The network for 'negative regulation of calcium ion import' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of calcium ion import

Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.

Homo sapiens
Name Description Probability Func Analog Organism
MED15 mediator complex subunit 15 0.983
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.950
ZNF263 zinc finger protein 263 0.778
TRIM17 tripartite motif containing 17 0.641
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative) 0.605
TRIM39 tripartite motif containing 39 0.581
SP100 SP100 nuclear antigen 0.502
TRIM43 tripartite motif containing 43 0.322
IRF1 interferon regulatory factor 1 0.314
TRIM26 tripartite motif containing 26 0.308
TUBGCP4 tubulin, gamma complex associated protein 4 0.303
IFI16 interferon, gamma-inducible protein 16 0.301
TRIM52 tripartite motif containing 52 0.274
TRIM5 tripartite motif containing 5 0.233
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.158
MCOLN1 mucolipin 1 0.154
UBE2U ubiquitin-conjugating enzyme E2U (putative) 0.148
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.130
IRF2 interferon regulatory factor 2 0.114
NMI N-myc (and STAT) interactor 0.113
SP110 SP110 nuclear body protein 0.112
IRF9 interferon regulatory factor 9 0.102
TRIM35 tripartite motif containing 35 0.100
UBE2Z ubiquitin-conjugating enzyme E2Z 0.098
TRIM22 tripartite motif containing 22 0.086
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.085
PML promyelocytic leukemia 0.085
TRIM8 tripartite motif containing 8 0.083
RNF130 ring finger protein 130 0.082
MR1 major histocompatibility complex, class I-related 0.080
SREBF1 sterol regulatory element binding transcription factor 1 0.078
TRIM6-TRIM34 TRIM6-TRIM34 readthrough 0.066
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.063
IFI44 interferon-induced protein 44 0.060
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 0.057
C19orf66 chromosome 19 open reading frame 66 0.053
PRKCA protein kinase C, alpha 0.051
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 0.049
DTX3L deltex 3-like (Drosophila) 0.047
PLSCR1 phospholipid scramblase 1 0.042
STAT2 signal transducer and activator of transcription 2, 113kDa 0.042
TRIM6 tripartite motif containing 6 0.040
PHF11 PHD finger protein 11 0.040
PIK3C2B phosphoinositide-3-kinase, class 2, beta polypeptide 0.040
RNF5 ring finger protein 5 0.037
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1 0.037
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.037
CTSO cathepsin O 0.034
SDSL serine dehydratase-like 0.034
ZBTB8A zinc finger and BTB domain containing 8A 0.033
MKRN3 makorin ring finger protein 3 0.032
TRIM25 tripartite motif containing 25 0.031
DAXX death-domain associated protein 0.030
MUL1 mitochondrial E3 ubiquitin protein ligase 1 0.026
BFAR bifunctional apoptosis regulator 0.025
RNF114 ring finger protein 114 0.025
TRIM34 tripartite motif containing 34 0.025
BTN3A2 butyrophilin, subfamily 3, member A2 0.025
GIMAP2 GTPase, IMAP family member 2 0.024
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.023
RNF166 ring finger protein 166 0.023
PLCD4 phospholipase C, delta 4 0.023
MAGEF1 melanoma antigen family F, 1 0.022
SAMD9 sterile alpha motif domain containing 9 0.022
BTN3A3 butyrophilin, subfamily 3, member A3 0.022
UBE2D2 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) 0.022
TRIM21 tripartite motif containing 21 0.022
MAGEA1 melanoma antigen family A, 1 (directs expression of antigen MZ2-E) 0.022
FADD Fas (TNFRSF6)-associated via death domain 0.021
USP4 ubiquitin specific peptidase 4 (proto-oncogene) 0.021
RERE arginine-glutamic acid dipeptide (RE) repeats 0.021
MEX3B mex-3 homolog B (C. elegans) 0.020
RNF25 ring finger protein 25 0.019
MYD88 myeloid differentiation primary response gene (88) 0.019
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 0.019
TDRD7 tudor domain containing 7 0.017
ETS1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.017
MKRN1 makorin ring finger protein 1 0.017
IL15RA interleukin 15 receptor, alpha 0.016
SPTB spectrin, beta, erythrocytic 0.016
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.016
TRIM31 tripartite motif containing 31 0.015
BTN2A1 butyrophilin, subfamily 2, member A1 0.015
PIAS3 protein inhibitor of activated STAT, 3 0.014
FHL3 four and a half LIM domains 3 0.014
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.014
GYPE glycophorin E (MNS blood group) 0.014
RLIM ring finger protein, LIM domain interacting 0.013
CHFR checkpoint with forkhead and ring finger domains 0.013
LY75 lymphocyte antigen 75 0.013
UBTD1 ubiquitin domain containing 1 0.013
ZNF221 zinc finger protein 221 0.012
HIPK2 homeodomain interacting protein kinase 2 0.012
RHD Rh blood group, D antigen 0.012
SLFN12 schlafen family member 12 0.012
MX2 myxovirus (influenza virus) resistance 2 (mouse) 0.011
LIPA lipase A, lysosomal acid, cholesterol esterase 0.011
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.011
NFYC nuclear transcription factor Y, gamma 0.011
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 0.011
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Nmdar1 NMDA receptor 1 0.312
Ent2 Equilibrative nucleoside transporter 2 0.270
AdoR Adenosine receptor 0.142
amn amnesiac 0.081
bol boule 0.079
be ben 0.075
GluRIIA Glutamate receptor IIA 0.056
fd85E forkhead domain 85E 0.049
DopR Dopamine receptor 0.049
CG17278 CG17278 gene product from transcript CG17278-RA 0.045
CG3164 CG3164 gene product from transcript CG3164-RA 0.033
CG11961 CG11961 gene product from transcript CG11961-RB 0.029
spict spichthyin 0.029
l(2)05510 lethal (2) 05510 0.028
CG6724 CG6724 gene product from transcript CG6724-RA 0.025
l(3)mbn lethal (3) malignant blood neoplasm 0.025
CG42640 CG42640 gene product from transcript CG42640-RA 0.024
Atg6 Autophagy-specific gene 6 0.022
CG42629 CG42629 gene product from transcript CG42629-RB 0.021
HDAC6 CG6170 gene product from transcript CG6170-RA 0.021
Stam Signal transducing adaptor molecule 0.018
CG10992 CG10992 gene product from transcript CG10992-RA 0.018
dpr5 CG5308 gene product from transcript CG5308-RA 0.017
ZnT35C CG3994 gene product from transcript CG3994-RA 0.016
Spt-I Serine palmitoyltransferase subunit I 0.016
CG12214 CG12214 gene product from transcript CG12214-RB 0.016
CG32711 CG32711 gene product from transcript CG32711-RA 0.015
KaiRIA CG18039 gene product from transcript CG18039-RA 0.014
CG32795 CG32795 gene product from transcript CG32795-RA 0.014
l(2)03659 lethal (2) 03659 0.013
caup caupolican 0.013
CG7860 CG7860 gene product from transcript CG7860-RA 0.013
Gld Glucose dehydrogenase 0.013
mdy midway 0.013
CrebB-17A Cyclic-AMP response element binding protein B at 17A 0.012
CG42542 CG42542 gene product from transcript CG42542-RE 0.012
CG11317 CG11317 gene product from transcript CG11317-RA 0.012
stj straightjacket 0.010
Muc91C Mucin 91C 0.010
NFAT NFAT homolog 0.010
shf shifted 0.010
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.316
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.156
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.099
Slco2b1 solute carrier organic anion transporter family, member 2b1 0.091
St18 suppression of tumorigenicity 18 0.083
Notch3 Notch homolog 3 (Drosophila) 0.068
Sdc3 syndecan 3 0.067
Csf1 colony stimulating factor 1 (macrophage) 0.066
Mrgprf MAS-related GPR, member F 0.065
Epor erythropoietin receptor 0.062
Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.060
Il9r interleukin 9 receptor 0.058
Gzmk granzyme K 0.058
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.057
G6pc glucose-6-phosphatase, catalytic subunit 0.056
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.056
Pecam1 platelet/endothelial cell adhesion molecule 1 0.053
Dcc deleted in colorectal carcinoma 0.052
Flt1 FMS-related tyrosine kinase 1 0.047
Gja6 gap junction protein, alpha 6 0.047
Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.047
Dspp dentin sialophosphoprotein 0.047
Slc22a25 solute carrier family 22, member 25 0.046
Hoxa1 homeo box A1 0.046
Insrr insulin receptor-related receptor 0.044
Avpr1b arginine vasopressin receptor 1B 0.043
Lims1 LIM and senescent cell antigen-like domains 1 0.042
Atp2a3 ATPase, Ca++ transporting, ubiquitous 0.042
Ednra endothelin receptor type A 0.041
N5 DNA binding protein N5 0.041
LOC286987 hemiferrin, transferrin-like protein 0.040
Grm8 glutamate receptor, metabotropic 8 0.040
Olr1867 olfactory receptor 1867 0.040
Faslg Fas ligand (TNF superfamily, member 6) 0.040
Drd3 dopamine receptor D3 0.040
Slc6a11 solute carrier family 6 (neurotransmitter transporter, GABA), member 11 0.038
Kcnc3 potassium voltage gated channel, Shaw-related subfamily, member 3 0.038
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.038
Prm3 protamine 3 0.038
Adam10 ADAM metallopeptidase domain 10 0.038
Smgb neonatal submandibular gland protein B 0.037
Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.037
Grm6 glutamate receptor, metabotropic 6 0.036
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.036
Utrn utrophin 0.036
Kynu kynureninase (L-kynurenine hydrolase) 0.036
Hand1 heart and neural crest derivatives expressed 1 0.036
Bcl2 B-cell CLL/lymphoma 2 0.036
Wfdc6a WAP four-disulfide core domain 6A 0.035
Slco1a1 solute carrier organic anion transporter family, member 1a1 0.034
Gpr1 G protein-coupled receptor 1 0.034
Teddm1 transmembrane epididymal protein 1 0.034
Accn2 amiloride-sensitive cation channel 2, neuronal 0.034
Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.034
Grin2c glutamate receptor, ionotropic, N-methyl D-aspartate 2C 0.033
Cela2a chymotrypsin-like elastase family, member 2A 0.033
Rup2 urinary protein 2 0.032
Acrv1 acrosomal vesicle protein 1 0.032
Oprk1 opioid receptor, kappa 1 0.031
Lad1 ladinin 1 0.031
Prodh2 proline dehydrogenase (oxidase) 2 0.031
Tgfbr3 transforming growth factor, beta receptor III 0.030
LOC690418 similar to Acidic proline-rich protein PRP25 precursor 0.029
Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.029
Pon1 paraoxonase 1 0.028
Pla2g2c phospholipase A2, group IIC 0.028
Slc6a7 solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 0.027
Afm afamin 0.027
Kcnh3 potassium voltage-gated channel, subfamily H (eag-related), member 3 0.027
Slc5a2 solute carrier family 5 (sodium/glucose cotransporter), member 2 0.027
Mamdc4 MAM domain containing 4 0.026
Ar androgen receptor 0.026
Htr5a 5-hydroxytryptamine (serotonin) receptor 5A 0.026
Nkx6-1 NK6 homeobox 1 0.026
Psg19 pregnancy specific glycoprotein 19 0.026
RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase 0.025
C3ar1 complement component 3a receptor 1 0.025
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.025
Slc30a2 solute carrier family 30 (zinc transporter), member 2 0.025
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.025
Spp2 secreted phosphoprotein 2 0.024
Adora2a adenosine A2a receptor 0.024
Hrh2 histamine receptor H 2 0.024
Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 0.024
Lepr leptin receptor 0.024
Smr3a submaxillary gland androgen regulated protein 3A 0.024
Agxt2 alanine-glyoxylate aminotransferase 2 0.023
RGD1310262 hypothetical LOC304650 0.023
Chrna4 cholinergic receptor, nicotinic, alpha 4 0.023
Atp7b ATPase, Cu++ transporting, beta polypeptide 0.023
Apoa4 apolipoprotein A-IV 0.023
Bcl2l10 BCL2-like 10 (apoptosis facilitator) 0.023
Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 0.023
Dao D-amino-acid oxidase 0.023
Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 0.022
Kif6 kinesin family member 6 0.022
Chrm2 cholinergic receptor, muscarinic 2 0.022
B3gat1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 0.022
Syt7 synaptotagmin VII 0.022
Cacna1e calcium channel, voltage-dependent, R type, alpha 1E subunit 0.022
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism