The network for 'activation of nf kappab inducing kinase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

activation of nf kappab inducing kinase activity

The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues.

Mus musculus
Name Description Probability Func Analog Organism
Map3k7 mitogen-activated protein kinase kinase kinase 7 1.000
Traf6 TNF receptor-associated factor 6 1.000
Ikbkg inhibitor of kappaB kinase gamma 1.000
Ikbkb inhibitor of kappaB kinase beta 1.000
Chuk conserved helix-loop-helix ubiquitous kinase 0.929
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.926
Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.919
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.910
Myd88 myeloid differentiation primary response gene 88 0.895
Hspa1b heat shock protein 1B 0.838
Umod uromodulin 0.711
Agtr1a angiotensin II receptor, type 1a 0.559
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.491
Irak3 interleukin-1 receptor-associated kinase 3 0.469
Rnf31 ring finger protein 31 0.378
Serpina1b serine (or cysteine) preptidase inhibitor, clade A, member 1B 0.346
Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 0.337
Smad1 MAD homolog 1 (Drosophila) 0.286
Ren1 renin 1 structural 0.273
Nr0b2 nuclear receptor subfamily 0, group B, member 2 0.253
Tifa TRAF-interacting protein with forkhead-associated domain 0.253
Gps1 G protein pathway suppressor 1 0.238
Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.222
Cd40 CD40 antigen 0.219
Skil SKI-like 0.182
Ube2n ubiquitin-conjugating enzyme E2N 0.171
Trafd1 TRAF type zinc finger domain containing 1 0.170
Irak1 interleukin-1 receptor-associated kinase 1 0.167
Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 0.167
Serpina3c serine (or cysteine) peptidase inhibitor, clade A, member 3C 0.166
Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.139
Lrg1 leucine-rich alpha-2-glycoprotein 1 0.137
Itch itchy, E3 ubiquitin protein ligase 0.134
Traf3ip2 TRAF3 interacting protein 2 0.109
Birc3 baculoviral IAP repeat-containing 3 0.109
Serpina1a serine (or cysteine) peptidase inhibitor, clade A, member 1A 0.097
C4b complement component 4B (Childo blood group) 0.094
Serpina3m serine (or cysteine) peptidase inhibitor, clade A, member 3M 0.092
Hp haptoglobin 0.089
Map3k1 mitogen-activated protein kinase kinase kinase 1 0.087
Agtr2 angiotensin II receptor, type 2 0.085
Lbp lipopolysaccharide binding protein 0.084
Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 0.079
Itih3 inter-alpha trypsin inhibitor, heavy chain 3 0.078
Ecsit ECSIT homolog (Drosophila) 0.074
Ltbr lymphotoxin B receptor 0.074
Peli2 pellino 2 0.072
Tmprss11e transmembrane protease, serine 11e 0.067
Cp ceruloplasmin 0.065
Cyld cylindromatosis (turban tumor syndrome) 0.064
Ahr aryl-hydrocarbon receptor 0.063
F9 coagulation factor IX 0.060
Zmpste24 zinc metallopeptidase, STE24 homolog (S. cerevisiae) 0.057
Map2k4 mitogen-activated protein kinase kinase 4 0.056
Igh immunoglobulin heavy chain complex 0.054
Gm11567 predicted gene 11567 0.053
Edar ectodysplasin-A receptor 0.053
Itih4 inter alpha-trypsin inhibitor, heavy chain 4 0.051
Card11 caspase recruitment domain family, member 11 0.051
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.050
Malt1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.049
Stat3 signal transducer and activator of transcription 3 0.049
Serpina1c serine (or cysteine) peptidase inhibitor, clade A, member 1C 0.047
Apoc4 apolipoprotein C-IV 0.046
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.045
Cyp2c50 cytochrome P450, family 2, subfamily c, polypeptide 50 0.043
Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 0.041
Alb albumin 0.041
Map3k3 mitogen-activated protein kinase kinase kinase 3 0.041
Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 0.040
Ripk2 receptor (TNFRSF)-interacting serine-threonine kinase 2 0.040
Slc10a6 solute carrier family 10 (sodium/bile acid cotransporter family), member 6 0.040
Sharpin SHANK-associated RH domain interacting protein 0.040
Il1r1 interleukin 1 receptor, type I 0.039
Apof apolipoprotein F 0.039
Ahsg alpha-2-HS-glycoprotein 0.038
Hspa1a heat shock protein 1A 0.038
Eda ectodysplasin-A 0.038
Steap4 STEAP family member 4 0.037
Traf2 TNF receptor-associated factor 2 0.037
Eln elastin 0.036
Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 0.036
Bcl6 B-cell leukemia/lymphoma 6 0.034
Bcl10 B-cell leukemia/lymphoma 10 0.033
Lcn2 lipocalin 2 0.033
Slc7a2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.032
Baat bile acid-Coenzyme A: amino acid N-acyltransferase 0.032
Slc12a1 solute carrier family 12, member 1 0.031
Smad5 MAD homolog 5 (Drosophila) 0.031
Lepr leptin receptor 0.031
Jag1 jagged 1 0.031
Kng1 kininogen 1 0.030
Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 0.030
C3 complement component 3 0.030
Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide 0.028
F10 coagulation factor X 0.027
Tdo2 tryptophan 2,3-dioxygenase 0.027
Id2 inhibitor of DNA binding 2 0.027
Pi16 peptidase inhibitor 16 0.027
Trp53 transformation related protein 53 0.026
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
TRAF6 TNF receptor-associated factor 6 1.000
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.992
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.992
IRAK2 interleukin-1 receptor-associated kinase 2 0.958
BCL10 B-cell CLL/lymphoma 10 0.938
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.910
TRAF3 TNF receptor-associated factor 3 0.908
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.848
TRAF2 TNF receptor-associated factor 2 0.838
CFLAR CASP8 and FADD-like apoptosis regulator 0.782
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.756
IRAK1 interleukin-1 receptor-associated kinase 1 0.751
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.735
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.693
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.608
BIRC3 baculoviral IAP repeat containing 3 0.585
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.569
SQSTM1 sequestosome 1 0.564
CD40 CD40 molecule, TNF receptor superfamily member 5 0.564
PELI3 pellino homolog 3 (Drosophila) 0.506
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.450
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.317
RIPK2 receptor-interacting serine-threonine kinase 2 0.268
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.266
GFER growth factor, augmenter of liver regeneration 0.261
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 0.244
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.215
NUMBL numb homolog (Drosophila)-like 0.212
ZNF512B zinc finger protein 512B 0.166
TRAF1 TNF receptor-associated factor 1 0.151
ZMYND11 zinc finger, MYND-type containing 11 0.139
COPS2 COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) 0.137
ZC3H12A zinc finger CCCH-type containing 12A 0.096
BBS10 Bardet-Biedl syndrome 10 0.084
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.074
TRAF5 TNF receptor-associated factor 5 0.073
TNIP2 TNFAIP3 interacting protein 2 0.062
C1orf93 chromosome 1 open reading frame 93 0.058
CD14 CD14 molecule 0.058
CARD11 caspase recruitment domain family, member 11 0.055
IRAK3 interleukin-1 receptor-associated kinase 3 0.040
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.038
TRAF3IP2 TRAF3 interacting protein 2 0.035
TRADD TNFRSF1A-associated via death domain 0.029
FAS Fas (TNF receptor superfamily, member 6) 0.028
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.027
MAP3K7 mitogen-activated protein kinase kinase kinase 7 0.021
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 0.020
ING2 inhibitor of growth family, member 2 0.019
GPS1 G protein pathway suppressor 1 0.016
PDPK1 3-phosphoinositide dependent protein kinase-1 0.016
ZBTB8A zinc finger and BTB domain containing 8A 0.016
FADD Fas (TNFRSF6)-associated via death domain 0.015
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.015
C9orf89 chromosome 9 open reading frame 89 0.015
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.014
KIAA1377 KIAA1377 0.011
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 0.011
LMO4 LIM domain only 4 0.011
PRKCB protein kinase C, beta 0.010
TANK TRAF family member-associated NFKB activator 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism