The network for 'negative regulation of g protein coupled receptor protein signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of g protein coupled receptor protein signaling pathway

Any process that stops, prevents, or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity.

Homo sapiens
Name Description Probability Func Analog Organism
IL8 interleukin 8 1.000
CXCL3 chemokine (C-X-C motif) ligand 3 0.998
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.983
CXCL2 chemokine (C-X-C motif) ligand 2 0.982
IL6 interleukin 6 (interferon, beta 2) 0.972
IL1B interleukin 1, beta 0.944
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.860
CCL2 chemokine (C-C motif) ligand 2 0.825
CCL4 chemokine (C-C motif) ligand 4 0.811
CCR5 chemokine (C-C motif) receptor 5 0.767
CCL20 chemokine (C-C motif) ligand 20 0.765
ARRB1 arrestin, beta 1 0.703
CCL8 chemokine (C-C motif) ligand 8 0.670
DPP4 dipeptidyl-peptidase 4 0.591
CXCL10 chemokine (C-X-C motif) ligand 10 0.581
ZNF496 zinc finger protein 496 0.554
CXCL5 chemokine (C-X-C motif) ligand 5 0.506
ICAM1 intercellular adhesion molecule 1 0.483
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.387
MPDZ multiple PDZ domain protein 0.376
CXCL9 chemokine (C-X-C motif) ligand 9 0.372
KLK10 kallikrein-related peptidase 10 0.344
CXCL6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.301
CXCL11 chemokine (C-X-C motif) ligand 11 0.286
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) 0.270
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.247
CCR1 chemokine (C-C motif) receptor 1 0.188
SOD2 superoxide dismutase 2, mitochondrial 0.178
GPRASP1 G protein-coupled receptor associated sorting protein 1 0.160
CCL13 chemokine (C-C motif) ligand 13 0.159
CCL5 chemokine (C-C motif) ligand 5 0.130
ADORA2A adenosine A2a receptor 0.113
ARMCX3 armadillo repeat containing, X-linked 3 0.110
UBD ubiquitin D 0.108
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 0.105
BCL2A1 BCL2-related protein A1 0.101
GPRASP2 G protein-coupled receptor associated sorting protein 2 0.097
ERCC8 excision repair cross-complementing rodent repair deficiency, complementation group 8 0.092
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 0.091
PI3 peptidase inhibitor 3, skin-derived 0.089
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.088
CDSN corneodesmosin 0.079
HDAC6 histone deacetylase 6 0.076
PLAUR plasminogen activator, urokinase receptor 0.074
VCAM1 vascular cell adhesion molecule 1 0.074
IER3 immediate early response 3 0.071
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.071
MAPT microtubule-associated protein tau 0.070
CALCA calcitonin-related polypeptide alpha 0.069
KLK8 kallikrein-related peptidase 8 0.066
RGS1 regulator of G-protein signaling 1 0.063
MAPK10 mitogen-activated protein kinase 10 0.062
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.062
NAMPT nicotinamide phosphoribosyltransferase 0.061
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.059
CFL1 cofilin 1 (non-muscle) 0.057
SELE selectin E 0.057
BBS10 Bardet-Biedl syndrome 10 0.056
MMP12 matrix metallopeptidase 12 (macrophage elastase) 0.055
CXCL13 chemokine (C-X-C motif) ligand 13 0.054
IL10 interleukin 10 0.051
CCL7 chemokine (C-C motif) ligand 7 0.049
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.048
KLK11 kallikrein-related peptidase 11 0.044
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.042
KLK7 kallikrein-related peptidase 7 0.040
CCL3 chemokine (C-C motif) ligand 3 0.038
GNMT glycine N-methyltransferase 0.038
IFNG interferon, gamma 0.037
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.037
DCTN1 dynactin 1 0.035
CCL11 chemokine (C-C motif) ligand 11 0.034
TNF tumor necrosis factor 0.034
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.034
CH25H cholesterol 25-hydroxylase 0.032
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.031
MMP9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 0.031
KLK2 kallikrein-related peptidase 2 0.030
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) 0.030
KLK3 kallikrein-related peptidase 3 0.029
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 0.029
PF4 platelet factor 4 0.029
ARRDC3 arrestin domain containing 3 0.027
KLK5 kallikrein-related peptidase 5 0.025
DLG2 discs, large homolog 2 (Drosophila) 0.025
REEP5 receptor accessory protein 5 0.025
ALB albumin 0.025
CD83 CD83 molecule 0.024
CCL19 chemokine (C-C motif) ligand 19 0.024
ARMCX2 armadillo repeat containing, X-linked 2 0.024
INHBA inhibin, beta A 0.024
BIRC3 baculoviral IAP repeat containing 3 0.024
IL7R interleukin 7 receptor 0.024
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.023
KYNU kynureninase 0.023
IL1RN interleukin 1 receptor antagonist 0.023
HIST2H2AB histone cluster 2, H2ab 0.023
LIF leukemia inhibitory factor (cholinergic differentiation factor) 0.023
CD163 CD163 molecule 0.022
CLEC7A C-type lectin domain family 7, member A 0.022
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.998
Per2 period homolog 2 (Drosophila) 0.998
Clock circadian locomotor output cycles kaput 0.995
Cry2 cryptochrome 2 (photolyase-like) 0.722
Arrb2 arrestin, beta 2 0.713
Adrb1 adrenergic receptor, beta 1 0.692
Arrb1 arrestin, beta 1 0.518
Per1 period homolog 1 (Drosophila) 0.498
Cckbr cholecystokinin B receptor 0.421
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.404
Pnpla2 patatin-like phospholipase domain containing 2 0.392
Cry1 cryptochrome 1 (photolyase-like) 0.390
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.341
Oprm1 opioid receptor, mu 1 0.311
Coro1a coronin, actin binding protein 1A 0.257
Pparg peroxisome proliferator activated receptor gamma 0.220
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.139
Adrb3 adrenergic receptor, beta 3 0.138
Nos1 nitric oxide synthase 1, neuronal 0.104
Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 0.099
Ppp1r9b protein phosphatase 1, regulatory subunit 9B 0.098
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.087
Ptprn2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.086
Cnr1 cannabinoid receptor 1 (brain) 0.080
Adrb2 adrenergic receptor, beta 2 0.080
Grm2 glutamate receptor, metabotropic 2 0.071
Rab6 RAB6, member RAS oncogene family 0.065
Nr3c1 nuclear receptor subfamily 3, group C, member 1 0.064
Kl klotho 0.063
Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) 0.059
Kcna4 potassium voltage-gated channel, shaker-related subfamily, member 4 0.054
Gad2 glutamic acid decarboxylase 2 0.053
Chrm1 cholinergic receptor, muscarinic 1, CNS 0.053
Crhr1 corticotropin releasing hormone receptor 1 0.050
Ghr growth hormone receptor 0.050
Pitx3 paired-like homeodomain transcription factor 3 0.049
Npas2 neuronal PAS domain protein 2 0.047
Rasa3 RAS p21 protein activator 3 0.046
Sstr4 somatostatin receptor 4 0.043
Pde6a phosphodiesterase 6A, cGMP-specific, rod, alpha 0.043
Calcrl calcitonin receptor-like 0.043
Oprd1 opioid receptor, delta 1 0.042
Sipa1 signal-induced proliferation associated gene 1 0.042
Pip4k2a phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.041
Hrh1 histamine receptor H1 0.041
Plekho1 pleckstrin homology domain containing, family O member 1 0.040
ND6 NADH dehydrogenase subunit 6 0.037
Sstr1 somatostatin receptor 1 0.036
Lepr leptin receptor 0.035
Per3 period homolog 3 (Drosophila) 0.035
Fshb follicle stimulating hormone beta 0.034
Sebox SEBOX homeobox 0.033
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.032
Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit 0.032
Prkaca protein kinase, cAMP dependent, catalytic, alpha 0.031
Pitpnm1 phosphatidylinositol transfer protein, membrane-associated 1 0.030
Lag3 lymphocyte-activation gene 3 0.030
Kcnq2 potassium voltage-gated channel, subfamily Q, member 2 0.030
Grk6 G protein-coupled receptor kinase 6 0.029
Pde6b phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide 0.027
Cdh10 cadherin 10 0.027
Nxph2 neurexophilin 2 0.026
Shc3 src homology 2 domain-containing transforming protein C3 0.026
Fezf2 Fez family zinc finger 2 0.026
Adora2a adenosine A2a receptor 0.025
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.025
Wipf1 WAS/WASL interacting protein family, member 1 0.024
Dlg2 discs, large homolog 2 (Drosophila) 0.024
Fosb FBJ osteosarcoma oncogene B 0.024
Gabrg3 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3 0.024
Sez6 seizure related gene 6 0.024
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.023
Rgs4 regulator of G-protein signaling 4 0.023
Csnk1e casein kinase 1, epsilon 0.023
Prkcb protein kinase C, beta 0.023
Grm1 glutamate receptor, metabotropic 1 0.023
Fli1 Friend leukemia integration 1 0.023
4632428N05Rik RIKEN cDNA 4632428N05 gene 0.023
Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) 0.023
Cer1 cerberus 1 homolog (Xenopus laevis) 0.023
Tyrobp TYRO protein tyrosine kinase binding protein 0.023
Dlg4 discs, large homolog 4 (Drosophila) 0.022
Gucy2e guanylate cyclase 2e 0.022
Map2k2 mitogen-activated protein kinase kinase 2 0.022
Fam105a family with sequence similarity 105, member A 0.022
Btn1a1 butyrophilin, subfamily 1, member A1 0.021
Clcnka chloride channel Ka 0.021
Rs1 retinoschisis (X-linked, juvenile) 1 (human) 0.021
Npy2r neuropeptide Y receptor Y2 0.021
Cplx1 complexin 1 0.020
Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 0.020
Oprk1 opioid receptor, kappa 1 0.020
Syn2 synapsin II 0.020
Mitf microphthalmia-associated transcription factor 0.020
Cel carboxyl ester lipase 0.020
Sstr3 somatostatin receptor 3 0.020
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 0.020
Opn1sw opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan) 0.019
Mkl1 MKL (megakaryoblastic leukemia)/myocardin-like 1 0.019
Trpc5 transient receptor potential cation channel, subfamily C, member 5 0.019
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Rattus norvegicus
Name Description Probability Func Analog Organism
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.147
Pde1b phosphodiesterase 1B, calmodulin-dependent 0.137
Znf483 zinc finger protein 483 0.116
Klrd1 killer cell lectin-like receptor, subfamily D, member 1 0.105
Htr6 5-hydroxytryptamine (serotonin) receptor 6 0.097
Fgf14 fibroblast growth factor 14 0.096
Dcc deleted in colorectal carcinoma 0.090
B3gat1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) 0.090
Acrv1 acrosomal vesicle protein 1 0.080
Coro1a coronin, actin binding protein 1A 0.074
Adora2a adenosine A2a receptor 0.061
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.061
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 0.058
Apba2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.056
Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 0.054
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.049
Grm6 glutamate receptor, metabotropic 6 0.049
Lcp2 lymphocyte cytosolic protein 2 0.047
Utrn utrophin 0.047
Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 0.046
Rftn2 raftlin family member 2 0.045
Rgs9 regulator of G-protein signaling 9 0.044
RGD1565493 similar to DKFZP434I092 protein 0.042
Fgf7 fibroblast growth factor 7 0.041
Cntn3 contactin 3 (plasmacytoma associated) 0.040
Gabra4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.039
Camk2g calcium/calmodulin-dependent protein kinase II gamma 0.039
Mpp2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.038
Scn4a sodium channel, voltage-gated, type IV, alpha subunit 0.036
Bsn bassoon 0.035
Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 0.034
Chrna4 cholinergic receptor, nicotinic, alpha 4 0.033
Prph2 peripherin 2 0.033
Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 0.032
Hoxc4 homeo box C4 0.032
Pdyn prodynorphin 0.031
Gng7 guanine nucleotide binding protein (G protein), gamma 7 0.030
Kitlg KIT ligand 0.030
Dnm3 dynamin 3 0.030
Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.030
Foxa3 forkhead box A3 0.030
Hpcal4 hippocalcin-like 4 0.030
Hrh3 histamine receptor H3 0.029
Fbxo10 F-box protein 10 0.029
Klrc1 killer cell lectin-like receptor subfamily C, member 1 0.028
Uncx UNC homeobox 0.028
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.028
Trim28 tripartite motif-containing 28 0.028
Sox17 SRY (sex determining region Y)-box 17 0.028
Camk2n2 calcium/calmodulin-dependent protein kinase II inhibitor 2 0.027
Trhr thyrotropin releasing hormone receptor 0.027
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.027
Grk1 G protein-coupled receptor kinase 1 0.027
N5 DNA binding protein N5 0.027
Gabra3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 0.027
Cd53 Cd53 molecule 0.027
Dcaf15 DDB1 and CUL4 associated factor 15 0.026
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.026
Pomc proopiomelanocortin 0.026
Cd247 Cd247 molecule 0.025
Sebox SEBOX homeobox 0.024
Itgam integrin, alpha M 0.024
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.024
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.024
Folh1 folate hydrolase 1 0.023
Glp1r glucagon-like peptide 1 receptor 0.023
Taf6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor 0.023
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.023
Inpp5d inositol polyphosphate-5-phosphatase D 0.022
Avp arginine vasopressin 0.022
Cd38 CD38 molecule 0.022
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.022
Ncan neurocan 0.022
Hcst hematopoietic cell signal transducer 0.022
Arrb2 arrestin, beta 2 0.022
Atp2a3 ATPase, Ca++ transporting, ubiquitous 0.022
Laptm5 lysosomal protein transmembrane 5 0.022
Hcrt hypocretin 0.022
Slc7a3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 0.021
Lnpep leucyl/cystinyl aminopeptidase 0.021
Kcnb2 potassium voltage gated channel, Shab-related subfamily, member 2 0.021
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.021
Syngap1 synaptic Ras GTPase activating protein 1 homolog (rat) 0.021
Nmur2 neuromedin U receptor 2 0.020
Unc5a unc-5 homolog A (C. elegans) 0.020
Psg29 pregnancy-specific glycoprotein 29 0.020
Spata2L spermatogenesis associated 2-like 0.020
Adora1 adenosine A1 receptor 0.020
Mapk7 mitogen-activated protein kinase 7 0.020
Syt7 synaptotagmin VII 0.020
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.019
Ptms parathymosin 0.019
Ccl3 chemokine (C-C motif) ligand 3 0.019
Srgn serglycin 0.019
Wdr7 WD repeat domain 7 0.018
Itpkb inositol 1,4,5-trisphosphate 3-kinase B 0.018
Drd1a dopamine receptor D1A 0.018
Git1 G protein-coupled receptor kinase interacting ArfGAP 1 0.018
Cdc42bpb CDC42 binding protein kinase beta (DMPK-like) 0.018
Impg2 interphotoreceptor matrix proteoglycan 2 0.018
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RLM1 Rlm1p 0.023
KDX1 Kdx1p 0.020
PPZ1 Ppz1p 0.020
MSG5 Msg5p 0.016
PTI1 Pti1p 0.015
CAB3 Cab3p 0.012
SRD1 Srd1p 0.011
YDR034W-B hypothetical protein 0.011
PDR15 Pdr15p 0.010
LEU2 Leu2p 0.010
ASK10 Ask10p 0.010
PPQ1 Ppq1p 0.010
YOL038C-A hypothetical protein 0.010
YLR264C-A hypothetical protein 0.010