The network for 'response to endogenous stimulus' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

response to endogenous stimulus

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.

Drosophila melanogaster
Name Description Probability Func Analog Organism
dlg1 discs large 1 0.938
rl rolled 0.825
dm diminutive 0.815
N Notch 0.765
Egfr Epidermal growth factor receptor 0.715
nej nejire 0.705
Mad Mothers against dpp 0.681
ap apterous 0.644
EcR Ecdysone receptor 0.634
Akt1 CG4006 gene product from transcript CG4006-RA 0.613
foxo forkhead box, sub-group O 0.609
pan pangolin 0.601
ftz-f1 ftz transcription factor 1 0.601
Sir2 CG5216 gene product from transcript CG5216-RA 0.572
argos CG4531 gene product from transcript CG4531-RA 0.565
put punt 0.517
S6k RPS6-p70-protein kinase 0.508
neuroligin CG13772 gene product from transcript CG13772-RA 0.470
Hsp68 Heat shock protein 68 0.464
ci cubitus interruptus 0.458
Trx-2 thioredoxin-2 0.457
hth homothorax 0.455
por porcupine 0.443
Tbh Tyramine beta hydroxylase 0.437
Stat92E Signal-transducer and activator of transcription protein at 92E 0.421
babo baboon 0.420
Dad Daughters against dpp 0.418
skpA CG16983 gene product from transcript CG16983-RD 0.409
tkv thickveins 0.384
Ras85D Ras oncogene at 85D 0.380
lea leak 0.378
Atg13 Autophagy-specific gene 13 0.370
LamC Lamin C 0.364
csw corkscrew 0.361
sina seven in absentia 0.355
Ssdp Sequence-specific single-stranded DNA-binding protein 0.349
Pez CG9493 gene product from transcript CG9493-RA 0.347
Mhc Myosin heavy chain 0.329
ttv tout-velu 0.327
CG7998 CG7998 gene product from transcript CG7998-RA 0.319
InR Insulin-like receptor 0.317
wts warts 0.315
usp ultraspiracle 0.313
phl pole hole 0.292
Spn27A Serpin 27A 0.282
mbc myoblast city 0.279
kn knot 0.274
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.265
shg shotgun 0.259
baz bazooka 0.257
Trh Tryptophan hydroxylase 0.248
hep hemipterous 0.247
rpr reaper 0.240
Tor Target of rapamycin 0.240
Ilp2 Insulin-like peptide 2 0.237
sfl sulfateless 0.236
Hsp70Ab Heat-shock-protein-70Ab 0.232
Met Methoprene-tolerant 0.231
Nup153 Nucleoporin 153 0.229
Pka-C1 cAMP-dependent protein kinase 1 0.219
jeb jelly belly 0.217
rols rolling pebbles 0.213
Abl Abl tyrosine kinase 0.212
Pkc98E Protein C kinase 98E 0.207
sns sticks and stones 0.206
Sulf1 Sulfated 0.205
ush u-shaped 0.204
Ilp5 Insulin-like peptide 5 0.204
Gyc76C Guanylyl cyclase at 76C 0.203
robo roundabout 0.202
dco discs overgrown 0.200
Ugt35a UDP-glycosyltransferase 35a 0.199
fru fruitless 0.198
CycG Cyclin G 0.197
ed echinoid 0.194
eve even skipped 0.194
shi shibire 0.189
Cdc42 CG12530 gene product from transcript CG12530-RA 0.189
Tl Toll 0.188
NFAT NFAT homolog 0.188
Hsp70Aa Heat-shock-protein-70Aa 0.188
drk downstream of receptor kinase 0.187
Itp-r83A Inositol 1,4,5,-tris-phosphate receptor 0.186
Nrg Neuroglian 0.184
Tequila CG4821 gene product from transcript CG4821-RE 0.183
rictor rapamycin-insensitive companion of Tor 0.176
ey eyeless 0.173
fz2 frizzled 2 0.172
fkh fork head 0.169
GLaz Glial Lazarillo 0.167
sNPF-R short neuropeptide F receptor 0.166
CG17450 CG17450 gene product from transcript CG17450-RB 0.163
TBPH CG10327 gene product from transcript CG10327-RC 0.163
tan tantalus 0.162
sog short gastrulation 0.161
Rac2 CG8556 gene product from transcript CG8556-RA 0.157
btl breathless 0.154
dsx doublesex 0.152
Wnk CG7177 gene product from transcript CG7177-RA 0.151
CG1347 CG1347 gene product from transcript CG1347-RB 0.151
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
let-60 Protein LET-60 0.534
pkg-1 Protein PKG-1 0.487
unc-104 Protein UNC-104 0.297
bar-1 Protein BAR-1 0.287
nhr-67 Protein NHR-67 0.279
daf-11 Protein DAF-11 0.226
vab-3 Protein VAB-3 0.201
egl-15 Protein EGL-15 0.201
eat-6 Protein EAT-6 0.177
tax-6 Protein TAX-6 0.171
mrp-1 Protein MRP-1 0.162
odr-3 Protein ODR-3 0.161
pry-1 Protein PRY-1 0.153
egl-44 Protein EGL-44 0.151
nhr-45 Protein NHR-45 0.146
egl-18 Protein EGL-18 0.142
pmk-1 Protein PMK-1 0.126
Y40C5A.1 Protein Y40C5A.1 0.120
unc-9 Protein UNC-9 0.116
cam-1 Protein CAM-1 0.114
ceh-20 Protein CEH-20 0.109
osm-5 Protein OSM-5 0.108
C12D12.1 Protein C12D12.1 0.108
egl-8 Protein EGL-8 0.108
par-5 Protein PAR-5 0.105
lmn-1 Protein LMN-1 0.103
sas-5 Protein SAS-5 0.101
ptr-11 Protein PTR-11 0.100
abl-1 Protein ABL-1 0.098
dpyd-1 Protein DPYD-1 0.096
hlh-1 Protein HLH-1 0.094
K02A11.3 Protein K02A11.3 0.092
ceh-18 Protein CEH-18 0.087
daf-2 Protein DAF-2 0.086
lag-1 Protein LAG-1 0.086
sma-4 Protein SMA-4 0.084
tag-320 Protein TAG-320 0.083
mec-4 Protein MEC-4 0.081
osm-6 Protein OSM-6 0.078
ttyh-1 Protein TTYH-1 0.077
sms-1 Protein SMS-1 0.077
ccch-1 Protein CCCH-1 0.077
plc-1 Protein PLC-1 0.076
dlk-1 Protein DLK-1 0.076
unc-29 Protein UNC-29 0.072
CELE_R10D12.1 Protein R10D12.1 0.071
pdfr-1 Protein PDFR-1 0.071
sdha-1 Protein SDHA-1 0.071
kin-20 Protein KIN-20 0.070
sax-7 Protein SAX-7 0.068
nhr-25 Protein NHR-25 0.066
mat-3 Protein MAT-3 0.065
peb-1 Protein PEB-1 0.065
aak-2 Protein AAK-2 0.062
ogdh-1 Protein OGDH-1 0.061
vit-6 Protein VIT-6 0.061
F28E10.1 Protein F28E10.1 0.061
unc-73 Protein UNC-73 0.059
vit-4 Protein VIT-4 0.057
hlh-11 Protein HLH-11 0.057
ace-1 Protein ACE-1 0.056
nipi-3 Protein NIPI-3 0.055
CELE_C08F8.6 Protein C08F8.6 0.055
tbb-2 Protein TBB-2 0.055
itx-1 Protein ITX-1 0.055
vit-5 Protein VIT-5 0.054
F13H6.1 Protein F13H6.1 0.052
F37H8.5 Protein F37H8.5 0.051
sma-3 Protein SMA-3 0.050
daf-1 Protein DAF-1 0.050
itr-1 Protein ITR-1 0.050
pkc-1 Protein PKC-1 0.050
tba-4 Protein TBA-4 0.049
tag-196 Protein TAG-196 0.049
cpr-4 Protein CPR-4 0.048
lin-25 Protein LIN-25 0.048
chaf-1 Protein CHAF-1 0.048
vit-2 Protein VIT-2 0.047
hlh-2 Protein HLH-2 0.047
C05D10.4 Protein C05D10.4 0.047
ida-1 Protein IDA-1 0.046
daf-16 Protein DAF-16 0.044
che-2 Protein CHE-2 0.044
cyp-35C1 Protein CYP-35C1 0.043
apy-1 Protein APY-1 0.043
pat-3 Protein PAT-3 0.043
nhr-6 Protein NHR-6 0.043
plc-3 Protein PLC-3 0.042
goa-1 Protein GOA-1 0.042
srp-6 Protein SRP-6 0.042
pha-4 Protein PHA-4 0.042
pde-4 Protein PDE-4 0.041
gtl-1 Protein GTL-1 0.041
unc-68 Protein UNC-68 0.041
T19D12.6 Protein T19D12.6 0.040
F46C5.6 Protein F46C5.6 0.040
tag-253 Protein TAG-253 0.040
ceh-44 Protein CEH-44 0.040
rhi-1 Protein RHI-1 0.040
CELE_Y57G11C.15 Protein Y57G11C.15 0.039
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Danio rerio
Name Description Probability Func Analog Organism
vasa vasa homolog 0.894
pcna proliferating cell nuclear antigen 0.889
bmp2b bone morphogenetic protein 2b 0.798
spry4 sprouty (Drosophila) homolog 4 0.787
fgf3 fibroblast growth factor 3 0.749
efnb2a ephrin B2a 0.615
chd chordin 0.586
notch1a notch homolog 1a 0.580
fabp11a fatty acid binding protein 11a 0.566
wnt10a wingless-type MMTV integration site family, member 10a 0.555
bmp2a bone morphogenetic protein 2a 0.537
dharma dharma 0.518
sox17 SRY-box containing gene 17 0.510
fgf8a fibroblast growth factor 8 a 0.488
fgf4 fibroblast growth factor 4 0.425
ctgf connective tissue growth factor 0.423
pitx3 paired-like homeodomain transcription factor 3 0.401
mef2ca myocyte enhancer factor 2ca 0.395
apoeb apolipoprotein Eb 0.393
esr1 estrogen receptor 1 0.393
ptch2 patched 2 0.374
tp53 tumor protein p53 0.349
tbx20 T-box 20 0.328
wnt9a wingless-type MMTV integration site family, member 9A 0.327
foxp2 forkhead box P2 0.327
oxtl oxytocin-like 0.313
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.301
robo3 roundabout homolog 3 0.299
crabp1b cellular retinoic acid binding protein 1b 0.297
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.284
snai1a snail homolog 1a (Drosophila) 0.283
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.281
sox9b SRY-box containing gene 9b 0.277
mstnb myostatin b 0.271
gata6 GATA-binding protein 6 0.264
pax7a paired box gene 7a 0.253
trpv6 transient receptor potential cation channel, subfamily V, member 6 0.245
wnt2 wingless-type MMTV integration site family member 2 0.235
per2 period homolog 2 (Drosophila) 0.235
rarab retinoic acid receptor, alpha b 0.233
avpl arginine vasopressin-like 0.233
igf1 insulin-like growth factor 1 0.231
gnrh3 gonadotropin-releasing hormone 3 0.229
krit1 KRIT1, ankyrin repeat containing 0.224
foxa2 forkhead box A2 0.221
pomca proopiomelanocortin a 0.218
vent ventral expressed homeobox 0.216
fabp10a fatty acid binding protein 10a, liver basic 0.206
gamt guanidinoacetate N-methyltransferase 0.204
mapk1 mitogen-activated protein kinase 1 0.197
spry2 sprouty homolog 2 0.196
osr1 odd-skipped related 1 (Drosophila) 0.195
cyp1a cytochrome P450, family 1, subfamily A 0.194
mao monoamine oxidase 0.188
sox32 SRY-box containing gene 32 0.187
fgfr1a fibroblast growth factor receptor 1a 0.185
mef2a myocyte enhancer factor 2a 0.181
th tyrosine hydroxylase 0.180
pax8 paired box gene 8 0.179
atp1b1a ATPase, Na+/K+ transporting, beta 1a polypeptide 0.177
dlx4a distal-less homeobox gene 4a 0.175
wnt1 wingless-type MMTV integration site family, member 1 0.173
tshb thyroid stimulating hormone, beta subunit 0.172
tbx1 T-box 1 0.172
runx2a runt-related transcription factor 2a 0.171
cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 0.169
oprk1 opioid receptor, kappa 1 0.169
sfrp1a secreted frizzled-related protein 1a 0.164
rag1 recombination activating gene 1 0.164
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.163
vtg3 vitellogenin 3, phosvitinless 0.163
jag1a jagged 1a 0.163
oprd1a opioid receptor, delta 1a 0.162
her12 hairy-related 12 0.162
slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.162
igf1ra insulin-like growth factor 1a receptor 0.162
tnfrsfa tumor necrosis factor receptor superfamily, member a 0.161
btg2 B-cell translocation gene 2 0.160
gh1 growth hormone 1 0.158
ef1a elongation factor 1-alpha 0.156
tie1 endothelium-specific receptor tyrosine kinase 1 0.155
aldob aldolase b, fructose-bisphosphate 0.152
gli2b GLI-Kruppel family member GLI2b 0.150
ddc dopa decarboxylase 0.147
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.147
nadl1.1 neural adhesion molecule L1.1 0.145
shbg sex hormone binding globulin 0.145
psen1 presenilin 1 0.144
paqr8 progestin and adipoQ receptor family member VIII 0.144
bmp1a bone morphogenetic protein 1a 0.144
oprm1 opioid receptor, mu 1 0.144
gli2a GLI-Kruppel family member GLI2a 0.144
esr2b estrogen receptor 2b 0.141
lft2 lefty2 0.141
ntrk2b neurotrophic tyrosine kinase, receptor, type 2b 0.140
vcana versican a 0.140
lef1 lymphocyte enhancer binding factor 1 0.136
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.135
inha inhibin, alpha 0.135
chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 0.135
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
MKS1 Mks1p 0.285
STE11 Ste11p 0.228
RAD52 Rad52p 0.216
ARO1 Aro1p 0.120
STE2 Ste2p 0.109
GPR1 Gpr1p 0.103
TOR1 Tor1p 0.087
SIF2 Sif2p 0.083
CYB2 Cyb2p 0.080
CDC55 Cdc55p 0.079
CAD1 Cad1p 0.073
RTG3 Rtg3p 0.072
UBP15 Ubp15p 0.072
URA2 Ura2p 0.071
BFR1 Bfr1p 0.070
CPR1 Cpr1p 0.069
SLG1 Slg1p 0.068
GND1 Gnd1p 0.066
ERR3 Err3p 0.065
PTR3 Ptr3p 0.064
CAK1 Cak1p 0.062
MLP2 Mlp2p 0.060
IZH4 Izh4p 0.060
BNA3 Bna3p 0.057
BCK1 Bck1p 0.057
SIP2 Sip2p 0.053
CAC2 Cac2p 0.051
TPK2 Tpk2p 0.051
HSP82 Hsp82p 0.051
SET1 Set1p 0.050
RAS2 Ras2p 0.050
GAD1 Gad1p 0.047
STE5 Ste5p 0.046
TAX4 Tax4p 0.046
YPT1 Ypt1p 0.045
KDX1 Kdx1p 0.045
RVB1 Rvb1p 0.044
HST1 Hst1p 0.044
ERR2 Err2p 0.043
PPH21 Pph21p 0.043
CMP2 Cmp2p 0.042
RAS1 Ras1p 0.042
COT1 Cot1p 0.041
ERR1 Err1p 0.040
CIC1 Cic1p 0.040
RHO1 Rho1p 0.040
MMS21 Mms21p 0.039
TPO4 Tpo4p 0.039
PTC6 Ptc6p 0.038
CLP1 Clp1p 0.037
GND2 Gnd2p 0.036
YPL150W hypothetical protein 0.035
NDI1 Ndi1p 0.035
NBP2 Nbp2p 0.034
LSM8 Lsm8p 0.034
CLU1 Clu1p 0.033
MIG1 Mig1p 0.033
GSC2 Gsc2p 0.033
TSL1 Tsl1p 0.033
APP1 App1p 0.032
BMH1 Bmh1p 0.032
MAM3 Mam3p 0.032
SDA1 Sda1p 0.031
STE50 Ste50p 0.031
HOS4 Hos4p 0.031
RTF1 Rtf1p 0.030
HOG1 Hog1p 0.030
JEN1 Jen1p 0.030
GCD7 Gcd7p 0.030
TIF6 Tif6p 0.030
YGR149W hypothetical protein 0.029
PGK1 Pgk1p 0.029
WAR1 War1p 0.029
SNT1 Snt1p 0.028
GPM1 Gpm1p 0.028
DAL80 Dal80p 0.027
OSH6 Osh6p 0.027
GPA2 Gpa2p 0.027
HHT1 Hht1p 0.027
PCL5 Pcl5p 0.027
PTC2 Ptc2p 0.027
END3 End3p 0.027
AVO2 Avo2p 0.027
YBR235W hypothetical protein 0.026
ARA2 Ara2p 0.026
CNB1 Cnb1p 0.026
YMR124W hypothetical protein 0.026
DCS2 Dcs2p 0.026
KCS1 Kcs1p 0.026
SAM1 Sam1p 0.026
SNF5 Snf5p 0.025
NGL3 Ngl3p 0.025
INP54 Inp54p 0.025
STE4 Ste4p 0.025
DDR48 Ddr48p 0.025
HRK1 Hrk1p 0.025
YJR085C hypothetical protein 0.024
TGL1 Tgl1p 0.024
SUP35 Sup35p 0.024
NMA111 Nma111p 0.024