The network for 'chordate embryonic development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

chordate embryonic development

The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.

Danio rerio
Name Description Probability Func Analog Organism
foxi1 forkhead box I1 0.999
sox9a SRY-box containing gene 9a 0.999
wnt11 wingless-type MMTV integration site family, member 11 0.999
fgf3 fibroblast growth factor 3 0.999
jag1b jagged 1b 0.998
gli2a GLI-Kruppel family member GLI2a 0.998
tbx1 T-box 1 0.997
notch1a notch homolog 1a 0.996
myf5 myogenic factor 5 0.996
chd chordin 0.993
crabp2a cellular retinoic acid binding protein 2, a 0.993
pax8 paired box gene 8 0.993
her1 hairy-related 1 0.993
barx1 BarH-like homeobox 1 0.992
edn1 endothelin 1 0.992
foxd3 forkhead box D3 0.991
hoxa3a homeo box A3a 0.990
prdm1a PR domain containing 1a, with ZNF domain 0.988
myod1 myogenic differentiation 1 0.988
dcc deleted in colorectal carcinoma 0.988
twist3 twist3 0.986
wnt5b wingless-type MMTV integration site family, member 5b 0.985
raraa retinoic acid receptor, alpha a 0.984
frem3 Fras1 related extracellular matrix 3 0.983
gata3 GATA-binding protein 3 0.983
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.981
csnk1a1 casein kinase 1, alpha 1 0.979
hoxb1b homeo box B1b 0.978
gli1 GLI-Kruppel family member 1 0.977
egr1 early growth response 1 0.977
twist1b twist1b 0.976
osr1 odd-skipped related 1 (Drosophila) 0.976
lhx5 LIM homeobox 5 0.976
twist1a twist1a 0.976
foxa2 forkhead box A2 0.971
gdf6a growth differentiation factor 6a 0.971
otpb orthopedia homolog b 0.970
tal1 T-cell acute lymphocytic leukemia 1 0.969
rarga retinoic acid receptor gamma a 0.968
rad21 RAD21 homolog (S. pombe) 0.967
atoh1a atonal homolog 1a 0.965
brpf1 bromodomain and PHD finger containing, 1 0.961
fras1 Fraser syndrome 1 0.960
hoxb6a homeo box B6a 0.958
nkx2.3 NK2 transcription factor related 3 0.953
msxe muscle segment homeobox E 0.951
tgfb3 transforming growth factor, beta 3 0.951
hoxd4a homeo box D4a 0.945
prdm5 PR domain containing 5 0.944
fgf4 fibroblast growth factor 4 0.943
mib mind bomb 0.942
dlx3b distal-less homeobox gene 3b 0.942
mecom MDS1 and EVI1 complex locus 0.940
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.940
tp63 tumor protein p63 0.940
pwp2h PWP2 periodic tryptophan protein homolog (yeast) 0.936
shhb sonic hedgehog b 0.930
plcb3 phospholipase C, beta 3 (phosphatidylinositol-specific) 0.929
foxg1a forkhead box G1a 0.929
fgf8a fibroblast growth factor 8 a 0.928
hoxa2b homeo box A2b 0.927
hoxb5a homeo box B5a 0.926
snai1b snail homolog 1b (Drosophila) 0.925
otx2 orthodenticle homolog 2 0.925
epha4b eph receptor A4b 0.920
hnf1ba HNF1 homeobox Ba 0.912
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.910
pax6b paired box gene 6b 0.909
wnt9a wingless-type MMTV integration site family, member 9A 0.907
foxe1 forkhead box E1 (thyroid transcription factor 2) 0.906
mab21l2 mab-21-like 2 0.904
xylt1 xylosyltransferase 1 0.903
fezf2 FEZ family zinc finger 2 0.902
dld deltaD 0.902
hhip hedgehog interacting protein 0.899
egr2b early growth response 2b 0.899
bmp2b bone morphogenetic protein 2b 0.899
tp53 tumor protein p53 0.898
pou3f3b POU class 3 homeobox 3b 0.898
prdm16 PR domain containing 16 0.897
rx2 retinal homeobox gene 2 0.897
sox10 SRY-box containing gene 10 0.895
pax2a paired box gene 2a 0.895
hoxa4a homeo box A4a 0.894
epb4.1l4 erythrocyte protein band 4.1-like 4 0.894
dla deltaA 0.892
sec24d SEC24 family, member D (S. cerevisiae) 0.892
foxa1 forkhead box A1 0.892
frem2a Fras1 related extracellular matrix protein 2a 0.888
hmx4 H6 family homeobox 4 0.887
hoxb5b homeo box B5b 0.885
sema3aa semaphorin 3aa 0.884
eya1 eyes absent homolog 1 0.883
lmx1b.2 LIM homeobox transcription factor 1, beta 2 0.877
wt1b wilms tumor 1b 0.865
pcdh10b protocadherin 10b 0.864
unc45b unc-45 homolog B (C. elegans) 0.863
sox32 SRY-box containing gene 32 0.861
actn3a actinin alpha 3a 0.859
lamb1a laminin, beta 1a 0.859
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
ESR1 estrogen receptor 1 1.000
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 1.000
SMAD3 SMAD family member 3 1.000
TP53 tumor protein p53 0.999
EP300 E1A binding protein p300 0.997
MAPK1 mitogen-activated protein kinase 1 0.989
CREBBP CREB binding protein 0.985
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.979
AR androgen receptor 0.974
BCL2 B-cell CLL/lymphoma 2 0.948
BRCA1 breast cancer 1, early onset 0.920
FN1 fibronectin 1 0.915
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.908
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.874
HDAC1 histone deacetylase 1 0.819
ZFYVE9 zinc finger, FYVE domain containing 9 0.805
NCOA3 nuclear receptor coactivator 3 0.802
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.802
ATN1 atrophin 1 0.799
H2AFX H2A histone family, member X 0.789
EPAS1 endothelial PAS domain protein 1 0.716
PAX3 paired box 3 0.706
COL1A1 collagen, type I, alpha 1 0.687
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.677
WDR5 WD repeat domain 5 0.670
MAPK14 mitogen-activated protein kinase 14 0.664
NCOR1 nuclear receptor corepressor 1 0.662
CTGF connective tissue growth factor 0.645
PGK1 phosphoglycerate kinase 1 0.638
IQGAP1 IQ motif containing GTPase activating protein 1 0.597
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.595
TAL1 T-cell acute lymphocytic leukemia 1 0.581
RB1 retinoblastoma 1 0.562
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.539
DUSP1 dual specificity phosphatase 1 0.513
TGFB1 transforming growth factor, beta 1 0.511
SMAD4 SMAD family member 4 0.499
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.477
MTA1 metastasis associated 1 0.470
TRIP6 thyroid hormone receptor interactor 6 0.459
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.459
JAG1 jagged 1 0.454
NCOA2 nuclear receptor coactivator 2 0.448
NBN nibrin 0.440
SMAD7 SMAD family member 7 0.438
NCOA1 nuclear receptor coactivator 1 0.436
APC adenomatous polyposis coli 0.418
SRPK2 SRSF protein kinase 2 0.408
HOXB5 homeobox B5 0.400
EGFR epidermal growth factor receptor 0.400
BCL2L1 BCL2-like 1 0.395
SMAD2 SMAD family member 2 0.394
SEC23A Sec23 homolog A (S. cerevisiae) 0.380
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.374
ENO1 enolase 1, (alpha) 0.373
BMP2 bone morphogenetic protein 2 0.371
SP1 Sp1 transcription factor 0.353
PSEN1 presenilin 1 0.348
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.347
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 0.347
NOTCH1 notch 1 0.337
JUN jun proto-oncogene 0.334
NRP1 neuropilin 1 0.330
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.320
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.319
CYR61 cysteine-rich, angiogenic inducer, 61 0.315
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.303
TCF4 transcription factor 4 0.302
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.295
CDC73 cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.289
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.270
RARA retinoic acid receptor, alpha 0.267
PML promyelocytic leukemia 0.264
SP3 Sp3 transcription factor 0.258
RASA1 RAS p21 protein activator (GTPase activating protein) 1 0.257
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.256
ERBB2IP erbb2 interacting protein 0.255
DAXX death-domain associated protein 0.255
SMAD1 SMAD family member 1 0.248
HIPK2 homeodomain interacting protein kinase 2 0.247
FANCD2 Fanconi anemia, complementation group D2 0.246
PPP1R12A protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.246
HOXD9 homeobox D9 0.243
RUNX1 runt-related transcription factor 1 0.234
PAX1 paired box 1 0.233
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.231
CTBP1 C-terminal binding protein 1 0.229
HDAC2 histone deacetylase 2 0.227
LMO4 LIM domain only 4 0.226
SOX2 SRY (sex determining region Y)-box 2 0.225
HMGA1 high mobility group AT-hook 1 0.220
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.208
EFTUD2 elongation factor Tu GTP binding domain containing 2 0.208
MBNL1 muscleblind-like (Drosophila) 0.206
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.206
FOXD3 forkhead box D3 0.206
NCK2 NCK adaptor protein 2 0.203
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.203
ATXN1 ataxin 1 0.201
CSNK1E casein kinase 1, epsilon 0.186
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Tgfbr2 transforming growth factor, beta receptor II 0.073
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.067
Bgn biglycan 0.054
Igfbp5 insulin-like growth factor binding protein 5 0.050
Cald1 caldesmon 1 0.049
Hoxb7 homeo box B7 0.046
Krt18 keratin 18 0.041
Tgfb1 transforming growth factor, beta 1 0.038
Ece1 endothelin converting enzyme 1 0.031
Dusp1 dual specificity phosphatase 1 0.031
Col3a1 collagen, type III, alpha 1 0.028
Ins2 insulin 2 0.028
Bmp6 bone morphogenetic protein 6 0.026
Smad7 SMAD family member 7 0.026
Sox17 SRY (sex determining region Y)-box 17 0.026
Egfr epidermal growth factor receptor 0.024
Vim vimentin 0.024
Olr1278 olfactory receptor 1278 0.024
Col8a1 collagen, type VIII, alpha 1 0.023
Fzd2 frizzled homolog 2 (Drosophila) 0.023
Pak2 p21 protein (Cdc42/Rac)-activated kinase 2 0.023
Trim47 tripartite motif-containing 47 0.023
Rac1 ras-related C3 botulinum toxin substrate 1 0.023
Dbh dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.023
Arnt aryl hydrocarbon receptor nuclear translocator 0.022
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.022
Foxe3 forkhead box E3 0.022
Ptbp1 polypyrimidine tract binding protein 1 0.022
LOC100134871 beta globin minor gene 0.021
Gja5 gap junction protein, alpha 5 0.021
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.021
Rara retinoic acid receptor, alpha 0.020
Lox lysyl oxidase 0.020
Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 0.020
Usf2 upstream transcription factor 2, c-fos interacting 0.020
Dag1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.020
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.020
Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.018
Nudt3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.018
Foxd3 forkhead box D3 0.018
Sod3 superoxide dismutase 3, extracellular 0.018
Teddm1 transmembrane epididymal protein 1 0.018
Fgfr1 Fibroblast growth factor receptor 1 0.017
Gna15 guanine nucleotide binding protein, alpha 15 0.017
Acvr1 activin A receptor, type I 0.017
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.016
Mllt4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.016
Plod1 procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1 0.016
Cryge crystallin, gamma E 0.016
Bcl2 B-cell CLL/lymphoma 2 0.016
Pcnxl3 pecanex-like 3 (Drosophila) 0.016
Nudc nuclear distribution gene C homolog (A. nidulans) 0.016
Lyst lysosomal trafficking regulator 0.016
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.016
Arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.016
Eif4a2 eukaryotic translation initiation factor 4A, isoform 2 0.016
Col12a1 collagen, type XII, alpha 1 0.016
Tcf12 transcription factor 12 0.015
Egr2 early growth response 2 0.015
Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1 0.015
Ltbr lymphotoxin beta receptor (TNFR superfamily, member 3) 0.015
Smad3 SMAD family member 3 0.015
Sdc3 syndecan 3 0.015
Slc4a2 solute carrier family 4 (anion exchanger), member 2 0.015
Vcp valosin-containing protein 0.014
Tp53 tumor protein p53 0.014
Jak2 Janus kinase 2 0.014
Phkg1 phosphorylase kinase, gamma 1 0.014
Add3 adducin 3 (gamma) 0.014
Dll3 delta-like 3 (Drosophila) 0.014
Creb1 cAMP responsive element binding protein 1 0.013
Psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.013
Fndc3b fibronectin type III domain containing 3B 0.013
RGD1309414 similar to KIAA0913 protein 0.013
Apoh apolipoprotein H (beta-2-glycoprotein I) 0.013
Klf2 Kruppel-like factor 2 (lung) 0.013
Ahnak AHNAK nucleoprotein 0.013
Cherp calcium homeostasis endoplasmic reticulum protein 0.013
Anpep alanyl (membrane) aminopeptidase 0.013
Jak1 Janus kinase 1 0.013
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.013
Slit3 slit homolog 3 (Drosophila) 0.013
Sirpa signal-regulatory protein alpha 0.013
Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.012
Cpne3 copine III 0.012
Fam100a family with sequence similarity 100, member A 0.012
Jub jub, ajuba homolog (Xenopus laevis) 0.012
Pfn1 profilin 1 0.012
Mprip myosin phosphatase Rho interacting protein 0.012
Dlc1 deleted in liver cancer 1 0.012
Psgb1 pregnancy-specific beta 1-glycoprotein 0.012
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.012
Mthfr methylenetetrahydrofolate reductase (NAD(P)H) 0.012
Gse1 genetic suppressor element 1 0.012
Max MYC associated factor X 0.012
Bmpr1a bone morphogenetic protein receptor, type IA 0.012
Anxa2 annexin A2 0.012
Xiap X-linked inhibitor of apoptosis 0.012
Fgfr2 fibroblast growth factor receptor 2 0.012
Socs3 suppressor of cytokine signaling 3 0.012
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism