The network for 'cardiac muscle fiber development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cardiac muscle fiber development

The process whose specific outcome is the progression of cardiac muscle fiber over time, from its formation to the mature structure.

Danio rerio
Name Description Probability Func Analog Organism
myod1 myogenic differentiation 1 0.942
myog myogenin 0.858
myf5 myogenic factor 5 0.655
tnnc1b troponin C type 1b (slow) 0.601
smyhc1 slow myosin heavy chain 1 0.488
ttna titin a 0.386
vmhc ventricular myosin heavy chain 0.358
myhz2 myosin, heavy polypeptide 2, fast muscle specific 0.332
unc45b unc-45 homolog B (C. elegans) 0.312
ttnb titin b 0.280
kdrl kinase insert domain receptor like 0.272
smyd1b SET and MYND domain containing 1b 0.268
tnni1al troponin I, skeletal, slow like 0.259
hsp90a.1 heat shock protein 90-alpha 1 0.251
hspb1 heat shock protein, alpha-crystallin-related, 1 0.173
tnni1b troponin I, skeletal, slow b 0.155
alcama activated leukocyte cell adhesion molecule a 0.127
bmp2b bone morphogenetic protein 2b 0.105
tcf12 transcription factor 12 0.105
xirp1 xin actin-binding repeat containing 1 0.105
rbfox1l RNA binding protein, fox-1 homolog (C. elegans) 1-like 0.104
mef2ca myocyte enhancer factor 2ca 0.101
podxl podocalyxin-like 0.100
cdh2 cadherin 2, neuronal 0.098
acta2 actin, alpha 2, smooth muscle, aorta 0.087
smyhc2 slow myosin heavy chain 2 0.087
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.086
actn3a actinin alpha 3a 0.081
mylz2 myosin, light polypeptide 2, skeletal muscle 0.077
gata6 GATA-binding protein 6 0.061
nppa natriuretic peptide precursor A 0.061
myhz1.1 myosin, heavy polypeptide 1.1, skeletal muscle 0.059
actn3b actinin alpha 3b 0.058
fabp2 fatty acid binding protein 2, intestinal 0.057
ntn2 netrin 2 0.057
aldoab aldolase a, fructose-bisphosphate, b 0.057
apobec2a apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a 0.054
desma desmin a 0.054
scn4ab sodium channel, voltage-gated, type IV, alpha, b 0.052
lbx2 ladybird homeobox homolog 2 (Drosophila) 0.052
fxr2 fragile X mental retardation, autosomal homolog 2 0.047
synpo2lb synaptopodin 2-like b 0.047
actn2 actinin, alpha 2 0.044
lft1 lefty1 0.041
tpm2 tropomyosin 2 (beta) 0.041
nova2 neuro-oncological ventral antigen 2 0.040
tpma alpha-tropomyosin 0.039
tnni2a.4 troponin I, skeletal, fast 2a.4 0.039
fgf10a fibroblast growth factor 10a 0.039
dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) 0.038
myhz1.2 myosin, heavy polypeptide 1.2, skeletal muscle 0.037
efnb2a ephrin B2a 0.035
zgc:66286 zgc:66286 0.035
zgc:171553 zgc:171553 0.033
vcana versican a 0.033
tnnt1 troponin T1, skeletal, slow 0.031
eng1a engrailed 1a 0.031
pcdh8 protocadherin 8 0.030
smyhc3 slow myosin heavy chain 3 0.028
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.028
col2a1a collagen type II, alpha-1a 0.027
popdc2 popeye domain containing 2 0.027
ptprsa protein tyrosine phosphatase, receptor type, s, a 0.026
syt11a synaptotagmin XIa 0.026
ryr3 ryanodine receptor 3 0.026
acta1a actin, alpha 1a, skeletal muscle 0.026
dlx3b distal-less homeobox gene 3b 0.025
prdm1a PR domain containing 1a, with ZNF domain 0.025
stac3 SH3 and cysteine rich domain 3 0.025
chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 0.024
pdlim7 PDZ and LIM domain 7 0.023
tbx5a T-box 5a 0.022
jam2a junctional adhesion molecule 2a 0.022
si:ch211-57k11.10 si:ch211-57k11.10 0.021
notch3 notch homolog 3 0.020
spry4 sprouty (Drosophila) homolog 4 0.020
actc1a actin, alpha, cardiac muscle 1a 0.020
duox dual oxidase 0.020
lamb2 laminin, beta 2 (laminin S) 0.019
txlnba taxilin beta a 0.018
gata5 GATA-binding protein 5 0.018
jam3b junctional adhesion molecule 3b 0.018
hhip hedgehog interacting protein 0.018
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.018
fn1 fibronectin 1 0.018
zgc:92429 zgc:92429 0.017
tgfb3 transforming growth factor, beta 3 0.017
wtip Wilms tumor 1 interacting protein 0.017
sox9a SRY-box containing gene 9a 0.017
ndrg4 N-myc downstream regulated gene 4 0.016
flncb filamin C, gamma b (actin binding protein 280) 0.016
rnasel1 ribonuclease like 1 0.015
pbx1a pre-B-cell leukemia transcription factor 1a 0.015
acta1b actin, alpha 1b, skeletal muscle 0.015
srl sarcalumenin 0.015
ntn1a netrin 1a 0.015
pparg peroxisome proliferator activated receptor gamma 0.015
pitx2 paired-like homeodomain transcription factor 2 0.015
ddx46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.015
pcdh2ac protocadherin 2 alpha c 0.014
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
TRIM63 tripartite motif containing 63 0.769
NEB nebulin 0.743
BMPR1A bone morphogenetic protein receptor, type IA 0.730
NRP1 neuropilin 1 0.706
FLNA filamin A, alpha 0.597
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.512
MYOZ1 myozenin 1 0.409
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.397
TTN titin 0.365
CAPN3 calpain 3, (p94) 0.246
TCAP titin-cap (telethonin) 0.216
FSTL1 follistatin-like 1 0.136
OBSL1 obscurin-like 1 0.096
ACTA2 actin, alpha 2, smooth muscle, aorta 0.080
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.053
MYL9 myosin, light chain 9, regulatory 0.053
MSN moesin 0.044
ASCC2 activating signal cointegrator 1 complex subunit 2 0.036
ACTN2 actinin, alpha 2 0.030
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.027
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.027
ANK1 ankyrin 1, erythrocytic 0.021
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.020
DDIT4 DNA-damage-inducible transcript 4 0.017
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.015
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.015
MYPN myopalladin 0.014
PBX1 pre-B-cell leukemia homeobox 1 0.014
GFI1B growth factor independent 1B transcription repressor 0.014
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 0.013
UBASH3B ubiquitin associated and SH3 domain containing B 0.013
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.012
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.012
NOG noggin 0.012
TRPM6 transient receptor potential cation channel, subfamily M, member 6 0.011
CDH5 cadherin 5, type 2 (vascular endothelium) 0.011
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.010
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.010
TPM4 tropomyosin 4 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Nos3 nitric oxide synthase 3, endothelial cell 0.970
Fgfr2 fibroblast growth factor receptor 2 0.944
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.930
Shh sonic hedgehog 0.922
Kdr kinase insert domain protein receptor 0.906
Tgfb2 transforming growth factor, beta 2 0.861
Fgf8 fibroblast growth factor 8 0.852
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.833
Gata6 GATA binding protein 6 0.797
Hand2 heart and neural crest derivatives expressed transcript 2 0.792
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.772
Flt4 FMS-like tyrosine kinase 4 0.759
Gata4 GATA binding protein 4 0.753
Pitx2 paired-like homeodomain transcription factor 2 0.740
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.709
Foxc2 forkhead box C2 0.616
Foxc1 forkhead box C1 0.577
Pax3 paired box gene 3 0.474
Ednra endothelin receptor type A 0.470
Rxra retinoid X receptor alpha 0.446
Vegfa vascular endothelial growth factor A 0.426
Cldn5 claudin 5 0.418
Hrc histidine rich calcium binding protein 0.410
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.394
Meox2 mesenchyme homeobox 2 0.387
Acvr1 activin A receptor, type 1 0.328
Sox9 SRY-box containing gene 9 0.327
Bmp4 bone morphogenetic protein 4 0.277
Tnni2 troponin I, skeletal, fast 2 0.275
Flt1 FMS-like tyrosine kinase 1 0.272
Jag1 jagged 1 0.270
Rarb retinoic acid receptor, beta 0.246
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.233
Ece1 endothelin converting enzyme 1 0.230
Notch2 Notch gene homolog 2 (Drosophila) 0.214
Tgfbr2 transforming growth factor, beta receptor II 0.212
Sox18 SRY-box containing gene 18 0.211
Myl3 myosin, light polypeptide 3 0.204
Tnnt3 troponin T3, skeletal, fast 0.197
Rarg retinoic acid receptor, gamma 0.192
Tbx1 T-box 1 0.191
Fgfr1 fibroblast growth factor receptor 1 0.189
Ptprb protein tyrosine phosphatase, receptor type, B 0.185
Tbx3 T-box 3 0.180
Chrd chordin 0.150
Ldb3 LIM domain binding 3 0.144
Ckmt2 creatine kinase, mitochondrial 2 0.139
Jup junction plakoglobin 0.137
Tek endothelial-specific receptor tyrosine kinase 0.131
Ckm creatine kinase, muscle 0.127
Chrm2 cholinergic receptor, muscarinic 2, cardiac 0.122
Ctnnb1 catenin (cadherin associated protein), beta 1 0.121
Tnnc2 troponin C2, fast 0.118
Isl1 ISL1 transcription factor, LIM/homeodomain 0.115
Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 0.113
Egfr epidermal growth factor receptor 0.112
Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta 0.110
Nrp1 neuropilin 1 0.109
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.109
Cox8b cytochrome c oxidase, subunit VIIIb 0.107
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.103
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.102
Eng endoglin 0.101
Art1 ADP-ribosyltransferase 1 0.096
Cnn1 calponin 1 0.096
Gpc3 glypican 3 0.094
Myl7 myosin, light polypeptide 7, regulatory 0.092
Itga8 integrin alpha 8 0.091
Cox6a2 cytochrome c oxidase, subunit VI a, polypeptide 2 0.089
Rasip1 Ras interacting protein 1 0.088
Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.086
Actn2 actinin alpha 2 0.086
Csrp3 cysteine and glycine-rich protein 3 0.085
Kcnk3 potassium channel, subfamily K, member 3 0.084
Gja1 gap junction protein, alpha 1 0.079
Slc9a3r2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.077
Nos1 nitric oxide synthase 1, neuronal 0.076
Gja4 gap junction protein, alpha 4 0.075
Lama5 laminin, alpha 5 0.072
Tbx5 T-box 5 0.072
Sox4 SRY-box containing gene 4 0.071
Cav1 caveolin 1, caveolae protein 0.070
Des desmin 0.070
Pgam2 phosphoglycerate mutase 2 0.070
Emcn endomucin 0.069
Bmp6 bone morphogenetic protein 6 0.068
Myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.067
Actb actin, beta 0.065
Clec3b C-type lectin domain family 3, member b 0.064
Col1a1 collagen, type I, alpha 1 0.063
Bmpr1a bone morphogenetic protein receptor, type 1A 0.063
Smo smoothened homolog (Drosophila) 0.062
Cacna1s calcium channel, voltage-dependent, L type, alpha 1S subunit 0.061
Sgcg sarcoglycan, gamma (dystrophin-associated glycoprotein) 0.060
Myom1 myomesin 1 0.059
Xirp1 xin actin-binding repeat containing 1 0.059
Myl1 myosin, light polypeptide 1 0.059
Ramp2 receptor (calcitonin) activity modifying protein 2 0.058
She src homology 2 domain-containing transforming protein E 0.057
Cdh5 cadherin 5 0.057
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism