The network for 'inner ear morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

inner ear morphogenesis

The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.

Mus musculus
Name Description Probability Func Analog Organism
Eya1 eyes absent 1 homolog (Drosophila) 1.000
Pax2 paired box gene 2 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Shh sonic hedgehog 1.000
Vangl2 vang-like 2 (van gogh, Drosophila) 0.999
Foxg1 forkhead box G1 0.999
Gbx2 gastrulation brain homeobox 2 0.999
Pax3 paired box gene 3 0.999
Foxc1 forkhead box C1 0.999
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.999
Hoxa1 homeobox A1 0.998
Chd7 chromodomain helicase DNA binding protein 7 0.997
Fgf8 fibroblast growth factor 8 0.996
Dlx5 distal-less homeobox 5 0.995
Hand2 heart and neural crest derivatives expressed transcript 2 0.994
Otx2 orthodenticle homolog 2 (Drosophila) 0.994
Tbx3 T-box 3 0.993
Msx1 homeobox, msh-like 1 0.993
Fgfr2 fibroblast growth factor receptor 2 0.992
Hand1 heart and neural crest derivatives expressed transcript 1 0.991
Pax6 paired box gene 6 0.990
Sall4 sal-like 4 (Drosophila) 0.989
Nog noggin 0.988
Prrx1 paired related homeobox 1 0.988
Fgf10 fibroblast growth factor 10 0.987
Gli2 GLI-Kruppel family member GLI2 0.987
Pax8 paired box gene 8 0.985
Efnb2 ephrin B2 0.985
Sox2 SRY-box containing gene 2 0.985
Rarg retinoic acid receptor, gamma 0.981
Jag1 jagged 1 0.981
Foxc2 forkhead box C2 0.977
Bmp7 bone morphogenetic protein 7 0.973
Ptk7 PTK7 protein tyrosine kinase 7 0.969
Pou4f3 POU domain, class 4, transcription factor 3 0.969
Gata3 GATA binding protein 3 0.966
Kcne1 potassium voltage-gated channel, Isk-related subfamily, member 1 0.966
Pitx2 paired-like homeodomain transcription factor 2 0.964
Cdh23 cadherin 23 (otocadherin) 0.964
Lmx1b LIM homeobox transcription factor 1 beta 0.964
Bmp4 bone morphogenetic protein 4 0.958
Fgfr1 fibroblast growth factor receptor 1 0.957
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.954
Hoxa2 homeobox A2 0.952
Ush1g Usher syndrome 1G homolog (human) 0.949
Hoxd13 homeobox D13 0.941
Hmx3 H6 homeobox 3 0.937
Tgfb2 transforming growth factor, beta 2 0.937
Rarb retinoic acid receptor, beta 0.928
Pax9 paired box gene 9 0.925
Neurod1 neurogenic differentiation 1 0.914
Lhx3 LIM homeobox protein 3 0.906
Pou3f3 POU domain, class 3, transcription factor 3 0.889
Isl1 ISL1 transcription factor, LIM/homeodomain 0.888
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.882
Tcfap2a transcription factor AP-2, alpha 0.880
Gdnf glial cell line derived neurotrophic factor 0.878
Lmx1a LIM homeobox transcription factor 1 alpha 0.876
Msx2 homeobox, msh-like 2 0.874
Hes1 hairy and enhancer of split 1 (Drosophila) 0.867
Ednra endothelin receptor type A 0.866
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.856
Grxcr1 glutaredoxin, cysteine rich 1 0.844
Gsc goosecoid homeobox 0.839
Hoxd3 homeobox D3 0.834
Hoxb1 homeobox B1 0.827
T brachyury 0.824
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.813
Hoxa13 homeobox A13 0.807
Espn espin 0.800
Pbx1 pre B-cell leukemia transcription factor 1 0.793
Kiss1 KiSS-1 metastasis-suppressor 0.780
Emx2 empty spiracles homolog 2 (Drosophila) 0.775
Ush1c Usher syndrome 1C homolog (human) 0.764
Chrd chordin 0.763
Pitx1 paired-like homeodomain transcription factor 1 0.763
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.758
Sall1 sal-like 1 (Drosophila) 0.755
Smad1 MAD homolog 1 (Drosophila) 0.748
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.742
Myo6 myosin VI 0.742
Srrm4 serine/arginine repetitive matrix 4 0.741
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.733
Prrx2 paired related homeobox 2 0.731
Neurog3 neurogenin 3 0.716
Gli1 GLI-Kruppel family member GLI1 0.705
Sox9 SRY-box containing gene 9 0.704
Insm1 insulinoma-associated 1 0.704
Snai1 snail homolog 1 (Drosophila) 0.701
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.700
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.694
Emx1 empty spiracles homolog 1 (Drosophila) 0.692
Sall3 sal-like 3 (Drosophila) 0.690
Atoh1 atonal homolog 1 (Drosophila) 0.686
Spry4 sprouty homolog 4 (Drosophila) 0.673
Dlx1 distal-less homeobox 1 0.671
Tbx1 T-box 1 0.669
Fgf5 fibroblast growth factor 5 0.667
Hmx1 H6 homeobox 1 0.659
Acvr1 activin A receptor, type 1 0.657
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
dla deltaA 0.994
eya1 eyes absent homolog 1 0.994
mib mind bomb 0.990
gata3 GATA-binding protein 3 0.990
bmp4 bone morphogenetic protein 4 0.986
bmp2b bone morphogenetic protein 2b 0.986
fgf3 fibroblast growth factor 3 0.978
hnf1ba HNF1 homeobox Ba 0.969
flh floating head 0.957
tbx1 T-box 1 0.948
dlx2a distal-less homeobox gene 2a 0.935
msxc muscle segment homeobox C 0.930
pax2a paired box gene 2a 0.927
atoh1b atonal homolog 1b 0.914
ndr2 nodal-related 2 0.903
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.900
dlx5a distal-less homeobox gene 5a 0.893
fgf17 fibroblast growth factor 17 0.879
gpr126 G protein-coupled receptor 126 0.854
sox10 SRY-box containing gene 10 0.844
chd chordin 0.841
sox2 SRY-box containing gene 2 0.839
dlx4b distal-less homeobox gene 4b 0.831
hand2 heart and neural crest derivatives expressed transcript 2 0.822
fgfr4 fibroblast growth factor receptor 4 0.804
gbx2 gastrulation brain homeo box 2 0.801
six4b sine oculis homeobox homolog 4b 0.800
hmx3 homeo box (H6 family) 3 0.795
slc12a2 solute carrier family 12 (potassium/chloride transporters), member 2 0.795
jag1b jagged 1b 0.794
foxc1a forkhead box C1a 0.760
foxi1 forkhead box I1 0.759
eve1 even-skipped-like1 0.759
bmp2a bone morphogenetic protein 2a 0.734
ncs1a neuronal calcium sensor 1a 0.734
dlx4a distal-less homeobox gene 4a 0.725
pax8 paired box gene 8 0.724
igfbp3 insulin-like growth factor binding protein 3 0.721
gli2a GLI-Kruppel family member GLI2a 0.680
shha sonic hedgehog a 0.672
myo7aa myosin VIIAa 0.655
foxg1a forkhead box G1a 0.653
tbx16 T-box gene 16 0.651
osr1 odd-skipped related 1 (Drosophila) 0.638
gli1 GLI-Kruppel family member 1 0.637
gata2a GATA-binding protein 2a 0.632
pitx3 paired-like homeodomain transcription factor 3 0.632
tbx2b T-box 2b 0.618
ntla no tail a 0.600
dlc deltaC 0.593
wls wntless homolog (Drosophila) 0.591
isl1 islet1 0.583
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.580
kdrl kinase insert domain receptor like 0.580
pitx2 paired-like homeodomain transcription factor 2 0.572
dlx2b distal-less homeobox gene 2b 0.561
fgfr1a fibroblast growth factor receptor 1a 0.557
dacha dachshund a 0.548
fgf10a fibroblast growth factor 10a 0.522
jag2 jagged 2 0.521
edn1 endothelin 1 0.516
rx2 retinal homeobox gene 2 0.511
sox9a SRY-box containing gene 9a 0.496
foxa2 forkhead box A2 0.496
hhip hedgehog interacting protein 0.491
snai1b snail homolog 1b (Drosophila) 0.490
pcdh10b protocadherin 10b 0.476
twist3 twist3 0.471
prdm1a PR domain containing 1a, with ZNF domain 0.469
tgfb3 transforming growth factor, beta 3 0.460
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.454
fgf8a fibroblast growth factor 8 a 0.453
myod1 myogenic differentiation 1 0.450
shhb sonic hedgehog b 0.449
emx3 empty spiracles homeobox 3 0.442
aldh1a3 aldehyde dehydrogenase 1 family, member A3 0.441
pax9 paired box gene 9 0.435
dlx6a distal-less homeobox gene 6a 0.432
ved ventrally expressed dharma/bozozok antagonist 0.431
eya4 eyes absent homolog 4 (Drosophila) 0.430
irx1b iroquois homeobox protein 1, b 0.429
irx3a iroquois homeobox protein 3a 0.419
atoh1a atonal homolog 1a 0.412
cldnh claudin h 0.411
tp63 tumor protein p63 0.408
wnt1 wingless-type MMTV integration site family, member 1 0.395
atp1a1a.2 ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide 0.395
barhl2 BarH-like 2 0.387
sall4 sal-like 4 (Drosophila) 0.378
hmx2 H6 family homeobox 2 0.374
atp1b2b ATPase, Na+/K+ transporting, beta 2b polypeptide 0.374
ascl1a achaete-scute complex-like 1a (Drosophila) 0.361
wnt7aa wingless-type MMTV integration site family, member 7Aa 0.354
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.345
raraa retinoic acid receptor, alpha a 0.344
etv5b ets variant 5b 0.341
irx5a iroquois homeobox protein 5a 0.340
hoxb3a homeo box B3a 0.338
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.330
wnt3 wingless-type MMTV integration site family, member 3 0.328
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.998
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.901
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.893
VEGFA vascular endothelial growth factor A 0.870
DHCR7 7-dehydrocholesterol reductase 0.870
FSTL1 follistatin-like 1 0.865
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.813
TRIP6 thyroid hormone receptor interactor 6 0.792
CSNK1E casein kinase 1, epsilon 0.764
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.755
TAL1 T-cell acute lymphocytic leukemia 1 0.747
CHD8 chromodomain helicase DNA binding protein 8 0.722
TBC1D10A TBC1 domain family, member 10A 0.721
SEC23A Sec23 homolog A (S. cerevisiae) 0.696
NOTCH3 notch 3 0.662
INSR insulin receptor 0.632
NOTCH1 notch 1 0.615
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.604
CHD7 chromodomain helicase DNA binding protein 7 0.584
BMP1 bone morphogenetic protein 1 0.574
NKX2-1 NK2 homeobox 1 0.560
BMPR1A bone morphogenetic protein receptor, type IA 0.559
PTCH1 patched 1 0.507
ATN1 atrophin 1 0.495
ZFYVE9 zinc finger, FYVE domain containing 9 0.484
PPARA peroxisome proliferator-activated receptor alpha 0.381
USH1C Usher syndrome 1C (autosomal recessive, severe) 0.374
MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) 0.369
FGF10 fibroblast growth factor 10 0.368
PDZK1 PDZ domain containing 1 0.351
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.348
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 0.347
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.336
BBS10 Bardet-Biedl syndrome 10 0.336
MSX2 msh homeobox 2 0.320
AXIN1 axin 1 0.314
DHCR24 24-dehydrocholesterol reductase 0.298
IDI1 isopentenyl-diphosphate delta isomerase 1 0.293
HNF4A hepatocyte nuclear factor 4, alpha 0.284
COL2A1 collagen, type II, alpha 1 0.282
PAX2 paired box 2 0.280
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.271
WT1 Wilms tumor 1 0.267
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.263
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.258
SC4MOL sterol-C4-methyl oxidase-like 0.254
GRB10 growth factor receptor-bound protein 10 0.250
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.247
SIX3 SIX homeobox 3 0.245
TJP2 tight junction protein 2 (zona occludens 2) 0.236
FGFR2 fibroblast growth factor receptor 2 0.235
HOXC8 homeobox C8 0.231
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.230
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.226
LRRK2 leucine-rich repeat kinase 2 0.223
APC adenomatous polyposis coli 0.220
HOXA10 homeobox A10 0.218
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.203
HIPK2 homeodomain interacting protein kinase 2 0.199
KRTAP4-12 keratin associated protein 4-12 0.190
FGF1 fibroblast growth factor 1 (acidic) 0.190
GOPC golgi-associated PDZ and coiled-coil motif containing 0.187
IRS1 insulin receptor substrate 1 0.183
RNF11 ring finger protein 11 0.182
LHX1 LIM homeobox 1 0.177
ACAN aggrecan 0.177
SIM2 single-minded homolog 2 (Drosophila) 0.172
MDFI MyoD family inhibitor 0.170
USH1G Usher syndrome 1G (autosomal recessive) 0.168
KCTD1 potassium channel tetramerisation domain containing 1 0.167
DLX2 distal-less homeobox 2 0.167
FZD1 frizzled homolog 1 (Drosophila) 0.166
SH3BP4 SH3-domain binding protein 4 0.163
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 0.159
SOX1 SRY (sex determining region Y)-box 1 0.154
CEP164 centrosomal protein 164kDa 0.152
HNF1B HNF1 homeobox B 0.144
CAV1 caveolin 1, caveolae protein, 22kDa 0.143
LRP6 low density lipoprotein receptor-related protein 6 0.143
FGF8 fibroblast growth factor 8 (androgen-induced) 0.142
LBX1 ladybird homeobox 1 0.142
FOXA2 forkhead box A2 0.142
ADAM12 ADAM metallopeptidase domain 12 0.140
FADS1 fatty acid desaturase 1 0.138
EGFR epidermal growth factor receptor 0.135
PAX8 paired box 8 0.133
WNT7A wingless-type MMTV integration site family, member 7A 0.131
HOXD9 homeobox D9 0.130
AFF2 AF4/FMR2 family, member 2 0.128
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.128
PRPF3 PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) 0.126
FRS2 fibroblast growth factor receptor substrate 2 0.124
HOXB9 homeobox B9 0.122
SLC9A3R2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.121
MSX1 msh homeobox 1 0.121
SQLE squalene epoxidase 0.119
LHX2 LIM homeobox 2 0.118
VAX2 ventral anterior homeobox 2 0.117
TWIST1 twist homolog 1 (Drosophila) 0.117
HMGA2 high mobility group AT-hook 2 0.115
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Rattus norvegicus
Name Description Probability Func Analog Organism
Nr4a2 nuclear receptor subfamily 4, group A, member 2 0.101
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.054
Nfib nuclear factor I/B 0.046
App amyloid beta (A4) precursor protein 0.043
Fam65a family with sequence similarity 65, member A 0.039
Dab2 disabled homolog 2 (Drosophila) 0.034
Golph3 golgi phosphoprotein 3 (coat-protein) 0.033
Fgfr1 Fibroblast growth factor receptor 1 0.032
Mapk3 mitogen activated protein kinase 3 0.030
Col5a1 collagen, type V, alpha 1 0.030
Hk1 hexokinase 1 0.029
Galr2 galanin receptor 2 0.026
Kl Klotho 0.026
Igfbp7 insulin-like growth factor binding protein 7 0.026
Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.025
Sirpa signal-regulatory protein alpha 0.025
Slc18a3 solute carrier family 18 (vesicular acetylcholine), member 3 0.025
Tgfbr2 transforming growth factor, beta receptor II 0.024
Glg1 golgi apparatus protein 1 0.023
Aif1l allograft inflammatory factor 1-like 0.023
Unc5b unc-5 homolog B (C. elegans) 0.022
Hhip Hedgehog-interacting protein 0.022
Vdr vitamin D (1,25- dihydroxyvitamin D3) receptor 0.022
Syngap1 synaptic Ras GTPase activating protein 1 homolog (rat) 0.022
Lyve1 lymphatic vessel endothelial hyaluronan receptor 1 0.022
Igsf1 immunoglobulin superfamily, member 1 0.022
Sept8 septin 8 0.022
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.021
Crip2 cysteine-rich protein 2 0.021
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.021
Proc protein C 0.021
Egr2 early growth response 2 0.021
RGD1305627 hypothetical LOC314467 0.020
Pxdn peroxidasin homolog (Drosophila) 0.020
Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 0.020
Dlg4 discs, large homolog 4 (Drosophila) 0.020
Gucy2g guanylate cyclase 2G 0.019
Fyn FYN oncogene related to SRC, FGR, YES 0.019
Ccnd2 cyclin D2 0.019
Scarf2 scavenger receptor class F, member 2 0.019
Slc22a7 solute carrier family 22 (organic anion transporter), member 7 0.019
Pax8 paired box 8 0.019
Rgr retinal G protein coupled receptor 0.019
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.019
Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.018
Htr6 5-hydroxytryptamine (serotonin) receptor 6 0.018
Kcnip3 Kv channel interacting protein 3, calsenilin 0.018
Igf2 insulin-like growth factor 2 0.018
Cxxc4 CXXC finger 4 0.018
Bmp1 bone morphogenetic protein 1 0.018
Src v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.018
Akt2 v-akt murine thymoma viral oncogene homolog 2 0.018
Marcks myristoylated alanine rich protein kinase C substrate 0.018
Igfbp5 insulin-like growth factor binding protein 5 0.018
Myl9 myosin, light chain 9, regulatory 0.018
Nfix nuclear factor I/X (CCAAT-binding transcription factor) 0.018
Grm5 glutamate receptor, metabotropic 5 0.018
Akt1 v-akt murine thymoma viral oncogene homolog 1 0.017
Prdm12 PR domain containing 12 0.017
Kcnd1 potassium voltage-gated channel, Shal-related subfamily, member 1 0.017
Ppp2r2c protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform 0.017
Ppap2b phosphatidic acid phosphatase type 2B 0.017
Cit citron 0.017
Gna12 guanine nucleotide binding protein (G protein) alpha 12 0.017
Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 0.016
Vax1 ventral anterior homeobox 1 0.016
Ldlr low density lipoprotein receptor 0.016
Nr4a1 nuclear receptor subfamily 4, group A, member 1 0.016
LOC100361486 rCG55595-like 0.016
Tgfb3 transforming growth factor, beta 3 0.016
Shox2 short stature homeobox 2 0.016
Nfic nuclear factor I/C 0.016
Akap4 A kinase (PRKA) anchor protein 4 0.016
Acan aggrecan 0.016
Dchs1 dachsous 1 (Drosophila) 0.016
Trpv4 transient receptor potential cation channel, subfamily V, member 4 0.016
Ehf ets homologous factor 0.016
Notch1 Notch homolog 1, translocation-associated (Drosophila) 0.016
B4galt2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 0.015
Irs3 insulin receptor substrate 3 0.015
Eef2 eukaryotic translation elongation factor 2 0.015
Galr3 galanin receptor 3 0.015
Sox4 SRY (sex determining region Y)-box 4 0.015
Ddah1 dimethylarginine dimethylaminohydrolase 1 0.015
Map3k3 mitogen activated protein kinase kinase kinase 3 0.015
Esr1 estrogen receptor 1 0.015
Sox17 SRY (sex determining region Y)-box 17 0.015
Rhoa ras homolog gene family, member A 0.015
Itpr2 inositol 1,4,5-triphosphate receptor, type 2 0.015
Map2 microtubule-associated protein 2 0.015
Aldh7a1 aldehyde dehydrogenase 7 family, member A1 0.015
Pnma1 paraneoplastic antigen MA1 0.015
Sardh sarcosine dehydrogenase 0.015
Unc5a unc-5 homolog A (C. elegans) 0.015
Hapln1 hyaluronan and proteoglycan link protein 1 0.015
Mast2 microtubule associated serine/threonine kinase 2 0.015
Arf6 ADP-ribosylation factor 6 0.014
Kctd15 potassium channel tetramerisation domain containing 15 0.014
Npy5r neuropeptide Y receptor Y5 0.014
Scarb1 scavenger receptor class B, member 1 0.014
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism