IMP

Process View

Danio rerio

2 genes annotated in zebrafish

muscle hypertrophy

The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "muscle hypertrophy"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "muscle hypertrophy" (in gray)

Name	Description	Probability	Func Analog Organism
mef2ca	myocyte enhancer factor 2ca	0.086	Mouse
nrxn2a	neurexin 2a	0.085
chrna1	cholinergic receptor, nicotinic, alpha polypeptide 1	0.069
fabp11a	fatty acid binding protein 11a	0.058
zgc:86757	zgc:86757	0.057
cx45.6	connexin 45.6	0.051
tmem59l	transmembrane protein 59-like and transmembrane protein 59-like	0.044
hspb12	heat shock protein, alpha-crystallin-related, b12	0.044
pparg	peroxisome proliferator activated receptor gamma	0.043
hspb9	heat shock protein, alpha-crystallin-related, 9	0.042
nkx2.5	NK2 transcription factor related 5	0.041
vtg1	vitellogenin 1	0.039
hspb8	heat shock protein, alpha-crystallin-related, b8	0.035	Zebrafish
arpc3	actin related protein 2/3 complex, subunit 3	0.032
gata5	GATA-binding protein 5	0.031
blm	Bloom syndrome	0.030
grin1a	glutamate receptor, ionotropic, N-methyl D-aspartate 1a	0.030
tbx20	T-box 20	0.030
slc6a9	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	0.029
hspb7	heat shock protein family, alpha-crystallin-related, b7	0.029
adrb2a	adrenergic receptor, beta 2a	0.029
xirp1	xin actin-binding repeat containing 1	0.028
slc8a1a	solute carrier family 8 (sodium/calcium exchanger), member 1a	0.028
nr2e3	nuclear receptor subfamily 2, group E, member 3	0.028
hspb11	heat shock protein, alpha-crystallin-related, b11	0.028	Zebrafish
recql5	RecQ protein-like 5	0.027
smyd1b	SET and MYND domain containing 1b	0.026
zgc:112257	zgc:112257	0.026
scn1ba	sodium channel, voltage-gated, type I, beta a	0.025
ctsl1a	cathepsin L, 1 a	0.023
arpc5b	actin related protein 2/3 complex, subunit 5B	0.023
gpia	glucose phosphate isomerase a	0.023
cpa4	carboxypeptidase A4	0.022
slc30a2	solute carrier family 30 (zinc transporter), member 2	0.021
myca	myelocytomatosis oncogene a	0.021
lifrb	leukemia inhibitory factor receptor alpha b	0.021
cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.020
wu:fb01h12	wu:fb01h12	0.020
fabp7a	fatty acid binding protein 7, brain, a	0.020
kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2	0.019
slc6a4a	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4A	0.019
hsp90a.1	heat shock protein 90-alpha 1	0.019
gfap	glial fibrillary acidic protein	0.019
desma	desmin a	0.019
psenen	presenilin enhancer 2 homolog	0.019
htr1aa	5-hydroxytryptamine (serotonin) receptor 1A a	0.019
ccng1	cyclin G1	0.018
tnnt2a	troponin T2a, cardiac	0.018
itga7	integrin, alpha 7	0.018
LOC798872	deiodinase 3	0.018
nexn	nexilin (F actin binding protein)	0.018
arhgdia	Rho GDP dissociation inhibitor (GDI) alpha	0.018
cntn1a	contactin 1a	0.018
tpm4	tropomyosin 4	0.018
ube2l3a	ubiquitin-conjugating enzyme E2L 3a	0.018
sncb	synuclein, beta	0.017
wnt10a	wingless-type MMTV integration site family, member 10a	0.017
rbm24a	RNA binding motif protein 24a	0.017
ndrg4	N-myc downstream regulated gene 4	0.016
cmyb	transcription factor cmyb	0.016
smyd2b	SET and MYND domain containing 2b	0.016
tnnt1	troponin T1, skeletal, slow	0.016
brd4	bromodomain containing 4	0.015
alcamb	activated leukocyte cell adhesion molecule b	0.015
cryaa	crystallin, alpha A	0.015	Zebrafish
slc16a10	solute carrier family 16, member 10 (aromatic amino acid transporter)	0.015
hsp70	heat shock cognate 70-kd protein	0.015
ptch1	patched 1	0.015
cx43	connexin 43	0.015
copeb	core promoter element binding protein	0.014
unc45b	unc-45 homolog B (C. elegans)	0.014
hhex	hematopoietically expressed homeobox	0.014
glra1	glycine receptor, alpha 1	0.014
fas	Fas (TNF receptor superfamily, member 6)	0.014
sncga	synuclein, gamma a	0.014
rhoua	ras homolog gene family, member Ua	0.014
hspb6	heat shock protein, alpha-crystallin-related, b6	0.014
gata6	GATA-binding protein 6	0.014
tpm3	tropomyosin 3	0.014
zgc:193504	zgc:193504	0.014
lpp	LIM domain containing preferred translocation partner in lipoma	0.014
epo	erythropoietin	0.014
cdc42	cell division cycle 42	0.014
m17	IL-6 subfamily cytokine M17	0.014
jam2a	junctional adhesion molecule 2a	0.014
gadd45ba	growth arrest and DNA-damage-inducible, beta a	0.014
vamp1	vesicle-associated membrane protein 1	0.014
rab3c	RAB3C, member RAS oncogene family	0.014
myf6	myogenic factor 6	0.014
cacna1ab	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b	0.013
zgc:110188	zgc:110188	0.013
pawrl	PRKC, apoptosis, WT1, regulator like	0.013
zgc:86903	zgc:86903	0.013
mef2cb	myocyte enhancer factor 2cb	0.013	Mouse
aldocb	aldolase C, fructose-bisphosphate, b	0.013
pabpc4	poly(A) binding protein, cytoplasmic 4 (inducible form)	0.013
mta3	metastasis associated family, member 3	0.013
fabp3	fatty acid binding protein 3, muscle and heart	0.013
onecut1	one cut domain, family member 1	0.013
timm17a	translocase of inner mitochondrial membrane 17 homolog A (yeast)	0.013
dharma	dharma	0.012
wnt5a	wingless-type MMTV integration site family, member 5a	0.012
anxa6	annexin A6	0.012
chac1	ChaC, cation transport regulator-like 1	0.012
smyhc1	slow myosin heavy chain 1	0.012
tbx18	T-box 18	0.012
chrne	cholinergic receptor, nicotinic, epsilon	0.012
zgc:91930	zgc:91930	0.012
ndel1a	nudE nuclear distribution gene E homolog like 1 (A. nidulans) A	0.012
veph	ventricular zone expressed PH domain protein	0.012
ryr2b	ryanodine receptor 2b (cardiac)	0.012
tbx1	T-box 1	0.012
hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.012
sp7	Sp7 transcription factor	0.012
zfyve26	zinc finger, FYVE domain containing 26	0.012
hcrt	hypocretin (orexin) neuropeptide precursor	0.012
mbnl2	muscleblind-like 2 (Drosophila)	0.012
cd74	CD74 molecule, major histocompatibility complex, class II invariant chain	0.012
chrnb3b	cholinergic receptor, nicotinic, beta polypeptide 3b	0.012
tnfa	tumor necrosis factor a (TNF superfamily, member 2)	0.012
dusp1	dual specificity phosphatase 1	0.012
igfbp1a	insulin-like growth factor binding protein 1a	0.012
htr1ab	5-hydroxytryptamine (serotonin) receptor 1A b	0.012
ttna	titin a	0.012
bad	BCL2-antagonist of cell death	0.012
hoxc1a	homeo box C1a	0.012
wnt2	wingless-type MMTV integration site family member 2	0.011
tes	testis derived transcript (3 LIM domains)	0.011
fam20b	family with sequence similarity 20, member B (H. sapiens)	0.011
plcxd3	phosphatidylinositol-specific phospholipase C, X domain containing 3	0.011
mef2bnb	mef2b neighbor	0.011
igfbp1b	insulin-like growth factor binding protein 1b	0.011
tnnc1a	troponin C type 1a (slow)	0.011
si:dkey-236e20.2	si:dkey-236e20.2	0.011
oprk1	opioid receptor, kappa 1	0.011
stmn1b	stathmin 1b	0.011
ppm1f	protein phosphatase 1F (PP2C domain containing)	0.011
chrm2a	cholinergic receptor, muscarinic 2a	0.011
nlgn1	neuroligin 1	0.011
pth2	parathyroid hormone 2	0.011
mef2a	myocyte enhancer factor 2a	0.011
suv39h1a	suppressor of variegation 3-9 homolog 1a	0.011
spi1l	spleen focus forming virus (SFFV) proviral integration oncogene spi1 like	0.011
sardh	sarcosine dehydrogenase	0.011
adrb2b	adrenergic receptor, beta 2b	0.011
adipor2	adiponectin receptor 2	0.011
sycp3l	synaptonemal complex protein 3 like	0.011
jun	jun proto-oncogene	0.011
zgc:91835	zgc:91835	0.011
svil	supervillin	0.011
ppargc1al	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha like	0.011
adkb	adenosine kinase b	0.010
zgc:91870	zgc:91870	0.010
cyp2aa4	cytochrome P450, family 2, subfamily AA, polypeptide 4	0.010
arl6ip1	ADP-ribosylation factor-like 6 interacting protein 1	0.010
slc2a1a	solute carrier family 2 (facilitated glucose transporter), member 1a	0.010
hspb2	heat shock protein, alpha-crystallin-related, b2	0.010	Zebrafish
dynlt3	dynein, light chain, Tctex-type 3	0.010
txndc5	thioredoxin domain containing 5	0.010
ddt	D-dopachrome tautomerase	0.010
srrm4	serine/arginine repetitive matrix 4	0.010
impdh2	IMP (inosine monophosphate) dehydrogenase 2	0.010
tdh	L-threonine dehydrogenase	0.010
gadd45aa	growth arrest and DNA-damage-inducible, alpha, a	0.010