The network for 'fear response' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

fear response

The response of an organism to a perceived external threat.

Homo sapiens
Name Description Probability Func Analog Organism
BCL2L1 BCL2-like 1 1.000
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.831
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.830
DLG4 discs, large homolog 4 (Drosophila) 0.684
BAX BCL2-associated X protein 0.673
CRHR1 corticotropin releasing hormone receptor 1 0.667
CRH corticotropin releasing hormone 0.645
BAK1 BCL2-antagonist/killer 1 0.583
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 0.533
KIFC2 kinesin family member C2 0.525
ESR1 estrogen receptor 1 0.422
RPL18A ribosomal protein L18a 0.380
AMBRA1 autophagy/beclin-1 regulator 1 0.351
KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) 0.342
MYLK2 myosin light chain kinase 2 0.315
PPP5C protein phosphatase 5, catalytic subunit 0.297
ZNF784 zinc finger protein 784 0.278
HDAC4 histone deacetylase 4 0.277
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.254
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.215
UBXN2A UBX domain protein 2A 0.212
LPL lipoprotein lipase 0.206
VDAC2 voltage-dependent anion channel 2 0.183
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.167
BIK BCL2-interacting killer (apoptosis-inducing) 0.158
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 0.155
BID BH3 interacting domain death agonist 0.139
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 0.134
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.126
HIPK2 homeodomain interacting protein kinase 2 0.116
CCKBR cholecystokinin B receptor 0.104
EP300 E1A binding protein p300 0.101
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.099
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.089
DUSP23 dual specificity phosphatase 23 0.085
HDAC9 histone deacetylase 9 0.075
WDR20 WD repeat domain 20 0.074
PFN1 profilin 1 0.073
BBS10 Bardet-Biedl syndrome 10 0.072
RAI1 retinoic acid induced 1 0.068
KCNA4 potassium voltage-gated channel, shaker-related subfamily, member 4 0.067
DDX24 DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 0.065
CYCS cytochrome c, somatic 0.063
GSK3A glycogen synthase kinase 3 alpha 0.061
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.061
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.060
DLAT dihydrolipoamide S-acetyltransferase 0.058
FHL1 four and a half LIM domains 1 0.053
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.052
ASCC2 activating signal cointegrator 1 complex subunit 2 0.052
PGK1 phosphoglycerate kinase 1 0.052
VDAC1 voltage-dependent anion channel 1 0.050
NLGN1 neuroligin 1 0.049
LDHA lactate dehydrogenase A 0.049
BECN1 beclin 1, autophagy related 0.042
MAPK8 mitogen-activated protein kinase 8 0.041
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.040
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 0.040
NAF1 nuclear assembly factor 1 homolog (S. cerevisiae) 0.040
MEF2A myocyte enhancer factor 2A 0.040
TP53BP2 tumor protein p53 binding protein, 2 0.039
CRMP1 collapsin response mediator protein 1 0.039
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.036
ACAT2 acetyl-CoA acetyltransferase 2 0.036
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.036
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 0.035
SMS spermine synthase 0.034
AKAP13 A kinase (PRKA) anchor protein 13 0.034
UVRAG UV radiation resistance associated gene 0.033
RAD23B RAD23 homolog B (S. cerevisiae) 0.031
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.031
ZMYND11 zinc finger, MYND-type containing 11 0.031
DLG2 discs, large homolog 2 (Drosophila) 0.030
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 0.029
BAI1 brain-specific angiogenesis inhibitor 1 0.028
EEA1 early endosome antigen 1 0.028
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.028
FKBP8 FK506 binding protein 8, 38kDa 0.028
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.028
BBC3 BCL2 binding component 3 0.027
ACTL6B actin-like 6B 0.027
NCOA1 nuclear receptor coactivator 1 0.027
HK1 hexokinase 1 0.027
NCKAP1 NCK-associated protein 1 0.027
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.026
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.026
CADM3 cell adhesion molecule 3 0.026
VPS33B vacuolar protein sorting 33 homolog B (yeast) 0.026
DYNLL1 dynein, light chain, LC8-type 1 0.025
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.025
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 0.025
SOD1 superoxide dismutase 1, soluble 0.025
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.025
DBN1 drebrin 1 0.025
EMX1 empty spiracles homeobox 1 0.025
MRPL20 mitochondrial ribosomal protein L20 0.024
PPID peptidylprolyl isomerase D 0.024
PLXNA3 plexin A3 0.024
BTBD2 BTB (POZ) domain containing 2 0.024
RIBC2 RIB43A domain with coiled-coils 2 0.023
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.999
Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) 0.992
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.976
Drd2 dopamine receptor D2 0.956
Gabrb2 gamma-aminobutyric acid (GABA) A receptor, subunit beta 2 0.944
Neurod1 neurogenic differentiation 1 0.942
Dlg4 discs, large homolog 4 (Drosophila) 0.935
Grid1 glutamate receptor, ionotropic, delta 1 0.795
Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) 0.790
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 0.785
Emx1 empty spiracles homolog 1 (Drosophila) 0.781
Gabra2 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2 0.671
Gria4 glutamate receptor, ionotropic, AMPA4 (alpha 4) 0.631
Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) 0.606
Cacng2 calcium channel, voltage-dependent, gamma subunit 2 0.560
Gabra1 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 0.555
Gad2 glutamic acid decarboxylase 2 0.554
Ntrk3 neurotrophic tyrosine kinase, receptor, type 3 0.547
Hand1 heart and neural crest derivatives expressed transcript 1 0.544
Bdnf brain derived neurotrophic factor 0.494
Pgr progesterone receptor 0.480
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.426
Neurog2 neurogenin 2 0.423
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.413
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.389
Shc3 src homology 2 domain-containing transforming protein C3 0.381
Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) 0.363
Bcl2 B-cell leukemia/lymphoma 2 0.360
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.349
Lep leptin 0.340
Rho rhodopsin 0.339
Cux2 cut-like homeobox 2 0.336
Cntn4 contactin 4 0.321
Grik2 glutamate receptor, ionotropic, kainate 2 (beta 2) 0.300
Sstr4 somatostatin receptor 4 0.295
Bsn bassoon 0.292
Adrb1 adrenergic receptor, beta 1 0.278
Camk2a calcium/calmodulin-dependent protein kinase II alpha 0.275
Cnr1 cannabinoid receptor 1 (brain) 0.272
Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 0.272
Adm adrenomedullin 0.265
Kcnj11 potassium inwardly rectifying channel, subfamily J, member 11 0.257
Rims1 regulating synaptic membrane exocytosis 1 0.251
Nxph2 neurexophilin 2 0.246
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.238
Pdx1 pancreatic and duodenal homeobox 1 0.232
Scn1a sodium channel, voltage-gated, type I, alpha 0.221
Dab1 disabled homolog 1 (Drosophila) 0.209
Cacnb2 calcium channel, voltage-dependent, beta 2 subunit 0.208
Nos1 nitric oxide synthase 1, neuronal 0.200
Pnpla2 patatin-like phospholipase domain containing 2 0.196
Kcna4 potassium voltage-gated channel, shaker-related subfamily, member 4 0.193
Grm8 glutamate receptor, metabotropic 8 0.190
Oprk1 opioid receptor, kappa 1 0.188
Gabrd gamma-aminobutyric acid (GABA) A receptor, subunit delta 0.179
Lhx6 LIM homeobox protein 6 0.179
Nxph1 neurexophilin 1 0.179
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.178
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 0.178
Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 0.177
Kcnd1 potassium voltage-gated channel, Shal-related family, member 1 0.177
Stx1b syntaxin 1B 0.173
Grm2 glutamate receptor, metabotropic 2 0.166
Lrp1b low density lipoprotein-related protein 1B (deleted in tumors) 0.166
Nhlh1 nescient helix loop helix 1 0.166
Npy2r neuropeptide Y receptor Y2 0.162
Shh sonic hedgehog 0.158
Mecom MDS1 and EVI1 complex locus 0.150
Kl klotho 0.150
Gabrg2 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 0.149
Npy5r neuropeptide Y receptor Y5 0.145
Syn2 synapsin II 0.142
Kcnq2 potassium voltage-gated channel, subfamily Q, member 2 0.141
Gabra5 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5 0.139
Plcb1 phospholipase C, beta 1 0.138
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.137
Prph2 peripherin 2 0.136
Epha5 Eph receptor A5 0.134
Mmp24 matrix metallopeptidase 24 0.128
Gabra3 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3 0.126
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.125
Cdh8 cadherin 8 0.124
Nrg3 neuregulin 3 0.122
Adra2c adrenergic receptor, alpha 2c 0.116
Oprl1 opioid receptor-like 1 0.114
Fxyd7 FXYD domain-containing ion transport regulator 7 0.113
Npas1 neuronal PAS domain protein 1 0.111
Neurog3 neurogenin 3 0.111
Cckbr cholecystokinin B receptor 0.110
Fgf14 fibroblast growth factor 14 0.110
Slc18a3 solute carrier family 18 (vesicular monoamine), member 3 0.109
Pcdh10 protocadherin 10 0.109
Hdac4 histone deacetylase 4 0.109
Onecut1 one cut domain, family member 1 0.107
Kcnk3 potassium channel, subfamily K, member 3 0.105
Calb1 calbindin 1 0.103
Crb2 crumbs homolog 2 (Drosophila) 0.102
Dlx1 distal-less homeobox 1 0.102
Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) 0.102
Tac2 tachykinin 2 0.101
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Rattus norvegicus
Name Description Probability Func Analog Organism
Dlgap3 discs, large (Drosophila) homolog-associated protein 3 0.177
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.068
Foxe3 forkhead box E3 0.058
Lin7b lin-7 homolog b (C. elegans) 0.049
Chrne cholinergic receptor, nicotinic, epsilon 0.046
Kl Klotho 0.043
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.038
Il13 interleukin 13 0.038
Accn3 amiloride-sensitive cation channel 3 0.037
Adrb1 adrenergic, beta-1-, receptor 0.033
Grm6 glutamate receptor, metabotropic 6 0.028
Oprd1 opioid receptor, delta 1 0.027
Ucn urocortin 0.026
Htr6 5-hydroxytryptamine (serotonin) receptor 6 0.026
Slc6a5 solute carrier family 6 (neurotransmitter transporter, glycine), member 5 0.024
Slc8a2 solute carrier family 8 (sodium/calcium exchanger), member 2 0.023
Pdyn prodynorphin 0.022
Lim2 lens intrinsic membrane protein 2 0.021
Crybb3 crystallin, beta B3 0.021
Hyal2 hyaluronoglucosaminidase 2 0.019
Nppa natriuretic peptide precursor A 0.018
Scn4a sodium channel, voltage-gated, type IV, alpha subunit 0.018
Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 0.018
Prp15 proline-rich protein 15 0.017
Sst somatostatin 0.017
Ppy pancreatic polypeptide 0.016
Mfrp membrane frizzled-related protein 0.016
Csf3 colony stimulating factor 3 (granulocyte) 0.016
Mgat3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase 0.015
Crhr1 corticotropin releasing hormone receptor 1 0.015
Lep leptin 0.015
Gria1 glutamate receptor, ionotropic, AMPA 1 0.014
Olr226 olfactory receptor 226 0.014
Htr5b 5-hydroxytryptamine (serotonin) receptor 5B 0.014
Chrm1 cholinergic receptor, muscarinic 1 0.014
Synpo synaptopodin 0.014
Mmp7 matrix metallopeptidase 7 0.013
Chrnb2 cholinergic receptor, nicotinic, beta 2 (neuronal) 0.013
Arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.013
Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 0.012
P2ry4 pyrimidinergic receptor P2Y, G-protein coupled, 4 0.012
Rhbdl1 rhomboid, veinlet-like 1 (Drosophila) 0.012
Il12b interleukin 12B 0.012
Esr2 estrogen receptor 2 (ER beta) 0.012
Aanat arylalkylamine N-acetyltransferase 0.011
Rin1 Ras and Rab interactor 1 0.011
Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 0.011
Mef2d myocyte enhancer factor 2D 0.011
Reg3g regenerating islet-derived 3 gamma 0.010
Psg19 pregnancy specific glycoprotein 19 0.010
RT1-DOa RT1 class II, locus DOa 0.010
Gdf10 growth differentiation factor 10 0.010
Hnf1a HNF1 homeobox A 0.010
Kcnh7 potassium voltage-gated channel, subfamily H (eag-related), member 7 0.010
Chga chromogranin A 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism