The network for 'developmental programmed cell death' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

developmental programmed cell death

The activation of endogenous cellular processes that result in the death of a cell as part of its development.

Danio rerio
Name Description Probability Func Analog Organism
pax8 paired box gene 8 0.846
eng2a engrailed 2a 0.828
tp73 tumor protein p73 0.701
ptf1a pancreas specific transcription factor, 1a 0.547
ascl1a achaete-scute complex-like 1a (Drosophila) 0.481
baxa bcl2-associated X protein, a 0.427
flh floating head 0.425
jag2 jagged 2 0.382
wnt1 wingless-type MMTV integration site family, member 1 0.347
otx5 orthodenticle homolog 5 0.342
nr2e3 nuclear receptor subfamily 2, group E, member 3 0.331
vsx2 visual system homeobox 2 0.311
sox10 SRY-box containing gene 10 0.281
hoxd11a homeo box D11a 0.233
slc15a2 solute carrier family 15 (H+/peptide transporter), member 2 0.226
evx1 even-skipped homeobox 1 0.219
nkx2.2a NK2 transcription factor related 2a 0.211
pax2b paired box gene 2b 0.205
bmp4 bone morphogenetic protein 4 0.202
pax5 paired box gene 5 0.195
lhx2b LIM homeobox 2b 0.178
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.171
cobl cordon-bleu homolog (mouse) 0.167
wnt7bb wingless-type MMTV integration site family, member 7Bb 0.167
neurog1 neurogenin 1 0.153
egr2b early growth response 2b 0.147
atoh7 atonal homolog 7 0.146
tfe3b transcription factor binding to IGHM enhancer 3b 0.145
sox9b SRY-box containing gene 9b 0.141
wnt8b wingless-type MMTV integration site family, member 8b 0.140
si:dkeyp-7c9.1 si:dkeyp-7c9.1 0.137
neurod4 neurogenic differentiation 4 0.135
fgfr1a fibroblast growth factor receptor 1a 0.133
eng1a engrailed 1a 0.130
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.125
irx3b iroquois homeobox protein 3b 0.123
mmp9 matrix metalloproteinase 9 0.122
nkx2.3 NK2 transcription factor related 3 0.119
hhip hedgehog interacting protein 0.118
cdkn1a cyclin-dependent kinase inhibitor 1A 0.117
cmyb transcription factor cmyb 0.117
fgf8b fibroblast growth factor 8 b 0.116
notch3 notch homolog 3 0.115
ccdc151 coiled-coil domain containing 151 0.113
fgf3 fibroblast growth factor 3 0.110
pou3f3b POU class 3 homeobox 3b 0.109
sfrp5 secreted frizzled-related protein 5 0.109
tbx2b T-box 2b 0.109
lrrc6 leucine rich repeat containing 6 0.108
eya1 eyes absent homolog 1 0.107
foxi1 forkhead box I1 0.105
notch1a notch homolog 1a 0.105
rx1 retinal homeobox gene 1 0.104
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.103
rx2 retinal homeobox gene 2 0.100
fgf22 fibroblast growth factor 22 0.100
pdlim2 PDZ and LIM domain 2 (mystique) 0.097
hoxc5a homeo box C5a 0.097
gata3 GATA-binding protein 3 0.097
chpf chondroitin polymerizing factor 0.095
phox2a paired-like homeobox 2a 0.094
lhx5 LIM homeobox 5 0.093
per2 period homolog 2 (Drosophila) 0.092
oc90 otoconin 90 0.092
osr2 odd-skipped related 2 (Drosophila) 0.090
prdm16 PR domain containing 16 0.089
hoxa5a homeo box A5a 0.089
prox1 prospero-related homeobox gene 1 0.089
dharma dharma 0.088
crb1 crumbs homolog 1 (Drosophila) 0.086
fgf10a fibroblast growth factor 10a 0.084
slc12a2 solute carrier family 12 (potassium/chloride transporters), member 2 0.082
rorca RAR-related orphan receptor C a 0.081
dla deltaA 0.079
gadd45aa growth arrest and DNA-damage-inducible, alpha, a 0.078
exorh extra-ocular rhodopsin 0.078
tmem2 transmembrane protein 2 0.077
dlb deltaB 0.076
hnf4a hepatocyte nuclear factor 4, alpha 0.076
sbf1 SET binding factor 1 0.075
vwa2 von Willebrand factor A domain containing 2 0.075
mafba v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) 0.075
mitfa microphthalmia-associated transcription factor a 0.074
pou3f3a POU class 3 homeobox 3a 0.074
pax6a paired box gene 6a 0.073
pcsk5a proprotein convertase subtilisin/kexin type 5a 0.073
wu:fc23b05 wu:fc23b05 0.072
cyp19a1a cytochrome P450, family 19, subfamily A, polypeptide 1a 0.071
uba1 ubiquitin-like modifier activating enzyme 1 0.070
crb2a crumbs homolog 2a 0.069
nr5a2 nuclear receptor subfamily 5, group A, member 2 0.068
hoxc11a homeo box C11a 0.068
vsx1 visual system homeobox 1 homolog, chx10-like 0.068
wt1a wilms tumor 1a 0.067
dll4 delta-like 4 (Drosophila) 0.067
mab21l2 mab-21-like 2 0.067
gdnf glial cell derived neurotrophic factor 0.067
foxe1 forkhead box E1 (thyroid transcription factor 2) 0.066
ihha Indian hedgehog homolog a 0.064
cdh6 cadherin 6 0.064
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Dcp-1 Death caspase-1 0.980
hep hemipterous 0.960
fkh fork head 0.891
jar jaguar 0.883
Atg18 Autophagy-specific gene 18 0.877
ci cubitus interruptus 0.859
EcR Ecdysone receptor 0.839
Tak1 TGF-beta activated kinase 1 0.827
Atg9 Autophagy-specific gene 9 0.819
Pi3K59F Phosphotidylinositol 3 kinase 59F 0.812
dpp decapentaplegic 0.798
shn schnurri 0.793
wg wingless 0.777
Atg1 Autophagy-specific gene 1 0.768
Eip93F CG18389 gene product from transcript CG18389-RB 0.751
puc puckered 0.742
Atg8a Autophagy-specific gene 8a 0.735
trp transient receptor potential 0.702
th thread 0.690
bif bifocal 0.684
dm diminutive 0.684
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.660
debcl death executioner Bcl-2 homologue 0.655
Ser Serrate 0.623
ninaE neither inactivation nor afterpotential E 0.618
Nc Nedd2-like caspase 0.610
nej nejire 0.598
Pak PAK-kinase 0.594
Jra Jun-related antigen 0.589
CG11347 CG11347 gene product from transcript CG11347-RE 0.565
L Lobe 0.543
cnc cap-n-collar 0.523
rap retina aberrant in pattern 0.484
Rfabg Retinoid- and fatty acid-binding glycoprotein 0.483
Eip74EF Ecdysone-induced protein 74EF 0.472
sd scalloped 0.472
smi35A smell impaired 35A 0.460
rpr reaper 0.458
Peb Protein ejaculatory bulb 0.452
Tor Target of rapamycin 0.449
crb crumbs 0.428
ovo CG6824 gene product from transcript CG6824-RE 0.426
egr eiger 0.421
RagA CG11968 gene product from transcript CG11968-RA 0.408
Sox14 Sox box protein 14 0.403
Src42A Src oncogene at 42A 0.399
trx trithorax 0.399
loco locomotion defects 0.397
inaD inactivation no afterpotential D 0.352
ik2 IkappaB kinase-like 2 0.346
opa odd paired 0.340
eIF-4a Eukaryotic initiation factor 4a 0.337
hth homothorax 0.319
kto kohtalo 0.305
bsk basket 0.303
esg escargot 0.303
PEK pancreatic eIF-2alpha kinase 0.303
LysB Lysozyme B 0.297
drpr draper 0.297
Cad99C CG31009 gene product from transcript CG31009-RB 0.297
Egfr Epidermal growth factor receptor 0.296
pyd polychaetoid 0.275
sra sarah 0.273
edl ETS-domain lacking 0.269
tin tinman 0.267
Rac1 CG2248 gene product from transcript CG2248-RA 0.267
CecA1 Cecropin A1 0.263
B52 CG10851 gene product from transcript CG10851-RB 0.263
Atg7 Autophagy-specific gene 7 0.258
gsb gooseberry 0.252
Trf2 TATA box binding protein-related factor 2 0.249
ago archipelago 0.248
ed echinoid 0.246
Hsc70-4 Heat shock protein cognate 4 0.246
Sod Superoxide dismutase 0.242
pic piccolo 0.241
trc tricornered 0.238
fz2 frizzled 2 0.236
vri vrille 0.235
garz gartenzwerg 0.235
hkb huckebein 0.235
BG4 CG12297 gene product from transcript CG12297-RA 0.233
Abd-B Abdominal B 0.229
wun2 wunen-2 0.229
Parp Poly-(ADP-ribose) polymerase 0.225
RASSF8 CG5053 gene product from transcript CG5053-RA 0.225
msn misshapen 0.223
Rh6 Rhodopsin 6 0.223
bchs blue cheese 0.218
CG14540 CG14540 gene product from transcript CG14540-RA 0.216
tws twins 0.215
CG34168 CG34168 gene product from transcript CG34168-RA 0.213
CecA2 Cecropin A2 0.213
tsh teashirt 0.209
dsx doublesex 0.205
cathD CG1548 gene product from transcript CG1548-RA 0.204
Cat Catalase 0.200
Myo10A unconventional myosin class XV 0.197
LysC Lysozyme C 0.195
ttk tramtrack 0.193
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Homo sapiens
Name Description Probability Func Analog Organism
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.947
E2F4 E2F transcription factor 4, p107/p130-binding 0.944
RB1 retinoblastoma 1 0.943
BTRC beta-transducin repeat containing 0.906
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.895
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.887
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.874
BCL2 B-cell CLL/lymphoma 2 0.813
FGFR1 fibroblast growth factor receptor 1 0.798
RXRA retinoid X receptor, alpha 0.733
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.724
C2orf65 chromosome 2 open reading frame 65 0.719
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.700
NLRC4 NLR family, CARD domain containing 4 0.682
BAD BCL2-associated agonist of cell death 0.677
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.659
IL1R1 interleukin 1 receptor, type I 0.640
BCL2L1 BCL2-like 1 0.618
TBX5 T-box 5 0.586
BAK1 BCL2-antagonist/killer 1 0.583
NOTCH1 notch 1 0.555
FBXW11 F-box and WD repeat domain containing 11 0.485
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.480
RUNX1 runt-related transcription factor 1 0.478
STK3 serine/threonine kinase 3 0.398
GFI1B growth factor independent 1B transcription repressor 0.380
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.350
BAX BCL2-associated X protein 0.349
FBXO7 F-box protein 7 0.340
JAG1 jagged 1 0.337
NOTCH3 notch 3 0.313
RARA retinoic acid receptor, alpha 0.306
APC adenomatous polyposis coli 0.294
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha 0.293
KITLG KIT ligand 0.291
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.269
TFDP1 transcription factor Dp-1 0.259
PKP4 plakophilin 4 0.258
RYBP RING1 and YY1 binding protein 0.253
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.247
CDK6 cyclin-dependent kinase 6 0.241
RBL2 retinoblastoma-like 2 (p130) 0.227
NKX2-1 NK2 homeobox 1 0.220
NGF nerve growth factor (beta polypeptide) 0.217
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.210
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 0.209
LIN9 lin-9 homolog (C. elegans) 0.206
CTGF connective tissue growth factor 0.204
CDK2 cyclin-dependent kinase 2 0.202
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1 0.202
IL1RAP interleukin 1 receptor accessory protein 0.199
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.196
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.195
TRIP6 thyroid hormone receptor interactor 6 0.195
BID BH3 interacting domain death agonist 0.190
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 0.185
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.177
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.168
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.167
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.162
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.157
CCNE1 cyclin E1 0.148
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.147
E2F2 E2F transcription factor 2 0.142
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.140
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.138
BECN1 beclin 1, autophagy related 0.137
IL1RN interleukin 1 receptor antagonist 0.135
STRN3 striatin, calmodulin binding protein 3 0.135
BIK BCL2-interacting killer (apoptosis-inducing) 0.134
CCT8 chaperonin containing TCP1, subunit 8 (theta) 0.134
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.132
HR hairless homolog (mouse) 0.132
MED25 mediator complex subunit 25 0.130
TP53BP2 tumor protein p53 binding protein, 2 0.128
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.118
HNF1A HNF1 homeobox A 0.116
AMOTL2 angiomotin like 2 0.115
AHR aryl hydrocarbon receptor 0.113
E2F6 E2F transcription factor 6 0.113
ZFYVE9 zinc finger, FYVE domain containing 9 0.112
CCND1 cyclin D1 0.112
CUX1 cut-like homeobox 1 0.110
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.108
MAPK8 mitogen-activated protein kinase 8 0.106
PARK2 parkinson protein 2, E3 ubiquitin protein ligase (parkin) 0.106
GSK3B glycogen synthase kinase 3 beta 0.105
BBC3 BCL2 binding component 3 0.101
LIN54 lin-54 homolog (C. elegans) 0.095
MAPK1 mitogen-activated protein kinase 1 0.092
BANP BTG3 associated nuclear protein 0.092
MAGEA2 melanoma antigen family A, 2 0.091
PARP1 poly (ADP-ribose) polymerase 1 0.091
BCL2A1 BCL2-related protein A1 0.089
AMBRA1 autophagy/beclin-1 regulator 1 0.087
EP300 E1A binding protein p300 0.087
LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila) 0.085
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.085
FKBP8 FK506 binding protein 8, 38kDa 0.085
RIPK2 receptor-interacting serine-threonine kinase 2 0.084
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 0.994
Gli3 GLI-Kruppel family member GLI3 0.991
Wnt3a wingless-related MMTV integration site 3A 0.988
Pax8 paired box gene 8 0.972
Pax2 paired box gene 2 0.951
Trp53 transformation related protein 53 0.946
Otx2 orthodenticle homolog 2 (Drosophila) 0.903
Fgfr2 fibroblast growth factor receptor 2 0.891
Zeb1 zinc finger E-box binding homeobox 1 0.872
Pax3 paired box gene 3 0.835
Bcl2 B-cell leukemia/lymphoma 2 0.826
Pitx2 paired-like homeodomain transcription factor 2 0.816
Pten phosphatase and tensin homolog 0.806
Msx1 homeobox, msh-like 1 0.791
Prrx1 paired related homeobox 1 0.785
Fgf8 fibroblast growth factor 8 0.784
Gli2 GLI-Kruppel family member GLI2 0.748
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.746
Vegfa vascular endothelial growth factor A 0.718
Lef1 lymphoid enhancer binding factor 1 0.676
Emx1 empty spiracles homolog 1 (Drosophila) 0.665
Rb1 retinoblastoma 1 0.651
Pax6 paired box gene 6 0.649
Nkx1-2 NK1 transcription factor related, locus 2 (Drosophila) 0.629
Tbx3 T-box 3 0.620
Hand2 heart and neural crest derivatives expressed transcript 2 0.603
Lep leptin 0.598
Gata6 GATA binding protein 6 0.597
Pax9 paired box gene 9 0.582
Dll1 delta-like 1 (Drosophila) 0.566
Foxg1 forkhead box G1 0.544
Notch2 Notch gene homolog 2 (Drosophila) 0.528
Foxc1 forkhead box C1 0.527
Tbx2 T-box 2 0.523
Lmx1a LIM homeobox transcription factor 1 alpha 0.515
Kit kit oncogene 0.492
Fgfr1 fibroblast growth factor receptor 1 0.483
Psen1 presenilin 1 0.474
Bdnf brain derived neurotrophic factor 0.472
En1 engrailed 1 0.468
Tcf3 transcription factor 3 0.467
Gata4 GATA binding protein 4 0.445
Dlx5 distal-less homeobox 5 0.442
Hoxc6 homeobox C6 0.429
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.429
Igh immunoglobulin heavy chain complex 0.419
Hes1 hairy and enhancer of split 1 (Drosophila) 0.406
Ntf3 neurotrophin 3 0.403
Ctnnb1 catenin (cadherin associated protein), beta 1 0.382
Msx2 homeobox, msh-like 2 0.377
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.374
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.373
Hoxd13 homeobox D13 0.369
Hoxd11 homeobox D11 0.368
Fzd8 frizzled homolog 8 (Drosophila) 0.367
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.357
Hoxd3 homeobox D3 0.355
Gdnf glial cell line derived neurotrophic factor 0.353
Ptf1a pancreas specific transcription factor, 1a 0.351
Insm1 insulinoma-associated 1 0.349
Cd40 CD40 antigen 0.346
Phex phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) 0.343
Pdx1 pancreatic and duodenal homeobox 1 0.341
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.334
Hoxa2 homeobox A2 0.330
Lhx5 LIM homeobox protein 5 0.327
Hoxa1 homeobox A1 0.325
Vax1 ventral anterior homeobox containing gene 1 0.325
Sox7 SRY-box containing gene 7 0.321
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.304
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.303
Fgf15 fibroblast growth factor 15 0.303
Sox2 SRY-box containing gene 2 0.297
Hoxa13 homeobox A13 0.295
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.285
Adra2b adrenergic receptor, alpha 2b 0.282
Prrx2 paired related homeobox 2 0.279
Eya1 eyes absent 1 homolog (Drosophila) 0.278
Wt1 Wilms tumor 1 homolog 0.278
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.277
Tcf15 transcription factor 15 0.267
Uncx UNC homeobox 0.260
Nog noggin 0.247
Pthlh parathyroid hormone-like peptide 0.240
Ptprb protein tyrosine phosphatase, receptor type, B 0.239
Efna2 ephrin A2 0.237
Lhx1 LIM homeobox protein 1 0.232
Neurog2 neurogenin 2 0.228
Wnt1 wingless-related MMTV integration site 1 0.227
Myod1 myogenic differentiation 1 0.223
Tgfb2 transforming growth factor, beta 2 0.222
Apaf1 apoptotic peptidase activating factor 1 0.220
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.218
Ret ret proto-oncogene 0.216
Alx4 aristaless-like homeobox 4 0.213
Clcnka chloride channel Ka 0.211
Gja3 gap junction protein, alpha 3 0.210
Nkx6-1 NK6 homeobox 1 0.209
Lama5 laminin, alpha 5 0.207
Emx2 empty spiracles homolog 2 (Drosophila) 0.202
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Rattus norvegicus
Name Description Probability Func Analog Organism
Psap prosaposin 0.019
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.016
Slc29a2 solute carrier family 29 (nucleoside transporters), member 2 0.016
Ptprc protein tyrosine phosphatase, receptor type, C 0.016
Pdcl phosducin-like 0.014
Rnase1 ribonuclease, RNase A family, 1 (pancreatic) 0.014
Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog 0.014
Casp2 caspase 2 0.013
Nras neuroblastoma ras oncogene 0.013
Bcl2 B-cell CLL/lymphoma 2 0.013
Gja5 gap junction protein, alpha 5 0.012
Psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.012
Ptpn18 protein tyrosine phosphatase, non-receptor type 18 0.012
Casp8 caspase 8 0.012
Tspo translocator protein 0.012
Nlgn3 neuroligin 3 0.011
Nrarp Notch-regulated ankyrin repeat protein 0.011
Foxe1 forkhead box E1 (thyroid transcription factor 2) 0.011
Adar adenosine deaminase, RNA-specific 0.011
Crybb1 crystallin, beta B1 0.011
Skap2 src kinase associated phosphoprotein 2 0.011
Met met proto-oncogene 0.011
Parp14 poly (ADP-ribose) polymerase family, member 14 0.011
Dhfr dihydrofolate reductase 0.011
Itgb7 integrin, beta 7 0.011
A3galt2 alpha 1,3-galactosyltransferase 2 0.011
Olr837 olfactory receptor 837 0.010
Dchs1 dachsous 1 (Drosophila) 0.010
Cybb cytochrome b-245, beta polypeptide 0.010
Ctsc cathepsin C 0.010
Zp1 zona pellucida glycoprotein 1 (sperm receptor) 0.010
Hes5 hairy and enhancer of split 5 (Drosophila) 0.010
Ralgds ral guanine nucleotide dissociation stimulator 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism