The network for 'cellular macromolecule localization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular macromolecule localization

Any process in which a macromolecule is transported to, and/or maintained in, a specific location at the level of a cell. Localization at the cellular level encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.

Danio rerio
Name Description Probability Func Analog Organism
nanos3 nanos homolog 3 0.292
cdh1 cadherin 1, epithelial 0.169
nkx2.2a NK2 transcription factor related 2a 0.168
pitx3 paired-like homeodomain transcription factor 3 0.166
smad1 MAD homolog 1 (Drosophila) 0.148
igf1ra insulin-like growth factor 1a receptor 0.142
ccna2 cyclin A2 0.135
alcamb activated leukocyte cell adhesion molecule b 0.134
flot2a flotillin 2a 0.131
sept2 septin 2 0.127
arpc5a actin related protein 2/3 complex, subunit 5A 0.123
ddx46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.122
wnt11r wingless-type MMTV integration site family, member 11, related 0.118
met met proto-oncogene (hepatocyte growth factor receptor) 0.117
shhb sonic hedgehog b 0.108
lama2 laminin, alpha 2 0.107
hspa4a heat shock protein 4a 0.106
dag1 dystroglycan 1 0.097
pak2a p21 (CDKN1A)-activated kinase 2a 0.094
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.090
efnb2a ephrin B2a 0.085
acvr1b activin A receptor, type IB 0.084
lamb2 laminin, beta 2 (laminin S) 0.082
rangap1 Ran GTPase activating protein 1 0.081
pkd2 polycystic kidney disease 2 0.079
hsp90a.1 heat shock protein 90-alpha 1 0.078
nf1a neurofibromin 1a 0.077
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.075
lama4 laminin, alpha 4 0.075
cxcr4a chemokine (C-X-C motif) receptor 4a 0.071
sumo2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 0.068
mtp microsomal triglyceride transfer protein 0.068
snai1a snail homolog 1a (Drosophila) 0.067
arl6 ADP-ribosylation factor-like 6 0.066
acvr1l activin A receptor, type I like 0.064
ptch2 patched 2 0.063
atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.062
fgf3 fibroblast growth factor 3 0.061
rag1 recombination activating gene 1 0.061
ap2a1 adaptor-related protein complex 2, alpha 1 subunit 0.060
lamc1 laminin, gamma 1 0.059
neb nebulin 0.058
calb2b calbindin 2b, (calretinin) 0.057
krt8 keratin 8 0.057
rap1b RAS related protein 1b 0.056
rab1a RAB1A, member RAS oncogene family 0.056
ilk integrin linked kinase 0.056
itgb1b.2 integrin, beta 1b.2 0.055
ahctf1 AT hook containing transcription factor 1 0.055
sulf1 sulfatase 1 0.055
flncb filamin C, gamma b (actin binding protein 280) 0.054
pabpc1a poly A binding protein, cytoplasmic 1 a 0.054
cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 0.053
cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.053
sars seryl-tRNA synthetase 0.053
arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.052
pcna proliferating cell nuclear antigen 0.052
ef1a elongation factor 1-alpha 0.051
unc45b unc-45 homolog B (C. elegans) 0.050
tmem2 transmembrane protein 2 0.050
hsp90a.2 heat shock protein 90-alpha 2 0.050
mef2ca myocyte enhancer factor 2ca 0.048
csnk1da casein kinase 1, delta a 0.048
twist1a twist1a 0.048
fzd7b frizzled homolog 7b 0.047
