The network for 'osteoclast development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

osteoclast development

The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.

Homo sapiens
Name Description Probability Func Analog Organism
PILRA paired immunoglobin-like type 2 receptor alpha 0.964
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.960
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.877
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.875
SMN1 survival of motor neuron 1, telomeric 0.832
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.731
ANXA1 annexin A1 0.558
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.550
S100A10 S100 calcium binding protein A10 0.437
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.291
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.240
FYN FYN oncogene related to SRC, FGR, YES 0.214
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.151
PTAFR platelet-activating factor receptor 0.146
PDCD6 programmed cell death 6 0.142
ANXA5 annexin A5 0.129
SIGLEC7 sialic acid binding Ig-like lectin 7 0.129
HCK hemopoietic cell kinase 0.127
NDEL1 nudE nuclear distribution gene E homolog (A. nidulans)-like 1 0.124
LCK lymphocyte-specific protein tyrosine kinase 0.120
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.120
NMT2 N-myristoyltransferase 2 0.104
S100A11 S100 calcium binding protein A11 0.102
VIM vimentin 0.096
HK3 hexokinase 3 (white cell) 0.084
FCN1 ficolin (collagen/fibrinogen domain containing) 1 0.068
CD33 CD33 molecule 0.062
DOCK7 dedicator of cytokinesis 7 0.061
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.055
SPI1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.054
PTK2 PTK2 protein tyrosine kinase 2 0.053
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 0.048
GRB7 growth factor receptor-bound protein 7 0.044
CD163 CD163 molecule 0.042
LGALS1 lectin, galactoside-binding, soluble, 1 0.041
EXT2 exostosin 2 0.041
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 0.040
C1orf93 chromosome 1 open reading frame 93 0.039
TMSB4X thymosin beta 4, X-linked 0.036
BBS10 Bardet-Biedl syndrome 10 0.033
TSC22D1 TSC22 domain family, member 1 0.033
BIN2 bridging integrator 2 0.031
CYTH4 cytohesin 4 0.030
ANXA2 annexin A2 0.029
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.029
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 0.028
SIGLEC9 sialic acid binding Ig-like lectin 9 0.027
NLRP3 NLR family, pyrin domain containing 3 0.027
CCR1 chemokine (C-C motif) receptor 1 0.027
TK1 thymidine kinase 1, soluble 0.026
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 0.025
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.025
TMSB10 thymosin beta 10 0.024
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 0.024
LGALS3 lectin, galactoside-binding, soluble, 3 0.024
CD63 CD63 molecule 0.024
TREM1 triggering receptor expressed on myeloid cells 1 0.024
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.023
FPR2 formyl peptide receptor 2 0.023
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 0.022
GDI1 GDP dissociation inhibitor 1 0.022
LMO4 LIM domain only 4 0.022
ALG2 asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae) 0.022
ITGB5 integrin, beta 5 0.022
CYBB cytochrome b-245, beta polypeptide 0.022
PSAP prosaposin 0.022
ANXA4 annexin A4 0.022
ARF4 ADP-ribosylation factor 4 0.021
SNX9 sorting nexin 9 0.021
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.021
CMKLR1 chemokine-like receptor 1 0.021
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 0.021
ZNF431 zinc finger protein 431 0.020
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 0.020
VSIG4 V-set and immunoglobulin domain containing 4 0.020
FPR1 formyl peptide receptor 1 0.020
APLP2 amyloid beta (A4) precursor-like protein 2 0.020
TYMP thymidine phosphorylase 0.020
EMR1 egf-like module containing, mucin-like, hormone receptor-like 1 0.020
NPC2 Niemann-Pick disease, type C2 0.020
UBE2D1 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) 0.020
CTSB cathepsin B 0.020
C7orf64 chromosome 7 open reading frame 64 0.019
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.019
CD86 CD86 molecule 0.019
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 0.018
FN1 fibronectin 1 0.018
CASP5 caspase 5, apoptosis-related cysteine peptidase 0.018
NOD2 nucleotide-binding oligomerization domain containing 2 0.017
HEXB hexosaminidase B (beta polypeptide) 0.017
ANXA3 annexin A3 0.017
AOAH acyloxyacyl hydrolase (neutrophil) 0.017
SIGLEC10 sialic acid binding Ig-like lectin 10 0.017
EMP1 epithelial membrane protein 1 0.017
VCAN versican 0.017
GRAP2 GRB2-related adaptor protein 2 0.017
CFP complement factor properdin 0.017
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 0.017
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 0.016
MS4A4A membrane-spanning 4-domains, subfamily A, member 4 0.016
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
tie1 endothelium-specific receptor tyrosine kinase 1 0.933
cdh5 cadherin 5 0.901
sox7 SRY-box containing gene 7 0.813
runx1 runt-related transcription factor 1 0.803
si:ch211-235f6.2 si:ch211-235f6.2 0.737
kita kit receptor a 0.680
mitfa microphthalmia-associated transcription factor a 0.665
cmyb transcription factor cmyb 0.620
etv2 ets variant gene 2 0.603
lcp1 lymphocyte cytosolic plastin 1 0.504
tie2 endothelium-specific receptor tyrosine kinase 2 0.311
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.297
gata1a GATA binding protein 1a 0.296
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.288
csf1ra colony stimulating factor 1 receptor, a 0.280
tal1 T-cell acute lymphocytic leukemia 1 0.256
tagln2 transgelin 2 0.247
dll4 delta-like 4 (Drosophila) 0.238
kdrl kinase insert domain receptor like 0.229
erg v-ets erythroblastosis virus E26 oncogene like (avian) 0.224
cyp1a cytochrome P450, family 1, subfamily A 0.206
flt4 fms-related tyrosine kinase 4 0.196
sc:d812 sc:d812 0.176
fabp11a fatty acid binding protein 11a 0.166
fli1a friend leukemia integration 1a 0.159
bnc2 basonuclin 2 0.158
atp6v0ca ATPase, H+ transporting, lysosomal, V0 subunit c, a 0.154
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.132
mmp9 matrix metalloproteinase 9 0.127
slc45a2 solute carrier family 45, member 2 0.106
dusp5 dual specificity phosphatase 5 0.102
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.102
stab2 stabilin 2 0.097
fras1 Fraser syndrome 1 0.083
dab2 disabled homolog 2 (Drosophila) 0.077
mpx myeloid-specific peroxidase 0.076
prox1 prospero-related homeobox gene 1 0.069
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.067
fancl Fanconi anemia, complementation group L 0.060
ltk leukocyte tyrosine kinase 0.059
gpr182 G protein-coupled receptor 182 0.058
vegfaa vascular endothelial growth factor Aa 0.055
hbbe1.1 hemoglobin beta embryonic-1.1 0.049
vegfc vascular endothelial growth factor c 0.044
cdh23 cadherin-like 23 0.043
calcrla calcitonin receptor-like a 0.043
mb myoglobin 0.039
pink1 PTEN induced putative kinase 1 0.038
ntn4 netrin 4 0.038
fli1b friend leukemia integration 1b 0.038
vsg1 vessel-specific 1 0.038
aqp1a.1 aquaporin 1a, tandem duplicate 1 0.036
agr2 anterior gradient homolog 2 (Xenopus laevis) 0.035
klf2a Kruppel-like factor 2a 0.035
tyrp1b tyrosinase-related protein 1b 0.034
pmela premelanosome protein a 0.033
dnm2 dynamin 2 0.032
yrk Yes-related kinase 0.032
mapk3 mitogen-activated protein kinase 3 0.032
ntrk3b neurotrophic tyrosine kinase, receptor, type 3b 0.032
tmem88a transmembrane protein 88 a 0.030
s100v2 S100 calcium binding protein V2 0.030
anxa1a annexin A1a 0.030
ift88 intraflagellar transport 88 homolog 0.030
tgfb3 transforming growth factor, beta 3 0.030
pnp4a purine nucleoside phosphorylase 4a 0.030
mcamb melanoma cell adhesion molecule b 0.029
mvp major vault protein 0.029
efnb2a ephrin B2a 0.029
aqp8a.1 aquaporin 8a, tandem duplicate 1 0.028
aplnrb apelin receptor b 0.028
ndel1a nudE nuclear distribution gene E homolog like 1 (A. nidulans) A 0.028
st8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.027
gfi1.1 growth factor independent 1.1 0.027
tyr tyrosinase 0.026
nrp1a neuropilin 1a 0.026
elmo1 engulfment and cell motility 1 (ced-12 homolog, C. elegans) 0.026
ccbe1 collagen and calcium binding EGF domains 1 0.026
fcho2 FCH domain only 2 0.026
atp6v1e1b ATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b 0.026
cldnb claudin b 0.025
zgc:100919 zgc:100919 0.025
gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 0.025
mpp5a membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a) 0.024
zgc:110789 zgc:110789 0.024
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.024
bdnf brain-derived neurotrophic factor 0.024
zgc:112329 zgc:112329 0.024
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.023
lyz lysozyme 0.023
tbx20 T-box 20 0.023
epas1b endothelial PAS domain protein 1b 0.023
gch2 GTP cyclohydrolase 2 0.022
hspa12b heat shock protein 12B 0.022
cntn2 contactin 2 0.022
fev FEV (ETS oncogene family) 0.022
ednrb1 endothelin receptor B 0.021
lmo2 LIM domain only 2 (rhombotin-like 1) 0.021
socs1 suppressor of cytokine signaling 1 0.021
plxnd1 plexin D1 0.020
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Tnf tumor necrosis factor 0.804
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.670
Csf1 colony stimulating factor 1 (macrophage) 0.554
Cd19 CD19 antigen 0.451
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.442
Ikzf1 IKAROS family zinc finger 1 0.434
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.358
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.250
Ptprc protein tyrosine phosphatase, receptor type, C 0.234
Cd40 CD40 antigen 0.219
Ltb lymphotoxin B 0.217
Plcg2 phospholipase C, gamma 2 0.172
Cd247 CD247 antigen 0.147
Lta lymphotoxin A 0.105
Il2rg interleukin 2 receptor, gamma chain 0.092
Ctsk cathepsin K 0.085
Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 0.073
Il7 interleukin 7 0.073
Ndel1 nuclear distribution gene E-like homolog 1 (A. nidulans) 0.069
Prkce protein kinase C, epsilon 0.064
Grb2 growth factor receptor bound protein 2 0.056
Blnk B-cell linker 0.054
Pou2af1 POU domain, class 2, associating factor 1 0.054
Fcgr2b Fc receptor, IgG, low affinity IIb 0.053
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.049
Csf1r colony stimulating factor 1 receptor 0.040
Tyrobp TYRO protein tyrosine kinase binding protein 0.039
Cxcr5 chemokine (C-X-C motif) receptor 5 0.038
Il2rb interleukin 2 receptor, beta chain 0.036
Jak3 Janus kinase 3 0.035
Hcst hematopoietic cell signal transducer 0.033
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.029
Ifng interferon gamma 0.027
Was Wiskott-Aldrich syndrome homolog (human) 0.026
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.025
Il4 interleukin 4 0.024
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.024
Cbl Casitas B-lineage lymphoma 0.022
Fyb FYN binding protein 0.022
S100a10 S100 calcium binding protein A10 (calpactin) 0.022
Vdr vitamin D receptor 0.020
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.020
Tox thymocyte selection-associated high mobility group box 0.020
Clnk cytokine-dependent hematopoietic cell linker 0.019
Ccr6 chemokine (C-C motif) receptor 6 0.018
Btk Bruton agammaglobulinemia tyrosine kinase 0.018
Igh immunoglobulin heavy chain complex 0.018
Cd40lg CD40 ligand 0.017
Cxcl13 chemokine (C-X-C motif) ligand 13 0.017
AF251705 cDNA sequence AF251705 0.016
Inpp5d inositol polyphosphate-5-phosphatase D 0.016
Il15 interleukin 15 0.014
Cd96 CD96 antigen 0.014
Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 0.014
Anxa1 annexin A1 0.014
Ptpre protein tyrosine phosphatase, receptor type, E 0.013
Cd22 CD22 antigen 0.013
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.011
Fcgr1 Fc receptor, IgG, high affinity I 0.011
Il1b interleukin 1 beta 0.011
Zap70 zeta-chain (TCR) associated protein kinase 0.011
Cd160 CD160 antigen 0.010
Ccl4 chemokine (C-C motif) ligand 4 0.010
Itk IL2-inducible T-cell kinase 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism