The network for 'regulation of interleukin 6 production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of interleukin 6 production

Any process that modulates the frequency, rate, or extent of interleukin-6 production.

Rattus norvegicus
Name Description Probability Func Analog Organism
Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.183
Hspa5 heat shock protein 5 0.167
Gja6 gap junction protein, alpha 6 0.145
Ccl4 chemokine (C-C motif) ligand 4 0.136
Gzmk granzyme K 0.119
Ccl3 chemokine (C-C motif) ligand 3 0.110
Casp12 caspase 12 0.091
LOC24906 RoBo-1 0.090
Mmp12 matrix metallopeptidase 12 0.085
Fosl1 fos-like antigen 1 0.078
Fgr Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog 0.077
Npffr2 neuropeptide FF receptor 2 0.073
Il1b interleukin 1 beta 0.072
Acrv1 acrosomal vesicle protein 1 0.063
Junb jun B proto-oncogene 0.061
Sox17 SRY (sex determining region Y)-box 17 0.061
Csf1 colony stimulating factor 1 (macrophage) 0.059
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.054
Faslg Fas ligand (TNF superfamily, member 6) 0.053
Slc7a3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 0.051
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.049
Cxcl2 chemokine (C-X-C motif) ligand 2 0.047
Il9r interleukin 9 receptor 0.043
Stat3 signal transducer and activator of transcription 3 0.041
Errfi1 ERBB receptor feedback inhibitor 1 0.038
Calhm2 calcium homeostasis modulator 2 0.037
Cxcl6 chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2) 0.037
Hspa8 heat shock protein 8 0.037
Avp arginine vasopressin 0.036
St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 0.036
Pdia6 protein disulfide isomerase family A, member 6 0.035
Zfp36 zinc finger protein 36 0.034
Il2rg interleukin 2 receptor, gamma 0.034
Adora2a adenosine A2a receptor 0.034
Cfp complement factor properdin 0.033
Ltbr lymphotoxin beta receptor (TNFR superfamily, member 3) 0.033
C5ar1 complement component 5a receptor 1 0.033
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.031
Il6 interleukin 6 0.031
Cxcr3 chemokine (C-X-C motif) receptor 3 0.030
Arhgap4 Rho GTPase activating protein 4 0.030
Shc1 SHC (Src homology 2 domain containing) transforming protein 1 0.030
Prl8a7 prolactin family 8, subfamily a, member 7 0.029
Tnni3 troponin I type 3 (cardiac) 0.029
Rhbdl1 rhomboid, veinlet-like 1 (Drosophila) 0.029
Il1r1 interleukin 1 receptor, type I 0.028
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.028
Syt8 synaptotagmin VIII 0.027
Ghr growth hormone receptor 0.027
Grm6 glutamate receptor, metabotropic 6 0.027
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.027
A2m alpha-2-macroglobulin 0.026
Ciita class II, major histocompatibility complex, transactivator 0.026
Rps6ka1 ribosomal protein S6 kinase polypeptide 1 0.026
Sh2b3 SH2B adaptor protein 3 0.026
Socs3 suppressor of cytokine signaling 3 0.026
Slc22a7 solute carrier family 22 (organic anion transporter), member 7 0.026
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.025
Lpl lipoprotein lipase 0.025
Ptprz1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.024
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.024
Pax6 paired box 6 0.024
Alox5 arachidonate 5-lipoxygenase 0.024
Ifna1 interferon-alpha 1 0.023
Itgam integrin, alpha M 0.023
Ms4a2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) 0.023
Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 0.023
Rassf5 Ras association (RalGDS/AF-6) domain family member 5 0.022
Tlr4 toll-like receptor 4 0.022
Jun Jun oncogene 0.022
Ptger2 prostaglandin E receptor 2 (subtype EP2) 0.022
Hspe1 heat shock protein 1 (chaperonin 10) 0.021
Mcpt3 mast cell peptidase 3 0.021
Slc14a2 solute carrier family 14 (urea transporter), member 2 0.021
Dusp1 dual specificity phosphatase 1 0.020
Pip prolactin induced protein 0.020
Fgb fibrinogen beta chain 0.020
Gm2a GM2 ganglioside activator 0.020
Edn1 endothelin 1 0.020
Myd88 myeloid differentiation primary response gene 88 0.019
C1qtnf6 C1q and tumor necrosis factor related protein 6 0.019
Nradd neurotrophin receptor associated death domain 0.019
RGD1309079 similar to Ab2-095 0.019
Ece1 endothelin converting enzyme 1 0.019
RGD1561143 similar to cell surface receptor FDFACT 0.019
Gfpt1 glutamine fructose-6-phosphate transaminase 1 0.018
Chrna7 cholinergic receptor, nicotinic, alpha 7 0.018
Mmp8 matrix metallopeptidase 8 0.018
LOC690358 similar to PR domain containing 11 0.018
Olr416 olfactory receptor 416 0.018
Mapk14 mitogen activated protein kinase 14 0.018
LOC681996 similar to AHA1, activator of heat shock 90kDa protein ATPase homolog 1 0.018
Epor erythropoietin receptor 0.017
Ptafr platelet-activating factor receptor 0.017
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.017
RGD1305793 similar to hypothetical protein FLJ20154 0.016
Csf2rb colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) 0.016
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 0.016
Oprk1 opioid receptor, kappa 1 0.016
Adora2b adenosine A2B receptor 0.015
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
MYD88 myeloid differentiation primary response gene (88) 0.997
IRAK2 interleukin-1 receptor-associated kinase 2 0.962
IRAK1 interleukin-1 receptor-associated kinase 1 0.913
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.808
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.707
MAP2K4 mitogen-activated protein kinase kinase 4 0.659
LAMP1 lysosomal-associated membrane protein 1 0.373
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.348
BIRC3 baculoviral IAP repeat containing 3 0.339
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.337
JUN jun proto-oncogene 0.251
TLR4 toll-like receptor 4 0.217
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.196
TRAF1 TNF receptor-associated factor 1 0.177
SMAD3 SMAD family member 3 0.160
ZC3H12A zinc finger CCCH-type containing 12A 0.132
TRADD TNFRSF1A-associated via death domain 0.128
CD14 CD14 molecule 0.119
ZNF496 zinc finger protein 496 0.114
ARRB2 arrestin, beta 2 0.114
CPNE6 copine VI (neuronal) 0.105
IL1R1 interleukin 1 receptor, type I 0.099
PELI3 pellino homolog 3 (Drosophila) 0.087
IL10RA interleukin 10 receptor, alpha 0.087
TRAF6 TNF receptor-associated factor 6 0.083
TLR2 toll-like receptor 2 0.083
HSF1 heat shock transcription factor 1 0.079
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.077
IRAK3 interleukin-1 receptor-associated kinase 3 0.072
IL22RA1 interleukin 22 receptor, alpha 1 0.067
TICAM2 toll-like receptor adaptor molecule 2 0.063
UBASH3B ubiquitin associated and SH3 domain containing B 0.060
PYDC2 pyrin domain containing 2 0.060
LYN v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.059
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.057
MAPK14 mitogen-activated protein kinase 14 0.055
SETD8 SET domain containing (lysine methyltransferase) 8 0.055
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.055
AXL AXL receptor tyrosine kinase 0.054
TRAF2 TNF receptor-associated factor 2 0.054
BIRC2 baculoviral IAP repeat containing 2 0.053
C19orf50 chromosome 19 open reading frame 50 0.051
MEFV Mediterranean fever 0.047
IL22RA2 interleukin 22 receptor, alpha 2 0.046
TNF tumor necrosis factor 0.045
GATA2 GATA binding protein 2 0.044
NLRC4 NLR family, CARD domain containing 4 0.044
TNIP1 TNFAIP3 interacting protein 1 0.043
LAPTM5 lysosomal protein transmembrane 5 0.042
SOCS3 suppressor of cytokine signaling 3 0.041
IRAK4 interleukin-1 receptor-associated kinase 4 0.038
TXN thioredoxin 0.037
SOD2 superoxide dismutase 2, mitochondrial 0.037
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.036
CCL20 chemokine (C-C motif) ligand 20 0.035
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.035
MARK2 MAP/microtubule affinity-regulating kinase 2 0.035
FADD Fas (TNFRSF6)-associated via death domain 0.034
GNMT glycine N-methyltransferase 0.033
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 0.033
TOLLIP toll interacting protein 0.030
TRIM21 tripartite motif containing 21 0.028
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.027
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 0.026
SH3KBP1 SH3-domain kinase binding protein 1 0.026
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.025
JAK1 Janus kinase 1 0.025
LMO2 LIM domain only 2 (rhombotin-like 1) 0.025
HSPB1 heat shock 27kDa protein 1 0.024
DUSP1 dual specificity phosphatase 1 0.022
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.022
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 0.021
SYK spleen tyrosine kinase 0.021
ZC3H12C zinc finger CCCH-type containing 12C 0.021
CCR1 chemokine (C-C motif) receptor 1 0.021
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.020
BAG3 BCL2-associated athanogene 3 0.020
EPOR erythropoietin receptor 0.020
BTK Bruton agammaglobulinemia tyrosine kinase 0.020
HDAC9 histone deacetylase 9 0.020
SP1 Sp1 transcription factor 0.020
TRIM22 tripartite motif containing 22 0.019
TNIP2 TNFAIP3 interacting protein 2 0.019
LY86 lymphocyte antigen 86 0.019
ATF2 activating transcription factor 2 0.018
HSPA6 heat shock 70kDa protein 6 (HSP70B') 0.018
PLEK pleckstrin 0.018
CXCL2 chemokine (C-X-C motif) ligand 2 0.018
HSPH1 heat shock 105kDa/110kDa protein 1 0.018
KIAA1712 KIAA1712 0.018
CFL1 cofilin 1 (non-muscle) 0.018
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 0.017
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.017
LIMK1 LIM domain kinase 1 0.017
C14orf43 chromosome 14 open reading frame 43 0.017
TRIM34 tripartite motif containing 34 0.017
ARRB1 arrestin, beta 1 0.017
LRP6 low density lipoprotein receptor-related protein 6 0.017
SLAMF1 signaling lymphocytic activation molecule family member 1 0.017
IRF7 interferon regulatory factor 7 0.017
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Mus musculus
Name Description Probability Func Analog Organism
Tlr4 toll-like receptor 4 1.000
Myd88 myeloid differentiation primary response gene 88 1.000
Tnf tumor necrosis factor 1.000
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 1.000
Lyz2 lysozyme 2 1.000
Map3k14 mitogen-activated protein kinase kinase kinase 14 0.994
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.979
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.977
Il1r1 interleukin 1 receptor, type I 0.973
Lta lymphotoxin A 0.972
Il4 interleukin 4 0.966
Traf6 TNF receptor-associated factor 6 0.956
Otx2 orthodenticle homolog 2 (Drosophila) 0.952
Ikzf1 IKAROS family zinc finger 1 0.950
Irak4 interleukin-1 receptor-associated kinase 4 0.883
Cd44 CD44 antigen 0.883
Cd40 CD40 antigen 0.862
Arrb2 arrestin, beta 2 0.861
Il1b interleukin 1 beta 0.857
Fas Fas (TNF receptor superfamily member 6) 0.852
Nlrp3 NLR family, pyrin domain containing 3 0.851
Chrna3 cholinergic receptor, nicotinic, alpha polypeptide 3 0.840
Stat3 signal transducer and activator of transcription 3 0.810
Il10 interleukin 10 0.806
Casp1 caspase 1 0.789
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.789
Foxn1 forkhead box N1 0.785
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.691
Emx1 empty spiracles homolog 1 (Drosophila) 0.679
Trim30d tripartite motif-containing 30D 0.666
Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.666
Clec4n C-type lectin domain family 4, member n 0.662
Igh immunoglobulin heavy chain complex 0.654
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.649
Pax2 paired box gene 2 0.649
Birc3 baculoviral IAP repeat-containing 3 0.613
Ptgs2 prostaglandin-endoperoxide synthase 2 0.563
Ccl2 chemokine (C-C motif) ligand 2 0.550
Prf1 perforin 1 (pore forming protein) 0.537
Emx2 empty spiracles homolog 2 (Drosophila) 0.518
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 0.505
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.503
Arrb1 arrestin, beta 1 0.494
Gbx2 gastrulation brain homeobox 2 0.483
Ccl4 chemokine (C-C motif) ligand 4 0.460
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.456
Ifng interferon gamma 0.453
Gdnf glial cell line derived neurotrophic factor 0.447
Mefv Mediterranean fever 0.444
Cd19 CD19 antigen 0.443
Btk Bruton agammaglobulinemia tyrosine kinase 0.427
Trim30a tripartite motif-containing 30A 0.426
Il2 interleukin 2 0.425
Lif leukemia inhibitory factor 0.418
Il1rl1 interleukin 1 receptor-like 1 0.409
Lhx1 LIM homeobox protein 1 0.404
Inpp5d inositol polyphosphate-5-phosphatase D 0.396
Chrnb4 cholinergic receptor, nicotinic, beta polypeptide 4 0.393
Cd14 CD14 antigen 0.391
Pthlh parathyroid hormone-like peptide 0.381
Fgr Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog 0.373
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.365
Lyn Yamaguchi sarcoma viral (v-yes-1) oncogene homolog 0.364
Mmp9 matrix metallopeptidase 9 0.358
Ifnar1 interferon (alpha and beta) receptor 1 0.358
Wnt1 wingless-related MMTV integration site 1 0.355
Wnt4 wingless-related MMTV integration site 4 0.343
Ptprc protein tyrosine phosphatase, receptor type, C 0.332
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.331
Irak3 interleukin-1 receptor-associated kinase 3 0.315
Hspa5 heat shock protein 5 0.314
Ltbr lymphotoxin B receptor 0.313
Card11 caspase recruitment domain family, member 11 0.309
Apoe apolipoprotein E 0.307
Gbp5 guanylate binding protein 5 0.282
Pax6 paired box gene 6 0.274
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.271
Il6 interleukin 6 0.267
Zic3 zinc finger protein of the cerebellum 3 0.263
En1 engrailed 1 0.262
Cd33 CD33 antigen 0.260
Phox2b paired-like homeobox 2b 0.250
Stat1 signal transducer and activator of transcription 1 0.250
Nodal nodal 0.249
Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 0.247
Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 0.241
Cxcl13 chemokine (C-X-C motif) ligand 13 0.239
Cblb Casitas B-lineage lymphoma b 0.239
Gli2 GLI-Kruppel family member GLI2 0.227
Mmp8 matrix metallopeptidase 8 0.216
Phc1 polyhomeotic-like 1 (Drosophila) 0.215
Il7 interleukin 7 0.210
Hcst hematopoietic cell signal transducer 0.208
Il1rn interleukin 1 receptor antagonist 0.208
Fasl Fas ligand (TNF superfamily, member 6) 0.208
Rel reticuloendotheliosis oncogene 0.203
Sharpin SHANK-associated RH domain interacting protein 0.200
Tcf3 transcription factor 3 0.196
Cebpd CCAAT/enhancer binding protein (C/EBP), delta 0.195
Tcra T-cell receptor alpha chain 0.194
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism