The network for 'appendage development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

appendage development

The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch.

Drosophila melanogaster
Name Description Probability Func Analog Organism
Rho1 CG8416 gene product from transcript CG8416-RB 1.000
mys myospheroid 1.000
fz frizzled 0.999
ara araucan 0.998
gbb glass bottom boat 0.998
emc extra macrochaetae 0.997
Rac1 CG2248 gene product from transcript CG2248-RA 0.994
lola longitudinals lacking 0.992
fj four-jointed 0.991
argos CG4531 gene product from transcript CG4531-RA 0.990
hh hedgehog 0.990
how held out wings 0.988
mam mastermind 0.987
fng fringe 0.987
dally division abnormally delayed 0.985
ash2 absent, small, or homeotic discs 2 0.978
tws twins 0.976
hipk homeodomain interacting protein kinase 0.976
dsh dishevelled 0.973
fz2 frizzled 2 0.973
rl rolled 0.972
Ser Serrate 0.972
Ras85D Ras oncogene at 85D 0.972
Tollo CG6890 gene product from transcript CG6890-RA 0.967
rho rhomboid 0.966
shg shotgun 0.964
Gap1 GTPase-activating protein 1 0.962
Egfr Epidermal growth factor receptor 0.959
ttv tout-velu 0.954
arm armadillo 0.953
mew multiple edematous wings 0.950
sbb scribbler 0.949
Src64B Src oncogene at 64B 0.948
LanB1 CG7123 gene product from transcript CG7123-RA 0.947
EcR Ecdysone receptor 0.943
CG32372 CG32372 gene product from transcript CG32372-RA 0.942
Moe Moesin 0.939
ed echinoid 0.938
Lim3 CG10699 gene product from transcript CG10699-RB 0.938
chic chickadee 0.936
spi spitz 0.935
eya eyes absent 0.935
Mkp3 Mitogen-activated protein kinase phosphatase 3 0.933
dac dachshund 0.932
dve defective proventriculus 0.932
Snoo Sno oncogene 0.927
sha shavenoid 0.926
Dad Daughters against dpp 0.925
mirr mirror 0.923
Akt1 CG4006 gene product from transcript CG4006-RA 0.922
dco discs overgrown 0.922
Bre1 CG10542 gene product from transcript CG10542-RA 0.918
eyg eyegone 0.918
if inflated 0.915
ap apterous 0.914
Ssdp Sequence-specific single-stranded DNA-binding protein 0.910
al aristaless 0.908
ab abrupt 0.905
sgl sugarless 0.902
Su(H) Suppressor of Hairless 0.899
Bx Beadex 0.896
heph hephaestus 0.891
bi bifid 0.889
mxc multi sex combs 0.889
vvl ventral veins lacking 0.883
rok Rho-kinase 0.877
neur neuralized 0.875
Pkn Protein kinase related to protein kinase N 0.874
wg wingless 0.872
ds dachsous 0.869
drk downstream of receptor kinase 0.867
nct nicastrin 0.866
ct cut 0.863
G-oalpha47A G protein oalpha 47A 0.859
csw corkscrew 0.857
sd scalloped 0.857
crb crumbs 0.849
rg rugose 0.846
kn knot 0.845
hth homothorax 0.843
Dll Distal-less 0.836
sog short gastrulation 0.835
ft fat 0.833
ey eyeless 0.830
os outstretched 0.825
Pak PAK-kinase 0.825
JIL-1 CG6297 gene product from transcript CG6297-RA 0.818
Mob2 CG11711 gene product from transcript CG11711-RC 0.814
O-fut1 O-fucosyltransferase 1 0.806
kuz kuzbanian 0.804
tkv thickveins 0.802
CkIalpha Casein kinase Ialpha 0.794
Sema-1a CG18405 gene product from transcript CG18405-RD 0.793
Sp1 CG1343 gene product from transcript CG1343-RB 0.793
MYPT-75D CG6896 gene product from transcript CG6896-RA 0.789
foxo forkhead box, sub-group O 0.783
smt3 CG4494 gene product from transcript CG4494-RA 0.781
Doc2 Dorsocross2 0.779
Mad Mothers against dpp 0.777
Cul-3 Cullin-3 0.774
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
fgf8a fibroblast growth factor 8 a 0.999
chd chordin 0.998
bmp2b bone morphogenetic protein 2b 0.994
bmp2a bone morphogenetic protein 2a 0.991
hoxc8a homeo box C8a 0.989
prdm1a PR domain containing 1a, with ZNF domain 0.989
bmp4 bone morphogenetic protein 4 0.984
tfap2a transcription factor AP-2 alpha 0.983
hoxa9a homeo box A9a 0.983
shha sonic hedgehog a 0.981
hoxc4a homeo box C4a 0.980
fgf3 fibroblast growth factor 3 0.976
pax2a paired box gene 2a 0.975
twist3 twist3 0.961
bmp1a bone morphogenetic protein 1a 0.957
cdh2 cadherin 2, neuronal 0.955
msxc muscle segment homeobox C 0.955
hoxc6a homeo box C6a 0.953
wnt5b wingless-type MMTV integration site family, member 5b 0.952
col1a1a collagen, type I, alpha 1a 0.946
frem2a Fras1 related extracellular matrix protein 2a 0.945
hoxb1b homeo box B1b 0.943
eve1 even-skipped-like1 0.940
hoxb5b homeo box B5b 0.938
eya1 eyes absent homolog 1 0.936
tbx2b T-box 2b 0.923
hoxa13b homeo box A13b 0.910
gbx2 gastrulation brain homeo box 2 0.910
fgf24 fibroblast growth factor 24 0.905
tbx18 T-box 18 0.886
dlx4b distal-less homeobox gene 4b 0.886
hnf1ba HNF1 homeobox Ba 0.883
hoxa9b homeo box A9b 0.883
gsc goosecoid 0.881
rarab retinoic acid receptor, alpha b 0.878
fgf10a fibroblast growth factor 10a 0.875
hoxa5a homeo box A5a 0.875
hoxa11b homeo box A11b 0.851
fn1 fibronectin 1 0.847
hoxd10a homeo box D10a 0.845
boc brother of CDO 0.843
hoxd4a homeo box D4a 0.843
crabp2a cellular retinoic acid binding protein 2, a 0.828
cdx4 caudal type homeo box transcription factor 4 0.811
tbx1 T-box 1 0.808
lef1 lymphocyte enhancer binding factor 1 0.804
ptch1 patched 1 0.786
fras1 Fraser syndrome 1 0.775
six4a sine oculis homeobox homolog 4a 0.761
msxb muscle segment homeobox B 0.751
mib mind bomb 0.747
atoh1a atonal homolog 1a 0.733
frem1a Fras1 related extracellular matrix 1a 0.719
robo3 roundabout homolog 3 0.719
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.708
hoxc9a homeo box C9a 0.701
dlx4a distal-less homeobox gene 4a 0.694
szl sizzled 0.688
hoxb3a homeo box B3a 0.684
msxd muscle segment homeobox D 0.682
hoxb5a homeo box B5a 0.675
vcana versican a 0.672
sox9a SRY-box containing gene 9a 0.671
hoxb6a homeo box B6a 0.670
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.653
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.645
myf5 myogenic factor 5 0.645
flh floating head 0.640
pou5f1 POU domain, class 5, transcription factor 1 0.636
twist1b twist1b 0.633
hoxb6b homeo box B6b 0.631
lama5 laminin, alpha 5 0.630
neo1 neogenin 1 0.615
evx1 even-skipped homeobox 1 0.613
hmx4 H6 family homeobox 4 0.612
col5a1 procollagen, type V, alpha 1 0.608
dlx5a distal-less homeobox gene 5a 0.602
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.601
itga3b integrin, alpha 3b 0.600
pcsk5b proprotein convertase subtilisin/kexin type 5b 0.586
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.586
rx2 retinal homeobox gene 2 0.586
isl2a islet2a 0.579
vsx2 visual system homeobox 2 0.568
pax6b paired box gene 6b 0.544
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.540
cyp26a1 cytochrome P450, subfamily XXVIA, polypeptide 1 0.530
msxe muscle segment homeobox E 0.525
meis2.1 myeloid ecotropic viral integration site 2.1 0.522
pcdh8 protocadherin 8 0.516
vcanb versican b 0.516
hoxd11a homeo box D11a 0.516
fsta follistatin a 0.505
ccm2 cerebral cavernous malformation 2 0.503
pax9 paired box gene 9 0.502
myod1 myogenic differentiation 1 0.493
wnt3a wingless-type MMTV integration site family, member 3A 0.491
irx3a iroquois homeobox protein 3a 0.485
edn1 endothelin 1 0.484
six4b sine oculis homeobox homolog 4b 0.478
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Homo sapiens
Name Description Probability Func Analog Organism
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.000
FHL2 four and a half LIM domains 2 0.976
ZNF43 zinc finger protein 43 0.867
SMAD3 SMAD family member 3 0.827
JAG1 jagged 1 0.621
TGFB1 transforming growth factor, beta 1 0.550
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.548
SUFU suppressor of fused homolog (Drosophila) 0.526
ZNF253 zinc finger protein 253 0.436
FN1 fibronectin 1 0.420
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.401
ENG endoglin 0.398
ZNF273 zinc finger protein 273 0.380
ZNF675 zinc finger protein 675 0.299
COL1A1 collagen, type I, alpha 1 0.288
MEIS1 Meis homeobox 1 0.272
BMP2 bone morphogenetic protein 2 0.271
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.260
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.241
SKIL SKI-like oncogene 0.231
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.180
PAX3 paired box 3 0.155
ZNF91 zinc finger protein 91 0.151
BMP1 bone morphogenetic protein 1 0.129
COL7A1 collagen, type VII, alpha 1 0.127
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.126
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.124
HDAC1 histone deacetylase 1 0.117
COL6A1 collagen, type VI, alpha 1 0.114
BMPR1A bone morphogenetic protein receptor, type IA 0.112
ZNF708 zinc finger protein 708 0.111
HOXA10 homeobox A10 0.109
FBLN1 fibulin 1 0.105
TGFBR1 transforming growth factor, beta receptor 1 0.101
CHRD chordin 0.099
ZNF430 zinc finger protein 430 0.091
PDZD11 PDZ domain containing 11 0.087
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.086
ATN1 atrophin 1 0.085
PSEN1 presenilin 1 0.084
ZNF85 zinc finger protein 85 0.080
FLNA filamin A, alpha 0.080
ZNF93 zinc finger protein 93 0.080
SMAD4 SMAD family member 4 0.073
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.071
GDF5 growth differentiation factor 5 0.071
PPARA peroxisome proliferator-activated receptor alpha 0.070
ACVR1 activin A receptor, type I 0.069
CHD7 chromodomain helicase DNA binding protein 7 0.069
HOXC8 homeobox C8 0.066
BMPR1B bone morphogenetic protein receptor, type IB 0.064
MEIS2 Meis homeobox 2 0.061
GATA4 GATA binding protein 4 0.057
ARRB1 arrestin, beta 1 0.057
BMP4 bone morphogenetic protein 4 0.056
HOXD13 homeobox D13 0.056
BMP7 bone morphogenetic protein 7 0.056
HOXC11 homeobox C11 0.055
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.054
THBS1 thrombospondin 1 0.054
FGF10 fibroblast growth factor 10 0.054
FSTL1 follistatin-like 1 0.053
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.052
ZNF117 zinc finger protein 117 0.050
TLN1 talin 1 0.049
HOXD9 homeobox D9 0.049
RXRA retinoid X receptor, alpha 0.048
CHD4 chromodomain helicase DNA binding protein 4 0.048
RARG retinoic acid receptor, gamma 0.047
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.047
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.047
NCOR2 nuclear receptor corepressor 2 0.046
TJP1 tight junction protein 1 (zona occludens 1) 0.044
COL2A1 collagen, type II, alpha 1 0.044
RBBP4 retinoblastoma binding protein 4 0.044
EPS8 epidermal growth factor receptor pathway substrate 8 0.044
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.043
SOX2 SRY (sex determining region Y)-box 2 0.040
FKBP1A FK506 binding protein 1A, 12kDa 0.040
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.039
SETD8 SET domain containing (lysine methyltransferase) 8 0.038
DLX4 distal-less homeobox 4 0.038
RAB14 RAB14, member RAS oncogene family 0.038
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 0.038
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.037
DLX5 distal-less homeobox 5 0.036
BAK1 BCL2-antagonist/killer 1 0.036
LBX1 ladybird homeobox 1 0.036
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.036
ZNF254 zinc finger protein 254 0.036
APP amyloid beta (A4) precursor protein 0.035
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.033
WNT1 wingless-type MMTV integration site family, member 1 0.033
PIAS1 protein inhibitor of activated STAT, 1 0.033
FOXF2 forkhead box F2 0.032
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 0.031
NGFR nerve growth factor receptor 0.031
LRP6 low density lipoprotein receptor-related protein 6 0.031
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.031
COL1A2 collagen, type I, alpha 2 0.029
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Mus musculus
Name Description Probability Func Analog Organism
Gli3 GLI-Kruppel family member GLI3 1.000
Shh sonic hedgehog 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Rarg retinoic acid receptor, gamma 1.000
Foxc1 forkhead box C1 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Sox2 SRY-box containing gene 2 1.000
Pax6 paired box gene 6 1.000
Pax2 paired box gene 2 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Gli2 GLI-Kruppel family member GLI2 1.000
Bmp7 bone morphogenetic protein 7 1.000
Fgf10 fibroblast growth factor 10 1.000
Msx2 homeobox, msh-like 2 1.000
Pax3 paired box gene 3 0.999
Hand1 heart and neural crest derivatives expressed transcript 1 0.999
Hoxa10 homeobox A10 0.999
Wnt5a wingless-related MMTV integration site 5A 0.999
Hoxa13 homeobox A13 0.999
Pten phosphatase and tensin homolog 0.999
Hoxd11 homeobox D11 0.998
Nog noggin 0.998
Pbx1 pre B-cell leukemia transcription factor 1 0.998
Fgfr1 fibroblast growth factor receptor 1 0.998
Prrx1 paired related homeobox 1 0.998
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.998
Msx1 homeobox, msh-like 1 0.997
Emx2 empty spiracles homolog 2 (Drosophila) 0.997
Hoxa11 homeobox A11 0.996
Tbx3 T-box 3 0.995
Wnt3a wingless-related MMTV integration site 3A 0.995
Fgf8 fibroblast growth factor 8 0.995
Emx1 empty spiracles homolog 1 (Drosophila) 0.994
Fgfr3 fibroblast growth factor receptor 3 0.994
Tcfap2a transcription factor AP-2, alpha 0.993
Rara retinoic acid receptor, alpha 0.992
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.992
Col1a1 collagen, type I, alpha 1 0.991
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.990
Rarb retinoic acid receptor, beta 0.990
Hoxd13 homeobox D13 0.989
Lef1 lymphoid enhancer binding factor 1 0.987
Isl1 ISL1 transcription factor, LIM/homeodomain 0.987
Chrd chordin 0.987
Smo smoothened homolog (Drosophila) 0.986
Dlx5 distal-less homeobox 5 0.985
Trp53 transformation related protein 53 0.984
Alx4 aristaless-like homeobox 4 0.984
Sox9 SRY-box containing gene 9 0.983
Sox11 SRY-box containing gene 11 0.982
Gsc goosecoid homeobox 0.980
Hoxa5 homeobox A5 0.978
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.977
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.974
Gbx2 gastrulation brain homeobox 2 0.972
Sall4 sal-like 4 (Drosophila) 0.972
Ptch1 patched homolog 1 0.969
Otx1 orthodenticle homolog 1 (Drosophila) 0.969
Twist2 twist homolog 2 (Drosophila) 0.964
Eya1 eyes absent 1 homolog (Drosophila) 0.961
Gas1 growth arrest specific 1 0.961
Hoxd3 homeobox D3 0.959
Rxra retinoid X receptor alpha 0.959
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.958
Nodal nodal 0.956
Lhx3 LIM homeobox protein 3 0.956
Foxc2 forkhead box C2 0.953
Psen1 presenilin 1 0.951
Hand2 heart and neural crest derivatives expressed transcript 2 0.949
Tbx15 T-box 15 0.948
Acvr1 activin A receptor, type 1 0.947
Hoxd10 homeobox D10 0.939
Col2a1 collagen, type II, alpha 1 0.939
Gdf5 growth differentiation factor 5 0.938
Foxh1 forkhead box H1 0.932
Tcfap2c transcription factor AP-2, gamma 0.928
Ctnnb1 catenin (cadherin associated protein), beta 1 0.928
Smad3 MAD homolog 3 (Drosophila) 0.924
Wt1 Wilms tumor 1 homolog 0.924
Thra thyroid hormone receptor alpha 0.924
Neurog3 neurogenin 3 0.920
Wnt6 wingless-related MMTV integration site 6 0.914
Hoxa9 homeobox A9 0.912
Bmp4 bone morphogenetic protein 4 0.911
Prrx2 paired related homeobox 2 0.909
Pax8 paired box gene 8 0.906
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.903
Hes1 hairy and enhancer of split 1 (Drosophila) 0.901
Lmx1a LIM homeobox transcription factor 1 alpha 0.901
Efna2 ephrin A2 0.893
Pou3f3 POU domain, class 3, transcription factor 3 0.890
Hoxb3 homeobox B3 0.885
Kit kit oncogene 0.884
Ptf1a pancreas specific transcription factor, 1a 0.883
En1 engrailed 1 0.880
Fgf9 fibroblast growth factor 9 0.873
Trp63 transformation related protein 63 0.868
Gdf11 growth differentiation factor 11 0.854
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.852
Fgf15 fibroblast growth factor 15 0.851
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Rattus norvegicus
Name Description Probability Func Analog Organism
Nfia nuclear factor I/A 0.017
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.017
Col12a1 collagen, type XII, alpha 1 0.013
Lef1 lymphoid enhancer binding factor 1 0.013
Col3a1 collagen, type III, alpha 1 0.011
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism