The network for 'regulation of programmed cell death' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of programmed cell death

Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes.

Rattus norvegicus
Name Description Probability Func Analog Organism
Mapk3 mitogen activated protein kinase 3 0.870
Cd44 Cd44 molecule 0.865
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.831
Hspb1 heat shock protein 1 0.808
Anxa4 annexin A4 0.776
Socs3 suppressor of cytokine signaling 3 0.772
Ar androgen receptor 0.752
Klf4 Kruppel-like factor 4 (gut) 0.724
Arpc1b actin related protein 2/3 complex, subunit 1B 0.673
Anxa5 annexin A5 0.664
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.661
Pfkfb3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.657
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.656
Ptprc protein tyrosine phosphatase, receptor type, C 0.650
Anxa2 annexin A2 0.647
RGD1564327 similar to integrin alpha 8 0.635
Cd14 CD14 molecule 0.620
Cd4 Cd4 molecule 0.611
Itgam integrin, alpha M 0.607
Nr4a2 nuclear receptor subfamily 4, group A, member 2 0.581
Errfi1 ERBB receptor feedback inhibitor 1 0.570
Flt1 FMS-related tyrosine kinase 1 0.558
Hspa1a heat shock 70kD protein 1A 0.557
Ddr1 discoidin domain receptor tyrosine kinase 1 0.550
Notch3 Notch homolog 3 (Drosophila) 0.549
St18 suppression of tumorigenicity 18 0.534
Hspa5 heat shock protein 5 0.522
Fos FBJ osteosarcoma oncogene 0.522
Agtr1a angiotensin II receptor, type 1a 0.518
Dusp1 dual specificity phosphatase 1 0.516
Cxcr5 chemokine (C-X-C motif) receptor 5 0.510
Ahsg alpha-2-HS-glycoprotein 0.505
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.501
Gjb3 gap junction protein, beta 3 0.496
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.488
Lilrb3l leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3-like 0.486
Alb albumin 0.486
Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.484
Prkar2a protein kinase, cAMP dependent regulatory, type II alpha 0.481
Fgfr2 fibroblast growth factor receptor 2 0.477
Ngf nerve growth factor (beta polypeptide) 0.474
Hsd3b6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 0.473
Lgals3 lectin, galactoside-binding, soluble, 3 0.470
Igfbp5 insulin-like growth factor binding protein 5 0.459
Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.458
Pdia4 protein disulfide isomerase family A, member 4 0.456
Egr1 early growth response 1 0.454
Slit3 slit homolog 3 (Drosophila) 0.449
Gzmb granzyme B 0.449
Hck hemopoietic cell kinase 0.446
Hsph1 heat shock 105/110 protein 1 0.446
P2rx2 purinergic receptor P2X, ligand-gated ion channel, 2 0.440
Prlhr prolactin releasing hormone receptor 0.436
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.435
Stip1 stress-induced phosphoprotein 1 0.434
Impdh2 IMP (inosine monophosphate) dehydrogenase 2 0.428
Ripk3 receptor-interacting serine-threonine kinase 3 0.427
Fosl1 fos-like antigen 1 0.426
Vip vasoactive intestinal peptide 0.424
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.420
Lmna lamin A 0.419
Ctrc chymotrypsin C (caldecrin) 0.409
Txnrd1 thioredoxin reductase 1 0.407
Tp53 tumor protein p53 0.405
Unc5b unc-5 homolog B (C. elegans) 0.401
Il8ra interleukin 8 receptor, alpha 0.400
Thbd thrombomodulin 0.399
Hspd1 heat shock protein 1 (chaperonin) 0.396
Cgm4 carcinoembryonic antigen gene family 4 0.391
Hand2 heart and neural crest derivatives expressed 2 0.391
Tcf4 transcription factor 4 0.389
Runx1 runt-related transcription factor 1 0.388
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.388
Fgd4 FYVE, RhoGEF and PH domain containing 4 0.365
Elk3 ELK3, ETS-domain protein 0.362
Adora2a adenosine A2a receptor 0.360
Slc12a1 solute carrier family 12 (sodium/potassium/chloride transporters), member 1 0.360
Ccr3 chemokine (C-C motif) receptor 3 0.356
Gabarapl2 GABA(A) receptor-associated protein like 2 0.356
Mdm2 Mdm2 p53 binding protein homolog (mouse) 0.355
Klf2 Kruppel-like factor 2 (lung) 0.354
Npr3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) 0.354
Dnase1l3 deoxyribonuclease 1-like 3 0.354
Vegfa vascular endothelial growth factor A 0.352
Ifitm3 interferon induced transmembrane protein 3 0.352
Egr2 early growth response 2 0.351
Jak2 Janus kinase 2 0.350
Nrg1 neuregulin 1 0.348
Timp3 TIMP metallopeptidase inhibitor 3 0.345
Chrna2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 0.345
Ctsl1 cathepsin L1 0.344
Axl Axl receptor tyrosine kinase 0.344
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.343
Vim vimentin 0.343
Lepr leptin receptor 0.342
Vat1 vesicle amine transport protein 1 homolog (T californica) 0.341
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.339
Ftl ferritin, light polypeptide 0.339
Gabra1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.339
Cct4 chaperonin containing Tcp1, subunit 4 (delta) 0.337
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
egl-18 Protein EGL-18 0.541
bar-1 Protein BAR-1 0.393
mat-3 Protein MAT-3 0.245
sma-6 Protein SMA-6 0.194
hcp-3 Protein HCP-3 0.162
cam-1 Protein CAM-1 0.158
ceh-20 Protein CEH-20 0.149
trim-9 Protein TRIM-9 0.141
nhr-45 Protein NHR-45 0.139
hsp-1 Protein HSP-1 0.134
mab-31 Protein MAB-31 0.117
egl-46 Protein EGL-46 0.116
par-5 Protein PAR-5 0.113
F36D4.5 Protein F36D4.5 0.112
glp-1 Protein GLP-1 0.111
vav-1 Protein VAV-1 0.104
inx-3 Protein INX-3 0.101
F39B2.1 Protein F39B2.1 0.101
egl-44 Protein EGL-44 0.101
nhr-67 Protein NHR-67 0.097
egl-30 Protein EGL-30 0.097
vab-3 Protein VAB-3 0.090
hum-6 Protein HUM-6 0.087
ceh-44 Protein CEH-44 0.086
flt-1 Protein FLT-1 0.078
pha-4 Protein PHA-4 0.078
F31C3.2 Protein F31C3.2 0.078
egl-13 Protein EGL-13 0.076
soc-2 Protein SOC-2 0.071
drp-1 Protein DRP-1 0.071
ifp-1 Protein IFP-1 0.070
CELE_F14E5.2 Protein F14E5.2 0.069
sax-7 Protein SAX-7 0.068
hum-5 Protein HUM-5 0.067
pat-12 Protein PAT-12 0.065
F58B3.6 Protein F58B3.6 0.065
egl-5 Protein EGL-5 0.065
H24G06.1 Protein H24G06.1 0.062
inx-13 Protein INX-13 0.062
crt-1 Protein CRT-1 0.062
eor-1 Protein EOR-1 0.059
CELE_C12D8.1 Protein C12D8.1 0.058
pal-1 Protein PAL-1 0.058
ras-1 Protein RAS-1 0.058
sel-12 Protein SEL-12 0.056
unc-53 Protein UNC-53 0.056
let-60 Protein LET-60 0.055
acdh-3 Protein ACDH-3 0.055
xbp-1 Protein XBP-1 0.055
sos-1 Protein SOS-1 0.054
ifg-1 Protein IFG-1 0.054
egl-36 Protein EGL-36 0.054
rla-0 Protein RLA-0 0.053
sem-5 Protein SEM-5 0.053
F36A2.13 Protein F36A2.13 0.052
arf-3 Protein ARF-3 0.052
clic-1 Protein CLIC-1 0.052
pry-1 Protein PRY-1 0.052
daf-1 Protein DAF-1 0.052
nhr-2 Protein NHR-2 0.051
tag-320 Protein TAG-320 0.051
unc-43 Protein UNC-43 0.050
pdfr-1 Protein PDFR-1 0.048
unc-85 Protein UNC-85 0.048
atg-18 Protein ATG-18 0.047
unc-52 Protein UNC-52 0.047
unc-37 Protein UNC-37 0.046
C35C5.3 Protein C35C5.3 0.045
R74.8 Protein R74.8 0.045
F48A11.4 Protein F48A11.4 0.045
mel-11 Protein MEL-11 0.044
rilp-1 Protein RILP-1 0.044
hlh-14 Protein HLH-14 0.043
vha-13 Protein VHA-13 0.043
zip-7 Protein ZIP-7 0.043
svh-2 Protein SVH-2 0.043
ceh-27 Protein CEH-27 0.042
imp-2 Protein IMP-2 0.042
cfim-2 Protein CFIM-2 0.042
egl-8 Protein EGL-8 0.042
rpt-3 Protein RPT-3 0.042
bre-1 Protein BRE-1 0.042
lin-29 Protein LIN-29 0.041
tct-1 Protein TCT-1 0.041
egl-23 Protein EGL-23 0.041
dlc-1 Protein DLC-1 0.041
rars-1 Protein RARS-1 0.041
zyg-1 Protein ZYG-1 0.041
T28C6.7 Protein T28C6.7 0.040
F55C12.5 Protein F55C12.5 0.040
sel-10 Protein SEL-10 0.039
CELE_W02F12.4 Protein W02F12.4 0.039
exc-5 Protein EXC-5 0.038
ahcy-1 Protein AHCY-1 0.038
rnr-2 Protein RNR-2 0.038
htz-1 Protein HTZ-1 0.038
sac-1 Protein SAC-1 0.037
C27A12.7 Protein C27A12.7 0.037
eat-6 Protein EAT-6 0.037
cdc-6 Protein CDC-6 0.036
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Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 0.852
osr1 odd-skipped related 1 (Drosophila) 0.845
bmp2b bone morphogenetic protein 2b 0.818
fgf8a fibroblast growth factor 8 a 0.755
pax2a paired box gene 2a 0.722
hand2 heart and neural crest derivatives expressed transcript 2 0.692
tal1 T-cell acute lymphocytic leukemia 1 0.681
rad21 RAD21 homolog (S. pombe) 0.581
kdrl kinase insert domain receptor like 0.574
ptf1a pancreas specific transcription factor, 1a 0.554
chd chordin 0.535
baxa bcl2-associated X protein, a 0.529
gsc goosecoid 0.527
rarga retinoic acid receptor gamma a 0.516
tbx20 T-box 20 0.492
gata3 GATA-binding protein 3 0.485
cmyb transcription factor cmyb 0.470
piwil2 piwi-like 2 (Drosophila) 0.467
tp53 tumor protein p53 0.460
efnb2a ephrin B2a 0.455
evx1 even-skipped homeobox 1 0.443
myod1 myogenic differentiation 1 0.421
sema3aa semaphorin 3aa 0.417
tgfb3 transforming growth factor, beta 3 0.413
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.405
fgfr1a fibroblast growth factor receptor 1a 0.402
brd4 bromodomain containing 4 0.386
fgfr3 fibroblast growth factor receptor 3 0.380
fgf3 fibroblast growth factor 3 0.370
tnfrsfa tumor necrosis factor receptor superfamily, member a 0.354
nfkbiaa nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a 0.339
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.336
alcamb activated leukocyte cell adhesion molecule b 0.336
dmd dystrophin 0.324
shha sonic hedgehog a 0.319
wt1a wilms tumor 1a 0.312
aplnrb apelin receptor b 0.306
raraa retinoic acid receptor, alpha a 0.303
plcg1 phospholipase C, gamma 1 0.301
fn1 fibronectin 1 0.288
tp63 tumor protein p63 0.285
runx2b runt-related transcription factor 2b 0.275
egr2b early growth response 2b 0.270
wnt4a wingless-type MMTV integration site family, member 4a 0.262
nadl1.2 neural adhesion molecule L1.2 0.254
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.253
sox11b SRY-box containing gene 11b 0.251
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.248
hspa5 heat shock protein 5 0.248
hhip hedgehog interacting protein 0.245
foxo3b forkhead box O3b 0.243
rag1 recombination activating gene 1 0.241
dld deltaD 0.229
fsta follistatin a 0.227
tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.227
nrg2a neuregulin 2a 0.225
gadd45ba growth arrest and DNA-damage-inducible, beta a 0.224
sox32 SRY-box containing gene 32 0.223
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.222
gpr126 G protein-coupled receptor 126 0.221
lef1 lymphocyte enhancer binding factor 1 0.220
tuba1 tubulin, alpha 1 0.218
sulf2l sulfatase 2, like 0.217
ef1a elongation factor 1-alpha 0.208
csnk1da casein kinase 1, delta a 0.208
tshb thyroid stimulating hormone, beta subunit 0.207
th tyrosine hydroxylase 0.206
bactin2 bactin2 0.201
msxc muscle segment homeobox C 0.200
mcl1a myeloid cell leukemia sequence 1a 0.200
ube2i ubiquitin-conjugating enzyme E2I 0.197
dlx6a distal-less homeobox gene 6a 0.196
nrp1a neuropilin 1a 0.194
wu:fv91b12 wu:fv91b12 0.193
pax6b paired box gene 6b 0.193
pkd2 polycystic kidney disease 2 0.192
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.190
notch1a notch homolog 1a 0.187
cdh1 cadherin 1, epithelial 0.187
six3b sine oculis homeobox homolog 3b 0.185
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.185
rargb retinoic acid receptor, gamma b 0.185
eml2 echinoderm microtubule associated protein like 2 0.185
LOC797832 similar to signal peptide, CUB domain, EGF-like 1 0.182
btg2 B-cell translocation gene 2 0.178
nkx2.3 NK2 transcription factor related 3 0.177
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.176
id3 inhibitor of DNA binding 3 0.175
rnd3a Rho family GTPase 3a 0.173
mib mind bomb 0.173
bbc3 BCL2 binding component 3 0.171
wnt1 wingless-type MMTV integration site family, member 1 0.170
eve1 even-skipped-like1 0.167
pcdh18b protocadherin 18b 0.163
boc brother of CDO 0.163
gng5 guanine nucleotide binding protein (G protein), gamma 5 0.162
rhoab ras homolog gene family, member Ab 0.161
fzd7a frizzled homolog 7a 0.160
her9 hairy-related 9 0.157
barx1 BarH-like homeobox 1 0.157
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Drosophila melanogaster
Name Description Probability Func Analog Organism
nej nejire 0.988
CG11347 CG11347 gene product from transcript CG11347-RE 0.986
Ras85D Ras oncogene at 85D 0.980
kay kayak 0.976
Akt1 CG4006 gene product from transcript CG4006-RA 0.945
ex expanded 0.941
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.919
ci cubitus interruptus 0.894
Atg1 Autophagy-specific gene 1 0.857
dm diminutive 0.835
rpr reaper 0.811
Pak PAK-kinase 0.810
Moe Moesin 0.796
CaMKII Calcium/calmodulin-dependent protein kinase II 0.794
Src42A Src oncogene at 42A 0.787
Rbf Retinoblastoma-family protein 0.782
G-salpha60A G protein salpha 60A 0.775
alpha-Cat alpha Catenin 0.767
gig gigas 0.749
tsr twinstar 0.747
Mhc Myosin heavy chain 0.733
hep hemipterous 0.728
crol crooked legs 0.696
Nop60B Nucleolar protein at 60B 0.691
Rac1 CG2248 gene product from transcript CG2248-RA 0.673
slmb supernumerary limbs 0.650
put punt 0.645
shn schnurri 0.639
drk downstream of receptor kinase 0.628
wg wingless 0.626
ik2 IkappaB kinase-like 2 0.622
Dab Disabled 0.620
Dcp-1 Death caspase-1 0.611
dsh dishevelled 0.587
EcR Ecdysone receptor 0.571
lea leak 0.560
Egfr Epidermal growth factor receptor 0.551
rap retina aberrant in pattern 0.546
tkv thickveins 0.543
S6k RPS6-p70-protein kinase 0.531
Ubx Ultrabithorax 0.519
rst roughest 0.514
nkd naked cuticle 0.514
Aos1 CG12276 gene product from transcript CG12276-RA 0.512
Tsc1 CG6147 gene product from transcript CG6147-RA 0.512
CSN5 COP9 complex homolog subunit 5 0.495
Pten CG5671 gene product from transcript CG5671-RB 0.494
tin tinman 0.489
Hrb98DE Heterogeneous nuclear ribonucleoprotein at 98DE 0.485
ecd ecdysoneless 0.476
Mad Mothers against dpp 0.465
Antp Antennapedia 0.465
Rac2 CG8556 gene product from transcript CG8556-RA 0.448
elav embryonic lethal abnormal vision 0.442
rdx roadkill 0.425
Adf1 Adh transcription factor 1 0.414
usp ultraspiracle 0.397
Eip74EF Ecdysone-induced protein 74EF 0.396
sty sprouty 0.395
Atpalpha Na pump alpha subunit 0.388
NetB Netrin-B 0.388
ato atonal 0.387
Nrg Neuroglian 0.387
p120ctn Adherens junction protein p120 0.386
Int6 Int6 homologue 0.381
H Hairless 0.372
Dp DP transcription factor 0.371
spen split ends 0.368
Eip93F CG18389 gene product from transcript CG18389-RB 0.366
Su(H) Suppressor of Hairless 0.356
bi bifid 0.348
X11L CG5675 gene product from transcript CG5675-RB 0.347
InR Insulin-like receptor 0.345
baz bazooka 0.345
Snr1 Snf5-related 1 0.338
cutlet CG33122 gene product from transcript CG33122-RA 0.335
Tak1 TGF-beta activated kinase 1 0.332
debcl death executioner Bcl-2 homologue 0.331
ptc patched 0.325
RASSF8 CG5053 gene product from transcript CG5053-RA 0.324
th thread 0.324
Mtl Mig-2-like 0.320
CG7998 CG7998 gene product from transcript CG7998-RA 0.315
mrn marionette 0.312
slp1 sloppy paired 1 0.311
Rab11 Rab-protein 11 0.309
wee CG4488 gene product from transcript CG4488-RA 0.309
ey eyeless 0.307
jar jaguar 0.306
lola longitudinals lacking 0.304
CG14869 CG14869 gene product from transcript CG14869-RB 0.301
rictor rapamycin-insensitive companion of Tor 0.300
SoxN SoxNeuro 0.299
dnc dunce 0.299
sli slit 0.297
Rel Relish 0.295
CG9772 CG9772 gene product from transcript CG9772-RB 0.295
l(2)gl lethal (2) giant larvae 0.295
btsz bitesize 0.290
LamC Lamin C 0.287
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
BMH1 Bmh1p 0.020
SLT2 Slt2p 0.019
STI1 Sti1p 0.017
CDC34 Cdc34p 0.013
PIL1 Pil1p 0.012