The network for 'regulation of natural killer cell mediated cytotoxicity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of natural killer cell mediated cytotoxicity

Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity.

Homo sapiens
Name Description Probability Func Analog Organism
B2M beta-2-microglobulin 1.000
HLA-A major histocompatibility complex, class I, A 1.000
HLA-C major histocompatibility complex, class I, C 1.000
HLA-B major histocompatibility complex, class I, B 1.000
HLA-G major histocompatibility complex, class I, G 1.000
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.000
HLA-F major histocompatibility complex, class I, F 0.999
HLA-E major histocompatibility complex, class I, E 0.998
KLRD1 killer cell lectin-like receptor subfamily D, member 1 0.993
TAPBP TAP binding protein (tapasin) 0.990
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.984
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 0.981
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 0.906
PILRA paired immunoglobin-like type 2 receptor alpha 0.895
IL2RB interleukin 2 receptor, beta 0.805
SLAMF1 signaling lymphocytic activation molecule family member 1 0.623
PTPN6 protein tyrosine phosphatase, non-receptor type 6 0.595
ITM2B integral membrane protein 2B 0.495
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 0.474
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.473
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2 0.461
GBA glucosidase, beta, acid 0.408
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) 0.344
SIGLEC7 sialic acid binding Ig-like lectin 7 0.248
PTAFR platelet-activating factor receptor 0.235
HK3 hexokinase 3 (white cell) 0.234
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.208
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.207
IL23A interleukin 23, alpha subunit p19 0.198
GZMK granzyme K (granzyme 3; tryptase II) 0.175
IFNG interferon, gamma 0.174
ARRB2 arrestin, beta 2 0.166
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 0.132
GNLY granulysin 0.127
INSR insulin receptor 0.119
PRF1 perforin 1 (pore forming protein) 0.111
KLRC3 killer cell lectin-like receptor subfamily C, member 3 0.106
KLRC2 killer cell lectin-like receptor subfamily C, member 2 0.105
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.089
CD33 CD33 molecule 0.073
BTN3A1 butyrophilin, subfamily 3, member A1 0.073
PGCP plasma glutamate carboxypeptidase 0.070
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 0.066
NKG7 natural killer cell group 7 sequence 0.055
HEXB hexosaminidase B (beta polypeptide) 0.054
CMKLR1 chemokine-like receptor 1 0.050
IL18RAP interleukin 18 receptor accessory protein 0.048
NCSTN nicastrin 0.046
CXCR6 chemokine (C-X-C motif) receptor 6 0.045
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 0.043
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.042
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.042
KLRG1 killer cell lectin-like receptor subfamily G, member 1 0.042
STAP2 signal transducing adaptor family member 2 0.042
HCST hematopoietic cell signal transducer 0.041
BTN3A2 butyrophilin, subfamily 3, member A2 0.040
CCL5 chemokine (C-C motif) ligand 5 0.038
SIGLEC9 sialic acid binding Ig-like lectin 9 0.037
PSAP prosaposin 0.037
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 0.036
CCL4 chemokine (C-C motif) ligand 4 0.036
MAPK10 mitogen-activated protein kinase 10 0.036
KLRC4 killer cell lectin-like receptor subfamily C, member 4 0.035
CD160 CD160 molecule 0.035
RAB14 RAB14, member RAS oncogene family 0.035
TJP1 tight junction protein 1 (zona occludens 1) 0.035
XCL2 chemokine (C motif) ligand 2 0.034
ARRB1 arrestin, beta 1 0.034
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.033
KLRF1 killer cell lectin-like receptor subfamily F, member 1 0.033
FPR2 formyl peptide receptor 2 0.033
EPOR erythropoietin receptor 0.033
HFE hemochromatosis 0.032
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.032
CD84 CD84 molecule 0.032
BTN3A3 butyrophilin, subfamily 3, member A3 0.032
IL12A interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) 0.031
AOAH acyloxyacyl hydrolase (neutrophil) 0.031
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 0.031
CD226 CD226 molecule 0.030
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 0.030
NLRP3 NLR family, pyrin domain containing 3 0.029
TXK TXK tyrosine kinase 0.029
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 0.028
CD3G CD3g molecule, gamma (CD3-TCR complex) 0.028
FTH1 ferritin, heavy polypeptide 1 0.028
HCP5 HLA complex P5 0.026
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 0.026
TBX21 T-box 21 0.026
EMR1 egf-like module containing, mucin-like, hormone receptor-like 1 0.026
SIRPB1 signal-regulatory protein beta 1 0.025
NPC2 Niemann-Pick disease, type C2 0.025
PYHIN1 pyrin and HIN domain family, member 1 0.025
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.024
KIR2DL2 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 and killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2 0.023
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 0.023
TAPBPL TAP binding protein-like 0.022
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) 0.021
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 0.021
CTSW cathepsin W 0.021
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
im:7141132 im:7141132 0.089
zgc:101598 zgc:101598 0.051
defbl3 defensin, beta-like 3 0.041
fxr2 fragile X mental retardation, autosomal homolog 2 0.036
itln1 intelectin 1 0.036
sb:cb134 sb:cb134 0.035
fbln4 fibulin 4 0.029
eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 0.026
itln3 intelectin 3 0.025
fcho2 FCH domain only 2 0.025
jhdm1da jumonji C domain containing histone demethylase 1 homolog Da (S. cerevisiae) 0.024
sb:cb429 sb:cb429 0.022
tlr22 toll-like receptor 22 0.021
tnfrsf18 tumor necrosis factor receptor superfamily, member 18 0.020
wu:fb80e01 wu:fb80e01 0.019
cry1a cryptochrome 1a 0.018
zgc:112992 zgc:112992 0.018
slc12a3 solute carrier family 12 (sodium/chloride transporters), member 3 0.017
dmrt1 doublesex and mab-3 related transcription factor 1 0.017
ppp2r5ea protein phosphatase 2, regulatory subunit B', epsilon isoform a 0.016
im:7135980 im:7135980 0.016
tlr4bb toll-like receptor 4b, duplicate b 0.015
nitr13 novel immune-type receptor 13 0.015
lpp LIM domain containing preferred translocation partner in lipoma 0.014
gsk3b glycogen synthase kinase 3 beta 0.014
zgc:172101 zgc:172101 0.014
nitr8 novel immune-type receptor 8 0.014
LOC555739 serine/threonine-protein kinase LMTK1-like 0.013
oxsr1a oxidative-stress responsive 1a 0.013
im:7152557 im:7152557 0.013
waca WW domain containing adaptor with coiled-coil a 0.013
wnt10b wingless-type MMTV integration site family, member 10b 0.013
kpna3 karyopherin (importin) alpha 3 0.012
ip6k2 inositol hexaphosphate kinase 2 0.012
atp2b4 ATPase, Ca++ transporting, plasma membrane 4 0.012
nitr12 novel immune-type receptor 12 0.012
arl4aa ADP-ribosylation factor-like 4aa 0.011
sipa1l1 signal-induced proliferation-associated 1 like 1 0.011
cx39.9 connexin 39.9 0.011
npy4r neuropeptide Y receptor Y4 0.011
heg heart of glass 0.011
smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.011
angptl3 angiopoietin-like 3 0.011
nitr4a novel immune-type receptor 4a 0.011
sult1st4 sulfotransferase family 1, cytosolic sulfotransferase 4 0.011
tlr9 toll-like receptor 9 0.011
znf148 zinc finger protein 148 0.010
gatsl2 GATS protein-like 2 0.010
fryl furry homolog-like (Drosophila) 0.010
phrf1 PHD and ring finger domains 1 0.010
LOC569720 rho GTPase-activating protein 32-like 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
H2-K1 histocompatibility 2, K1, K region 0.986
Tapbp TAP binding protein 0.981
H2-D1 histocompatibility 2, D region locus 1 0.965
Klrk1 killer cell lectin-like receptor subfamily K, member 1 0.937
Slamf1 signaling lymphocytic activation molecule family member 1 0.907
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.855
Klra9 killer cell lectin-like receptor subfamily A, member 9 0.844
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.827
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.745
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.644
Irf9 interferon regulatory factor 9 0.602
Klrc1 killer cell lectin-like receptor subfamily C, member 1 0.589
H2-Q7 histocompatibility 2, Q region locus 7 0.585
B2m beta-2 microglobulin 0.556
Gzma granzyme A 0.485
Fasl Fas ligand (TNF superfamily, member 6) 0.424
Stat1 signal transducer and activator of transcription 1 0.357
Trim21 tripartite motif-containing 21 0.352
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.316
Gzmk granzyme K 0.288
Il6 interleukin 6 0.288
H2-Q6 histocompatibility 2, Q region locus 6 0.258
Gbp2 guanylate binding protein 2 0.248
Irgm2 immunity-related GTPase family M member 2 0.247
Itk IL2-inducible T-cell kinase 0.217
Xcl1 chemokine (C motif) ligand 1 0.201
Klra7 killer cell lectin-like receptor, subfamily A, member 7 0.197
Igtp interferon gamma induced GTPase 0.192
Gzmb granzyme B 0.181
H2-Q8 histocompatibility 2, Q region locus 8 0.181
Gbp7 guanylate binding protein 7 0.156
Irf1 interferon regulatory factor 1 0.153
Psmb10 proteasome (prosome, macropain) subunit, beta type 10 0.148
Ncr1 natural cytotoxicity triggering receptor 1 0.136
Pyhin1 pyrin and HIN domain family, member 1 0.135
Parp14 poly (ADP-ribose) polymerase family, member 14 0.127
Klra3 killer cell lectin-like receptor, subfamily A, member 3 0.115
Il18rap interleukin 18 receptor accessory protein 0.086
Irgm1 immunity-related GTPase family M member 1 0.085
Stat2 signal transducer and activator of transcription 2 0.084
Arrb1 arrestin, beta 1 0.084
Klrb1b killer cell lectin-like receptor subfamily B member 1B 0.082
Cd7 CD7 antigen 0.081
AW112010 expressed sequence AW112010 0.078
Slamf7 SLAM family member 7 0.069
BC147527 cDNA sequence BC147527 0.067
Il18r1 interleukin 18 receptor 1 0.067
Nkg7 natural killer cell group 7 sequence 0.066
Ifi35 interferon-induced protein 35 0.065
Stat4 signal transducer and activator of transcription 4 0.064
Klrg1 killer cell lectin-like receptor subfamily G, member 1 0.064
Tgtp2 T-cell specific GTPase 2 0.062
Ccr9 chemokine (C-C motif) receptor 9 0.059
Gbp3 guanylate binding protein 3 0.057
Klrb1c killer cell lectin-like receptor subfamily B member 1C 0.056
Cd84 CD84 antigen 0.055
Klrb1f killer cell lectin-like receptor subfamily B member 1F 0.055
H2-Q5 histocompatibility 2, Q region locus 5 0.054
Il2ra interleukin 2 receptor, alpha chain 0.053
Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 0.053
Cxcl9 chemokine (C-X-C motif) ligand 9 0.050
Iigp1 interferon inducible GTPase 1 0.048
Emr4 EGF-like module containing, mucin-like, hormone receptor-like sequence 4 0.047
Ccr3 chemokine (C-C motif) receptor 3 0.047
Ctsw cathepsin W 0.046
Cd160 CD160 antigen 0.045
Pilrb1 paired immunoglobin-like type 2 receptor beta 1 0.045
Cd180 CD180 antigen 0.044
Nmi N-myc (and STAT) interactor 0.044
Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein 0.044
Il4ra interleukin 4 receptor, alpha 0.044
Ccl5 chemokine (C-C motif) ligand 5 0.043
Prf1 perforin 1 (pore forming protein) 0.042
Aoah acyloxyacyl hydrolase 0.042
Cd244 CD244 natural killer cell receptor 2B4 0.042
Parp10 poly (ADP-ribose) polymerase family, member 10 0.041
Icos inducible T-cell co-stimulator 0.039
H2-Eb1 histocompatibility 2, class II antigen E beta 0.039
Klra8 killer cell lectin-like receptor, subfamily A, member 8 0.039
Parp9 poly (ADP-ribose) polymerase family, member 9 0.038
Ifi47 interferon gamma inducible protein 47 0.037
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.036
Zfp36 zinc finger protein 36 0.036
Cxcr6 chemokine (C-X-C motif) receptor 6 0.036
Gbp1 guanylate binding protein 1 0.035
Uba7 ubiquitin-like modifier activating enzyme 7 0.035
Cd3g CD3 antigen, gamma polypeptide 0.035
Klrb1a killer cell lectin-like receptor subfamily B member 1A 0.033
Fcrla Fc receptor-like A 0.033
Slfn1 schlafen 1 0.032
Itgax integrin alpha X 0.031
Cd2 CD2 antigen 0.030
Il10 interleukin 10 0.030
C920025E04Rik RIKEN cDNA C920025E04 gene 0.030
Bex6 brain expressed gene 6 0.030
Sh2d2a SH2 domain protein 2A 0.029
Klra5 killer cell lectin-like receptor, subfamily A, member 5 0.029
Slamf6 SLAM family member 6 0.029
Klra17 killer cell lectin-like receptor, subfamily A, member 17 0.029
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.028
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Rattus norvegicus
Name Description Probability Func Analog Organism
RT1-EC2 RT1 class Ib, locus EC2 0.987
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.596
Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) 0.539
RT1-CE12 RT1 class I, locus CE12 0.294
Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 0.197
Mmp12 matrix metallopeptidase 12 0.124
Gzmb granzyme B 0.120
Tap2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.105
Nkg7 natural killer cell group 7 sequence 0.082
Rt1.aa MHC class I RT1.Aa alpha-chain 0.057
Prf1 perforin 1 (pore forming protein) 0.052
Cd2 Cd2 molecule 0.047
Klrb1a killer cell lectin-like receptor subfamily B, member 1A 0.041
Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein 0.039
Gzmk granzyme K 0.037
Klra5 killer cell lectin-like receptor, subfamily A, member 5 0.035
Sell selectin L 0.032
Oas1a 2'-5' oligoadenylate synthetase 1A 0.032
RT1-S3 RT1 class Ib, locus S3 0.030
Klra17 killer cell lectin-like receptor, subfamily A, member 17 0.029
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.025
Cd8a CD8a molecule 0.021
LOC100364500 RT1 class I, locus CE11-like 0.019
Neurl3 neuralized homolog 3 (Drosophila) 0.017
Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) 0.017
Cd247 Cd247 molecule 0.016
Ccr2 chemokine (C-C motif) receptor 2 0.015
Mcpt8 mast cell protease 8 0.014
Gimap4 GTPase, IMAP family member 4 0.013
RT1-M3-1 RT1 class Ib, locus M3, gene 1 0.013
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.013
RT1-Cl RT1 class Ib, locus Cl 0.013
Ccl5 chemokine (C-C motif) ligand 5 0.013
Apcs amyloid P component, serum 0.012
Cxcl10 chemokine (C-X-C motif) ligand 10 0.012
Arhgap15 Rho GTPase activating protein 15 0.011
Apol3 apolipoprotein L, 3 0.011
Zcwpw1 zinc finger, CW-type with PWWP domain 1 0.010
Irf1 interferon regulatory factor 1 0.010
Il7r interleukin 7 receptor 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism