type 1a	0.032
h2afvl	H2A histone family, member V, like	0.032
dlx3b	distal-less homeobox gene 3b	0.031
msxd	muscle segment homeobox D	0.031
thbs1	thrombospondin 1	0.030	Human Mouse
sulf1	sulfatase 1	0.029	Human
mmd2	progestin and adipoQ receptor 10	0.028
rbp4	retinol binding protein 4, plasma	0.028
hmgb2a	high-mobility group box 2a	0.028	Human
wtip	Wilms tumor 1 interacting protein	0.027
col1a1a	collagen, type I, alpha 1a	0.026
ntn4	netrin 4	0.026
mbp	myelin basic protein	0.026
e2f7	E2F transcription factor 7	0.026
nfkbiab	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b	0.025
stab2	stabilin 2	0.024
mcamb	melanoma cell adhesion molecule b	0.024
itgav	integrin, alpha V	0.023
meis4.1a	myeloid ecotropic viral integration site 4.1a	0.023
pvalb9	parvalbumin 9	0.023
acvr1l	activin A receptor, type I like	0.022
sepp1b	selenoprotein P, plasma, 1b	0.022
itgb3b	integrin beta 3b	0.022
mib	mind bomb	0.022
ca2	carbonic anhydrase II	0.022
ikzf1	IKAROS family zinc finger 1 (Ikaros)	0.022
pea3	ETS-domain transcription factor pea3	0.021
col5a2l	collagen, type V, alpha 2-like	0.021
plxnd1	plexin D1	0.021
nrp1a	neuropilin 1a	0.020
col12a1	collagen, type XII, alpha 1	0.020
plxna3	plexin A3	0.020
epas1b	endothelial PAS domain protein 1b	0.020
podxl	podocalyxin-like	0.020
cdh23	cadherin-like 23	0.019
ecrg4a	esophageal cancer related gene 4a	0.019
zbtb4	zinc finger and BTB domain containing 4	0.019
zgc:110409	zgc:110409	0.019
birc2	baculoviral IAP repeat-containing 2	0.019
aldh1l1	aldehyde dehydrogenase 1 family, member L1	0.019
midn	midnolin	0.019
sdc2	syndecan 2	0.018
fbxo32	F-box protein 32	0.018
ptprjb	protein tyrosine phosphatase, receptor type, J b	0.018
barx1	BarH-like homeobox 1	0.018
dll4	delta-like 4 (Drosophila)	0.017
hs3st3b1b	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1b	0.017
she	Src homology 2 domain containing E	0.017
fn1	fibronectin 1	0.017
actn3a	actinin alpha 3a	0.017
pax7b	paired box gene 7b	0.017
f2r	coagulation factor II (thrombin) receptor	0.016
lef1	lymphocyte enhancer binding factor 1	0.016
desma	desmin a	0.016
hsp47	heat shock protein 47	0.016
tnfsf10l	tumor necrosis factor (ligand) superfamily, member 10 like	0.016
eya2	eyes absent homolog 2 (Drosophila)	0.016
col2a1a	collagen type II, alpha-1a	0.016
gfap	glial fibrillary acidic protein	0.016
chac1	ChaC, cation transport regulator-like 1	0.015
cyp1a	cytochrome P450, family 1, subfamily A	0.015
gata2a	GATA-binding protein 2a	0.015
vhl	von Hippel-Lindau tumor suppressor	0.015
apoa4	apolipoprotein A-IV	0.015
zgc:85866	zgc:85866	0.015
hoxb8a	homeo box B8a	0.015
pvrl1b	poliovirus receptor-related 1b	0.014
cpeb4	cytoplasmic polyadenylation element binding protein 4	0.014
LOC554173	abnormal spindles	0.014
pld1a	phospholipase D1a	0.014
unc45a	unc-45 homolog A (C. elegans)	0.014
plekhg5a	pleckstrin homology domain containing, family G (with RhoGef domain) member 5a	0.014
kita	kit receptor a	0.014
prkcz	protein kinase C, zeta	0.013
hmga2	high mobility group AT-hook 2	0.013
frem2a	Fras1 related extracellular matrix protein 2a	0.013
sdprb	serum deprivation response b	0.013
prdm5	PR domain containing 5	0.013
szl	sizzled	0.013
hoxb10a	homeo box B10a	0.013
si:ch211-215l11.5	si:ch211-215l11.5	0.013
dlx4b	distal-less homeobox gene 4b	0.013
apob	apolipoprotein B	0.013
vgll4l	vestigial like 4 like	0.013
prkaa1	protein kinase, AMP-activated, alpha 1 catalytic subunit	0.013
plekhh1	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	0.012
atp5ib	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit e, duplicate b	0.012
zgc:66326	zgc:66326	0.012
cadps2	Ca2+-dependent activator protein for secretion 2	0.012
fgfr1b	fibroblast growth factor receptor 1b	0.012
clec14a	C-type lectin domain family 14, member A	0.012
slc39a13	solute carrier family 39 (zinc transporter), member 13	0.012
LOC566480	hypothetical protein LOC566480	0.012
ubiad1	UbiA prenyltransferase domain containing 1	0.012
fgfr3	fibroblast growth factor receptor 3	0.012	Mouse
rbm4.1	RNA binding motif protein 4.1	0.012
slc27a2	solute carrier family 27 (fatty acid transporter), member 2	0.012
gpr182	G protein-coupled receptor 182	0.011
zgc:123296	zgc:123296	0.011
ebf3	early B-cell factor 3	0.011
trpv6	transient receptor potential cation channel, subfamily V, member 6	0.011
cebpd	CCAAT/enhancer binding protein (C/EBP), delta	0.011
tfpia	tissue factor pathway inhibitor a	0.011
pdgfb	platelet derived growth factor, B polypeptide	0.011
her6	hairy-related 6	0.011
mpp6b	membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6)	0.011
celsr1b	cadherin EGF LAG seven-pass G-type receptor 1b	0.011
notch1a	notch homolog 1a	0.011
ext1a	exostoses (multiple) 1a	0.011
mapk12	mitogen-activated protein kinase 12	0.011
ecscr	endothelial cell-specific chemotaxis regulator	0.011
jag2	jagged 2	0.011	Zebrafish
prmt8b	protein arginine methyltransferase 8b	0.011
sema3fb	semaphorin 3fb	0.011
nus1	nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)	0.011
tfa	transferrin-a	0.010
nog3	noggin 3	0.010
dkk2	dickkopf homolog 2 (Xenopus laevis)	0.010
tagln	transgelin	0.010
pfkfb1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.010
pkp2	plakophilin 2	0.010
sox1a	SRY-box containing gene 1a	0.010
LOC100332039	ectonucleotide pyrophosphatase/phosphodiesterase family member 2-like	0.010
nfkbiaa	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a	0.010
micall2a	mical-like 2a	0.010