myod1 myogenic differentiation 1 0.047
csrp1a cysteine and glycine-rich protein 1a 0.047
cntn1a contactin 1a 0.046
boc brother of CDO 0.046
musk muscle, skeletal, receptor tyrosine kinase 0.044
cd63 Cd63 antigen 0.044
bmp1a bone morphogenetic protein 1a 0.044
pwp2h PWP2 periodic tryptophan protein homolog (yeast) 0.043
foxa2 forkhead box A2 0.043
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.042
LOC100535549 cytoplasmic polyadenylation element-binding protein 4-like 0.042
nr3c1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.042
ilf2 interleukin enhancer binding factor 2 0.042
cntn1b contactin 1b 0.041
gnaia guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a 0.041
dlg2 discs, large (Drosophila) homolog 2 0.040
yap1 Yes-associated protein 1 0.040
chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 0.037
ywhaba tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a 0.037
cxcr4b chemokine (C-X-C motif), receptor 4b 0.037
aplnra apelin receptor a 0.036
fbn2b fibrillin 2b 0.036
ptgs1 prostaglandin-endoperoxide synthase 1 0.036
ppp2cb protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform 0.036
dcun1d5 DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae) 0.035
copa coatomer protein complex, subunit alpha 0.035
igf1rb insulin-like growth factor 1b receptor 0.035
sncgb synuclein, gamma b (breast cancer-specific protein 1) 0.035
per3 period homolog 3 (Drosophila) 0.035
arpc4 actin related protein 2/3 complex, subunit 4 0.035
cul1a cullin 1a 0.034
rhoab ras homolog gene family, member Ab 0.034
dkk1b dickkopf 1b 0.033
ube2i ubiquitin-conjugating enzyme E2I 0.033
zgc:153129 zgc:153129 0.033
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
mpk-1 Protein MPK-1 0.537
par-5 Protein PAR-5 0.335
atn-1 Protein ATN-1 0.307
zyg-8 Protein ZYG-8 0.302
D1081.8 Protein D1081.8 0.273
npp-7 Protein NPP-7 0.238
goa-1 Protein GOA-1 0.224
flh-1 Protein FLH-1 0.224
dnj-12 Protein DNJ-12 0.177
unc-52 Protein UNC-52 0.166
imb-2 Protein IMB-2 0.163
stam-1 Protein STAM-1 0.156
daf-3 Protein DAF-3 0.148
nphp-4 Protein NPHP-4 0.147
sem-5 Protein SEM-5 0.145
ftt-2 Protein FTT-2 0.144
egl-44 Protein EGL-44 0.141
cpt-1 Protein CPT-1 0.139
baf-1 Protein BAF-1 0.139
hcp-4 Protein HCP-4 0.137
F33H2.3 Protein F33H2.3 0.137
spc-1 Protein SPC-1 0.135
dsh-2 Protein DSH-2 0.133
unc-9 Protein UNC-9 0.125
hsp-1 Protein HSP-1 0.123
lin-25 Protein LIN-25 0.122
ZK418.9 Protein ZK418.9 0.120
npp-20 Protein NPP-20 0.111
glp-1 Protein GLP-1 0.106
arl-8 Protein ARL-8 0.105
zfp-1 Protein ZFP-1 0.103
rab-1 Protein RAB-1 0.102
sad-1 Protein SAD-1 0.101
syg-1 Protein SYG-1 0.101
snr-1 Protein SNR-1 0.100
ntl-4 Protein NTL-4 0.099
pdl-1 Protein PDL-1 0.099
egl-8 Protein EGL-8 0.098
egal-1 Protein EGAL-1 0.097
mbk-2 Protein MBK-2 0.097
cls-2 Protein CLS-2 0.097
gei-17 Protein GEI-17 0.096
sop-3 Protein SOP-3 0.096
spr-5 Protein SPR-5 0.093
mtr-4 Protein MTR-4 0.091
ajm-1 Protein AJM-1 0.091
rab-3 Protein RAB-3 0.089
swsn-4 Protein SWSN-4 0.089
F32B5.7 Protein F32B5.7 0.087
F33H1.4 Protein F33H1.4 0.085
npp-9 Protein NPP-9 0.084
csnk-1 Protein CSNK-1 0.083
rpn-1 Protein RPN-1 0.083
unc-83 Protein UNC-83 0.082
F10G8.8 Protein F10G8.8 0.082
unc-10 Protein UNC-10 0.081
hif-1 Protein HIF-1 0.080
T01C3.2 Protein T01C3.2 0.079
ain-1 Protein AIN-1 0.079
mig-2 Protein MIG-2 0.079
crn-5 Protein CRN-5 0.079
rpn-3 Protein RPN-3 0.078
unc-108 Protein UNC-108 0.078
T14B1.1 Protein T14B1.1 0.078
lron-3 Protein LRON-3 0.078
ess-2 Protein ESS-2 0.077
cab-1 Protein CAB-1 0.077
H43E16.1 Protein H43E16.1 0.077
F56D2.6 Protein F56D2.6 0.077
rpt-5 Protein RPT-5 0.075
unc-85 Protein UNC-85 0.074
glo-4 Protein GLO-4 0.074
unc-59 Protein UNC-59 0.074
let-502 Protein LET-502 0.074
cmd-1 Protein CMD-1 0.073
Y43H11AL.1 Protein Y43H11AL.1 0.073
hmp-1 Protein HMP-1 0.073
eat-18 Protein EAT-18 0.073
ldb-1 Protein LDB-1 0.073
mig-15 Protein MIG-15 0.072
lin-23 Protein LIN-23 0.071
hmg-1.2 Protein HMG-1.2 0.071
ZK858.6 Protein ZK858.6 0.071
chaf-1 Protein CHAF-1 0.070
let-60 Protein LET-60 0.069
spd-5 Protein SPD-5 0.069
pha-4 Protein PHA-4 0.069
pdi-3 Protein PDI-3 0.069
nap-1 Protein NAP-1 0.068
npl-4.2 Protein NPL-4.2 0.068
lag-1 Protein LAG-1 0.068
swsn-1 Protein SWSN-1 0.067
bbs-8 Protein BBS-8 0.067
ttm-4 Protein TTM-4 0.067
ubl-5 Protein UBL-5 0.066
lin-37 Protein LIN-37 0.066
sma-1 Protein SMA-1 0.066
dcr-1 Protein DCR-1 0.065
dpy-30 Protein DPY-30 0.065
mel-11 Protein MEL-11 0.064
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Rab11 Rab-protein 11 0.998
TER94 CG2331 gene product from transcript CG2331-RA 0.988
par-6 CG5884 gene product from transcript CG5884-RA 0.983
eya eyes absent 0.972
aPKC atypical protein kinase C 0.971
Mad Mothers against dpp 0.970
Rab5 Rab-protein 5 0.967
Ras85D Ras oncogene at 85D 0.955
cpb capping protein beta 0.950
cpa capping protein alpha 0.942
baz bazooka 0.929
Lam Lamin 0.927
BicD Bicaudal D 0.917
Dlic Dynein light intermediate chain 0.910
raps rapsynoid 0.908
Cdc42 CG12530 gene product from transcript CG12530-RA 0.907
rhea CG6831 gene product from transcript CG6831-RA 0.898
ens ensconsin 0.898
Hel25E Helicase at 25E 0.887
Rheb CG1081 gene product from transcript CG1081-RA 0.871
gbb glass bottom boat 0.854
Moe Moesin 0.842
ci cubitus interruptus 0.836
Act5C Actin 5C 0.832
asp abnormal spindle 0.825
slmb supernumerary limbs 0.823
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.812
Khc Kinesin heavy chain 0.765
sqh spaghetti squash 0.754
aux auxillin 0.737
ptc patched 0.734
Pp2B-14D Protein phosphatase 2B at 14D 0.713
Fs(2)Ket Female sterile (2) Ketel 0.700
Pi3K21B CG2699 gene product from transcript CG2699-RA 0.684
spn-E spindle E 0.678
fog folded gastrulation 0.669
Mer Merlin 0.646
hth homothorax 0.644
shn schnurri 0.638
phl pole hole 0.636
l(2)gl lethal (2) giant larvae 0.617
ecd ecdysoneless 0.616
Hrb27C Heterogeneous nuclear ribonucleoprotein at 27C 0.615
so sine oculis 0.609
mago mago nashi 0.608
Lis-1 Lissencephaly-1 0.607
beta4GalNAcTA CG8536 gene product from transcript CG8536-RA 0.604
sax saxophone 0.602
usp ultraspiracle 0.585
glo glorund 0.576
Pka-C1 cAMP-dependent protein kinase 1 0.572
LamC Lamin C 0.570
rok Rho-kinase 0.569
dm diminutive 0.561
tacc transforming acidic coiled-coil protein 0.561
aop anterior open 0.555
bsk basket 0.555
hpo hippo 0.554
lsn larsen 0.553
Myb Myb oncogene-like 0.549
Npc1a Niemann-Pick type C-1a 0.544
Aats-trp Tryptophanyl-tRNA synthetase 0.540
pum pumilio 0.538
gro groucho 0.537
trc tricornered 0.533
sqd squid 0.526
Ets97D Ets at 97D 0.523
RASSF8 CG5053 gene product from transcript CG5053-RA 0.515
Vps36 Vacuolar protein sorting 36 0.514
ninaE neither inactivation nor afterpotential E 0.512
Rac1 CG2248 gene product from transcript CG2248-RA 0.507
endos endosulfine 0.507
bs blistered 0.498
stck steamer duck 0.497
ebi CG4063 gene product from transcript CG4063-RA 0.497
sas-6 spindle assembly abnormal 6 0.489
msps mini spindles 0.484
Sir2 CG5216 gene product from transcript CG5216-RA 0.484
chic chickadee 0.472
Atg1 Autophagy-specific gene 1 0.471
sina seven in absentia 0.465
Rab6 Rab-protein 6 0.464
l(3)01239 lethal (3) 01239 0.464
rst roughest 0.459
msn misshapen 0.456
rl rolled 0.456
Pp1-87B Protein phosphatase 1 at 87B 0.455
ics icarus 0.452
TSG101 tumor suppressor protein 101 0.451
l(1)dd4 lethal (1) discs degenerate 4 0.449
dally division abnormally delayed 0.445
jagn jagunal 0.435
Cul-2 Cullin-2 0.427
Tif-IA CG3278 gene product from transcript CG3278-RA 0.424
Src64B Src oncogene at 64B 0.423
pita CG3941 gene product from transcript CG3941-RA 0.418
shot short stop 0.417
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.416
feo fascetto 0.415
stai stathmin 0.413
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.933
Gria2 glutamate receptor, ionotropic, AMPA 2 0.687
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.664
Rap1b RAP1B, member of RAS oncogene family 0.603
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.599
Mapk1 mitogen activated protein kinase 1 0.584
Myadm myeloid-associated differentiation marker 0.507
S100a10 S100 calcium binding protein A10 0.505
Rhoa ras homolog gene family, member A 0.488
Pfn1 profilin 1 0.478
Cltc clathrin, heavy chain (Hc) 0.431
Zranb2 zinc finger, RAN-binding domain containing 2 0.429
Actr3 ARP3 actin-related protein 3 homolog (yeast) 0.399
Hsph1 heat shock 105/110 protein 1 0.369
Grin2a glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.332
Cops7a COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) 0.303
Rraga Ras-related GTP binding A 0.302
Arpc1b actin related protein 2/3 complex, subunit 1B 0.298
Capza2 capping protein (actin filament) muscle Z-line, alpha 2 0.265
Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.255
Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 0.249
App amyloid beta (A4) precursor protein 0.227
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.219
Tpm3 tropomyosin 3, gamma 0.217
Rtn4 reticulon 4 0.216
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.215
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.212
Anxa2 annexin A2 0.209
Kctd13 potassium channel tetramerisation domain containing 13 0.208
Stip1 stress-induced phosphoprotein 1 0.206
Kif1b kinesin family member 1B 0.202
Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.198
Ppp2ca protein phosphatase 2, catalytic subunit, alpha isoform 0.197
Dlg1 discs, large homolog 1 (Drosophila) 0.196
Calm2 calmodulin 2 0.196
Grin1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.196
Gabarapl2 GABA(A) receptor-associated protein like 2 0.194
Cdc42 cell division cycle 42 (GTP binding protein) 0.193
Arf1 ADP-ribosylation factor 1 0.191
Itgb1 integrin, beta 1 0.188
Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha isoform 0.187
Grip2 glutamate receptor interacting protein 2 0.187
Ppp2r2c protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform 0.183
Wdr1 WD repeat domain 1 0.183
Kcna3 potassium voltage-gated channel, shaker-related subfamily, member 3 0.181
Nap1l1 nucleosome assembly protein 1-like 1 0.176
Ncdn neurochondrin 0.176
Anxa4 annexin A4 0.175
Col3a1 collagen, type III, alpha 1 0.174
Rhob ras homolog gene family, member B 0.174
Tcof1 Treacher Collins-Franceschetti syndrome 1 homolog (human) 0.172
Sumo1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.170
Jak2 Janus kinase 2 0.167
Ppp2r1a protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform 0.163
Snx6 sorting nexin 6 0.162
Psma2 proteasome (prosome, macropain) subunit, alpha type 2 0.159
Nlgn3 neuroligin 3 0.159
Acta2 smooth muscle alpha-actin 0.157
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.156
Nrxn3 neurexin 3 0.155
Zfand6 zinc finger, AN1-type domain 6 0.155
Kcnd2 potassium voltage-gated channel, Shal-related subfamily, member 2 0.154
Arpc2 actin related protein 2/3 complex, subunit 2 0.154
Csf3 colony stimulating factor 3 (granulocyte) 0.152
Rhoc ras homolog gene family, member C 0.151
Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.149
Actr2 ARP2 actin-related protein 2 homolog (yeast) 0.149
Stxbp1 syntaxin binding protein 1 0.148
Khdrbs1 KH domain containing, RNA binding, signal transduction associated 1 0.148
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.146
Stx12 syntaxin 12 0.141
Nrxn1 neurexin 1 0.141
Synj1 synaptojanin 1 0.140
Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 0.137
Mprip myosin phosphatase Rho interacting protein 0.137
Apbb1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.134
LOC100362824 caveolin 2-like 0.133
Pdc phosducin 0.133
Eif4a2 eukaryotic translation initiation factor 4A, isoform 2 0.133
Cdc37 cell division cycle 37 homolog (S. cerevisiae) 0.131
Dlgap3 discs, large (Drosophila) homolog-associated protein 3 0.131
Ctnnd2 catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein) 0.131
Stx1a syntaxin 1A (brain) 0.130
Pdcl phosducin-like 0.130
Pkia protein kinase (cAMP-dependent, catalytic) inhibitor alpha 0.129
Rab7a RAB7A, member RAS oncogene family 0.128
Jak1 Janus kinase 1 0.127
Sirpa signal-regulatory protein alpha 0.127
Akt1s1 AKT1 substrate 1 (proline-rich) 0.127
Pitpna phosphatidylinositol transfer protein, alpha 0.125
Atp6v0a1 ATPase, H+ transporting, lysosomal V0 subunit A1 0.124
Dnm1l dynamin 1-like 0.123
Pdcd6 programmed cell death 6 0.123
Dpysl3 dihydropyrimidinase-like 3 0.123
LOC100362155 cysteine and histidine rich 1 0.122
Clic1 chloride intracellular channel 1 0.121
Cask calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.120
Syt4 synaptotagmin IV 0.120
Dnajb1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.119
Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide 0.119
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism